Article
Physiology
Jerry Yu
Summary: In the study, creeping behavior was observed in 62 out of 137 SAR units examined in anesthetized rabbits. Creeping refers to the phenomenon where unit discharge either declines slowly or increases when lung inflation pressure is constant. Creeping is likely the result of encoder switching from low to high discharge SAR units.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Review
Clinical Neurology
Juan S. Leon-Ariza, Mario A. Mosquera, Vitaly Siomin, Angelo Fonseca, Daniel S. Leon-Ariza, Mayra A. Gualdron, Fidias E. Leon-Sarmiento
Summary: This study reviewed scientific publications on vagal nerve somatosensory-evoked potential (VSEP) findings in individuals with brain disorders and presented new physiological explanations. Results showed that VSEP is not a brain-evoked potential but muscle activity induced by electrical stimulation, arguing against its use for assessing the parasympathetic system.
CLINICAL EEG AND NEUROSCIENCE
(2022)
Article
Neurosciences
Maia Terashvili, Bhavana Talluri, Watchareepohn Palangmonthip, Kenneth A. Iczkowski, Patrick Sanvanson, Bidyut K. Medda, Banani Banerjee, Christopher W. Cunningham, Jyoti N. Sengupta
Summary: The study found that the low-efficiency analgesic drug BOM can produce analgesia by attenuating mechanotransduction functions of bladder afferent fibers, and also has significant alleviating effects in the bladder pain behavior model.
Article
Cell Biology
Meike C. Ploeg, Chantal Munts, Frits W. Prinzen, Neil A. Turner, Marc van Bilsen, Frans A. van Nieuwenhoven
Summary: In this study, Piezo1 was identified as a mediator of stretch-induced Nppb expression, as well as other remodeling genes, in cardiac fibroblasts.
Article
Chemistry, Physical
Shailaja Seetharaman, Benoit Vianay, Vanessa Roca, Aaron J. Farrugia, Chiara De Pascalis, Batiste Boeda, Florent Dingli, Damarys Loew, Stephane Vassilopoulos, Alexander Bershadsky, Manuel Thery, Sandrine Etienne-Manneville
Summary: Mechanotransduction is a process where cells sense mechanical properties of their environment, with integrin-mediated focal adhesions being crucial sites. The crosstalk between microtubules and actin in mechanotransduction affects cell adhesion and migration. Substrate-rigidity-dependent microtubule acetylation controls YAP translocation, focal adhesion distribution, actomyosin contractility, and cell migration.
Article
Robotics
Youcan Yan, Zhe Hu, Zhengbao Yang, Wenzhen Yuan, Chaoyang Song, Jia Pan, Yajing Shen
Summary: The research presents a soft tactile sensor with self-decoupling and super-resolution abilities, which can accurately measure forces and achieve 60-fold super-resolved accuracy enhancement. The sensor's application can help robots accomplish challenging tasks and provide new insights into various applications in the robotics field.
Article
Cell Biology
Guang Zuo, Yidan Gao, Guangtong Lu, Ming Bu, Jun Liu, Juncha Zhang, Xisheng Fan, Hao Chen, Xuesong Wang, Yanfen She
Summary: In this study, the anti-inflammatory effects of auriculotherapy in the treatment of acne vulgaris were explored. The results showed that auricular bloodletting therapy, auricular point sticking, and a combination of both therapies could improve the inflammatory symptoms of acne and reduce inflammatory cytokines.
MEDIATORS OF INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Vanessa Judith Flegler, Akiko Rasmussen, Karina Borbil, Lea Boten, Hsuan-Ai Chen, Hanna Deinlein, Julia Halang, Kristin Hellmanzik, Jessica Loeffler, Vanessa Schmidt, Cihan Makbul, Christian Kraft, Rainer Hedrich, Tim Rasmussen, Bettina Boettcher
Summary: MscS channel opens when delipidated by detergents and closes after addition of detergent-solubilized lipids, supporting the model that lipid extrusion causes gating. The distribution of aliphatic chains during gating suggests that lipids leave the complex on the cytosolic side under high lateral tension, and flow into gaps on the periplasmic side.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Agnieszka Brochocka, Aleksandra Nowak, Hanna Zajaczkowska, Marta Sieradzka
Summary: The paper explores various dispersive systems for sensing toxic substance-ammonia, ultimately selecting the most effective sensor containing rGO.
Article
Neurosciences
Coty M. Cooper, Ariana Q. Farrand, Michael C. Andresen, Eric Beaumont
Summary: This study suggests that in VNS therapy, a mid-collicular knife cut (KC) reduces the basal spontaneous activity of second-order NTS neurons receiving myelinated vagal input, and acute VNS increases activity in these neurons. Furthermore, the KC interrupts VNS activation of higher order NTS neurons and second-order NTS neurons receiving unmyelinated vagal input, indicating the importance of supramedullary descending projections to NTS in amplifying the peripheral neuronal signal from VNS.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Kristi A. Streeter, Michael D. Sunshine, Paul W. Davenport, David D. Fuller
Summary: The activation of phrenic afferents enhances contralateral phrenic motor amplitude when large-diameter fibers are activated, while recruitment of small-diameter fibers is associated with changes in burst frequency and cardiovascular parameters. Episodic activation of large-diameter phrenic afferents may also induce short-term plasticity.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Po-Yu Ho, Tsu Yu Chou, Chuen Kam, Wenbin Huang, Zikai He, Alfonso H. W. Ngan, Sijie Chen
Summary: In this study, a dual organelle-targeting fluorescent probe was developed to map the mechanical environment in live cells. The probe can target the plasma membrane and intracellular mitochondria, allowing visualization of changes in membrane tension in response to different mechanical stimuli. Computational simulations were used to investigate the sensing mechanism of the probe. This study provides a valuable tool for studying organelle interactions in mechanobiology.
Review
Cell Biology
Shuying Yang, Sergey V. Plotnikov
Summary: Cells in the human body respond to environmental cues, and tissue mechanics play a key role in disease development. During inflammation, tissue stiffness is upregulated, promoting immune cell response and fibrotic phenotype formation.
Article
Physiology
Piotr Krutki, Wlodzimierz Mrowczynski, Jan Celichowski, Marcin Baczyk
Summary: This study provides new insights into neuronal plasticity following repeated mechanical loading. Through electrophysiological experiments on rat lumbar motoneurons, we demonstrate that low-volume whole body vibration applied systematically for 5 weeks enhances synaptic excitation from primary muscle afferents. The adaptive changes are characterized by higher amplitudes and shorter rise times of monosynaptic EPSPs in the vibrated group compared to the control.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuanglong Xiao, Jing Xu, Jun Tan, Shengyan Zhang, Nian Wang, Ruiyun Wang, Pengcheng Yang, Tao Bai, Jun Song, Zhaohong Shi, Wenliang Lyu, Lei Zhang, Xiaohua Hou
Summary: Zhizhu Kuanzhong (ZZKZ) is a traditional Chinese medicine that has been widely used in clinical therapy for functional dyspepsia (FD). This study aimed to evaluate the pharmacological effects and mechanisms of action of ZZKZ on gastric hypersensitivity and motor dysfunction in a rat model of FD. The results showed that ZZKZ improved FD-related gastric hypersensitivity and motor dysfunction, and the gastric 5-HT system with lower 5-HT3 activity and increased 5-HT4 distribution was involved in the mechanisms of ZZKZ underlying the treatment of FD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Kate Sutherland, Aidan J. Weichard, Margot J. Davey, Rosemary S. C. Horne, Peter A. Cistulli, Gillian M. Nixon
SLEEP AND BREATHING
(2020)
Article
Clinical Neurology
Ahmad A. Bamagoos, Danny J. Eckert, Kate Sutherland, Joachim Ngiam, Peter A. Cistulli
SLEEP AND BREATHING
(2020)
Review
Dentistry, Oral Surgery & Medicine
G. J. Lavigne, A. Herrero Babiloni, G. Beetz, C. Dal Fabbro, K. Sutherland, N. Huynh, P. A. Cistulli
JOURNAL OF DENTAL RESEARCH
(2020)
Letter
Critical Care Medicine
Bhajan Singh, Greg Maislin, Brendan T. Keenan, Nigel McArdle, Diego R. Mazzotti, Ulysses Magalang, Allan I. Pack
Article
Critical Care Medicine
Fabiola G. Rizzatti, Diego R. Mazzotti, Jesse Mindel, Greg Maislin, Brendan T. Keenan, Lia Bittencourt, Ning-Hung Chen, Peter A. Cistulli, Nigel McArdle, Frances M. Pack, Bhajan Singh, Kate Sutherland, Bryndis Benediktsdottir, Ingo Fietze, Thorarinn Gislason, Diane C. Lim, Thomas Penzel, Bernd Sanner, Fang Han, Qing Yun Li, Richard Schwab, Sergio Tufik, Allan Pack, Ulysses J. Magalang
Review
Clinical Neurology
Diane C. Lim, Diego R. Mazzotti, Kate Sutherland, Jesse W. Mindel, Jinyoung Kim, Peter A. Cistulli, Ulysses J. Magalang, Allan I. Pack, Philip de Chazal, Thomas Penzel
SLEEP MEDICINE REVIEWS
(2020)
Review
Clinical Neurology
Seren Ucak, Hasthi U. Dissanayake, Kate Sutherland, Philip de Chazal, Peter A. Cistulli
Summary: Obstructive sleep apnea (OSA) is a common condition that increases the risk of cardiovascular diseases, with sympathetic overactivity being a primary contributing factor. Heart rate variability (HRV) can evaluate shifts in the autonomic nervous system, aiding in treatment response and cardiovascular risk detection in OSA patients. New technologies aim to enhance HRV analysis efficiency for quicker processing, improved diagnosis of OSA, and better detection of cardiovascular risk.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Gurpreet Chaggar, Kate Sutherland, Fang Han, Ingo Fietze, Thomas Penzel, Bryndis Benediktsdottir, Thorarinn Gislason, Ulysses Magalang, Allan Pack, Bhajan Singh, Nigel McArdle, Lia Bittencourt, Qing Yun Li, Ning Hung Chen, Philip de Chazal, Peter A. Cistulli, Yu Sun Bin
Summary: The study found that women who snore during pregnancy continue snoring in later life but do not appear more likely to develop OSA. The findings are limited by self-reported data and a small number of women who reported snoring during pregnancy.
Article
Medicine, General & Internal
Mark Bastianelli, Lucy Huang, Paige Moore, Isma Zafar Iqbal, Charmaine M. Woods, Eng H. Ooi
Summary: In patients undergoing EMLP surgery for frontal sinus pathology, there were no significant differences in peri-operative time to healing between patients using a mucosal flap to cover the exposed bone on one side of the neo-ostium compared to those not using a flap. Post-operative SNOT-22 and UPSIT scores improved.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Julie Huynh, Charmaine M. Woods, Eng H. Ooi
Summary: This study investigated parental perceptions of the effects of tonsillectomy on their child's quality of life in an Australian public health system. The results showed that pediatric tonsillectomy improves quality of life with sustained benefits in the long term. However, there is no improvement in the patient's quality of life while awaiting surgery.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Lachlan Cook, Charmaine Woods, Tracey Nicholls, Eng H. Ooi
Summary: This study aimed to assess whether head and neck cancer treatment at Flinders Medical Centre in Australia was delivered within the recommended timeframe and identify factors associated with treatment delays. The results showed that delays in treatment initiation were associated with patients undergoing primary radiotherapy treatment and those requiring prophylactic gastrostomy tube insertion. Treatment initiation beyond the recommended timeframe did not significantly impact overall survival or disease-free survival.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Alice Hatt, Elizabeth Brown, David J. Berlowitz, Fergal O'Donoghue, Hailey Meaklim, Alan Connelly, Graeme Jackson, Kate Sutherland, Peter A. Cistulli, Bon San Bonne Lee, Lynne E. Bilston
Summary: Patients with obstructive sleep apnoea (OSA) after cervical spinal cord injury (SCI) exhibit heterogeneous pharyngeal dilator muscle responses during quiet breathing, similar to non-SCI OSA patients. However, as a group, SCI OSA patients appear to be more similar to non-SCI OSA patients than to healthy controls of similar age and BMI. This may indicate altered pharyngeal pressure reflex responses in some individuals with SCI.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Clinical Neurology
Kate Sutherland, Oyku Dalci, Peter A. Cistulli
SLEEP MEDICINE CLINICS
(2021)
Article
Medicine, General & Internal
Lia Stepan, Lucy Huang, Julie Huynh, Phillip Xie, Charmaine M. Woods, Eng H. Ooi
Summary: The study assessed the outcomes of Bizact(TM) device for tonsillectomy in a pediatric population, showing effectiveness in treating common indications for pediatric tonsillectomy and significantly improving children's quality of life postoperatively.
MEDICINA-LITHUANIA
(2021)
Proceedings Paper
Engineering, Biomedical
Nadi Sadr, Yu Sun Bin, Kate Sutherland, Kristina Cook, Hasthi Dissanayake, Peter Cistulli, Philip de Chazal
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
(2020)