Article
Biochemistry & Molecular Biology
Laeticia Scherler, Sofia N. Verouti, Daniel Ackermann, Bruno Vogt, Genevieve Escher
Summary: In this study, adenine was used to induce nephropathy in mice, showing the loss of protective effects of renal cholesterol and vitamin D-3 metabolism under this condition. It was found that adenine enhanced cholesterol efflux and eliminated lipids in feces, which had a protective effect against atherosclerosis but also affected bone growth.
Article
Immunology
Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Summary: Research shows that PINK1 protein plays a crucial role in modulating the immune response during EAE, potentially contributing to the pathogenesis of neuroinflammatory and other associated conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Heather S. Hain, Rahul Pandey, Marina Bakay, Bryan P. Strenkowski, Danielle Harrington, Micah Romer, William W. Motley, Jian Li, Eunjoo Lancaster, Lindsay Roth, Judith B. Grinspan, Steven S. Scherer, Hakon Hakonarson
Summary: CLEC16A plays a role in autophagy/mitophagy processes and its genetic variants are implicated in multiple autoimmune diseases. Inducible whole-body knockout of Clec16a in mice resulted in an inflammatory neurodegenerative phenotype resembling spinocerebellar ataxia. The study suggests a potential link between CLEC16A, ISG15, and downstream autoimmune and inflammatory processes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Xi Cheng, Yu Tang, D. J. Vidyadhara, Ben-Zheng Li, Michael Zimmerman, Alexandr Pak, Sanghamitra Nareddula, Paige Alyssa Edens, Sreeganga S. Chandra, Alexander A. Chubykin
Summary: The lack of auxilin leads to deficits in presynaptic plasticity and visual cortical functions, as well as affecting eye movement responses. This suggests that abnormalities in presynaptic endocytosis function may have an impact in the early stages of Parkinson's disease.
Article
Medicine, Research & Experimental
Jie Gao, Nian Zhou, Yongkang Wu, Mengna Lu, Qixue Wang, Chenyi Xia, Mingmei Zhou, Ying Xu
Summary: PS cDKO mice show metabolic and microbiotic changes at both early and mature ages, with disturbed metabolic pathways involving glycine, serine and threonine metabolism, glyoxylate and dicarboxylate metabolism, pentose and glucuronate interconversions, starch and sucrose metabolism, and citrate cycle. The altered gut microbiota, including increases in Lactobacillus and decreases in norank_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, Mucispirillum, and Odoribacter, are associated with differential metabolite levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Jianxiang Xue, Linto Thomas, Sathish Kumar Murali, Moshe Levi, Robert A. Fenton, Jessica A. Dominguez Rieg, Timo Rieg
Summary: Intestinal NHE3 has a significant contribution to P-i homeostasis. In contrast to effects described for tenapanor on P-i homeostasis, NHE3(IEC-KO) mice show enhanced, rather than reduced, intestinal P-i uptake.
Article
Biochemistry & Molecular Biology
Krisztina Nikovics, Cedric Castellarin, Xavier Holy, Marjorie Durand, Halima Morin, Abdelhafid Bendahmane, Anne-Laure Favier
Summary: Understanding bone homeostasis and regeneration is of great clinical and scientific importance for the development of bone therapy. Macrophages play a crucial role in bone regeneration during healing. In situ hybridization and hybridization chain reaction can be used to explore gene expression in bone tissues.
Article
Cell Biology
Andrea Maset, Marco Albanesi, Antonio di Soccio, Martina Canova, Marco dal Maschio, Claudia Lodovichi
Summary: The LRRK2 gene is a major genetic determinant of familiar Parkinson's disease and plays a crucial role in intracellular signaling pathways. Studies in mice with a null mutation in the LRRK2 gene show deficits in olfactory behavior and significant impairments in gamma rhythms and odorant-evoked activity at the circuit level.
Article
Nutrition & Dietetics
Heidi L. Collins, Steven J. Adelman, Dustie N. Butteiger, Jonathan D. Bortz
Summary: The objective of this study was to determine the effect of choline supplementation on atherosclerosis progression in Apoe(-/-) mice expressing human cholesterol ester transfer protein (hCETP). The results showed that despite increased plasma TMAO levels, choline supplementation did not promote atherosclerosis development.
Review
Biochemistry & Molecular Biology
Krisztina Nikovics, Anne-Laure Favier
Summary: Understanding the pivotal role of macrophages in inflammation and tissue regeneration post-injury is crucial. Recent advancements in macrophage biology studies have revealed distinctive features of in vivo macrophages, emphasizing the importance of precise characterization for developing new healing treatments. Improvements in in situ macrophage identification using antigen surface markers and cytokine secretion identification have led to specific patterns in macrophage characterization.
