Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 140, Issue -, Pages 474-478Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2015.01.016
Keywords
SERS; Silver colloid; Benzylpenicillin sodium (NaBP); Raman spectroscopy
Categories
Funding
- National Natural Science Foundation of People's Republic of China [21003063, 21473078, 21273091, 21327803]
- Natural Science Foundation of Heilongjiang Province of China [B201418]
- Program for New Century Excellent Talents in Heilongjiang Provincial University [1253-NCET-023]
- National Undergraduate Training Programs for Innovation and Entrepreneurship [201410222021]
- Postgraduate Scientific Research Innovation Project of Jiamusi University [LM2014_067]
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At present, fluorescence spectroscopy, ultraviolet spectroscopy and infrared spectroscopy are usually used to detect drug molecules, however the information about using Raman spectroscopy to detect drug molecules is very few. In this work normal Raman spectroscopy and surface-enhanced Raman spectroscopy were utilized to study benzylpenicillin sodium (NaBP). The results show that NaBP is close to the surface of silver substrate through the carboxyl group, and the detection limit of NaBP is reduced to 1 x 10(-7) mol/L. Accordingly, the quantitative analysis of NaBP can be carried out in the range of 1 x 10(-4)-1 x 10(-7) mol/L concentration. And it is proved that NaBP is not stable in acid and alkali conditions and the decomposition reaction is very complex. (C) 2015 Elsevier B.V. All rights reserved.
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