Article
Clinical Neurology
Sneha Chenji, Emily Cox, Natalia Jaworska, Rose M. Swansburg, Frank P. MacMaster
Summary: The study explored the relationship between body mass index (BMI) and hippocampal volume in youth with major depressive disorder (MDD). Results showed a reduction in right hippocampal volume in MDD youth with normal BMI, and a negative association between left hippocampal volume and BMI in MDD youth with high BMI. The findings suggest that BMI may play a role in the variability of hippocampal volume in MDD, highlighting the importance of considering BMI effects in future analyses.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Luigi F. Saccaro, Julian Gaviria, Dimitri Van De Ville, Camille Piguet
Summary: This study found that there are differences in the dynamic functional connectivity (dFC) of the hippocampus in bipolar disorder (BD) patients compared to healthy controls. The bilateral hippocampal dFC with the somatomotor networks (SMN) was reduced in BD, while the dFC between the left hippocampus and the midcingulo-insular salience system (SN) was higher. The dFC between the bilateral hippocampus and the default mode network (DMN) correlated with depression scores in BD. Pathological hyperconnectivity between the DMN, SMN, and frontoparietal network (FPN) was also modulated by depression scores in BD. Overall, this study provides insights into the neural architecture underlying BD and suggests that dFC markers may improve detection and treatment of BD patients.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Xiaowei Jiang, Xinrui Wang, Linna Jia, Ting Sun, Jiahui Kang, Yifang Zhou, Shengnan Wei, Feng Wu, Lingtao Kong, Fei Wang, Yanqing Tang
Summary: The study combined MRI and follow-up to investigate the pathologic changes in MDD and BD patients, revealing distinct alterations in gray matter volume and functional connectivity in the brain, providing a scientific basis for differential diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Hsueh-Ying Chen, C. Blake Wilson, Robert Tycko
Summary: The spatial resolution of MRI is limited by signal detection sensitivity, but can be improved by performing measurements at low temperature and using dynamic nuclear polarization (DNP) technique. This allows for higher resolution and shorter data acquisition times, offering a promising direction for high-resolution MRI studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Andrea Boscutti, Alessandro Pigoni, Giuseppe Delvecchio, Matteo Lazzaretti, Gian Mario Mandolini, Paolo Girardi, Adele Ferro, Michela Sala, Vera Abbiati, Marco Cappucciati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Matteo Balestrieri, Giuseppe Damante, Carolina Bonivento, Roberta Rossi, Livio Finos, Alessandro Serretti, Paolo Brambilla
Summary: Impulsivity levels were compared between individuals with bipolar disorder (BD) and healthy controls, with BD patients showing higher impulsivity levels. The BDNF rs6265 Met/Met homozygosis was associated with lower impulsivity scores, while the 5-HTTLPR SS genotype was linked to higher impulsivity scores in females only. Further studies with larger samples are needed to define the genetic basis of impulsivity in BD.
Article
Clinical Neurology
Hyeyoung Kim, Kyu-Man Han, Kwan Woo Choi, Woo-Suk Tae, Wooyoung Kang, Youbin Kang, Aram Kim, Byung-Joo Ham
Summary: The study examined the volume differences in each amygdala subregion in adults with and without MDD, using automatic segmentation of the nine nuclei of the amygdala. Patients with MDD showed significantly lower volumes in the entire amygdala and subregions compared to healthy volunteers, with no significant associations with antidepressant use, illness duration, or depression severity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Genetics & Heredity
Massimo Santoro, Mariacristina Siotto, Marco Germanotta, Alessia Mastrorosa, Dionysia Papadopoulou, Irene Aprile
Summary: The study investigated the methylation profile of SLC6A4 in 50 patients with subacute stroke and concluded that 5-HTTLPR polymorphisms and SLC6A4 promoter methylation could serve as potential biological markers for recovery in stroke patients undergoing rehabilitation. Significant changes in methylation levels were observed in specific CpG sites after rehabilitation, with a significant relationship found between LL, LS, and SS alleles and the outcome of rehabilitation interventions. Patients with LL and SS genotypes showed significant differences in favorable outcomes after rehabilitation.
