Review
Cell Biology
Amrita Kulkarni, Kumari Preeti, Kamatham Pushpa Tryphena, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri
Summary: Protein dyshomeostasis plays a key role in age-related neurodegenerative disorders, such as Parkinson's disease, characterized by the deposition of Lewy bodies composed of alpha-synuclein protein aggregates. The proper functioning of proteostasis, including unfolded protein response, ubiquitin-proteasome system, and autophagy-lysosome pathway, is crucial for protein synthesis, folding, confirmation, and degradation. Mutational changes in the genes involved in these pathways, as well as epigenetic modifications and microRNA-mediated transcriptional changes, contribute to proteostasis dysregulation. Defective proteostasis leads to the deposition of proteins, which can serve as potential biomarkers for early diagnosis of Parkinson's disease. Targeting different aspects of proteostasis machinery holds promise for delaying the accumulation of pathological hallmarks.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Lixue Lin, Yuye Lan, He Zhu, Lingling Yu, Shuang Wu, Wangyixuan Wan, Yang Shu, Hongchun Xiang, Tengfei Hou, Hong Zhang, Yan Ma, Wen Su, Man Li
Summary: In TS mice, chemogenetic inhibition of D1R- or D2R-containing neurons in the SNpc and dSTR alleviated stereotyped behavior and motor dysfunctions. On the other hand, activation of D1R-containing neurons in the dSTR may worsen stereotyped behavior in TS. This provides new targets for treatment and further studies on the pathogenesis of TS.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Anais Marie, Julien Leroy, Morgane Darricau, Serge Alfos, Veronique De Smedt-Peyrusse, Emmanuel Richard, Sylvie Vancassel, Clementine Bosch-Bouju
Summary: Vitamin A supplementation partially alleviates motor alterations and improves striatal function in a rat model of PD, suggesting a potential beneficial preventive approach for the disease.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Jiang-Peng Fan, Hui-Zhen Geng, Ya-Wei Ji, Tao Jia, Jennifer B. Treweek, An-An Li, Chun-Yi Zhou, Viviana Gradinaru, Cheng Xiao
Summary: Key components in the nigrostriatal DA system exhibit distinct aging patterns and may contribute to age-related alterations in locomotion and coordination.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Kamil Pradel, Gniewosz Drwiega, Tomasz Blasiak
Summary: Dopaminergic neurons in the midbrain are controlled by various brain structures, with the superior colliculus providing sensory input to the contralateral rostromedial tegmental nucleus (RMTg), an inhibitory input to dopaminergic neurons. Activation of the contralateral superior colliculus excites RMTg neurons, while stimulation of the ipsilateral side leads to both excitatory and inhibitory responses, suggesting a role of this pathway in orienting and motivation-driven locomotion of animals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Adelie Salin, Virginie Lardeux, Marcello Solinas, Pauline Belujon
Summary: This study found that dopamine activity in the VTA is decreased in rats with extended access to cocaine, while there were no changes in dopamine activity in the SNc. These changes in VTA dopamine activity may contribute to the negative emotional state and the incubation of drug seeking during abstinence.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The present study investigated the effects of apelin on the spontaneous firing activity of nigral dopaminergic neurons and found that it may serve as a neuroprotective factor in Parkinson's disease.
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The neuropeptide apelin modulates the firing activity of nigral dopaminergic neurons and may serve as a neuroprotective factor in Parkinson's disease.
Article
Neurosciences
Vignayanandam Ravindernath-Jayashree Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, V. Srinivasa Chakravarthy
Summary: Parkinson's disease is caused by the progressive loss of dopaminergic cells in the substantia nigra pars compacta, possibly linked to metabolic deficiency. L-DOPA treatment for PD may have toxic effects on neurons. A proposed computational model aims to investigate the mechanism behind neurodegeneration and offer insights for therapeutic development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R. Vickstrom, Vladislav Friedman, Thomas J. Kelly, Xiaowen Bai, Li Zhao, Cecilia J. Hillard, Qing-Song Liu
Summary: The selective CB2 agonist GW842166x has protective effects against 6-OHDA-induced loss of dopamine neurons and associated motor deficits in mice, potentially through modulation of dopamine neuron firing activity. The neuroprotective effects of GW842166x were prevented by the CB2 receptor antagonist AM630, indicating a CB2-dependent mechanism. Electrophysiological recordings suggest that GW842166x may reduce dopamine neuron vulnerability to 6-OHDA by decreasing action potential firing and associated calcium load.
Article
Clinical Neurology
Ernest W. W. Wang, Gregory L. L. Brown, Mechelle M. M. Lewis, Leslie C. C. Jellen, Cunfeng Pu, Melinda L. L. Johnson, Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huang
Summary: This retrospective study found that susceptibility MRI metrics in the substantia nigra pars compacta (SNc) are associated with glial density and tau burden, key neuropathologic features in parkinsonism. The results highlight the importance of MRI in assessing the pathological characteristics of SNc in Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Young Hee Sung, Young Noh, Eung Yeop Kim
Summary: Thin-section neuromelanin-sensitive MRI provides insights into the affected regions of the substantia nigra pars compacta in early-stage Parkinson's disease, with specific areas (nigrosome 1 and 2) showing significant spatial differences between patients and healthy subjects.
HUMAN BRAIN MAPPING
(2021)
Article
Biology
Sage S. Frehner, Kip T. Dooley, Michelle C. Palumbo, Aaron L. Smith, Mark M. Goodman, Karen L. Bales, Sara M. Freeman
Summary: This study found significantly lower levels of OXTR in females with autism compared to other groups. There were no differences in mRNA levels for either gene across the four groups. These results suggest that dysregulation in OXTR protein translation or increased OXTR internalization/recycling may contribute to the differences in social symptoms seen in females with autism.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yining Gao, Hongxia Li, Huoqing Luo, You Ni, Yifan Feng, Lu He, Qinming Zhou, Ji Hu, Sheng Chen
Summary: This study investigated the underlying mechanisms of movement disorders caused by anti-IgLON5 antibodies. The results showed that mice injected with these antibodies exhibited persistent movement impairments for up to 3 months, which may be related to impaired dopaminergic pathway and neurodegenerative changes induced by the antibodies.
Article
Biochemistry & Molecular Biology
Kathryn L. Todd, Janusz Lipski, Peter S. Freestone
Summary: This study identified a distinct population of dopamine neurons that project to the tail region of the striatum, separate from the classic nigrostriatal pathway. The tail striatum was found to have lower basal and evoked dopamine levels, as well as diverse dopamine release kinetics compared to the dorsolateral striatum. Stimulation of the subthalamic nucleus (STN) exclusively evoked dopamine release in the tail striatum, likely mediated by the SNL. These findings suggest the existence of a novel dopamine pathway to the tail striatum, largely independent of the classic nigrostriatal pathway, and highlight the STN as an important modulator of dopamine release in this pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Salvatore Novello, Daniela Mercatelli, Federica Albanese, Chiara Domenicale, Alberto Brugnoli, Elisabetta D'Aversa, Silvia Vantaggiato, Sandra Dovero, Valentina Murtaj, Luca Presotto, Monica Borgatti, Derya R. Shimshek, Erwan Bezard, Rosa Maria Moresco, Sara Belloli, Michele Morari
Summary: The G2019S mutation of LRRK2 increases the risk of idiopathic Parkinson's disease and enhances susceptibility to environmental toxins through increased kinase activity. LRRK2 kinase inhibitors have neuroprotective effects in a mouse model.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Erwan Bezard
Summary: This opinion paper addresses the issue of conceptual sloppiness and poor methodological characterization in Parkinson's disease research, emphasizing its negative impact on progress and proposing a remedy.