Article
Pharmacology & Pharmacy
Delma Veron, Pardeep K. Aggarwal, Qi Li, Gilbert Moeckel, Michael Kashgarian, Alda Tufro
Summary: Vascular endothelial growth factor-a (VEGF-A) and nitric oxide (NO) play crucial roles in maintaining the homeostasis of the glomerular filtration barrier, and their dysregulation is observed in diabetic kidney disease (DKD). In this study, the authors investigated the effects of inducible podocyte VEGF-A knockdown (VEGF(KD)) in diabetic mice and endothelial nitric oxide synthase knockout mice (eNOS(-/-)). The findings showed that podocyte VEGF-A and eNOS deficiency resulted in diffuse glomerulosclerosis in mice, and compensatory NO and thiol generation prevented severe proteinuria and glomerular filtration rate (GFR) loss in VEGF(KD) diabetic mice with intact eNOS. On the other hand, induction of VEGF(KD) in eNOS(-/-):VEGF(KD) mice led to massive proteinuria and renal failure, resembling DKD in the absence of diabetes. The study also identified abnormal S-nitrosylation of certain proteins as a potential mechanism underlying the development of advanced glomerulosclerosis and renal failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seon-Young Park, Hyejin Yang, Soyoung Kim, Juwon Yang, Hyemin Go, Hyunsu Bae
Summary: This study proposes a strategy for alpha-syn specific Treg expansion and demonstrates its neuroprotective effects on Parkinson's disease in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shigeto Sato, Sachiko Noda, Satoru Torii, Taku Amo, Aya Ikeda, Manabu Funayama, Junji Yamaguchi, Takahiro Fukuda, Hiromi Kondo, Norihiro Tada, Satoko Arakawa, Masahiko Watanabe, Yasuo Uchiyama, Shigeomi Shimizu, Nobutaka Hattori
Summary: The inactivation of constitutive autophagy leads to the formation of cytoplasmic inclusions in neurons. The relationship between impaired autophagy and Lewy bodies (LBs) remains unknown. Studies have shown that p62 aggregates derived from an autophagic defect might serve as 'seeds' for LB formation, while CHCHD2 protein regulates mitochondrial morphology and p62 homeostasis by controlling the level of OPA1, impacting inclusion body formation and dopaminergic neuronal loss in an age-dependent manner.
HUMAN MOLECULAR GENETICS
(2021)
Article
Neurosciences
Ryan J. Keenan, Sara Oberrauch, Romke Bron, Cameron J. Nowell, Leesa M. Challis, Daniel Hoyer, Laura H. Jacobson
Summary: The research indicates that tau protein may impact the orexin system, including LC OX(1)Rs, shedding light on the mechanism of sleep/wake disturbances in AD and FTD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Bao Ngoc Tran, Lucie Valek, Annett Wilken-Schmitz, Dominik Christian Fuhrmann, Dimitry Namgaladze, Ilka Wittig, Irmgard Tegeder
Summary: The study showed that Nucleoredoxin plays a crucial role in neuronal function, impacting neuronal plasticity and synaptic protein activity. Mice deficient in synaptic protein Nestin-NXN-/- displayed normal behavior in tests, but showed reduced interest in rewards.
Article
Endocrinology & Metabolism
Yue Liu, Zhiguo Xie, Xiaoxiao Sun, Yanfei Wang, Yang Xiao, Shuoming Luo, Gan Huang, Xia Li, Ying Xia, Zhiguang Zhou
Summary: This study aimed to establish a systematic screening strategy to select candidates for genetic testing among patients with maturity-onset diabetes of the young. A total of 1279 participants were successfully screened using the AACM strategy, with mutations found in a small portion of the cohort. Whole-exome sequencing was used to identify gene mutations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Endocrinology & Metabolism
Shan Pan, Mengyu Li, Haibo Yu, Zhiguo Xie, Xia Li, Xianlan Duan, Gan Huang, Zhiguang Zhou
Summary: In this study, miR-143-3p expression was found to be upregulated in ADM patients, with FOSL2 identified as its target gene. By modulating FOSL2, miR-143-3p may participate in the pathogenesis of ADM by regulating the inflammatory reaction.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Yan Chen, Ying Xia, Zhiguo Xie, Ting Zhong, Rong Tang, Xia Li, Zhiguang Zhou
Summary: This study aimed to investigate the association between PR status and HLA genotypes in patients with T1D. The results showed that patients carrying susceptible HLA genotypes were less prone to undergo PR, and the recovery extent of beta-cell function during the PR phase was lower in adults.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Jiaqi Li, Lifang Li, Xiaoxiao Sun, Tuo Deng, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: Epigenetic modifications, particularly DNA methylation regulated by TET enzymes, play crucial roles in regulating gene expression and have been implicated in the development of autoimmune and autoinflammatory diseases. The TET family proteins, especially Tet2, function as gene regulators and have potential as antitumor drug targets due to their ability to oxidize methylcytosine to hydroxymethylcytosine. Further research on Tet2 in immune response regulation and its effects on inflammatory gene expression may provide new therapeutic targets for related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Haipeng Pang, Xiaoxiao Sun, Shuoming Luo, Jian Lin, Xiajie Shi, Yang Xiao, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: This study found that the CARDS gene SNP rs2043211 was significantly associated with GADA positivity in T1DM patients, but the polymorphisms of rs10403848 and rs2043211 were not associated with susceptibility to T1DM.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Haipeng Pang, Shuoming Luo, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: The study aimed to quantitatively assess the relationship between polymorphisms rs231775 and rs3087243 of CTLA-4 gene and LADA through meta-analysis, revealing significant associations between these polymorphisms and the risk of LADA. Subgroup analyses also indicated positive associations between rs231775 and LADA in different ethnic groups, suggesting potential risk factors and genetic biomarkers for LADA.
