Review
Biochemistry & Molecular Biology
Felipe Borges Almeida, Graziano Pinna, Helena Maria Tannhauser Barros
Summary: This article discusses the role of the HPA axis under stressful conditions and the importance of allopregnanolone in promoting negative feedback mechanisms to restore homeostasis. Chronic, repeated exposure to stress may lead to dysfunction, contributing to the pathogenesis of major depressive disorder and post-traumatic stress disorder (PTSD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychiatry
Felim Murphy, Anurag Nasa, Dearbhla Cullinane, Kesidha Raajakesary, Areej Gazzaz, Vitallia Sooknarine, Madeline Haines, Elena Roman, Linda Kelly, Aisling O'Neill, Mary Cannon, Darren William Roddy
Summary: Studies show that early life stress impacts developmental trajectories and can create vulnerability to psychological and psychiatric issues later in life. The mechanisms affecting the developing brain in children and the incorporation of adverse environmental stimuli into the adult brain are important areas of research focus.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Environmental Sciences
Jia Luo, Zheng Yan, Yao Shen, Denong Liu, Mingli Su, Jie Yang, Jiarong Xie, Hui Gao, Julin Yang, Aiming Liu
Summary: This study found that chronic low-intensity noise exposure exacerbated NAFLD in mice on a high-fat diet, affecting lipid metabolism and inflammation levels in the liver. Activation of the HPA axis played a critical role in the development of NAFLD, while depression played an intermediate role in exacerbating the condition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Endocrinology & Metabolism
Giada Ostinelli, Anais Scovronec, Sylvain Iceta, Anne-Sophie Ouellette, Simone Lemieux, Laurent Biertho, Catherine Begin, Andreanne Michaud, Andre Tchernof
Summary: The cortisol awakening response (CAR) and hair cortisol concentration (HCC) are reliable markers of hypothalamus-pituitary-adrenal axis activity, with HCC showing a significant positive correlation with adiposity. Inconsistencies in cortisol sampling and CAR computation make comparisons between studies difficult, but overall trait measurement of HCC is associated with increased general and abdominal adiposity in humans.
Article
Endocrinology & Metabolism
Raphael Hirtz, Lars Libuda, Anke Hinney, Manuel Foecker, Judith Buehlmeier, Jochen Antel, Paul-Martin Holterhus, Alexandra Kulle, Cordula Kiewert, Johannes Hebebrand, Corinna Grasemann
Summary: In adolescents with major depressive disorder (MDD), dysfunction of the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis is common, but the function of these two axes is only loosely related. This differs from findings in adults and suggests age-related maturational adjustments in the regulation of the HPA and HPT axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Renjie Hu, Wenhui Zhang, Ran Li, Li Qin, Rucheng Chen, Lu Zhang, Weijia Gu, Qinghua Sun, Cuiqing Liu
Summary: New evidence suggests that exposure to ambient PM2.5 is associated with metabolic syndrome, with potential impact on the hypothalamic-pituitary-adrenal axis and disruption of circadian rhythms. The study found that PM2.5 exposure significantly affected the expression of clock genes in the hypothalamus and adrenal gland, leading to disturbances in metabolic homeostasis. This research provides insights into the mechanisms through which ambient PM2.5 exposure may contribute to metabolic disorders.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Neurosciences
Chaselyn Ruffaner-Hanson, Shahani Noor, Melody S. Sun, Elizabeth Solomon, Lidia Enriquez Marquez, Dominique E. Rodriguez, Andrea M. Allan, Kevin K. Caldwell, Ludmila N. Bakhireva, Erin D. Milligan
Summary: This review explores the physiological, cellular, and molecular factors that are involved in the alteration of the developing fetal brain stress circuits and responses of the hypothalamic-pituitary-adrenal (HPA) axis caused by maternal stress and prenatal alcohol exposure (PAE). The role of the placenta in these processes is emphasized. Alterations in the fetal HPA axis can lead to long-term dysregulation of the brain stress-response system. The review also addresses the reciprocal interactions between the neuroimmune and neuroendocrine systems during fetal development, as well as the impact of maternal stress and PAE on later-life stress responses and mood dysregulation.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tal Belity, Michal Horowitz, Jay R. Hoffman, Yoram Epstein, Yaron Bruchim, Doron Todder, Hagit Cohen
Summary: Exposure to high ambient temperature can have extensive effects on brain structure and function. This study found that preconditioning with heat stress can improve resilience to predator-scent stress and may involve the induction of heat shock protein-70. Targeting this protein could be an attractive strategy for treating stress-related psychopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biology
Isabella Robertson-Dixon, Melanie J. Murphy, Sheila G. Crewther, Nina Riddell
Summary: This systematic review evaluated the effects of daytime exposure to lights of different spectral wavelength characteristics and luminance intensity on cortisol levels in healthy individuals. The analysis indicated that exposure to bright lights of any color during the late night or early morning can significantly increase cortisol secretion, and exposure to bright lights with stronger short-wavelength (blue/green) components in the early morning typically induces greater increases in cortisol. Therefore, the circadian regulation of cortisol is sensitive to the wavelength composition of environmental lighting.
