Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome

Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface

(2014) Lucia A. Ruocco et al.   PLoS One

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

(2013) Yun Li et al.   Cell Stem Cell

Rho GTPase signaling at the synapse: Implications for intellectual disability

(2013) Wei Ba et al.   EXPERIMENTAL CELL RESEARCH

Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance

(2013) Conor Liston et al.   NATURE NEUROSCIENCE

CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2013) Stefano Loizzo et al.   PLoS One

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats

(2013) Lucia A. Ruocco et al.   SYNAPSE

Activation of 5-HT7 Serotonin Receptors Reverses Metabotropic Glutamate Receptor-Mediated Synaptic Plasticity in Wild-Type and Fmr1 Knockout Mice, a Model of Fragile X Syndrome

(2012) Lara Costa et al.   BIOLOGICAL PSYCHIATRY

5-HT7R/G12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner

(2012) F. Kobe et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Rett syndrome treatment in mouse models: Searching for effective targets and strategies

(2012) Laura Ricceri et al.   NEUROPHARMACOLOGY

Effect of stress on hippocampal nociceptin expression in the rat

(2012) Paola Nativio et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation

(2012) Marlena Wosiski-Kuhn et al.   SYNAPSE

Rho GTPases as regulators of morphological neuroplasticity

(2011) Maria Auer et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

The 5-HT7 receptor in learning and memory

(2011) Amanda J. Roberts et al.   HIPPOCAMPUS

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

Noninvasive in vivo assessment of muscle impairment in the mdx mouse model – A comparison of two common wire hanging methods with two different results

(2011) Silvan M. Klein et al.   JOURNAL OF NEUROSCIENCE METHODS

Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives

(2011) Anne Matthys et al.   MOLECULAR NEUROBIOLOGY

Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice

(2011) Walter Adriani et al.   NEUROPHARMACOLOGY

Modulation of RhoGTPases Improves the Behavioral Phenotype and Reverses Astrocytic Deficits in a Mouse Model of Rett Syndrome

(2011) Bianca De Filippis et al.   NEUROPSYCHOPHARMACOLOGY

Fractionation of Spatial Memory in GRM2/3 (mGlu2/mGlu3) Double Knockout Mice Reveals a Role for Group II Metabotropic Glutamate Receptors at the Interface Between Arousal and Cognition

(2011) Louisa Lyon et al.   NEUROPSYCHOPHARMACOLOGY

Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

(2010) Marco B Rust et al.   EMBO JOURNAL

Physiological Activation of Synaptic Rac>PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome

(2010) L. Y. Chen et al.   JOURNAL OF NEUROSCIENCE

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor

(2010) Peter B. Hedlund et al.   NEUROSCIENCE LETTERS

Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

(2010) Marcello Leopoldo et al.   PHARMACOLOGY & THERAPEUTICS

The 5-HT7 receptor is involved in allocentric spatial memory information processing

(2009) Gor Sarkisyan et al.   BEHAVIOURAL BRAIN RESEARCH

Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches

(2009) Laura Ricceri et al.   BEHAVIOURAL PHARMACOLOGY

Early postnatal behavioral changes in theMecp2-308 truncation mouse model of Rett syndrome

(2009) B. De Filippis et al.   GENES BRAIN AND BEHAVIOR

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

(2009) Christopher S. Rex et al.   JOURNAL OF CELL BIOLOGY

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

The 5-HT7 receptor and disorders of the nervous system: an overview

(2009) Peter B. Hedlund   PSYCHOPHARMACOLOGY

Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat

(2008) Antonella Gasbarri et al.   BEHAVIOURAL BRAIN RESEARCH

Structural Modifications ofN-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-piperazinehexanamides: Influence on Lipophilicity and 5-HT7Receptor Activity. Part III

(2008) Marcello Leopoldo et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-HT7 receptors in the modulation of cognitive processes

(2007) Agata Cifariello et al.   BEHAVIOURAL BRAIN RESEARCH