Article
Biochemistry & Molecular Biology
Guangjin Gu, Bin Zhu, Jie Ren, Xiaomeng Song, Baoyou Fan, Han Ding, Jun Shang, Heng Wu, Junjin Li, Hongda Wang, Jinze Li, Zhijian Wei, Shiqing Feng
Summary: This study aimed to investigate whether activating the Ang-(1-7)/MasR axis can regulate local neuroinflammation to achieve functional recovery after SCI. The results showed that activating the Ang-(1-7)/MasR axis can effectively improve the inflammatory microenvironment after spinal cord injury, promote the polarization of microglia/macrophages towards the M2 phenotype, and support the recovery of motor function. Therefore, using Ang-(1-7) as a treatment strategy for spinal cord injury is suggested to minimize the negative consequences of the inflammatory microenvironment.
CELL AND BIOSCIENCE
(2023)
Review
Neurosciences
Soshi Samejima, Richard Henderson, Jared Pradarelli, Sarah E. Mondello, Chet T. Moritz
Summary: Spinal cord injuries often result in permanent physical impairments despite being incomplete disruptions. However, remaining connections between the brain and spinal cord can induce neural plasticity to improve sensorimotor function, even years post-injury. This review provides an overview of evidence for motor recovery, plasticity, and interventions in spinal cord stimulation for motor control restoration. It discusses both open-loop and closed-loop stimulation approaches, as well as mechanisms of spinal cord neuromodulation for sensorimotor recovery, aiming to advance rehabilitation for spinal cord injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Zhao, Ailang Pang, Saige Yin, Meifeng Yang, Xuemei Zhang, Rong Zhang, Jingfei Liu, Yuanqi Gu, Shanshan Li, Yan Hu, Yue Zhang, Yingchun Ba, Buliang Meng, Xinwang Yang
Summary: OM-LV20 promotes structural and functional recovery of spinal cord injury by increasing neuronal survival, enhancing BDNF and TrkB expression, and regulating oxidative stress balance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: This study investigated the effects of Top1 inhibition in a spinal cord injury (SCI) model. The results showed that administration of the Top1 inhibitor CPT improved locomotor functional recovery, reduced neuronal loss, and decreased neutrophil infiltration in mice with SCI. Additionally, CPT inhibited pyroptosis and suppressed neuroinflammation both in vivo and in vitro.
Article
Neurosciences
Wei-wei Deng, Guang-yan Wu, Ling-xia Min, Zhou Feng, Hui Chen, Ming-liang Tan, Jian-feng Sui, Hong-liang Liu, Jing-ming Hou
Summary: Activation of glutamate neurons in the primary motor cortex can significantly improve motor function scores in rats, shorten the incubation period of motor evoked potentials, and increase motor potentials' amplitude. Accurate activation of the primary motor cortex can effectively promote tissue recovery and neurofilament growth, while also increasing the content of some growth-related proteins at the injured site. These findings suggest that selective activation of glutamate neurons in the primary motor cortex may play a significant role in promoting functional recovery after SCI and understanding the neural cell mechanism involved in recovery induced by motor cortex stimulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Ilyas M. Kabdesh, Svetlana S. Arkhipova, Yana O. Mukhamedshina, Victoria James, Albert A. Rizvanov, Yuri A. Chelyshev
Summary: NG2/CSPG4-expressing cells play an important role in neuroregeneration and synaptic plasticity, with a specific response pattern observed in spinal cord injury.
Article
Clinical Neurology
Chun-Qiu Dai, Ming Gao, Xiao-Dong Lin, Bai-Jie Xue, Ying Liang, Mu-Lan Xu, Xiang-Bo Wu, Gui-Qing Cheng, Xu Hu, Chen-Guang Zhao, Hua Yuan, Xiao-Long Sun
Summary: After SCI, the excitability of the M1 lower extremity area decreases or disappears. The M1 hand area of SCI patients encodes the activity information of both the upper and lower extremities. The characteristics of M1 hand area CSE changes after SCI and its correlation with extremities motor function are still unknown.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Conor McHugh, Clare Taylor, David Mockler, Neil Fleming
Summary: A systematic review evaluated the efficacy of epidural spinal cord stimulation (ESCS) for improving motor function in individuals with spinal cord injury (SCI). While most studies reported some improvement in motor activity with ESCS, the quality of reviewed studies was found to be poor and data heterogeneity prevented a meta-analysis. Therefore, the therapeutic efficacy of ESCS remains inconclusive.
NEUROREHABILITATION
(2021)
Article
Medicine, Research & Experimental
Zili He, Jiqing Du, Yu Zhang, Yitie Xu, Qian Huang, Qingwei Zhou, Min Wu, Yao Li, Xie Zhang, Hongyu Zhang, Yuepiao Cai, Keyong Ye, Xiangyang Wang, Yingze Zhang, Qi Han, Jian Xiao
Summary: Increasing evidence suggests that defects in autophagy and autophagy-lysosomal pathway (ALP) may contribute to endothelial barrier disruption following acute traumatic spinal cord injury (SCI). This study investigates whether Kruppel-like factor 2 (KLF2) coordinates ALP in endothelial cells in SCI. The results demonstrate that KLF2 is a key contributor to SCI-mediated ALP dysfunction and blood-spinal cord barrier (BSCB) disruption, and could be a promising pharmacological target for SCI management and treatment.
Article
Clinical Neurology
Chengcai Li, Shaoxin Huang, Wu Zhou, Zhiping Xie, Shenke Xie, Meihua Li
Summary: This study investigated the molecular and cellular biological changes in the cerebellum after spinal cord injury (SCI). The results showed that SCI can lead to secondary changes in the cerebellum, which may affect functional recovery. These findings provide potential biomarkers for evaluating secondary changes in the brain after SCI.
WORLD NEUROSURGERY
(2022)
Article
Chemistry, Multidisciplinary
Taoyang Yuan, Yu Shao, Xu Zhou, Qian Liu, Zhichao Zhu, Bini Zhou, Yuanchen Dong, Nicholas Stephanopoulos, Songbai Gui, Hao Yan, Dongsheng Liu
Summary: Researchers have developed a DNA hydrogel to repair spinal cord gap in rats, promoting proliferation and differentiation of stem cells for functional recovery. This hydrogel system shows great potential in clinical trials and could be adaptable to other tissue regeneration applications.
ADVANCED MATERIALS
(2021)
Article
Medicine, General & Internal
Ricardo Siu, Edward H. Brown, Samineh Mesbah, Federica Gonnelli, Tanvi Pisolkar, V. Reggie Edgerton, Alexander V. Ovechkin, Yury P. Gerasimenko
Summary: This study conducted a case-study to test a neuro-rehabilitative approach that combines multi-segmental spinal cord transcutaneous electrical stimulation (scTS) with locomotor training for a chronic spinal cord injury (SCI) patient. The results suggest that this approach can improve kinematics and promote locomotor recovery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Ashmwe, Katja Posa, Alexander Ruehrnoessl, Johannes Christoph Heinzel, Patrick Heimel, Michael Mock, Barbara Schaedl, Claudia Keibl, Sebastien Couillard-Despres, Heinz Redl, Rainer Mittermayr, David Hercher
Summary: This study investigated the effects of low-energy ESWT on recovery in spinal cord injury and identified changes in miRNA expression patterns. The results showed that ESWT significantly improved motor function in both subacute and chronic experimental settings.
Article
Neurosciences
Ilyas M. Kabdesh, Yana O. Mukhamedshina, Svetlana S. Arkhipova, Davran K. Sabirov, Maxim S. Kuznecov, Alexandra B. Vyshtakalyuk, Albert A. Rizvanov, Victoria James, Yuri A. Chelyshev
Summary: This study investigated cellular and molecular gradients following spinal cord injury (SCI) using a rat contusion model. The expression of NG2, astrocyte markers, and axonal markers was analyzed at different distances from the injury site on 7 and 30 days post-injury (dpi). The results showed a gradient of NG2 expression, with the highest concentrations near the injury site. The expression of astrocyte markers increased close to the injury site but spread more distally by 30 dpi. Surprisingly, the expression of the perisynaptic marker GLT-1 increased in remote areas. The number of 5-HT+ axons decreased in the caudal direction, consistent with a decrease in beta 3-tubulin. These findings indicate significant cellular and molecular reactions in both the damaged area and adjacent and remote areas, which is important for assessing axonal growth.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Urmi Sengupta, Marcos J. Guerrero-Munoz, Diana L. Castillo-Carranza, Cristian A. Lasagna-Reeves, Julia E. Gerson, Adriana A. Paulucci-Holthauzen, Shashirekha Krishnamurthy, Malika Farhed, George R. Jackson, Rakez Kayed
BIOLOGICAL PSYCHIATRY
(2015)
Article
Cell Biology
Poonam Desai, Jun Yang, Bing Tian, Hong Sun, Mridul Kalita, Hyunsu Ju, Adriana Paulucci-Holthauzen, Yingxin Zhao, Allan R. Brasier, Rovshan G. Sadygov
CELLULAR SIGNALLING
(2015)
Article
Neurosciences
J. R. Perez-Polo, H. C. Rea, K. M. Johnson, M. A. Parsley, G. C. Unabia, G. -Y. Xu, D. Prough, D. S. DeWitt, A. A. Paulucci-Holthauzen, K. Werrbach-Perez, C. E. Hulsebosch
JOURNAL OF NEUROSCIENCE RESEARCH
(2016)
Article
Virology
Jesus A. Silvas, Vsevolod L. Popov, Adriana Paulucci-Holthauzen, Patricia V. Aguilar
JOURNAL OF VIROLOGY
(2016)
Article
Neurosciences
You-Qing Cai, Wei Wang, Adriana Paulucci-Holthauzen, Zhizhong Z. Pan
JOURNAL OF NEUROSCIENCE
(2018)
Article
Microbiology
Vasudevan Achuthan, Jill M. Perreira, Gregory A. Sowd, Maritza Puray-Chavez, William M. McDougall, Adriana Paulucci-Holthauzen, Xiaolin Wu, Hind J. Fadel, Eric M. Poeschla, Asha S. Multani, Stephen H. Hughes, Stefan G. Sarafianos, Abraham L. Brass, Alan N. Engelman
CELL HOST & MICROBE
(2018)
Article
Biochemistry & Molecular Biology
Kyoung-Jae Choi, Phoebe S. Tsoi, Mandi Muhammad Moosa, Adriana Paulucci-Holthauzen, Shih-Chu Jeff Liao, Josephine C. Ferreon, Allan Chris M. Ferreon
Article
Oncology
Anantha L. Marisetty, Li Lu, Bethany L. Veo, Bin Liu, Cristian Coarfa, Mohamed Mostafa Kamal, Dina Hamada Kassem, Khushboo Irshad, Yungang Lu, Joy Gumin, Verlene Henry, Adriana Paulucci-Holthauzen, Ganesh Rao, Veerabhadran Baladandayuthapani, Frederick F. Lang, Gregory N. Fuller, Sadhan Majumder
Article
Neurosciences
Anna Yu-Szu Huang, Junsung Woo, Debosmita Sardar, Brittney Lozzi, Navish A. Bosquez Huerta, Chia-Ching John Lin, Daniela Felice, Antrix Jain, Adriana Paulucci-Holthauzen, Benjamin Deneen
Article
Biochemistry & Molecular Biology
Min Huang, Xu Feng, Dan Su, Gang Wang, Chao Wang, Mengfan Tang, Adriana Paulucci-Holthauzen, Traver Hart, Junjie Chen
Article
Cell Biology
Ryan Baumert, Hong Ji, Adriana Paulucci-Holthauzen, Aaron Wolfe, Cari Sagum, Louis Hodgson, Jyothi Arikkath, Xiaojiang Chen, Mark T. Bedford, M. Neal Waxham, Pierre D. McCrea
JOURNAL OF CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash, Timothy C. Thompson
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Xin Zhou, Allyson Beilter, Zhaohui Xu, Ruli Gao, Shunbin Xiong, Adriana Paulucci-Holthauzen, Guillermina Lozano, Benoit de Crombrugghe, Richard Gorlick
Summary: This study identified chondrocytes as an additional source for mesenchymal progenitor cells (MPCs) and showed that Wnt/ss-catenin pathway discretely regulates the development from chondrocytes to C-MPC and subsequently from C-MPC to osteoblasts. Furthermore, the study unveiled a previously unrecognized functional link between ss-catenin and p53, with p53 playing a negative role in MPC osteogenic differentiation induced by Wnt/ss-catenin signaling.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Vanja Krneta-Stankic, Mark E. Corkins, Adriana Paulucci-Holthauzen, Malgorzata Kloc, Andrew B. Gladden, Rachel K. Miller
Summary: The study reveals that Daam1 plays a critical role in regulating E-cadherin-based intercellular adhesion, affecting the assembly and disassembly of cell contacts, and thus impacting the development and homeostasis of epithelial tissues.
Article
Neurosciences
Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, Pierre D. McCrea
Summary: Dendritic arborization is crucial for neuronal connectivity and function, and abnormal morphology is linked to neurological disorders. This study investigates the impact of four proteins involved in cytoskeletal remodeling on dendrite morphology, revealing their distinct roles. The expression of p120-catenin and delta-catenin correlates with increased dendritic length and branching, ARVCF-catenin has no observable effect, and p0071-catenin is associated with increased dendritic branching. These findings highlight the shared and unique roles of these proteins in dendrite morphogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
