Article
Neurosciences
Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido, Riqiang Yan
Summary: This text highlights the accumulation of lysosomal proteins in the early stages of neuritic plaques in Alzheimer's disease brains, suggesting that dysfunctional lysosomes may play a role in the growth of amyloid plaques. The presence of disease-associated microglia near plaques in aged AD mouse and human brains may reflect impaired lysosomal functions in neurons. Increased levels of SAP-C in AD mouse brains during plaque growth may contribute to lysosomal membrane leakage and loss of hydrolases.
MOLECULAR NEURODEGENERATION
(2021)
Article
Neurosciences
Can Zhang, Shivangi M. Inamdar, Swathi Swaminathan, Daniel R. Marenda, Aleister J. Saunders
Summary: This study identifies a loss-of-function mechanism of Ubiquilin-1 in Alzheimer's disease and highlights the significance of targeting Ubiquilin-1-mediated protein quality control as a potential therapeutic strategy.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Stefan Wendt, Sora Johnson, Nicholas L. Weilinger, Christopher Groten, Stefano Sorrentino, Jonathan Frew, Lucy Yang, Hyun B. Choi, Haakon B. Nygaard, Brian A. MacVicar
Summary: The inter-relationship between microglia dynamics and oxidative stress in dystrophic neurites at Alzheimer's Disease plaques may contribute to the pathological changes in neurons. Microglia preferentially enwrap neurites exhibiting the greatest degree of oxidative stress, and depletion of microglia leads to increased oxidative stress in neurites. These findings suggest a complex role of microglia in Alzheimer's Disease, with both neuroprotective and neurotoxic components.
Article
Clinical Neurology
Parichita Choudhury, Jonathan Graff-Radford, Jeremiah A. Aakre, Lincoln Wurtz, David S. Knopman, Neill R. Graff-Radford, Kejal Kantarci, Leah K. Forsberg, Julie A. Fields, Otto Pedraza, Qin Chen, Toji Miyagawa, Gregory S. Day, Philip Tipton, Rodolfo Savica, Hugo Botha, Christian Lachner, Brynn Dredla, R. Ross Reichard, Ronald C. Petersen, Dennis W. Dickson, Bradley F. Boeve, Tanis J. Ferman
Summary: An earlier onset of DLB was associated with men, RBD, and Lewy body disease without neocortical tangles. Women with DLB tended to be older, more cognitively impaired, less likely to have RBD, diagnosed later, and more likely to have neocortical tangles.
ALZHEIMERS & DEMENTIA
(2022)
Article
Genetics & Heredity
Giulia Vinceti, Chiara Gallingani, Elisabetta Zucchi, Ilaria Martinelli, Giulia Gianferrari, Cecilia Simonini, Roberta Bedin, Annalisa Chiari, Giovanna Zamboni, Jessica Mandrioli
Summary: This study reports a C9ORF72 family with different clinical phenotypes and cerebrospinal fluid biomarkers consistent with Alzheimer's disease pathology. The findings confirm the association between C9ORF72 expansion and Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Christopher Simon, Tomoko Soga, Hirotaka James Okano, Ishwar Parhar
Summary: Dementia with Lewy bodies (DLB) is characterized by the presence of alpha-synuclein-laden Lewy bodies in the brain, leading to significant damage to the brain's neuropsychological networks. However, there is still uncertainty surrounding the pathogenic role of alpha-synuclein in DLB pathobiology.
CELL AND BIOSCIENCE
(2021)
Article
Clinical Neurology
Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W. Scholz
Summary: The GBA gene is associated with risk for dementia with Lewy bodies (DLB) in patients without the APOE ε4 allele, while the APOE ε4 allele is associated with DLB co-pathology with Alzheimer's disease. APOE ε4 is not an independent driver of alpha-synuclein pathology in pure DLB, but GBA plays a significant role in the pure DLB subgroup.
Article
Medicine, General & Internal
Wichanon Sae-jie, Suangsuda Supasai, Mika Kivimaki, Jackie F. Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F. Schmidt, Tom R. Gaunt, Aroon Hingorani, Pimphen Charoen
Summary: This study uses triangulation of evidence from observational and Mendelian randomization studies to investigate the association and causation between ketone bodies and cognitive function. The results suggest that 3-beta-hydroxybutyrate (BOHBUT), the most abundant ketone metabolite, has a beneficial effect on cognitive performance and may delay cognitive impairment and reduce the risk of Alzheimer's disease.
Review
Medicine, General & Internal
Xingfeng Xu, Yan Su, Zhenyou Zou, Yali Zhou, Jianguo Yan
Summary: C9ORF72 encodes a 54-kDa protein with unknown function that is highly expressed in the central nervous system. Its hexanucleotide amplification is associated with neurodegenerative diseases, particularly ALS/FTD spectrum diseases. The causative role of C9ORF72 in AD and PD is still uncertain.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Hiroyuki Watanabe, Sakura Hikida, Manabu Ikeda, Etsuro Mori
Summary: This study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the prodromal phase of dementia with Lewy bodies (DLB). The clinical diagnosis of probable prodromal DLB accounted for more than 30% of cases in the aphasic MCI cohort, and language impairment was not very uncommon in prodromal DLB. Patients with cholinesterase inhibitor therapy showed improvement in general cognitive function, including language function.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Md Golam Sharoar, John Zhou, Marc Benoit, Wanxia He, Riqiang Yan
Summary: The formation of RIDNs, composed of abnormally clustered tubular ER and degenerating mitochondria, occurs early in the growth of amyloid plaques in AD brains. DCTN6 deficiency enhances RTN3 protein levels and hippocampus-specific RIDN formation in aging brains of transgenic mice. The DCTN6-RTN3 interaction mediates tubular ER trafficking in axons, and deficiency in DCTN6 impairs axonal ER trafficking, leading to abnormal ER accumulation and RIDN formation in aging mouse brains.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Maria Serpente, Chiara Fenoglio, Andrea Arighi, Giorgio G. Fumagalli, Marina Arcaro, Federica Sorrentino, Caterina Visconte, Elio Scarpini, Daniela Galimberti
Summary: The study found a significant increase in the frequency of C9orf72 intermediate repeat alleles in patients with Alzheimer's disease, but no significant differences were observed in other dementia patients compared to non-demented individuals. This suggests that C9orf72 intermediate repeat units may be a genetic risk factor for the occurrence of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Victor M. Barbera, Jordi Alom, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: In Alzheimer's disease, the inactive and active forms of acetylcholinesterase (AChE) exhibit differences in their glycosylation pattern, particularly in the presence of terminal mannoses in the active forms. Sporadic AD patients have reduced binding to terminal mannoses compared to non-demented individuals, while familial AD patients with PSEN1 gene mutations have higher binding. Furthermore, presenilin-1 (PS1) modulates AChE trafficking and maturation in Golgi regions, promoting the presence of active forms in the cell membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Irina Gurevich, Pooja Agarwal, PeiPei Zhang, John A. Dolorito, Stacie Oliver, Henry Liu, Nicholas Reitze, Nikhil Sarma, Isin Sinem Bagci, Kunju Sridhar, Visesha Kakarla, Vamsi K. Yenamandra, Mark O'Malley, Marco Prisco, Sara F. Tufa, Douglas R. Keene, Andrew P. South, Suma M. Krishnan, M. Peter Marinkovich
Summary: This study evaluated the use of an engineered viral vector, B-VEC, for the treatment of recessive dystrophic epidermolysis bullosa (RDEB) patients with wounds. The results showed that B-VEC promotes wound healing and is well-tolerated.
