Article
Pharmacology & Pharmacy
Sehwan Kim, Gyeong Joon Moon, Hyung Jun Kim, Do-Geun Kim, Jaekwang Kim, Youngpyo Nam, Chanchal Sharma, Eunju Leem, Shinrye Lee, Kyu-Sung Kim, Chang Man Ha, Catriona McLean, Byung Kwan Jin, Won-Ho Shin, Dong Woon Kim, Yong-Seok Oh, Chang-Won Hong, Sang Ryong Kim
Summary: This study found that pKr-2 was up-regulated in the hippocampi of patients with AD and 5XFAD mice, but not associated with amyloid-beta aggregation in 5XFAD mice. The up-regulation of pKr-2 expression was inhibited by preserving the blood-brain barrier, which reduced neurotoxic symptoms in 5XFAD mice such as hippocampal neurodegeneration and object memory decline.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuan Du, Eimear M. Byrne, Mei Chen, Heping Xu
Summary: The therapeutic potential of minocycline in a chronic model of AMD was investigated. The results showed that long-term minocycline treatment is safe and effective in controlling microglial activation and preserving visual function.
Article
Biochemistry & Molecular Biology
Jae Yeong Jeong, Rayul Wi, Young Cheul Chung, Byung Kwan Jin
Summary: The study investigated the expression of endogenous interleukin-13 (IL-13) in the hippocampus of prothrombin kringle-2 (pKr-2)-lesioned rats. The results show that IL-13 levels increased after pKr-2 injection, primarily in activated microglia/macrophages and neutrophils. Blocking IL-13 led to neuroprotection and inhibited oxidative damage, suggesting that endogenous IL-13 expressed in activated immune cells may be harmful to hippocampal neurons via oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Emma K. A. Schmidt, Pamela J. F. Raposo, Abel Torres-Espin, Keith K. Fenrich, Karim Fouad
Summary: The synthetic tetracycline derivative minocycline has been shown to have anti-inflammatory and neuroprotective properties, with potential therapeutic effects on central nervous system diseases and injuries. This study demonstrated that minocycline can improve gut dysbiosis and immune responses following spinal cord injury, which in turn may reduce anxiety-like behavior. However, while minocycline attenuated microglial activation, it did not impact lesion size or promote motor recovery.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Matea Juric, Varun Rawat, Radhika Amaradhi, Jacek Zielonka, Thota Ganesh
Summary: In this study, a new Nox2 inhibitor, TG15-132, was discovered to prevent oxygen consumption and reactive oxygen species formation. It also showed inhibitory effects on the expression of inflammatory cytokines and iNOS. TG15-132 has a relatively long plasma half-life and excellent brain permeability, making it a potential neuroprotective agent. Furthermore, it does not exhibit toxicity on vital organs or blood biomarkers.
Article
Medicine, Research & Experimental
Yazdan Naderi, Sara Khosraviani, Saba Nasiri, Fahimeh Hajiaghaei, Ehsan Aali, Tannaz Jamialahmadi, Maciej Banach, Amirhossein Sahebkar
Summary: The study evaluated the cardioprotective effects of minocycline against doxorubicin-induced cardiotoxicity in adult male rats. Results showed that minocycline significantly decreased the activity of lactate dehydrogenase and creatine kinase MB, while increasing the activity of catalase and superoxide dismutase in cardiac tissue. Minocycline also reduced the levels of malondialdehyde, TNF-alpha, and IL-18 in cardiac tissue, and alleviated the tissue damage caused by doxorubicin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Article
Immunology
Riccardo De Marco, Andrew W. Barritt, Mara Cercignani, Giulia Cabbai, Alessandro Colasanti, Neil A. Harrison
Summary: Inflammation can rapidly change motivational state and impair mood, leading to avoidance of pleasurable activities and increased sensitivity to negative stimuli, which can result in major depressive episodes. This study investigated whether minocycline inhibits the effects of lipopolysaccharide on reward/punishment sensitivity in humans, and found that it attenuated the inflammation-induced shift in reward versus punishment sensitivity.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Ryan J. Worthen, Eleonore Beurel
Summary: Postpartum depression is a common psychiatric complication associated with pregnancy and childbirth, negatively impacting the mother's quality of life and potentially affecting the child's development. It shares similarities with major depressive disorder and is linked to inflammation theory, with dysregulation and hyperactivation of the body's immune response to stress as contributing factors. The stress and changes faced by new mothers can harm critical brain systems, impair neuronal growth and repair, and alter mood and cognition.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Rania Z. ElGamal, Mariane G. Tadros, Esther T. Menze
Summary: This study evaluates the neuroprotective effects of the DPP4 inhibitor linagliptin in a rotenone-induced rat model of Parkinson's disease. The results show that linagliptin can prevent motor deficits and tissue damage caused by rotenone through anti-inflammatory, anti-apoptotic, and antioxidant mechanisms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katrin Colleselli, Anna Stierschneider, Christoph Wiesner
Summary: While inflammation is crucial for human survival in response to infection and injury, prolonged inflammation can be fatal. Toll-like receptors (TLRs) are important in initiating inflammatory processes, and TLR2, in particular, has been extensively studied and known to recognize a wide range of pathogens through heterodimerization. However, many unanswered questions still remain about the mechanisms of TLR2 in both health and disease. This review provides an up-to-date overview of TLR2, including its homo- and heterodimers, and discusses its pro- and anti-inflammatory properties and recent findings in infectious and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Run Jin, Aidan Kai Yeung Chan, Jingsong Wu, Tatia Mei Chun Lee
Summary: The review discusses the potential mechanisms and strategies for ameliorating age-related neurocognitive changes associated with inflammation, providing important insights for understanding the pathophysiological mechanisms of neurocognitive disorders and developing preventative measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, Jose Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jaattela, Terje Johansen, Gabor Juhasz, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Munz, Josef M. Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola
Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.
Article
Biochemistry & Molecular Biology
Larisa Chernyaeva, Giorgio Ratti, Laura Teirila, Satoshi Fudo, Uni Rankka, Anssi Pelkonen, Paula Korhonen, Katarzyna Leskinen, Salla Keskitalo, Kari Salokas, Christina Gkolfinopoulou, Katrina E. Crompton, Matti Javanainen, Lotta Happonen, Markku Varjosalo, Tarja Malm, Ville Leinonen, Angeliki Chroni, Paivi Saavalainen, Seppo Meri, Tommi Kajander, Adam J. M. Wollman, Eija Nissila, Karita Haapasalo
Summary: By studying the interaction between apoE4 and FH, it was found that this interaction affects the neurotoxicity and clearance of A beta 1-42, which is related to AD pathogenesis. ApoE and FH reduce the binding of A beta 1-42 to CR3 and the subsequent phagocytosis by microglia, leading to changes in gene expression related to AD. FH forms complement-resistant oligomers with apoE/A beta 1-42 complexes, and the formation of these complexes is isoform specific, with apoE2 and apoE3 having higher affinity to FH than apoE4. These complexes reduce A beta 1-42 oligomerization and toxicity, and colocalize with C1q on A beta plaques in the brain, providing important insights into AD pathogenesis and how the strongest genetic risk factor for AD predisposes to neuroinflammation in the early stages of the disease pathology.
Article
Clinical Neurology
Rachel E. James Bates, Eleanor Browne, Renee Schalks, Heather Jacobs, Li Tan, Puja Parekh, Roberta Magliozzi, Massimiliano Calabrese, Nicholas D. Mazarakis, Richard Reynolds
Summary: This study suggests that persistent increased levels of lymphotoxin-alpha in the cerebral meninges can lead to the formation of lymphoid-like structures and subsequent neurodegenerative and demyelinating pathology, similar to that seen in the progressive multiple sclerosis brain.
Article
Oncology
Yoon Kyung Jo, Na Yeon Park, Ji Hyun Shin, Doo Sin Jo, Ji-Eun Bae, Eun Sun Choi, Sungho Maeng, Hong Bae Jeon, Seon Ae Roh, Jong Wook Chang, Jin Cheon Kim, Dong-Hyung Cho
ANTICANCER RESEARCH
(2018)
Article
Geriatrics & Gerontology
Ju-Young Lee, Bitna Joo, Jin Han Nam, Hye Yeon Nam, Wonil Lee, Youngpyo Nam, Yongtaek Seo, Hye-Jin Kang, Hyun-Ji Cho, Young Pyo Jang, Jeongyeon Kim, Young-Man We, Ja Wook Koo, Hyang-Sook Hoe
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Jeong Yeob Baek, Jae Yeong Jeong, Kyoung In Kim, So-Yoon Won, Young Cheul Chung, Jin Han Nam, Eun Ju Cho, Tae-Beom Ahn, Eugene Bok, Won-Ho Shin, Byung Kwan Jin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Immunology
Ju-Young Lee, Jin Han Nam, Youngpyo Nam, Hye Yeon Nam, Gwangho Yoon, Eunhwa Ko, Sang-Bum Kim, Mahealani R. Bautista, Christina C. Capule, Takaoki Koyanagi, Geoffray Leriche, Hwan Geun Choi, Jerry Yang, Jeongyeon Kim, Hyang-Sook Hoe
JOURNAL OF NEUROINFLAMMATION
(2018)
Review
Biotechnology & Applied Microbiology
Haiyan Nan, Chanbum Park, Sungho Maeng
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Neurosciences
Kyoung In Kim, Jeong Yeob Baek, Young Cheul Chung, Jin Han Nam, Won-Ho Shin, Byung Kwan Jin
Summary: This study demonstrates that astrocytes produce endogenous CNTF through TRPV1-p70S6K signaling, which plays a neuroprotective role in Parkinson's disease. The findings suggest that targeting astrocytic TRPV1-p70S6K signaling may be a novel therapeutic strategy for PD.
