Article
Clinical Neurology
Jose G. Romano, Hannah Gardener, Iszet Campo-Bustillo, Yosef Khan, Sofie Tai, Nikesha Riley, Eric E. Smith, Ralph L. Sacco, Pooja Khatri, Heather M. Alger, Brian Mac Grory, Deepak Gulati, Navdeep S. Sangha, Jeffrey M. Craig, Karin E. Olds, Curtis G. Benesch, Adam G. Kelly, Scott S. Brehaut, Amit C. Kansara, Lee H. Schwamm
Summary: The study found that most patients with mild strokes had poor outcomes in the study. The primary outcome was a 90-day modified Rankin Scale score of 0 to 1, with secondary outcomes including good outcomes in the Barthel Index, Stroke Impact Scale-16, and European Quality of Life. Factors such as age, gender, race, and baseline NIHSS score were identified as predictors of worse outcomes.
Review
Neurosciences
Atsushi Mizuma, Midori A. Yenari
Summary: While treatments for acute stroke have improved, the focus has mainly been on revascularization strategies instead of neuroprotection. The lack of clinical translation of promising neuroprotective therapies may be attributed to historical oversight of comorbidities in stroke patients. Identifying effective treatments by incorporating comorbidities into stroke models could lead to new clinical level interventions.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tao Peng, Keith Booher, Melanie R. Moody, Xing Yin, Jaroslaw Aronowski, David D. Mcpherson, Sean I. Savitz, Hyunggun Kim, Shao-Ling Huang
Summary: This study demonstrates that the combination therapy of Xe-loaded liposomes and rtPA provides enhanced therapeutic efficacy in stroke treatment, leading to decreased neuronal cell death and mitigation of hemorrhagic side effects associated with late rtPA treatment.
Article
Immunology
Guangshuo Li, Yahui Hao, Chuanying Wang, Shang Wang, Yunyun Xiong, Xingquan Zhao
Summary: In this study, the relationship between neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) with in-hospital clinical outcomes in ischemic stroke patients treated with intravenous tissue plasminogen activator (IV tPA) was investigated. The results showed that NLR at 24 hours was associated with early neurological improvement (ENI), while NLR at 48 hours and LMR at 48 hours were closely related to favorable functional outcomes at discharge.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Editorial Material
Clinical Neurology
Ruining She, Jinwen Ge, Zhigang Mei
Summary: This article discusses the multifaceted functions of tPA in the central nervous system and explores the therapeutic potential of tPA in acute ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yang Ye, Quan Li, Chun-Shui Pan, Li Yan, Kai Sun, Xiao-Yi Wang, Shu-Qi Yao, Jing-Yu Fan, Jing-Yan Han
Summary: The study demonstrated that QiShenYiQi (QSYQ) can attenuate tPA-induced brain edema and hemorrhage by protecting blood-brain barrier integrity, partly through restoration of energy metabolism, inflammation protection, and Src/Caveolin signaling activation. QSYQ was shown to be an effective adjunctive therapy to increase the safety of delayed tPA thrombolysis for ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Xingping Quan, Yan Han, Pengde Lu, Yuanfu Ding, Qingfu Wang, Yiyang Li, Jianwen Wei, Qiaoxian Huang, Ruibing Wang, Yonghua Zhao
Summary: This study developed a novel tPA delivery platform (APLT-PA) based on Annexin V and platelet membrane for the treatment of ischemic stroke. APLT-PA exhibited high targeting efficiency by binding to activated platelets and showed significant thrombolysis and improvement in neurological function in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Hongyin Ma, Zhenmin Jiang, Jiayun Xu, Junqiu Liu, Zhen-Ni Guo
Summary: Ischemic stroke, caused by sudden reduction in cerebral blood flow, is a major cause of severe disability and death globally. The use of tissue plasminogen activator (tPA) for thrombolysis treatment has limitations, but nanotechnology-based strategies have shown promise in improving thrombolytic efficacy and targeted delivery of thrombolytic agents.
Article
Endocrinology & Metabolism
Enming J. Su, Daniel A. Lawrence
Summary: This white paper examines the current challenges in treating ischemic stroke in diabetic patients, emphasizing the need for a greater understanding of the mechanisms underlying the relationship between diabetes and cerebral vascular responses to ischemia. It also addresses the critical need to improve the efficacy and safety of thrombolysis, as well as the need for better characterization of the off-target actions of tPA, the only currently approved thrombolytic for ischemic stroke treatment.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Review
Hematology
Maxime Gauberti, Sara Martinez de Lizarrondo, Denis Vivien
Summary: Twenty-five years ago, intravenous thrombolysis has transformed the care for patients with acute ischemic stroke, and recent clinical trials have shown the benefits of mechanical thrombectomy. However, new strategies targeting tPA-resistant thrombi, such as tenecteplase, and experimental models targeting DNA and von Willebrand factor show promising results for improving stroke outcomes. Further research and trials are needed to enhance the effectiveness of thrombolysis in ischemic stroke patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Emergency Medicine
Allison Jolley, Madison McKnight, Kacie Clark
Summary: Tissue plasminogen activator (tPA) is a commonly used treatment for acute ischemic stroke (AIS), but it can have life-threatening adverse reactions. Retropharyngeal hematoma (RPH) following tPA administration is uncommon, and our case describes a unique presentation mimicking angioedema. The patient received cryoprecipitate for tPA reversal after CT and laboratory findings.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Milton H. Hamblin, Jean-Pyo Lee
Summary: Neural stem cell transplantation shows promise in treating ischemic stroke by potentially therapeutic actions against neurovascular injury. By secreting factors that stimulate endogenous repair mechanisms, NSCs can promote self-recovery in early-stage ischemic stroke and improve short-term and long-term stroke outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Guangshuo Li, Chuanying Wang, Shang Wang, Yunyun Xiong, Xingquan Zhao
Summary: Tenecteplase (TNK) has the potential to substitute alteplase in the treatment of ischemic stroke. Future TNK clinical trials targeting functional outcomes are needed.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Manon Kappelhof, Manon L. Tolhuisen, Kilian M. Treurniet, Bruna G. Dutra, Heitor Alves, Guang Zhang, Scott Brown, Keith W. Muir, Antoni Davalos, Yvo B. W. E. M. Roos, Jeffrey L. Saver, Andrew M. Demchuk, Tudor G. Jovin, Serge Bracard, Bruce C. Campbell, Aad van der Lugt, Francis Guillemin, Philip White, Michael D. Hill, Diederik W. J. Dippel, Peter J. Mitchell, Mayank Goyal, Henk A. Marquering, Charles B. L. M. Majoie
Summary: This study found that increased thrombus perviousness was associated with improved functional outcomes in patients with acute ischemic stroke. While control arm patients showed better outcomes with increased perviousness, there was no significant association in the EVT arm. Mortality and follow-up infarct volume decreased with higher thrombus attenuation increase in the overall population.
Article
Multidisciplinary Sciences
Anna Kufner, Huma Fatima Ali, Martin Ebinger, Jochen B. Fiebach, David S. Liebeskind, Matthias Endres, Bob Siegerink
Summary: The study found that smoking did not provide clear clinical benefit from endovascular therapy incorporating intra-arterial thrombolysis in ischemic stroke patients.
Editorial Material
Emergency Medicine
Scott D. Weingart, Robert L. Sherwin, Lillian L. Emlet, Isaac Tawil, Julie Mayglothling, Jon C. Rittenberger
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2013)
Article
Emergency Medicine
Scott D. Weingart, Richard M. Levitan
ANNALS OF EMERGENCY MEDICINE
(2012)
Letter
Emergency Medicine
Eric D. Schneider, Scott D. Weingart
ANNALS OF EMERGENCY MEDICINE
(2013)
Review
Anesthesiology
Seth Manoach, Scott D. Weingart, Jean Charchaflieh
JOURNAL OF CLINICAL ANESTHESIA
(2012)
Letter
Emergency Medicine
Scott D. Weingart
JOURNAL OF EMERGENCY MEDICINE
(2013)
Letter
Emergency Medicine
Scott D. Weingart
JOURNAL OF EMERGENCY MEDICINE
(2013)
Review
Critical Care Medicine
Deborah M. Stein, Vincent Roddy, John Marx, Wade S. Smith, Scott D. Weingart
NEUROCRITICAL CARE
(2012)
Review
Critical Care Medicine
Jan Claassen, Robert Silbergleit, Scott D. Weingart, Wade S. Smith
NEUROCRITICAL CARE
(2012)
Review
Critical Care Medicine
J. Stephen Huff, Robert D. Stevens, Scott D. Weingart, Wade S. Smith
NEUROCRITICAL CARE
(2012)
Review
Critical Care Medicine
Jonathan A. Edlow, Owen Samuels, Wade S. Smith, Scott D. Weingart
NEUROCRITICAL CARE
(2012)
Review
Critical Care Medicine
David B. Seder, Richard R. Riker, Andy Jagoda, Wade S. Smith, Scott D. Weingart
NEUROCRITICAL CARE
(2012)
Review
Critical Care Medicine
Stuart P. Swadron, Peter LeRoux, Wade S. Smith, Scott D. Weingart
NEUROCRITICAL CARE
(2012)
Review
Critical Care Medicine
Jon C. Rittenberger, Kees H. Polderman, Wade S. Smith, Scott D. Weingart
NEUROCRITICAL CARE
(2012)
Article
Critical Care Medicine
Dena A. Reiter, Christopher G. Strother, Scott D. Weingart
Letter
Critical Care Medicine
Scott D. Weingart