BIOCHEMICAL GENETICS
(2022)
Article
Endocrinology & Metabolism
Junlin Qiu, Xia Li, Wen Chen, Xiaoxi Ma, Zhiguo Xie, Gan Huang, Shuoming Luo, Zhiguang Zhou
Summary: The study found that the fulminant index (FI), specifically the ratio of K+ to HbA1c (K+/HbA1c), was the most effective indicator for distinguishing FT1D from initial DKA patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Review
Cell Biology
Jiaqi Li, Lifang Li, Yimeng Wang, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: Autoimmune diseases, affecting approximately 5% of the global population, are influenced by both environmental and genetic risk factors. Despite gaps in understanding disease pathogenesis, diagnosis, and treatment, DNA methylation modifications are gaining attention as potential biomarkers for these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Haipeng Pang, Jian Lin, Shuoming Luo, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: This article discusses the genetic factors and development mechanism of type 1 diabetes (T1D), emphasizing the role of genetics and the environment in its onset. Identified susceptible loci only have a small effect on the risk, and there is a phenomenon of "missing heritability". Further research on the genetics of T1D may provide new insights and therapeutic targets.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yan Chen, Qianrong Wang, Zhiguo Xie, Gan Huang, Li Fan, Xia Li, Zhiguang Zhou
Summary: The aim of this study was to investigate the impact of family history of type 2 diabetes (T2D) on the clinical phenotypes of patients with idiopathic type 1 diabetes (T1D). The results showed that idiopathic T1D patients with a family history of T2D were more likely to have features associated with T2D and better beta-cell function. The impact of T2D family history was consistently observed in idiopathic T1D patients regardless of HLA genotypes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Immunology
Haipeng Pang, Wenqi Fan, Xiajie Shi, Shuoming Luo, Yimeng Wang, Jian Lin, Yang Xiao, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou
Summary: This study identified the expression profiles of exosomal circRNA in T1DM patients for the first time and revealed their potential functions in T1DM. Additionally, the study found that the interactions between circRNA, miRNA, and genes may be involved in the progression of the disease.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Wenqi Fan, Xixi Nan, Yiman Peng, Xia Li, Yufei Xiang, Xiang Yan, Zhiguo Xie, Houde Zhou, Xiaohan Tang, Jin Cheng, Xiaohong Niu, Jing Liu, Qiuhe Ji, Linong Ji, Gan Huang, Zhiguang Zhou
Summary: This study investigated the distribution of IA-2A and ZnT8A in patients with T1D and LAD, as well as their association with clinical characteristics and HLA-DR-DQ genes. The results showed that IA-2A exhibited a bimodal distribution in T1D and LAD patients, and the presence of IA-2A could demonstrate partial LAD clinical characteristics. ZnT8A titre had a certain predictive value for islet functions in patients with LAD.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Ying Xia, Yan Chen, Xia Li, Shuoming Luo, Jian Lin, Gan Huang, Yang Xiao, Zhiying Chen, Zhiguo Xie, Zhiguang Zhou
Summary: This study investigated whether HLA Class I loci differentially modulated the risk for and clinical features of Chinese people with classic T1D and LADA. The findings showed that Class I alleles had distinct effects on the risk and clinical features of classic T1D compared to LADA. These Class I variants could serve as additional markers in future screening among Chinese people.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yan Chen, Yuting Xie, Ying Xia, Zhiguo Xie, Gan Huang, Li Fan, Zhiguang Zhou, Xia Li
Summary: Investigated the frequency, clinical characteristics, and HLA genotypes of idiopathic type 1 diabetes (T1D), finding that idiopathic T1D represents approximately 1/4 of newly diagnosed T1D cases and is associated with older age, higher body mass index, lower HbA1c, higher fasting and postprandial C-peptide levels, and a higher likelihood of having a family history of type 2 diabetes. Additionally, adult-onset and preserved beta-cell function patients with idiopathic T1D show lower HLA susceptibility.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Rong Song, Lingxiang Xie, Jin Ding, Yan Chen, Hailan Zou, Haipeng Pang, Yiman Peng, Ying Xia, Zhiguo Xie, Xia Li, Yang Xiao, Zhiguang Zhou, Jingyi Hu
Summary: The RPS26 gene rs1131017 polymorphism is associated with susceptibility to type 1 diabetes mellitus and LADA in the Chinese Han population, but not with type 2 diabetes mellitus. It is also correlated with clinical features of these diabetes types.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)