Article
Neurosciences
Elizabeth M. Doncheck, Eden M. Anderson, Chaz D. Konrath, Gage T. Liddiard, Margot C. DeBaker, Luke A. Urbanik, Matthew C. Hearing, John R. Mantsch
Summary: This study found that E2 activates ER beta and GPER1 in the PrL-PFC to attenuate the GABA-mediated constraint of key outputs that mediate cocaine seeking.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anesthesiology
Jae-Hwan Jang, Eun-Mo Song, Young-Ho Do, Sora Ahn, Ju-Young Oh, Tae-Yeon Hwang, Yeonhee Ryu, Songhee Jeon, Mi-Yeon Song, Hi-Joon Park
Summary: The study suggests that acupuncture can alleviate chronic pain-induced comorbid conditions by altering DNA methylation of Nr4a1, Rasgrp1, Rassf1, and Chkb in the prefrontal cortex.
Article
Neurosciences
Jing Wei, Jia Cheng, Nicholas J. Waddell, Zi-Jun Wang, Xiaodong Pang, Qing Cao, Aiyi Liu, Javed M. Chitaman, Kristen Abreu, Rahul Singh Jasrotia, Lara J. Duffney, Jinfeng Zhang, David M. Dietz, Jian Feng, Zhen Yan
Summary: Recent evidence indicates that chronic stress can lead to aberrant gene transcription through epigenetic mechanisms involving DNA methylation and DNMTs. Specifically, stress-induced reduction of Dnmt3a in the prefrontal cortex may contribute to synaptic dysfunction and behavioral abnormalities, affecting pathways related to glutamatergic synapse and cognitive-emotional processes.
Article
Psychiatry
Eric Poisel, Lea Zillich, Fabian Streit, Josef Frank, Marion M. Friske, Jerome C. Foo, Naguib Mechawar, Gustavo Turecki, Anita C. Hansson, Markus M. Noethen, Marcella Rietschel, Rainer Spanagel, Stephanie H. Witt
Summary: This study investigates epigenome-wide DNA methylation signatures in the human brain tissue of individuals with cocaine use disorder (CUD). The results show differential methylation associated with neurotransmission and neuroplasticity in CUD, supporting the impact of cocaine on brain circuits. Further research integrating epigenetic signatures with transcriptomic and proteomic data is needed.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomita
Summary: This study investigated the transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) to understand the clinical and biological differences of schizophrenia between males and females. The results showed that females with schizophrenia had more significantly changed genes compared to males, and these changes were mainly related to mitochondrial, ATP- and metal ion-binding relevant biological processes. The differentially expressed genes related to schizophrenia in females were involved in midbrain dopaminergic and GABA-ergic neurons and microglia. Additionally, analysis of a murine model revealed that the methylation and transcriptional expression of the ACSBG1 locus potentially impact the sex differences in gene transcription.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Renata Kabiljo, Alfredo Iacoangeli, Ammar Al-Chalabi, Ivana Rosenzweig
Summary: ALS is a devastating neurodegenerative disease with unclear association with the cerebellar role, recent findings suggest certain gene variants are significantly linked to ALS risk. Gene-based and tissue enrichment analysis show a specific relationship between cerebellar tissue and ALS, calling for a re-evaluation of cerebellar involvement in ALS pathology.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yu-Ping Tsai, Shih-Han Hung, Tsung-Ren Huang, William C. Sullivan, Shih-An Tang, Chun-Yen Chang
Summary: Through functional magnetic resonance imaging scans, the study found significant differences in brain activity between graphic design thinking processes and specific design activities, with more activity in the left prefrontal cortex in designs involving more graphic design thinking. These findings contribute to understanding the design process and suggest potential ways to promote graphic design thinking in landscape architecture.
Article
Chemistry, Multidisciplinary
Lan Yan, Ji-an Wei, Fengzhen Yang, Mei Wang, Siqi Wang, Tong Cheng, Xuanjun Liu, Yanbin Jia, Kwok-Fai So, Li Zhang
Summary: Physical exercise can alleviate mental disorders, especially anxiety disorders, by restoring the function of RNA N-6-methyladenosine (m6A) in the brain to improve resilience against chronic stress.
