Protective Effects of Hesperidin Against Amyloid-β (Aβ) Induced Neurotoxicity Through the Voltage Dependent Anion Channel 1 (VDAC1)-Mediated Mitochondrial Apoptotic Pathway in PC12 Cells

The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease

(2017) David H. Small et al.   JOURNAL OF ALZHEIMERS DISEASE

Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction

(2014) Vaibhav Gaur et al.   Pharmacological Reports

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy

(2012) Shang-Ming Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavonoids as antioxidants in plants: Location and functional significance

(2012) Giovanni Agati et al.   PLANT SCIENCE

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of β-amyloid (25-35) on mitochondrial function and expression of mitochondrial permeability transition pore proteins in rat hippocampal neurons

(2011) Rui Ren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

Hesperidin alleviates acetaminophen induced toxicity in wistar rats by abrogation of oxidative stress, apoptosis and inflammation

(2011) Shiekh Tanveer Ahmad et al.   TOXICOLOGY LETTERS

Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo

(2010) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hesperetin protects testicular toxicity of doxorubicin in rat: Role of NFκB, p38 and caspase-3

(2010) P.P. Trivedi et al.   FOOD AND CHEMICAL TOXICOLOGY

Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: Potential prophylactic ingredients for functional foods application

(2010) Deena Ramful et al.   TOXICOLOGY

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ Oligomers and Fibrillar Aggregates Induce Different Apoptotic Pathways in LAN5 Neuroblastoma Cell Cultures

(2009) Pasquale Picone et al.   BIOPHYSICAL JOURNAL

Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction

(2009) Ka Chen et al.   BRAIN RESEARCH

Hesperidin attenuates benzo[α] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance

(2009) HMM Arafa et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Bcl2 mitigates Ca2+ entry and mitochondrial Ca2+ overload through downregulation of L-type Ca2+ channels in PC12 cells

(2008) Natacha Díaz-Prieto et al.   CELL CALCIUM

Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells

(2008) Sam-Long Hwang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Uncovering the role of VDAC in the regulation of cell life and death

(2008) Varda Shoshan-Barmatz et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1

(2008) Salah Abu-Hamad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice

(2008) Eun Jeong Choi   LIFE SCIENCES

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

(2008) S. Hauptmann et al.   NEUROBIOLOGY OF AGING

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES