Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Milad Shirvaliloo
Summary: The article summarizes the importance of histones and their role in gene expression regulation. It highlights the significance of recent research on histone modifications published in Epigenomics since 2020.
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Article
Oncology
Tanja Rothhammer-Hampl, Franziska Liesenberg, Natalie Hansen, Sabine Hoja, Sabit Delic, Guido Reifenberger, Markus J. Riemenschneider
Summary: The investigation revealed significant downregulation of DIRAS-1 and DIRAS-2 genes in brain tumors, possibly influenced by epigenetic mechanisms. Treatment strategies to re-express these genes increased sensitivity to chemotherapy, indicating the involvement of these genes in DNA damage response pathways.
Review
Oncology
Md Sahab Uddin, Abdullah Al Mamun, Badrah S. Alghamdi, Devesh Tewari, Philippe Jeandet, Md Shahid Sarwar, Ghulam Md Ashraf
Summary: Research has shown that glioma progression is closely linked to different types of epigenetic phenomena, such as chromatin modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Targeting the genes and proteins that control these alterations can be an effective way to treat GBM. Treatment approaches include histone deacetylase inhibitors and DNA methyltransferase inhibitors.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Aidan J. Levinsky, Gregor McEdwards, Nasha Sethna, Mark A. Currie
Summary: H3K9 methyltransferases play crucial roles in genome stability, cell type-specific gene expression, and non-histone methylation. They are involved in histone modification and regulate the methylation of various non-histone targets, contributing to genome regulation and cellular functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Plant Sciences
Muthusamy Ramakrishnan, Mingbing Zhou, Stanislaus Antony Ceasar, Doulathunnisa Jaffar Ali, Theivanayagam Maharajan, Kunnummal Kurungara Vinod, Anket Sharma, Zishan Ahmad, Qiang Wei
Summary: Somatic embryogenesis is a complex process regulated by genetic and epigenetic factors, including DNA and histone modifications, as well as miRNA regulation. These regulations influence the transition of somatic cells and the development of embryos, with the potential for somatic cell regeneration.
PLANT CELL REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Maria Manou, Dimitrios S. Kanakoglou, Theodoros Loupis, Dimitrios M. Vrachnos, Stamatios Theocharis, Athanasios G. Papavassiliou, Christina Piperi
Summary: Salivary gland tumors (SGTs) are a rare and heterogeneous category of tumors with increasing understanding of their molecular mechanisms, poor prognosis, and potential therapeutic options. Genetic and epigenetic factors are involved in their heterogeneity and clinical phenotypes. Histone acetylation/deacetylation, through histone deacetylating factors (HDACs) and selective or pan-HDAC inhibitors (HDACis), plays an active role in the pathobiology of SGTs, suggesting potential treatment options. This article summarizes the molecular and epigenetic mechanisms of SGTs, focusing on the effects of histone acetylation/deacetylation on gene expression and the progress of HDACis in SGT therapy and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Chongyang Chen, Jingfang Liu
Summary: Thyroid cancer, particularly papillary thyroid cancer (PTC), is a common malignancy of the endocrine system. The incidence of PTC is increasing annually. Histone acetylation modification, an important epigenetic mechanism, plays a role in PTC cell proliferation, differentiation, and the treatment and prognosis of PTC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
John A. Wolugbom, Stephanie E. Areloegbe, Kehinde S. Olaniyi
Summary: PCOS-associated depression is characterized by neuroinflammation and elevated ACH levels, accompanied by increased expression of HDAC2/DNA methyltransferase in PFC and hippocampus. Acetate can protect against PCOS-associated depression by suppressing prefrontal and hippocampal DNA methylation and prefrontal but not hippocampal HDAC2 expression.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Immunology
Yuqin Niu, Jianxiang Chen, Yiting Qiao
Summary: Tumorigenesis often involves chronic inflammation and the tumor microenvironment (TME) consists of various cells and extracellular components. Tumor cells and other cells undergo genetic and epigenetic alterations in the TME, with macrophages being the most plastic immune cell type and playing a crucial role in these alterations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Fani Karagianni, Christina Piperi, Berta Casar, Dalia de la Fuente-vivas, Rocio Garcia-Gomez, Kyriaki Lampadaki, Vasiliki Pappa, Evangelia Papadavid
Summary: The combination of Resminostat and Ruxolitinib demonstrated significant antitumor effects in CTCL progression, inhibiting tumor growth, migration, invasion, and metastasis. The chick embryo chorioallantoic membrane (CAM) model was used to validate these effects, providing a preclinical in vivo model for pharmacological testing.
Review
Biochemistry & Molecular Biology
Debarati Rakshit, Sudipta Nayak, Snehashis Kundu, Efthalia Angelopoulou, Efstratios-Stylianos Pyrgelis, Christina Piperi, Awanish Mishra
Summary: Parkinson's disease (PD) is a common neurological disorder characterized by dopaminergic neurodegeneration in the brainstem. Garlic and its organosulfur compounds have shown protective effects against PD by targeting oxidative stress, mitochondrial dysfunction, and neuroinflammation-related mechanisms. However, stability issues and adverse effects need to be addressed for their potential use in clinical practice.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Chemistry, Medicinal
Evangelos Evangeliou, Grigorios Plemmenos, Andreas Chalazias, Christina Piperi
Summary: TRP channels play a crucial role in oral pathology, including pain transduction, inflammation, and bone resorption. TRPV1 is important in pulpitis and periodontitis, while TRPM2 is involved in reduced saliva secretion after radiation. TRPA1 and TRPV1 mediate trigeminal nerve pain. Several TRP agonists and antagonists, as well as specific targeting techniques, have shown potential in blocking pathological processes in oral diseases.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Graciela Lopez-Soop, Trine Husoy, Marcin Wlodzimierz Wojewodzic, Hege Hjertholm, Anastasia Spyropoulou, Effrosyni S. Katsanou, Petros Batakis, Katerina Kyriakopoulou, Kyriaki Machera, Hubert Dirven, Birgitte Lindeman, Nur Duale
Summary: Exposure to phthalates is common in Europe, and their effects on the human transcriptome are largely unknown. A study conducted on blood samples from the Norwegian EuroMix cohort revealed that phthalate exposure led to differential gene expression, with DINCH showing the highest number of differentially expressed genes. Gene ontology analysis indicated that the differentially expressed genes were mainly associated with cellular metabolism, while phthalate metabolites MnBP and DINCH showed enrichment in immunological function pathways. The study also found associations between phthalates and genes involved in the PPAR signaling pathway. Overall, DINCH had similar effects on gene expression as phthalates, despite being considered a substitute for them.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis Skouras, Antonios N. Gargalionis, Christina Piperi
Summary: Exosomes are small extracellular vesicles that play a crucial role in cellular communication by transmitting signals between cells. They are involved in various physiological and pathological processes, including tumor progression and neurodegenerative diseases. Gliomas, in particular, secrete exosomes that influence cell invasion, migration, immune tolerance, and resistance to treatment. These exosomes carry molecules that promote communication between cancer cells and surrounding cells, providing valuable information about the tumor. Engineered exosomes also show potential as a drug delivery system. This review discusses the role of exosomes in glioma pathogenesis, their diagnostic utility, and potential applications in treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Manou, Dimitrios S. Kanakoglou, Theodoros Loupis, Dimitrios M. Vrachnos, Stamatios Theocharis, Athanasios G. Papavassiliou, Christina Piperi
Summary: Salivary gland tumors (SGTs) are a rare and heterogeneous category of tumors with increasing understanding of their molecular mechanisms, poor prognosis, and potential therapeutic options. Genetic and epigenetic factors are involved in their heterogeneity and clinical phenotypes. Histone acetylation/deacetylation, through histone deacetylating factors (HDACs) and selective or pan-HDAC inhibitors (HDACis), plays an active role in the pathobiology of SGTs, suggesting potential treatment options. This article summarizes the molecular and epigenetic mechanisms of SGTs, focusing on the effects of histone acetylation/deacetylation on gene expression and the progress of HDACis in SGT therapy and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Filippos Anagnostakis, Michail Kokkorakis, Mariam Markouli, Christina Piperi
Summary: Solute carriers (SLCs) play a crucial role in brain physiology and homeostasis by transporting necessary substances across cell membranes. Their involvement in brain tumor development and progression has significant implications in the field of pharmacological targeting strategies and drug development. This review highlights the key structural and functional characteristics of SLCs in glioma pathogenesis, along with potential targeting options for CNS drug design and more effective glioma management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Christina Piperi, Mariam Markouli, Antonios N. N. Gargalionis, Kostas A. A. Papavassiliou, Athanasios G. G. Papavassiliou
Summary: This review summarizes recent research advances on RNA modifications involved in glioma progression and tumor microenvironment immunoregulation, as well as in the development of adaptive drug resistance. Current progress on major RNA modification targeting strategies is also summarized.
Article
Oncology
Alexios-Fotios A. Mentis, Kostas A. Papavassiliou, Christina Piperi, Athanasios G. Papavassiliou
Summary: Cancer and brain research have historically focused on studying brain cancer, but now there is increasing interest in the field of neuro-oncology and the regulation of tumorigenesis in the nervous system. Evidence suggests that somatic mutations in cancer-related genes are also present in noncancerous brain disorders, indicating shared molecular alterations between cancer development/progression and nervous system pathologies. Understanding these commonalities could lead to repurposing cancer drugs for brain disorders and improving our understanding of the basis of these diseases.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Marialena Pouliou, Marianna A. Koutsi, Lydia Champezou, Angeliki-Ioanna Giannopoulou, Giannis Vatsellas, Christina Piperi, Marios Agelopoulos
Summary: This study assesses the upregulation of metabolism-related transcription factors (TFs) in neuroblastoma cells due to the amplification of MYCN. The results reveal the regulatory mechanism of MYCN in the metabolic processes of neuroblastoma.
Review
Biochemistry & Molecular Biology
Panagiotis Skouras, Mariam Markouli, Theodosis Kalamatianos, George Stranjalis, Penelope Korkolopoulou, Christina Piperi
Summary: Liquid biopsy is a minimally invasive method for sampling and monitoring gliomas. Compared to tissue biopsy, it is less invasive and provides faster data for diagnosis, prognosis, and recurrence evaluation.
Review
Biology
Efthalia Angelopoulou, Efstratios-Stylianos Pyrgelis, Chetana Ahire, Prachi Suman, Awanish Mishra, Christina Piperi
Summary: Protein arginine methyltransferases (PRMTs), which regulate various cellular mechanisms, including neuronal cell survival and excitability, have been implicated in the pathophysiology of neurodegenerative diseases.
Review
Biology
Grigorios Plemmenos, Valentini Tzimogianni, Christina Fili, Christina Piperi
Summary: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer and lacks specific biomarkers or treatment options. High Mobility Group Box 1 (HMGB1) protein, which is frequently upregulated in head and neck cancers, has attracted scientific interest due to its association with OSCC progression. HMGB1 can interact with signaling molecules on OSCC cells, promoting growth, invasion, and metastasis. This review aims to explore the functional role and associated signaling of HMGB1 in OSCC for potential therapeutic targeting options.
Review
Medicine, General & Internal
Efthalia Angelopoulou, Evangelia Stanitsa, Claire Chrysanthi Karpodini, Anastasia Bougea, Dionysia Kontaxopoulou, Stella Fragkiadaki, Christos Koros, Vasiliki Epameinondas Georgakopoulou, George Fotakopoulos, Yiannis Koutedakis, Christina Piperi, Sokratis G. Papageorgiou
Summary: Depression is a common non-motor disorder in Parkinson's disease, affecting both patients and their caregivers. Pharmacological and non-pharmacological treatments are available, but the optimal approach for managing PD depression remains uncertain and challenging.
MEDICINA-LITHUANIA
(2023)
Review
Medicine, General & Internal
Efthalia Angelopoulou, Anastasia Bougea, Yam Nath Paudel, Vasiliki Epameinondas Georgakopoulou, Sokratis G. G. Papageorgiou, Christina Piperi
Summary: Parkinson's disease (PD) is a heterogeneous disorder with poorly understood pathological factors. Depression is a common non-motor symptom of PD, and genetic polymorphisms may influence the risk of depression in PD patients. This review explores the role of genetic factors in the development of PD depression, aiming to understand its molecular pathobiology and facilitate the development of targeted treatments.
MEDICINA-LITHUANIA
(2023)