Article
Substance Abuse
Chang Shu, David W. Sosnowski, Ran Tao, Amy Deep-Soboslay, Joel E. Kleinman, Thomas M. Hyde, Andrew E. Jaffe, Sarven Sabunciyan, Brion S. Maher
Summary: Opioid abuse is associated with changes in DNA methylation and epigenetic alterations may be related to opioid use behavior and genes associated with opioids. Further research is needed to specifically elucidate this association and understand the complex genetic mechanisms of opioid abuse.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Neurosciences
Arijana Demaili, Anna Portugalov, Michal Dudai, Mouna Maroun, Irit Akirav, Katharina Braun, Joerg Bock
Summary: Environmental factors experienced during early life or adolescence, such as stress, may increase the risk of behavioral and mental disorders later in life. The study focuses on the impact of early life stress and adolescent stress on the expression of regulatory elements of the endocannabinoid system in the medial prefrontal cortex of adult female rats. The results show that early life stress has a buffering effect on gene expression changes induced by adolescent stress. Additionally, these gene expression changes are associated with altered DNA methylation patterns in the promoter regions of the genes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alfredo Bellon, Vincent Feuillet, Alonso Cortez-Resendiz, Faycal Mouaffak, Lan Kong, L. Elliot Hong, Lilian De Godoy, Therese M. Jay, Anne Hosmalin, Marie-Odile Krebs
Summary: This study used Monocyte-Derived-Neuronal-like Cells (MDNCs) to investigate the dopamine pruning effects in the neuronal development of schizophrenia (SCZ) patients. The results showed that SCZ patients' cells differentiated more efficiently, extended longer neurites, but had less primary neurites. Additionally, medication in patients influenced the pruning effects under dopamine exposure.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
S. F. A. Axelsson, N. K. Horst, Naotaka Horiguchi, A. C. Roberts, T. W. Robbins
Summary: Studies have shown the significant role of ventrolateral prefrontal cortex (vlPFC) in higher order cognitive functions, with inactivation causing disruption in sequencing accuracy. Dopamine and serotonergic blockade had contrasting effects on performance, with dopamine producing error perseveration and serotonin significantly impairing accuracy.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
J. Blaze, A. Navickas, H. L. Phillips, S. Heissel, A. Plaza-Jennings, S. Miglani, H. Asgharian, M. Foo, C. D. Katanski, C. P. Watkins, Z. T. Pennington, B. Javidfar, S. Espeso-Gil, B. Rostandy, H. Alwaseem, C. G. Hahn, H. Molina, D. J. Cai, T. Pan, W. D. Yao, H. Goodarzi, F. Haghighi, S. Akbarian
Summary: The deficiency of neuronal Nsun2 leads to codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice. Disruption of neuronal tRNA cytosine methylation results in bi-directional changes in depression-related behaviors and alterations in the neuronal translatome. These findings highlight the importance of methylation sensitivity of glycinergic tRNAs in the adult prefrontal cortex and the link between synaptic plasticity and complex behaviors to epitranscriptomic modifications of cognate tRNAs and specific amino acids in the proteomic homeostasis.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Justin Treas, Priti Roy, Kamaleshwar P. Singh
Summary: This study found that coexposure to arsenic and estrogen can affect the expression of estrogen receptors and genes involved in estrogen metabolism in human prostate epithelial cells. The coexposure leads to increased expression of certain genes, decreased expression of detoxification genes, and hypermethylation of DNA repair genes. These findings provide a molecular basis for the potentiation of carcinogenicity in prostate epithelial cells when exposed to both arsenic and estrogen.
Article
Biochemistry & Molecular Biology
Valencia Fernandes, Anika Sood, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: This study aims to understand the effect of global DNA methylation on the cerebral complications of type 2 diabetes mice and its impact on maintaining synaptic fidelity. The results suggest that neuroepigenetic alterations, specifically DNA hypermethylation, may be involved in the prefrontal cortex of type 2 diabetes mice. This has implications for controlling neurological alterations in the brain.
MOLECULAR BIOLOGY REPORTS
(2022)