Article
Biochemistry & Molecular Biology
Haruka Endo, Shiho Tanaka, Satomi Adegawa, Fumika Ichino, Hiroko Tabunoki, Shingo Kikuta, Ryoichi Sato
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Takahiro Otsuki, Daisuke Uka, Hiromu Ito, Genki Ichinose, Momoka Nii, Satoru Morita, Takuma Sakamoto, Maaya Nishiko, Hiroko Tabunoki, Kazuya Kobayashi, Kenji Matsuura, Kikuo Iwabuchi, Jin Yoshimura
SCIENTIFIC REPORTS
(2019)
Article
Developmental Biology
Hitomi Ohno, Takuma Sakamoto, Rena Okochi, Maaya Nishiko, Shunya Sasaki, Hidemasa Bono, Hiroko Tabunoki, Kikkuo Iwabuchi
DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Yosui Nojima, Hidemasa Bono, Takeshi Yokoyama, Kikuo Iwabuchi, Ryoichi Sato, Katsuhiko Arai, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Takeru Nakazato, Jin Yoshimura, Hiroko Tabunoki, Kikuo Iwabuchi
Article
Multidisciplinary Sciences
Wakana Nakane, Hisashi Nakamura, Takeru Nakazato, Natsuki Kaminaga, Miho Nakano, Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Isao Ogiwara, Yoshikazu Kitano, Kikuo Iwabuchi, Kaoru Kinoshita, Richard J. Simpson, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2020)
Article
Entomology
Yumi Takano, Takuma Sakamoto, Hiroko Tabunoki, Jin Yoshimura, Kikuo Iwabuchi
Summary: Temperature plays a critical role in influencing animals, especially acclimation and challenge temperatures. Research shows that haemocyte concentration is affected by temperature, and increasing challenge temperature enhances phagocytic activity.
PHYSIOLOGICAL ENTOMOLOGY
(2021)
Correction
Multidisciplinary Sciences
Wakana Nakane, Hisashi Nakamura, Takeru Nakazato, Natsuki Kaminaga, Miho Nakano, Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Isao Ogiwara, Yoshikazu Kitano, Kikuo Iwabuchi, Kaoru Kinoshita, Richard J. Simpson, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shunya Sasaki, Maaya Nishiko, Takuma Sakamoto, Michael R. Kanost, Hiroko Tabunoki
Summary: The DJ-1 gene is highly conserved in insects, such as Tribolium castaneum, and plays an important role in antioxidative stress mechanisms. TcDJ-1 exhibits higher mRNA expression levels during early pupal and adult stages and knockout leads to increased sensitivity to oxidative stress.
Article
Entomology
Hidemasa Bono, Takuma Sakamoto, Takeya Kasukawa, Hiroko Tabunoki
Summary: This paper presents a workflow-based method for annotating gene functions in insects using transcribed sequence information and reference genome databases. The functional annotation information obtained greatly expands the possibilities of entomological research using genome editing. The improved workflow allows for more comprehensive utilization of transcriptome data and is applicable to other insects.
Article
Biochemistry & Molecular Biology
Jacob J. Weber, Lisa M. Brummett, Michelle E. Coca, Hiroko Tabunoki, Michael R. Kanost, Emily J. Ragan, Yoonseong Park, Maureen J. Gorman
Summary: The study found that transferrin-1 (Tsf1) plays a role in iron distribution and antimicrobial activity in Drosophila melanogaster, but has limited involvement in iron transport and protection against oxidative stress. Moreover, Tsf1 may function in providing iron for eggs and defending against infection.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biology
Takuma Sakamoto, Shunya Sasaki, Nobuki Yamaguchi, Miho Nakano, Hiroki Sato, Kikuo Iwabuchi, Hiroko Tabunoki, Richard J. Simpson, Hidemasa Bono
Summary: The study compared the nutritional metabolism system among flight-winged, flightless-winged, and flightless-wingless stick insect groups. Results indicated that carbohydrate metabolic processes may be related to the evolutionary process through which stick insects gain the ability of flight, as suggested by the differences in gene expression observed in the midgut transcriptome of different stick insect groups.
BMC RESEARCH NOTES
(2021)
Article
Multidisciplinary Sciences
Yuta Kobayashi, Yosui Nojima, Takuma Sakamoto, Kikuo Iwabuchi, Takeru Nakazato, Hidemasa Bono, Atsushi Toyoda, Asao Fujiyama, Michael R. Kanost, Hiroko Tabunoki
SCIENTIFIC REPORTS
(2019)
Article
Biology
Hiroko Tabunoki, Neal T. Dittmer, Maureen J. Gorman, Michael R. Kanost
BMC RESEARCH NOTES
(2019)
Article
Pharmacology & Pharmacy
Fumika Ichino, Hidemasa Bono, Takeru Nakazato, Atsushi Toyoda, Asao Fujiyama, Kikuo Iwabuchi, Ryoichi Sato, Hiroko Tabunoki
DRUG DISCOVERIES AND THERAPEUTICS
(2018)