Article
Immunology
Xinliang Kang, Yibo Li, Yiwen Zhao, Xinyuan Chen
Summary: The study demonstrates that CpG 1018 adjuvant significantly enhances influenza vaccine efficacy in aged mice and helps induce antibody responses against influenza virus. This provides important insights for boosting immune responses and improving influenza vaccine effectiveness in the elderly population.
Review
Oncology
Huanan Jia, Wei Huang, Chuanfeng Liu, Shiyu Tang, Jing Zhang, Chongli Chen, Yuan Tian, Wen Zhong
Summary: This review discusses the relationship between immunosenescence, skeletal muscle, and frailty, exploring immunosenescence as a potential therapeutic target to prevent frailty and extend healthspan, with emphasis on the effects of the COVID-19 pandemic on the elderly.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Rohit Sharma, Bhawna Diwan, Anamika Sharma, Jacek M. Witkowski
Summary: Immunological aging is strongly associated with the negative effects of human aging. Traditionally, the understanding of aging immune cells has focused on immunosenescence, but it is now realized that cellular senescence also plays a fundamental role in immunological aging. Emerging studies suggest that cellular senescence can occur in aging immune cells, contributing to various aspects of physiological aging. This review aims to provide an overview of immunosenescence and cellular senescence in immune cells, and highlights the importance of understanding cellular senescence in truly comprehending the concept of an "aged immune cell". Additionally, the review discusses the potential role of dietary factors in modulating immunosenescence and cellular senescence for nutrition-oriented immunotherapy during aging.
Review
Immunology
Nasser Hashemi Goradel, Mahnaz Nemati, Azam Bakhshandeh, Arash Arashkia, Babak Negahdari
Summary: Cancer vaccines have been developed as an interesting cancer immunotherapy approach to deliver tumor antigens and adjuvants to antigen-presenting cells (APCs). Nanotechnology-based vaccines, known as nanovaccines, address the limitations of traditional vaccines by co-delivering antigens and adjuvants to lymphoid organs and APCs, leading to potent anti-tumor immune responses. The formation of nanocomplexes between antigens and adjuvants based on electrostatic interactions has shown promising results in enhancing immune responses. This article summarizes the various platforms for developing cancer vaccines, discusses the advantages of using delivery systems, and focuses on the potential of nanocomplexes formation as cancer nanovaccine platforms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi, Mohsen Ghiasi, Hamid Kooshki, Mozafar Mohammadi, Jafar Amani, Nima Rezaei
Summary: New findings suggest that targeting aging pathways can improve the treatment of COVID-19. Boosting the immune system with new therapies can help elderly individuals with comorbidities fight against severe forms of the virus.
AGEING RESEARCH REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Review
Geriatrics & Gerontology
Mingxuan Chi, Zijun Tian, Kuai Ma, Yunlong Li, Li Wang, Moussa Ide Nasser, Chi Liu
Summary: Immunosenescence is the deterioration of the immune system associated with aging, leading to impaired immune protection and chronic inflammation. It is more pronounced in patients with kidney diseases and increases the risk of permanent renal damage and cardiovascular events. Biological drugs can be used to target the aging immune system and protect the kidneys.
Review
Immunology
Miguel angel Palacios-Pedrero, Albert D. M. E. Osterhaus, Tanja Becker, Husni Elbahesh, Guus F. Rimmelzwaan, Giulietta Saletti
Summary: Immunosenescence is a process associated with aging that leads to dysregulation of immune cells, increasing susceptibility to infections and reducing vaccine efficacy in older adults. Understanding immunosenescence can help in developing new strategies to enhance immune function in this vulnerable age group.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Francesca Rossi, Alessandra Di Paola, Elvira Pota, Maura Argenziano, Daniela Di Pinto, Maria Maddalena Marrapodi, Caterina Di Leva, Martina Di Martino, Chiara Tortora
Summary: Around 80% of children treated for childhood cancer become long-term survivors, but they often experience chronic late effects related to treatments. Frailty, characterized by vital organ failure and premature aging processes, is common in childhood cancer survivors due to a chronic low-grade inflammation known as inflamm-aging. Treatment strategies to counteract inflamm-aging and prevent side effects are important for improving the quality of life in these survivors.
Review
Cell Biology
Yustina M. Puspitasari, Stefano Ministrini, Lena Schwarz, Caroline Karch, Luca Liberale, Giovanni G. Camici
Summary: The improvements in healthcare services and quality of life are leading to a longer life expectancy, resulting in a larger population of elderly individuals who are more susceptible to age-related cardiovascular diseases. Inflammation has been recognized as a key factor in the pathogenesis of cardiovascular diseases, suggesting that inflamm-aging could potentially be a driver of age-related cardiovascular afflictions and a viable therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Review
Cardiac & Cardiovascular Systems
Luca Liberale, Lina Badimon, Fabrizio Montecucco, Thomas F. Luscher, Peter Libby, Giovanni G. Camici
Summary: Aging and inflammation both play key roles in cardiovascular and cerebrovascular diseases, recognizing the concept of inflamm-aging can lead to new therapeutic targets and options for the growing aging population. This review discusses recent scientific advances in understanding the pathways of inflamm-aging and its potential implications in clinical practice.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Geriatrics & Gerontology
Lei Dou, Yang Peng, Bin Zhang, Huiyuan Yang, Kai Zheng
Summary: Aging is associated with changes in the immune system and gut microbiota. These changes can lead to age-related diseases, and nutrition plays a role in immune function and gut microbiota. Immunonutrition is seen as a strategy for disease prevention and management, especially in age-related diseases.
Article
Geriatrics & Gerontology
Gemma Lombardi, Roberto Paganelli, Michele Abate, Alex Ireland, Raffaele Molino-Lova, Sandro Sorbi, Claudio Macchi, Raffaello Pellegrino, Angelo Di Iorio, Francesca Cecchi
Summary: Elevated lymphocyte counts and lymphocyte-to-monocyte ratio are associated with a clinical diagnosis of dementia, with the latter directly linked to any type of dementia. These markers may signify immunological changes in the brains of dementia patients and could serve as low-cost and easily accessible indicators for further research.
Article
Multidisciplinary Sciences
Rong Yang, Shanshan Zhou, Qibing Zhou
Summary: In vitro cancer cells treated with a new potent ICD inducer, NAP, followed by UVA irradiation, were effective tumor immunotherapy when combined with CpG adjuvant, leading to enhanced survival and activation of T cells in tumors.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Faith H. N. Howard, Haider Al-Janabi, Priya Patel, Katie Cox, Emily Smith, Jayakumar Vadakekolathu, A. Graham Pockley, Joe Conner, James F. Nohl, Dan A. Allwood, Cristal Collado-Rojas, Aneurin Kennerley, Sarah Staniland, Munitta Muthana
Summary: The coassembly of magnetic nanoparticles and herpes simplex virus enhances tumor targeting, protects the virus, promotes immune response, and leads to tumor shrinkage and increased survival.
Article
Oncology
Pauline Le Vu, Jayakumar Vadakekolathu, Sarra Idri, Holly Nicholls, Manon Cavaignac, Stephen Reeder, Masood A. Khan, Dennis Christensen, Alan Graham Pockley, Stephanie E. McArdle
Summary: The study found that peripheral blood of prostate cancer patients exhibits immune responsiveness to the MutPAP42mer peptide, and immunization of mice produces T cell-driven immunity against wild-type PAP, suggesting the potential for generating protective anti-tumor immunity in prostate cancer patients.
Article
Medicine, General & Internal
Andreas Tolf, Anna Wiberg, Malin Muller, Faisal Hayat Nazir, Ivan Pavlovic, Ida Lauren, Sara Mangsbo, Joachim Burman
Summary: For an optimal vaccine response from tozinameran, rituximab-treated patients with multiple sclerosis should be vaccinated as soon as possible, with rituximab treatment delayed until B-cell counts have reached at least 40/mu L. An additional vaccination with tozinameran should be considered at that point.
Article
Immunology
Ida Lauren, Sebastian Havervall, Henry Ng, Martin Lord, Aleksandra Pettke, Nina Greilert-Norin, Lena Gabrielsson, Aikaterini Chourlia, Catarina Amoedo-Leite, Vijay S. Josyula, Mohamed Eltahir, Iliana Kerzeli, August J. Falk, Jonathan Hober, Wanda Christ, Anna Wiberg, My Hedhammar, Hanna Tegel, Joachim Burman, Feifei Xu, Elisa Pin, Anna Manberg, Jonas Klingstrom, Gustaf Christoffersson, Sophia Hober, Peter Nilsson, Mia Philipson, Pierre Donnes, Robin Lindsay, Charlotte Thalin, Sara Mangsbo
Summary: This study investigates the correlation between symptomology and cellular immune responses post seroconversion to COVID-19. The findings demonstrate that the severity of the disease and specific COVID-19 symptoms are correlated with the magnitude of SARS-CoV-2-specific memory T cell responses. The study highlights the importance of cellular immune memory in understanding the immune response to COVID-19.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Letter
Infectious Diseases
Kim Blom, Ulrika Marking, Sebastian Havervall, Nina Greilert Norin, Max Gordon, Marina Garcia, Teghesti Tecleab, Wanda Christ, Mattias Forsell, Mia Phillipson, Peter Nilsson, Sara Mangsbo, Sophia Hober, Mikael Aberg, Jonas Klingstrom, Charlotte Thalin
LANCET INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Espen Basmo Ellingsen, Gergana Bounova, Iliana Kerzeli, Irantzu Anzar, Donjete Simnica, Elin Aamdal, Tormod Guren, Trevor Clancy, Artur Mezheyeuski, Else Marit Inderberg, Sara M. Mangsbo, Mascha Binder, Eivind Hovig, Gustav Gaudernack
Summary: This clinical trial evaluated the efficacy of a novel therapeutic cancer vaccine, UV1, in combination with ipilimumab, in patients with metastatic melanoma. It was found that the vaccine-induced T cells had clinical responses, regardless of established predictive biomarkers for checkpoint inhibitor efficacy. The combination of UV1 vaccine and checkpoint inhibitors warrants further investigation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Sara M. Mangsbo
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Oncology
Sophie Seier, Ali Bashiri Dezfouli, Philipp Lennartz, Alan Graham Pockley, Henriette Klein, Gabriele Multhoff
Summary: This study shows that elevated levels of circulating Hsp70 could be used as a tumor biomarker in NSCLC patients with advanced UICC stages. The levels of Hsp70 were significantly higher in advanced tumor stages compared to healthy controls and early-stage tumor patients, and the levels increased progressively with higher UICC tumor stages. Additionally, the proportions of CD4+ T helper cells were decreased, while the proportions of CD8+ cytotoxic T cells and CD94+ NK cells were increased. These findings suggest that measuring circulating Hsp70 levels may help predict advanced tumor stages in NSCLC.
Article
Biochemistry & Molecular Biology
Camilla Eriksson, Sunithi Gunasekera, Taj Muhammad, Mingshu Zhang, Ida Lauren, Sara M. Mangsbo, Martin Lord, Ulf Goransson
Summary: This study investigates the use of stable cyclic peptide scaffolds to present antigenic sequences derived from the spike protein of the SARS-CoV-2 virus. It shows that displaying epitopes on the scaffold improves reactivity and suggests diagnostic potential.