Article
Neurosciences
Jinhan Nam, Tapani K. Koppinen, Merja H. Voutilainen
Summary: This study demonstrated the therapeutic effects of dex in EAE by delaying clinical signs, motor defects, myelin and axon degeneration, immune cell infiltration, and neuroinflammatory activation in the early stages of the disease. Furthermore, the study highlighted the potential of mesencephalic astrocyte-derived neurotrophic factor (MANF) as a drug candidate for MS by showing its increased expression in dex-treated EAE mice and the improvement in clinical signs and motor behavior following hMANF administration. The time-dependent analysis provided insights into the disease progression and the link between MANF and EAE.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Integrative & Complementary Medicine
Jihwan Shin, Jeonghun Lee, Junhyuk Choi, Byung-Taek Ahn, Sang Chul Jang, Seung-Won You, Do-Yeon Koh, Sungho Maeng, Seung-Yun Cha
Summary: Depression is a globally prevalent disease, and the development of more effective therapeutic agents is essential. Studies have shown that Nelumbinis semen (NS) has potential antidepressant effects and rapid-onset efficacy. In animal models, NS improved depression-like behaviors and exerted antidepressant effects through specific biochemical changes.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Clinical Neurology
Francesca De Lorenzo, Patrick Luningschror, Jinhan Nam, Liam Beckett, Federica Pilotto, Emilia Galli, Paivi Lindholm, Cora Rudt von Collenberg, Simon Tii Mungwa, Sibylle Jablonka, Julia Kauder, Nadine Thau-Habermann, Susanne Petri, Dan Lindholm, Smita Saxena, Michael Sendtner, Mart Saarma, Merja H. Voutilainen
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons and has no cure or effective therapy. This study investigates the therapeutic effect of cerebral dopamine neurotrophic factor in rodent models of ALS and shows that it significantly halts disease progression and improves motor behavior. Cerebral dopamine neurotrophic factor rescues motor neurons from endoplasmic reticulum stress-related cell death and enhances motor neuron survival.
Review
Biochemistry & Molecular Biology
Ji Hye Yoon, JooHyun Hwang, Sung Un Son, Junhyuk Choi, Seung-Won You, Hyunwoo Park, Seung-Yun Cha, Sungho Maeng
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline. Despite efforts to find a cure, no proper treatment has been developed yet, and early diagnosis to prevent disease progression remains the only effective approach. The amyloid cascade hypothesis is the most widely known cause of AD, but other hypotheses, such as insulin resistance, have also been suggested. This article reviews the pathophysiological connection between brain metabolic insufficiency, insulin resistance, and AD pathology to explore how insulin resistance can contribute to AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ga-Young Choi, Hyun-Bum Kim, Eun-Sang Hwang, Ho-Sub Park, Jae-Min Cho, Young-Ki Ham, Jin-Hee Kim, Mi-Kyung Mun, Sungho Maeng, Ji-Ho Park
Summary: Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive learning and memory impairment. Naringin has therapeutic potential to reduce neuronal inflammation and apoptosis induced by A beta related with the BDNF/ TrkB/CREB signaling.
Article
Nutrition & Dietetics
Ga-Young Choi, Hyun-Bum Kim, Jae-Min Cho, Inturu Sreelatha, In-Seo Lee, Hee-Seok Kweon, Sehyun Sul, Sun Ae Kim, Sungho Maeng, Ji-Ho Park
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. Umbelliferone (UMB) is a compound known for its various beneficial properties, including antioxidant and anti-inflammatory effects. Studies have shown that UMB can improve cognitive impairment and enhance learning and memory in AD.
Article
Neurosciences
In-Seo Lee, Ga-Young Choi, Inturu Sreelatha, Ji-Won Yoon, Suk-Hee Youn, Sungho Maeng, Ji-Ho Park
Summary: The seriousness of aging-related diseases, particularly Alzheimer's disease (AD), has gained attention. Sinapic acid, found in various plant families, has been shown to have potential as a treatment for dementia caused by AD. Studies have demonstrated its effectiveness in restoring long-term potentiation (LTP) and cognitive impairment induced by cholinergic receptor blockade. Sinapic acid also showed a positive effect on neuroinflammatory processes and the reduction of certain factors associated with AD. Further research is needed to fully explore its effects on memory and learning.
Article
Biochemistry & Molecular Biology
Hyun-ju Lee, Hanwoong Woo, Ha-Eun Lee, Hyongjun Jeon, Ka-Young Ryu, Jin Han Nam, Seong Gak Jeon, HyunHee Park, Ji-Soo Lee, Kyung-Min Han, Sang Min Lee, Jeongyeon Kim, Ri Jin Kang, Young-Ho Lee, Jae-Ick Kim, Hyang-Sook Hoe
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Medicine, Research & Experimental
Kyoung In Kim, Jeong Yeob Baek, Jae Yeong Jeong, Jin Han Nam, Eun Su Park, Eugene Bok, Won-Ho Shin, Young Cheul Chung, Byung Kwan Jin
EXPERIMENTAL NEUROBIOLOGY
(2019)