Article
Neurosciences
Florent Laferriere, Stephane Claverol, Erwan Bezard, Francesca De Giorgi, Francois Ichas
Summary: The principal component of Lewy bodies and glial cytoplasmic inclusions is aggregated alpha-synuclein, and the inclusion bodies may cause cell death through the sequestration of partner proteins and organelles. Furthermore, the study found that the sarkosyl-insoluble proteomes of Parkinson's disease and multiple system atrophy have a significant overlap, consisting mainly of mitochondrial and neuronal synaptic proteins. Other fibrillization-prone proteins possibly cross-seeded by alpha-syn are not found in these extracts.
NPJ PARKINSONS DISEASE
(2022)
Article
Cell Biology
Marie-Laure Arotcarena, Federico N. Soria, Anthony Cunha, Evelyne Doudnikoff, Geoffrey Prevot, Jonathan Daniel, Mireille Blanchard-Desce, Philippe Barthelemy, Erwan Bezard, Sylvie Crauste-Manciet, Benjamin Dehay
Summary: Researchers have discovered that acidic nanoparticles can improve neurodegeneration and restore lysosomal function in Parkinson's disease, offering a new treatment strategy for this and other age-related proteinopathies.
Article
Clinical Neurology
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G. Meissner, Maria Trinidad Herrero, Miquel Vila, Jose A. Obeso, Erwan Bezard, Benjamin Dehay
Summary: Synucleinopathies, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, are characterized by the deposit of alpha-synuclein aggregates in neurons and glial cells. A study found that inoculating brain fractions containing glial cytoplasmic inclusions from multiple system atrophy patients into non-human primates resulted in neurodegeneration, oligodendrocyte loss, demyelination, neuroinflammation and alpha-synuclein pathology. These findings suggest the potential use of this experimental model for multiple system atrophy research and therapy development.
Article
Clinical Neurology
Leyre Merino-Galan, Haritz Jimenez-Urbieta, Marta Zamarbide, Tatiana Rodriguez-Chinchilla, Arantzazu Belloso-Iguerategui, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Ana Aiastui, Evelyne Doudnikoff, Erwan Bezard, Alberto Ouro, Shira Knafo, Belen Gago, Ana Quiroga-Varela, Maria Cruz Rodriguez-Oroz
Summary: In Parkinson's disease, synaptic impairment may occur before neuronal degeneration. By studying a rat model, we found that synaptic energetic failure and accumulation of dysfunctional organelles are the earliest events that happen at dopaminergic terminals, preceding structural changes and cell death. We also identified key proteins involved in these earliest functional abnormalities, which could be targeted for therapeutic interventions to delay or prevent the development of Parkinson's disease.
Article
Biochemistry & Molecular Biology
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferriere, Sebastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, Francois Ichas
Summary: The distinct neuropathological features and inclusion bodies in different alpha-Synucleinopathies reflect the strain diversity of invasive alpha-Syn amyloids. However, the contribution of non-amyloid factors to specific diseases is still uncertain. In Multiple System Atrophy, alpha-Syn inclusions in oligodendrocytes seem to result from the storage of amyloid aggregates pre-assembled in neurons. These inclusions originate from unique molecular properties or other factors dysregulated in MSA.
Article
Neurosciences
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andren
Summary: L-DOPA administration is the primary treatment for Parkinson's disease, but long-term use can cause a hyperkinetic side-effect called L-DOPA-induced dyskinesia. The severity of dyskinesia is correlated with the levels of specific abnormally processed peptides, such as des-tyrosine dynorphins, substance P (1-7), and substance P (1-9). The levels of active neuropeptides are associated with the concentration of L-DOPA in the putamen, while truncated neuropeptides are correlated with dyskinesia severity.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Morgane Darricau, Taxiarchis Katsinelos, Flavio Raschella, Tomislav Milekovic, Louis Crochemore, Qin Li, Gregoire Courtine, William A. McEwan, Benjamin Dehay, Erwan Bezard, Vincent Planche
Summary: This study demonstrates that progressive supranuclear palsy (PSP) patient-derived tau aggregates can induce motor and behavioral impairments in non-human primates, showing characteristics of prion-like seeding and spreading of PSP lesions. This pilot study paves the way for using PSP tau-injected macaques as a relevant animal model to accelerate drug development for this rare and fatal neurodegenerative disease.
Article
Neurosciences
Max Rybarski, David Mrohs, Katharina Osenberg, Maren Hemmersbach, Katharina Pfeffel, Joy Steinkamp, David Schmidt, Karina Violou, Ruth Schaening, Katja Schmidtke, Verian Bader, Michael Andriske, Pauline Bohne, Melanie D. Mark, Konstanze F. Winklhofer, Hermann Luebbert, Xin-Ran Zhu
Summary: Increasing evidence suggests the crucial role of astrocytes in the progression of Parkinson's disease (PD). This study reveals that parkin deletion in mesencephalic astrocytes impairs the differentiation of mesencephalic neurons and leads to the accumulation of damaged mitochondria. The upregulation of ER Ca2+-binding protein RCN1 and its role in ER-associated calcium dyshomeostasis highlight the importance of astrocyte function in PD pathomechanisms.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Juan Estaun-Panzano, Marie-Laure Arotcarena, Erwan Bezard
Summary: Synucleinopathies are a group of diseases characterized by the misfolding and aggregation of alpha-synuclein, leading to the formation of Lewy bodies. Studying the aggregation of alpha-synuclein is crucial for understanding these diseases, and recent breakthroughs have provided new insights into their mechanisms.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Neurosciences
Erwan Bezard, David Gray, Rouba Kozak, Matthew Leoni, Cari Combs, Sridhar Duvvuri
Summary: Currently available therapeutics for PD do not provide sustained and predictable relief from motor symptoms without significant adverse events (AEs). There is a need for a treatment that can effectively relieve motor symptoms with reduced risk of AEs.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemical Research Methods
Ibrahim Kaya, Luke S. Schembri, Anna Nilsson, Reza Shariatgorji, Sooraj Baijnath, Xiaoqun Zhang, Erwan Bezard, Per Svenningsson, Luke R. Odell, Per E. Andren
Summary: This study presents an on-tissue chemical derivatization MALDI mass spectrometry imaging approach for the comprehensive mapping of carboxyls and aldehydes in brain tissue sections. The approach successfully detected and imaged various carboxyl and aldehyde-containing endogenous metabolites simultaneously. The methodology provides a powerful tool for sensitive and simultaneous spatial molecular imaging of numerous aldehydes and carboxylic acids during pathological states in brain tissue.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Clinical Neurology
Miguel Lopez-Cuina, Paul Guerin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard
Summary: This study demonstrates that lowering brain GRK2 levels through delivery of a GRK2-specific miRNA can reverse central nervous system insulin resistance and provide neuroprotection in a mouse model of multiple system atrophy. These findings suggest that GRK2 may be a potential therapeutic target for the treatment of MSA.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Ibrahim Kaya, Anna Nilsson, Dominika Luptakova, Yachao He, Theodosia Vallianatou, Patrik Bjarterot, Per Svenningsson, Erwan Bezard, Per E. Andren
Summary: Metabolism of MPTP leads to the neurotoxin MPP+, which causes Parkinson's disease-like symptoms by destroying dopaminergic neurons in the brain. This study used mass spectrometry imaging to analyze glycerophospholipids and sphingolipids in monkey brains and found dysregulation of sulfatide metabolism in the MPTP-lesioned brain regions. Depletion of long-chain hydroxylated sulfatides suggests oxidative stress and damage to myelin in these regions. These findings contribute to our understanding of the molecular pathology of MPTP-induced parkinsonism and provide a basis for further research on dysregulated sulfatide metabolism in Parkinson's disease.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