Article
Multidisciplinary Sciences
Ulrika Marking, Sebastian Havervall, Nina Greilert Norin, Oscar Bladh, Wanda Christ, Max Gordon, Henry Ng, Kim Blom, Mia Phillipson, Sara Mangsbo, Jessica J. Alm, Anna Smed-Sorensen, Peter Nilsson, Sophia Hober, Mikael Aberg, Jonas Klingstroem, Charlotte Thalin
Summary: Vaccination provides protection against severe COVID-19 caused by SARS-CoV-2 omicron, but is less effective against infection. High levels of serum antibodies are shown to be protective against infection and linked to reduced viral load and time to viral clearance. Pre-omicron SARS-CoV-2 infection is independently associated with increased protection against omicron, largely mediated by mucosal spike-specific IgA responses.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Peter Vaupel, Helmut Piazena, Markus Notter, Andreas R. Thomsen, Anca-L. Grosu, Felix Scholkmann, Alan Graham Pockley, Gabriele Multhoff
Summary: Mild hyperthermia (mHT) has significant effects on tumor oxygenation, which enhances the efficacy of radiotherapy, chemotherapy, and immunotherapy. The underlying mechanisms and the extent of these effects are not fully understood. This review discusses the biological mechanisms induced by mHT that are relevant to radio-oncology and immunotherapy.
Article
Oncology
Iliana K. Kerzeli, Alexandros Kostakis, Polat Turker, Per-Uno Malmstroem, Tammer Hemdan, Artur Mezheyeuski, Douglas G. Ward, Richard T. Bryan, Ulrika Segersten, Martin Lord, Sara M. Mangsbo
Summary: In this study, plasma and urine samples from bladder cancer patients were analyzed to identify potential biomarkers. It was found that MMP7 and CCL23 levels were higher in plasma, while CD27 and CD40 levels were higher in urine. Increased levels of MMP12 in plasma were associated with shorter overall survival. Tumor-infiltrating macrophages were identified as a possible source of MMP12.
Article
Biochemistry & Molecular Biology
Alexia Xanthopoulos, Ann-Kathrin Samt, Christiane Guder, Nicholas Taylor, Erika Roberts, Hannah Herf, Verena Messner, Anskar Trill, Katharina Larissa Kreszentia Holzmann, Marion Kiechle, Vanadin Seifert-Klauss, Sebastian Zschaeck, Imke Schatka, Robert Tauber, Robert Schmidt, Katrin Enste, Alan Graham Pockley, Dominik Lobinger, Gabriele Multhoff
Summary: Hsp70 is overexpressed in many tumors and selectively presented on the plasma membrane of tumor cells. It can be considered a universal tumor biomarker. Circulating levels of Hsp70 can serve as a predictive biomarker for therapeutic failure in early-stage tumors and as a target for the isolation of circulating tumor cells in different tumor diseases.
Article
Clinical Neurology
Faisal Hayat Nazir, Anna Wiberg, Malin Mueller, Sara Mangsbo, Joachim Burman
Summary: Multiple sclerosis is a complex and heterogeneous disease that often starts as a clinically isolated syndrome. Autoantibodies play an important role in its pathogenesis, but their target has been difficult to identify. Cell-based methods have been developed as an alternative strategy for detecting autoantibodies. This study explored differences in antibody binding to oligodendroglial and neuronal cell-lines in serum and CSF samples from multiple sclerosis patients and controls, and found that the binding of immunoglobulin G from CSF to the human oligodendroglioma cell-line was the best discriminator between patients and controls, with a high sensitivity and specificity. The cell-based ELISA showed a high degree of accuracy in discriminating between multiple sclerosis patients and controls, with the disease course being the major determinant for antibody binding.
BRAIN COMMUNICATIONS
(2023)
Article
Sport Sciences
Karah J. Dring, Simon B. Cooper, Ryan A. Williams, John G. Morris, Caroline Sunderland, Gemma A. Foulds, A. Graham Pockley, Mary E. Nevill
Summary: Adiposity and physical fitness are important determinants of metabolic health in adolescents. Greater adiposity is associated with a poorer inflammatory profile, while better physical fitness is associated with better metabolic health. Future research should focus on interventions to reduce adiposity and improve physical fitness in order to promote lifelong health.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2022)