Enhanced phosphate absorption in intestinal epithelial cell‐specific NHE3 knockout mice

Significant Species Differences in Intestinal Phosphate Absorption between Dogs, Rats, and Monkeys

(2020) Yasuhiro ICHIDA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner.

(2020) Nobuhiro Hashimoto et al.   KIDNEY INTERNATIONAL

An inducible intestinal epithelial cell-specific NHE3 knockout mouse model mimicking congenital sodium diarrhea

(2020) Jianxiang Xue et al.   CLINICAL SCIENCE

EOS789, a novel pan-phosphate transporter inhibitor, is effective for the treatment of chronic kidney disease– mineral bone disorder.

(2020) Yoshinori Tsuboi et al.   KIDNEY INTERNATIONAL

Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease

(2020) Yasuhiro Ichida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

EOS789, a broad-spectrum inhibitor of phosphate transport, is safe with an indication of efficacy in a phase 1b randomized crossover trial in hemodialysis patients

(2020) Kathleen M. Hill Gallant et al.   KIDNEY INTERNATIONAL

Adenylyl cyclase 6 expression is essential for cholera toxin-induced diarrhea

(2019) Robert A Fenton et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy and Safety of Tenapanor in Patients with Hyperphosphatemia Receiving Maintenance Hemodialysis: A Randomized Phase 3 Trial

(2019) Geoffrey A. Block et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Paracellular transport of phosphate along the intestine

(2019) Thomas Knöpfel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Congenital Sodium Diarrhea by mutation of the SLC9A3 gene

(2019) Georges Dimitrov et al.   European Journal of Medical Genetics

Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function

(2019) Linto Thomas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Good publication practice in physiology 2019

(2019) Pontus B. Persson   Acta Physiologica

Expression, Localization, and Effect of High Salt Intake on Electroneutral Na+/HCO3– Cotransporter NBCn2 in Rat Small Intestine: Implication in Intestinal NaCl Absorption

(2019) Jin-Lin Wang et al.   Frontiers in Physiology

The effects of tenapanor on serum fibroblast growth factor 23 in patients receiving hemodialysis with hyperphosphatemia

(2018) Geoffrey A Block et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of variations in dietary Pi intake on intestinal Pi transporters (NaPi-IIb, PiT-1, and PiT-2) and phosphate-regulating factors (PTH, FGF-23, and MEPE)

(2018) Tatiana Martins Aniteli et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone cores formation in mice

(2018) Hiroo Tanaka et al.   JOURNAL OF HEPATOLOGY

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

(2018) Andrew J. King et al.   Science Translational Medicine

Contribution of NHE3 and dietary phosphate to lithium pharmacokinetics

(2018) Linto Thomas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis

(2017) Robert A. Fenton et al.   KIDNEY INTERNATIONAL

Expression profiling and immunolocalization of Na+-d-glucose-cotransporter 1 in mice employing knockout mice as specificity control indicate novel locations and differences between mice and rats

(2017) Ivana Vrhovac Madunić et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A phase 1 study of the safety, tolerability, pharmacodynamics, and pharmacokinetics of tenapanor in healthy Japanese volunteers

(2016) Susanne Johansson et al.   Clinical and Experimental Nephrology

Tenapanor hydrochloride for the treatment of constipation-predominant irritable bowel syndrome

(2015) Marta Zielińska et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Intestinal Depletion of NaPi-IIb/Slc34 a2 in Mice: Renal and Hormonal Adaptation

(2015) Nati Hernando et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD

(2014) E. D. Labonte et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Phosphate Wasting in the Absence of Adenylyl Cyclase 6

(2014) R. A. Fenton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intestinal Inhibition of the Na+/H+ Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na+ Uptake in Humans

(2014) A. G. Spencer et al.   Science Translational Medicine

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver X receptor-activating ligands modulate renal and intestinal sodium–phosphate transporters

(2011) Yupanqui A. Caldas et al.   KIDNEY INTERNATIONAL

Intestinal Npt2b Plays a Major Role in Phosphate Absorption and Homeostasis

(2009) Y. Sabbagh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY