Article
Neurosciences
Czarina Ramos, Stefano Lutzu, Miwako Yamasaki, Yuchio Yanagawa, Kenji Sakimura, Susumu Tomita, Masahiko Watanabe, Pablo E. Castillo
Summary: This study provides the first direct evidence of functional extrasynaptic kainate receptors (KARs) on mossy cells (MCs) in the hippocampus. These KARs are mainly located extrasynaptically and play a critical role in the activity of MCs. Increases in ambient glutamate can activate the KARs on MCs.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Wahab Imam Abdulmajeed, Kai-Yi Wang, Jei-Wei Wu, Musa Iyiola Ajibola, Irene Han-Juo Cheng, Cheng-Chang Lien
Summary: This study reveals the differential regulation of local and distant granule cell activity by mossy cells in the hippocampus, highlighting the distinct synaptic mechanisms involved. These findings provide new insights into the functional organization of hippocampal circuits.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biology
Laura Mundrucz, Angela Kecskes, Nora Henn-Mike, Peter Kobor, Peter Buzas, Rudi Vennekens, Miklos Kecskes
Summary: This study identified the presence of TRPM4 in hilar mossy cells in the hippocampus and showed that it regulates their intrinsic electrophysiological properties, including spontaneous activity and action potential dynamics. Furthermore, TRPM4 was found to contribute to mossy cell death following status epilepticus, thus modulating seizure susceptibility and epilepsy-related memory deficits.
Article
Neurosciences
Sang-Yoon Kim, Woochang Lim
Summary: We studied the disynaptic effect of hilar cells on pattern separation in a spiking neural network of the hippocampal dentate gyrus. We found that sparsity in the firing activity of granule cells can enhance the efficacy of pattern separation, and the disynaptic effects of mossy cells and HIPP cells are opposite. We also examined the association between sparsely synchronized rhythm and pattern separation in the population and individual firing behaviors.
COGNITIVE NEURODYNAMICS
(2022)
Article
Cell Biology
Kai-Yi Wang, Jei-Wei Wu, Jen-Kun Cheng, Chun-Chung Chen, Wai-Yi Wong, Robert G. Averkin, Gabor Tamas, Kazu Nakazawa, Cheng-Chang Lien
Summary: The study shows that increased activity of hippocampal mossy cells may reduce anxiety behaviors and could be a potential therapeutic target for anxiety disorders.
Review
Biochemistry & Molecular Biology
Angela Kecskes, Boldizsar Czeh, Miklos Kecskes
Summary: This review summarizes the role of mossy cells in healthy and overexcited hippocampus, discussing the controversy surrounding their involvement in temporal lobe epilepsy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Neurosciences
Yu-Chieh Hung, Yi-Jen Wu, Miao-Er Chien, Yu-Ting Lin, Cheng-Fang Tsai, Kuei-Sen Hsu
Summary: This study reveals the crucial role of hippocampal oxytocin receptor (OXTR) signaling in the discrimination of social stimuli. The OXTR-expressing hilar mossy cells (MCs) in the dentate gyrus regulate granule cell (GC) activity to enable social stimulus discrimination. Ablation of MC Oxtr impairs social stimulus discrimination in adult male mice, indicating the importance of MC OXTR signaling in social cognition.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Carolyn R. Houser, Zechun Peng, Xiaofei Wei, Christine S. Huang, Istvan Mody
Summary: Axonal projections of mossy cells in the dorsal and ventral dentate gyrus show considerable differences, suggesting potential functional divergence between these two regions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Lisa N. Miller, Craig Weiss, John F. Disterhoft
Summary: The dentate gyrus plays a crucial role in the formation of associative memories and previous studies have identified populations of cells that bridge the temporal gap during trace eyeblink conditioning. In this study, single-neuron recordings were performed to investigate the functional role of different cell types in the dentate gyrus during learning. The results showed that conditioned mice exhibited changes in firing rate in granule cells, mossy cells, and interneurons, suggesting their involvement in trace associative memory. Theta power also increased during stimuli presentation and decreased over time. These findings expand our understanding of dentate gyrus function and its potential disruptions in aging and disease.
Article
Neurosciences
Lindsey A. Smith, Anthoni M. Goodman, Lori L. McMahon
Summary: The dentate gyrus plays a crucial role in hippocampal signal processing and is one of the first brain regions affected in Alzheimer's disease. This study explores the increased excitability of dentate gyrus granule cells in TgF344-AD rats, which may contribute to the heightened depolarization during high-frequency synaptic activation.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Neurosciences
Catarina Orcinha, Antje Kilias, Enya Paschen, Marie Follo, Carola A. Haas
Summary: The loss of Reelin protein is associated with granule cell dispersion in mesial temporal lobe epilepsy. By using organotypic hippocampal slice cultures from transgenic mice, it was shown that Reelin prevents the migration of granule cells towards the hilar region following treatment with kainate. Additionally, the signaling pathway of Reelin was found to be affected by kainate treatment, suggesting a key role of Reelin in maintaining granule cell lamination in the dentate gyrus.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Priya Gami-Patel, Irene van Dijken, Lieke H. Meeter, Shamiram Melhem, Tjado H. J. Morrema, Wiep Scheper, John C. van Swieten, Annemieke J. M. Rozemuller, Anke A. Dijkstra, Jeroen J. M. Hoozemans
Summary: The study found increased presence of UPR markers in the hippocampus and cerebellum in C9-FTD patients, which were closely associated with the presence of dipeptide pathology and GVD. Higher levels of pPERK and peIF2α markers were observed in specific regions.
Article
Biochemistry & Molecular Biology
Felipe Fredes, Maria Alejandra Silva, Peter Koppensteiner, Kenta Kobayashi, Maximilian Joesch, Ryuichi Shigemoto
Summary: The study demonstrates the important role of a pathway between ventral mossy cells and dorsal granule cells in the hippocampus in the formation of novelty-induced memory, influencing the activation of dorsal granule cells through excitatory transmission; furthermore, the manipulation of ventral mossy cell activity can bidirectionally regulate the acquisition of novelty-induced contextual memory.
Article
Neurosciences
Thibault Cholvin, Thomas Hainmueller, Marlene Bartos
Summary: The study revealed that the spatial coding relationship between MEC and hippocampus is still unclear, with different characteristics observed in different environments. Decoding analysis showed that hippocampal principal cells provide more accurate and faster information about location and context than MEC inputs.
Article
Neurosciences
Ryan A. Cloyd, John Koren, Jose F. Abisambra, Bret N. Smith
Summary: Our study revealed that both tau(-/-) and htau mice exhibited reduced neuronal excitability compared to age-matched controls, indicating that functional tau absence has a stronger impact on neuronal excitability than the presence of pathologic tau. These findings suggest a more complex relationship between tau pathology and neuronal excitability than previously thought.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shinichi Hayashi, Yasukazu Nakahata, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Cell Biology
Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
JOURNAL OF CELL BIOLOGY
(2018)
Article
Plant Sciences
Yasuyo Yamaoka, Bae Young Choi, Hanul Kim, Seungjun Shin, Yeongho Kim, Sunghoon Jang, Won-Yong Song, Chung H. Cho, Hwan Su Yoon, Kenji Kohno, Youngsook Lee
Article
Psychiatry
Kazuhito Nakao, Vivek Jeevakumar, Sunny Zhihong Jiang, Yuko Fujita, Noelia B. Diaz, Carlos A. Pretell Annan, Karen L. Eskow Jaunarajs, Kenji Hashimoto, Juan E. Belforte, Kazu Nakazawa
SCHIZOPHRENIA BULLETIN
(2019)
Article
Biochemistry & Molecular Biology
Takushi Fujimoto, Orie Nakamura, Michiko Saito, Akio Tsuru, Masaki Matsumoto, Kenji Kohno, Kenji Inaba, Hiroshi Kadokura
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Urology & Nephrology
Jin Nakamura, Yuki Sato, Yuichiro Kitai, Shuichi Wajima, Shinya Yamamoto, Akiko Oguchi, Ryo Yamada, Keiichi Kaneko, Makiko Kondo, Eiichiro Uchino, Junichi Tsuchida, Keita Hirano, Kumar Sharma, Kenji Kohno, Motoko Yanagita
KIDNEY INTERNATIONAL
(2019)
Correction
Cell Biology
Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
JOURNAL OF CELL BIOLOGY
(2019)
Article
Neurosciences
G. Gomez, M. Escande, L. M. Suarez, L. Rela, J. E. Belforte, R. Moratalla, M. G. Murer, O. S. Gershanik, I. R. E. Taravini
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biology
Vivekanandan Shanmuganathan, Nina Schiller, Anastasia Magoulopoulou, Jingdong Cheng, Katharina Braunger, Florian Cymer, Otto Berninghausen, Birgitta Beatrix, Kenji Kohno, Gunnar von Heijne, Roland Beckmann
Review
Pharmacology & Pharmacy
Kazu Nakazawa, Kiran Sapkota
PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Neurosciences
Rodrigo J. Alvarez, Diego E. Pafundo, Camila L. Zold, Juan E. Belforte
JOURNAL OF NEUROSCIENCE
(2020)
Article
Cell Biology
Peixun Han, Yuichi Shichino, Tilman Schneider-Poetsch, Mari Mito, Satoshi Hashimoto, Tsuyoshi Udagawa, Kenji Kohno, Minoru Yoshida, Yuichiro Mishima, Toshifumi Inada, Shintaro Iwasaki
Article
Veterinary Sciences
Ryoko Akai, Michiko Saito, Kenji Kohno, Takao Iwawaki
EXPERIMENTAL ANIMALS
(2020)
Article
Biotechnology & Applied Microbiology
Chi Thanh Mai, Quynh Giang Le, Yuki Ishiwata-Kimata, Hiroshi Takagi, Kenji Kohno, Yukio Kimata
FEMS YEAST RESEARCH
(2018)