Article
Multidisciplinary Sciences
Masoumeh Kashkouli, Shahideh Jahanian Sadatmahalleh, Saeideh Ziaei, Anoshirvan Kazemnejad, Ashraf Saber, Hamid Darvishnia, Khadijeh Azarbayjani
Summary: This study aimed to investigate the relationship between plasma concentrations of arginine vasopressin (AVP) and the score of Edinburgh Postnatal Depression Scale (EPDS). The results showed a significant positive relationship between plasma AVP levels and EPDS score, with higher AVP concentrations in the depressed group compared to the non-depressed group. Multiparity and non-exclusive breastfeeding were associated with increased odds of postpartum depression (PPD), while maternal gender preference decreased the odds of PPD.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
A. Castillo-Campos, A. Gutierrez-Mata, J-L Charli, P. Joseph-Bravo
Summary: Chronic stress was found to blunt the responses of the thyroid axis and brown adipose tissue to cold exposure. The long-term effects of stress on noradrenergic and hormonal signaling may be responsible for thyroid dysfunction.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Dor Danan, Doron Todder, Joseph Zohar, Hagit Cohen
Summary: Endocannabinoids play a crucial role in response to stress and regulating the release of glucocorticoids, potentially contributing to the development of post-traumatic-stress-disorder (PTSD). Research shows elevated levels of 2-AG in the CSF of PTSD-phenotype rats, inversely correlated with corticosterone levels, and reduced levels of endocannabinoids in the hippocampus and hypothalamus in the PTSD-phenotype group, indicating a potential mechanism for PTSD symptomology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Daneng Wei, Yafei Zhao, Mengmeng Zhang, Lei Zhu, Li Wang, Xing Yuan, Chunjie Wu
Summary: The study showed that volatile oil of Zanthoxylum bungeanum had an ameliorative effect on anxiety behavior induced by chronic unpredictable stress, potentially through inhibiting HPA axis activation and restoring dysbiosis of gut microbiota. This finding provides a potential therapeutic strategy for stress-induced abnormalities in the microbiota-gut-brain axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Genetics & Heredity
Wenting Dai, Jiayu Wu, Yaguang Zhao, Fang Jiang, Ruizhi Zheng, Dan-Na Chen, Meichao Men, Jia-Da Li
Article
Medicine, Research & Experimental
Meichao Men, Wu Li, Hongsheng Chen, Jiayu Wu, Yong Feng, Hui Guo, Jia-Da Li
Article
Multidisciplinary Sciences
Xiaoliang Xing, Jing Zhang, Kunyang Wu, Beibei Cao, Xianfeng Li, Fang Jiang, Zhengmao Hu, Kun Xia, Jia-Da Li
SCIENTIFIC REPORTS
(2019)
Article
Genetics & Heredity
Taoxi Li, Yong Feng, Yalan Liu, Chufeng He, Jing Liu, Hongsheng Chen, Yuyuan Deng, Meng Li, Wu Li, Jian Song, Zhijie Niu, Shushan Sang, Jie Wen, Meichao Men, Xiaoya Chen, Jiada Li, Xuezhong Liu, Jie Ling
Article
Obstetrics & Gynecology
Meichao Men, Jiayu Wu, Yaguang Zhao, Xiaoliang Xing, Fang Jiang, Ruizhi Zheng, Jia-Da Li
FERTILITY AND STERILITY
(2020)
Article
Endocrinology & Metabolism
Jia-Da Li, Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Qiao Hou, Dan-Na Chen, Ruizhi Zheng, Renhe Yu, Wei Zhou, Meichao Men
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Genetics & Heredity
Wenting Dai, Jia-Da Li, Yaguang Zhao, Jiayu Wu, Fang Jiang, Dan-Na Chen, Ruizhi Zheng, Meichao Men
Article
Neurosciences
Xiaoliang Xing, Kunyang Wu, Yufan Dong, Yimei Zhou, Jing Zhang, Fang Jiang, Wang-Ping Hu, Jia-Da Li
Article
Cell Biology
Zongyang Lu, Zhen Liu, Wei Mao, Xinying Wang, Xiaoguo Zheng, Shanshan Chen, Beibei Cao, Shisheng Huang, Xuliang Zhang, Tao Zhou, Yu Zhang, Xingxu Huang, Qiang Sun, Jia-Da Li
CELL DEATH & DISEASE
(2020)
Article
Genetics & Heredity
Meichao Men, Xinying Wang, Jiayu Wu, Wang Zeng, Fang Jiang, Ruizhi Zheng, Jia-Da Li
Summary: The study investigated genotypic and phenotypic spectra of DUSP6, IL17RD, and SPRY4 in a large cohort of Chinese patients with IHH. Mutations in DUSP6 alone could cause IHH in an autosomal dominant manner, while IL17RD or SPRY4 mutations may synergistically lead to IHH phenotypes with variants in other IHH-associated genes.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Renbin Lu, Yufan Dong, Jia-Da Li
NUCLEIC ACIDS RESEARCH
(2020)
Article
Endocrinology & Metabolism
Qiao Hou, Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Dan-Na Chen, Ruizhi Zheng, Meichao Men, Jia-Da Li
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Ye Liang, JingJing Huan, Jia-Da Li, CanHua Jiang, ChangYun Fang, YongGang Liu
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Dengfeng Li, Fangfang Li, Lanlan Meng, Huafang Wei, Qianjun Zhang, Fang Jiang, Dan-Na Chen, Wei Li, Yue-Qiu Tan, Jia-Da Li
Summary: The study demonstrated that RNF216 plays a crucial role in regulation of meiosis during spermatogenesis in mice, with its deficiency leading to incomplete arrest of zygotene spermatocytes and apoptosis at the pachytene stage. Additionally, RNF216 was shown to interact with PRKACB and promote its degradation, resulting in elevated PKA activity in the testes.
Article
Multidisciplinary Sciences
Xinyu Li, Yufeng Cai, Yinghe Ding, Jia-Da Li, Guoqing Huang, Ye Liang, Linyong Xu
Summary: This study aimed to estimate the demand for isolation beds during the COVID-19 pandemic. A discrete simulation model was established to analyze the impact of various factors such as incubation period, hospital response speed, disease healing time, and population mobility on the epidemic and medical resource occupation. Multiple linear regression was used to predict the number of isolation beds, and the results showed that these factors significantly influenced the demand and number of beds.