Article
Clinical Neurology
Hongqi Xiao, Minlan Yuan, Hailong Li, Shiyi Li, Yang Du, Mei Wang, Hongru Zhu, Wei Zhang, Changjian Qiu, Xiaoqi Huang
Summary: The study demonstrates that the functional connectivity of the left hippocampus can predict early efficacy of antidepressants. The ROC curve analysis shows that the FC measures between the left hippocampus and the left inferior frontal gyrus and precuneus are crucial for differentiating early improved and non-improved depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Xiaotong Wen, Bukui Han, Huanhuan Li, Fengyu Dou, Guodong Wei, Gangqiang Hou, Xia Wu
Summary: Previous studies have suggested a connection between altered amygdala function and symptoms of major depressive disorder (MDD). This study aimed to examine how the interactions between the amygdala and other brain regions/networks are altered in MDD patients, using functional magnetic resonance imaging (fMRI) data.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Jianbo Xiu, Jiayu Li, Zeyue Liu, Hui Wei, Caiyun Zhu, Rongrong Han, Zijing Liu, Wanwan Zhu, Yan Shen, Qi Xu
Summary: Major depressive disorder (MDD) is a prevalent and devastating mental illness. The diagnosis of MDD currently lacks reliable biomarkers. This study identified and validated a potential DNA methylation biomarker for MDD in the Chinese Han population, and investigated its functional implications, which could improve the diagnosis and treatment of MDD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychology, Clinical
Akihiro Takamiya, Taishiro Kishimoto, Jinichi Hirano, Shiro Nishikata, Kyosuke Sawada, Shunya Kurokawa, Bun Yamagata, Toshiaki Kikuchi, Masaru Mimura
Summary: The study found that improvement in depressive symptoms after ECT was positively associated with changes in the right hippocampus-ventromedial prefrontal cortex connectivity and negatively associated with the right hippocampus-superior frontal gyrus connectivity. In addition, data-driven multivoxel pattern analysis identified additional clusters such as the thalamus, sensorimotor cortex, and precuneus that were associated with clinical improvement following ECT.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Gang Wu, Bohui Mei, Xiaofang Hou, Fukun Wang, Chen Zang, Xiaoya Zhang, Zhenjiang Zhang
Summary: Using diffusion tensor imaging data and tract-based spatial statistics, this study found microstructural abnormalities in white matter fibre tracts in patients with major depressive disorder (MDD), and these abnormalities were associated with illness duration. The reduced fibrous myelination levels were observed in the corpus callosum, corona radiata, and thalamic radiations in adults with MDD. These findings provide important insights into the understanding and treatment of MDD.
Article
Geriatrics & Gerontology
Jialin Hong, Yueqi Huang, Jianming Ye, Jianqing Wang, Xiaomei Xu, Yan Wu, Yi Li, Jialu Zhao, Ruipeng Li, Junlong Kang, Xiaobo Lai
Summary: The study proposes an automated MDD identification framework based on sMRI data, which utilizes 3D-ResNet to extract features and reconstructs them for MDD identification. The framework exhibits promising performance and outperforms other methods in the experiments.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Xiao-Li Sun, Li-Na Ma, Zhen-Zhu Chen, Yan-Bing Xiong, Jiao Jia, Yu Wang, Yan Ren
Summary: This study found significant differences in the metabolic phenotypes between bipolar disorder (BD), major depressive disorder (MDD), and healthy controls. Glycerolipid metabolism was significantly involved in both BD and MDD, while pyruvate metabolism was significantly involved in MDD. Pyruvate, choline, and acetate may be potential biomarkers for distinguishing MDD from BD, and pantothenic acid may be a potential biomarker for distinguishing BD from MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Summary: This study aimed to assess volumetric differences in hippocampal subfields between patients with major depressive disorder (MDD), treatment-resistant depression (TRD) and healthy controls (HC) using high-resolution MRI data. The results showed that MDD and TRD patients had reduced volume in the right-hemisphere CA2/3 subfield compared to HC. Negative correlations between subfield volumes and life-stressor checklist scores were also found. This study provides valuable insights into the pathophysiology of depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Tuba Dincer, Gulden Yorgancioglu-Budak, Akgun Olmez, Idris Er, Yavuz Dodurga, Ozmert M. A. Ozdemir, Bayram Toraman, Adem Yildirim, Nuran Sabir, Nurten A. Akarsu, C. Nur Semerci, Ersan Kalay
EUROPEAN JOURNAL OF HUMAN GENETICS
(2017)
Article
Medicine, Research & Experimental
Raphael Carapito, Martina Konantz, Catherine Paillard, Zhichao Miao, Angelique Pichot, Magalie S. Leduc, Yaping Yang, Katie L. Bergstrom, Donald H. Mahoney, Deborah L. Shardy, Ghada Alsaleh, Lydie Naegely, Aline Kolmer, Nicodeme Paul, Antoine Hanauer, Veronique Rolli, Joelle S. Mueller, Elisa Alghisi, Loic Sauteur, Cecile Macquin, Aurore Morlon, Consuelo Sebastia Sancho, Patrizia Amati-Bonneau, Vincent Procaccio, Anne-Laure Mosca-Boidron, Nathalie Marle, Nael Osmani, Olivier Lefebvre, Jacky G. Goetz, Sule Unal, Nurten A. Akarsu, Mirjana Radosavljevic, Marie-Pierre Chenard, Fanny Rialland, Audrey Grain, Marie-Christine Bene, Marion Eveillard, Marie Vincent, Julien Guy, Laurence Faivre, Christel Thauvin-Robinet, Julien Thevenon, Kasiani Myers, Mark D. Fleming, Akiko Shimamura, Elodie Bottollier-Lemallaz, Eric Westhof, Claudia Lengerke, Bertrand Isidor, Seiamak Bahram
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Psychiatry
Ece Durmusoglu, Onur Ugurlu, Sebnem Akan, Fatma Simsek, Gozde Kizilates, Omer Kitis, Burcu Aksoy Ozkul, Cagdas Eker, Kerry L. Coburn, Ali Saffet Gonul
COMPREHENSIVE PSYCHIATRY
(2018)
Article
Multidisciplinary Sciences
Aaron Seo, Orna Steinberg-Shemer, Sule Unal, Silvia Casadei, Tom Walsh, Fatma Gumruk, Stavit Shalev, Akiko Shimamura, Nurten Ayse Akarsu, Hannah Tamary, Mary-Claire King
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Andre Aleman, Kathryn I. Alpert, Carrie E. Bearden, Alessandro Bertolino, Catherine Bois, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena De la Serna, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Andrew Frankland, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Lieuwe de Haan, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Manon H. J. Hillegers, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Lydia Krabbendam, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Jan-Bernard C. Marsman, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Pablo Najt, Emma Neilson, Jason Newport, Jim van Os, Bronwyn Overs, Aysegul Ozerdem, Marco M. Picchioni, Anja Richter, Gloria Roberts, Aybala Saricicek Aydogan, Peter R. Schofield, Fatma Simsek, Jair C. Soares, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Henrik Walter, Lei Wang, Daniel R. Weinberger, Heather C. Whalley, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
BIOLOGICAL PSYCHIATRY
(2019)
Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Silvia Alonso-Lana, Carrie E. Bearden, Alessandro Bertolino, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Erick J. Canales-Rodriguez, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena de la Serna, Caterina del Mar Bonnin, Caroline Demro, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Mar Fatjo-Vilas, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Jose M. Goikolea, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Ceren Hidiroglu Ongun, Manon H. J. Hillegers, Josselin Houenou, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Leila Nabulsi, Jason Newport, Cheryl A. Olman, Jim van Os, Bronwyn J. Overs, Aysegul Ozerdem, Giulio Pergola, Marco M. Picchioni, Camille Piguet, Edith Pomarol-Clotet, Joaquim Radua, Ian S. Ramsay, Anja Richter, Gloria Roberts, Raymond Salvador, Aybala Saricicek Aydogan, Salvador Sarro, Peter R. Schofield, Esma M. Simsek, Fatma Simsek, Jair C. Soares, Scott R. Sponheim, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Eduard Vieta, Henrik Walter, Daniel R. Weinberger, Heather C. Whalley, Mon-Ju Wu, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Sophia I. Thomopoulos, Theo G. M. van Erp, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
Summary: First-degree relatives of patients diagnosed with schizophrenia show widespread thinner cortex, while relatives of patients diagnosed with bipolar disorder show widespread larger cortical surface area. Both groups have lower IQ scores compared to controls, with schizophrenia relatives showing more pronounced brain abnormalities and bipolar disorder relatives showing weaker effects after adjusting for IQ or educational attainment.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Can Ebru Bekircan-Kurt, Arda Cetinkaya, Rahsan Gocmen, Can Kosukcu, Figen Soylemezoglu, Ethem Murat Arsava, Asli Tuncer, Sevim Erdem-Ozdamar, Nurten A. Akarsu, Mehmet Akif Topcuoglu
Summary: This study identified a novel homozygous mutation in the HTRA1 gene in a family with a high number of members affected by cerebral small vessel disease. The study highlighted the phenotypic variability within homozygotes and heterozygotes, demonstrating that CARASIL and CADASIL type 2 are two clinical manifestations of the same disorder with different severities. Genetic testing and clinical follow-up should be offered to all family members with HTRA1 mutations, regardless of symptoms, due to the semi-dominant inheritance pattern of HTRA1-related phenotypes.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Hande Yildirim-Celik, Seda Eroglu, Kaya Oguz, Gulser Karakoc-Tugrul, Yigit Erdogan, Damla Isman-Haznedaroglu, Cagdas Eker, Ali Saffet Gonul
Summary: The study found that emotional contextual features play a role in facial emotion recognition, but this effect is not related to depression. Depressive patients have slower reaction times in recognizing facial emotions, possibly due to cognitive impairments.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Kaan Keskin, Mehmet Cagdas Eker, Ali Saffet Gonul, Georg Northoff
Summary: This study aims to investigate the relationship between self-focus and emotion regulation in major depressive disorder (MDD) by examining the global brain activity in specific regions associated with the self. The results show that MDD patients exhibit abnormal emotion regulation, especially in the regulation of negative emotions. Additionally, there is increased global brain activity in regions related to the mental and exteroceptive self in MDD patients. These findings support the hypothesis that increased self-focus in MDD contributes to abnormal regulation of negative emotions.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Hilal Subasi, Damla Isman-Haznedaroglu, Seda Eroglu, Yigit Erdogan, Mehmet Cagdas Eker, Ali Saffet Gonul
Summary: This study presents a case of psychiatric symptoms following flow diverter stent placement. The patient underwent cranial MRI, MRA, CTA, neuropsychological tests, LSRP, and WURS-25. Results showed personality changes and psychiatric symptoms occurred after the stent placement and persisted for two and a half years.
Article
Neurosciences
Burcu Ozkul, Cemre Candemir, Kaya Oguz, Seda Eroglu-Koc, Gozde Kizilates-Evin, Onur Ugurlu, Yigit Erdogan, Defne Dakota Mull, Mehmet Cagdas Eker, Omer Kitis, Ali Saffet Gonul
Summary: Group support plays a role in brain functioning, and the loss of social group support leads to reduced brain activity. Being part of a social group and receiving support enhances cognitive functioning, while the loss of group support activates brain regions associated with attention and survival.
Article
Psychiatry
Melek Hande Bulut Demir, Rahime Kaya, Ozgun Ozalay, Damla Isman Haznedaroglu, Yigit Erdogan, Omer Kitis, Tezan Bildik, Ali Saffet Gonul, Mehmet Cagdas Eker
Summary: The objective of this study was to explore the effects of sexual abuse on limbic and prefrontal cortex structures in adolescents. The findings showed that children with a history of sexual abuse had thinner prefrontal cortex, larger amygdala and hippocampus, and aberrations in threat detection, orientation, and response circuit. These adaptations may be beneficial in a dangerous environment in the short term.
SCANDINAVIAN JOURNAL OF CHILD AND ADOLESCENT PSYCHIATRY AND PSYCHOLOGY
(2023)
Article
Clinical Neurology
Nazan Dolapoglu, Banu Pinar Sarer Yurekli, Mehmet Cagdas Eker, Hayriye Elbi
Summary: The study showed a significantly higher frequency of metabolic syndrome in euthymic bipolar patients compared to the control group, although there was no significant difference in serum AgRP levels between the patient and control groups. Furthermore, there was no significant difference in serum AgRP levels between bipolar patients with metabolic syndrome and those without in both study groups.
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2021)
Proceedings Paper
Engineering, Biomedical
Ozkan Cigdem, Refik Soyak, Burhan Aydeniz, Kaya Oguz, Hasan Demirel, Omer Kitis, Cagdas Eker, Ali Saffet Gonul, Devrim Unay
2019 MEDICAL TECHNOLOGIES CONGRESS (TIPTEKNO)
(2019)
Meeting Abstract
Neurosciences
Sonja de Zwarte, Rachel Brouwer, Manon Hillegers, Wiepke Cahn, Hilleke Hulshoff Pol, Rene Kahn, Kathryn Alpert, Lei Wang, Elvira Bramon, Fergus Kane, Robin Murray, Tomas Hajek, Martin Alda, Gloria Roberts, Philip Mitchell, Peter Schofield, Janice Fullerton, Anja Richter, Oliver Gruber, Aurora Bonvino, Alessandro Bertolino, Annabella Di Giorgio, Xavier Caseras, Ali Saffet Gonul, Mehmet Cagdas Eker, Fatma Simsek, Scott Fears, Carrie Bearden, David Glahn, Theo van Erp, Paul Thompson, Ole Andreassen, Jessica Turner, Neeltje van Haren
BIOLOGICAL PSYCHIATRY
(2017)