Review
Biochemistry & Molecular Biology
Yulia Aleksandrova, Margarita Neganova
Summary: The relationship between oncological pathologies and neurodegenerative disorders is complex and has become a topic of interest among researchers. Recent scientific evidence suggests that various factors and processes contribute to the development of these diseases, revealing an intriguing connection between oncology and neurodegeneration. This review explores the links between oxidative stress, epigenetic dysregulation, and metabolic dysfunction in detail, and discusses the potential therapeutic approaches in current research. This comprehensive analysis helps in the development of advanced diagnostic tools and innovative pharmacological strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xueying Shao, Maja Hojvang Sorensen, Chao Fang, Raymond Chuen Chung Chang, Zhiqin Chu, Yuan Lin
Summary: This study found that the interaction between neurons and the extracellular matrix strengthens as neurons mature, resulting in reduced retraction response to injury. Adhesion cluster density in mature neurons is higher than in immature neurons, affecting their response to injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Liudmila Zakharova, Viktoria Sharova, Marina Izvolskaia
Summary: This paper discusses the reciprocal regulatory influence of GnRH and proinflammatory cytokines on the development of the immune system and hypothalamic-pituitary-gonadal system, and their functioning in adult offspring. It focuses on the effects of GnRH on thymus development and discusses the main mechanisms of reciprocal regulation between these systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Elena Abati, Arianna Manini, Giacomo Pietro Comi, Stefania Corti
Summary: Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. Inhibition of myostatin has shown potential in enhancing muscle growth and reducing muscle atrophy, making it a promising target for the treatment of motor neuron diseases. This review aims to describe the role of myostatin in these diseases, summarize preclinical and clinical studies of myostatin inhibitors, and discuss the promises and pitfalls of using these inhibitors in human settings, to aid the development of future clinical trials.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Food Science & Technology
Fei Xie, Jiakun Shen, Tianyi Liu, Min Zhou, Lee J. Johnston, Jingwen Zhao, Hongfu Zhang, Xi Ma
Summary: Nutrient sensing is crucial for maintaining body homeostasis and physiological functions. Gut taste receptors play important roles in sensing nutrients and regulating intestinal physiological activities, as well as appetite, body weight, and gut microbiota. Dysfunction of gut taste receptors may lead to digestive and metabolic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Irina I. Stoyanova, David Lutz
Summary: The neuronal cell adhesion and recognition molecule L1 not only maintains cell adhesion through interactions, but also enhances cell motility when cleaved into fragments. These fragments can be released into the extracellular space or internalized into the nucleus, transmitting extracellular signals to the cell interior. Proteolysis of L1 contributes to its functional diversity and plays a vital role in morphogenic events and regenerative processes in neuronal cells. Stimulating L1 proteolysis shows promise as a therapeutic tool for injured nervous systems. The collective findings shed light on the diverse functions of L1 and its fragments, and provide mechanistic insights into adhesion molecule proteolysis in the developing and diseased nervous system.
Review
Medicine, General & Internal
Lorenzo Onorato, Mariantonietta Pisaturo, Clarissa Camaioni, Pierantonio Grimaldi, Alessio Vinicio Codella, Federica Calo, Nicola Coppola
Summary: It is important to be aware of the risk of HBV reactivation during immunosuppressive treatments, particularly in non-oncological patients. Currently, data on HBVr in these populations are limited, and clear recommendations for management are lacking.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Aleksandra Bandzerewicz, Agnieszka Gadomska-Gajadhur
Summary: The existence of orderly structures like tissues and organs is possible by cell adhesion, a process where cells attach to neighbouring cells and extracellular matrix. The extracellular matrix, composed of collagens, elastin, proteoglycans, and glycoproteins, serves as a storehouse for signaling factors. Tissue disruption may require the use of implants for reconstitution, detailing the host response and surface properties modifications.
Review
Plant Sciences
Xiaoxiao Liu, Li Wan
Summary: Plant NLR proteins play a crucial role in providing immunity and inducing cell death. Sensor NLRs directly or indirectly recognize pathogen effector proteins to initiate immune signaling, while helper NLRs function downstream of sensor NLRs in transmitting immune signals. Recent breakthrough studies on the structures and functions of plant NLR proteins have significantly advanced our understanding of NLR biology.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Neurosciences
Paula Unzueta-Larrinaga, Rocio Barrena-Barbadillo, Ines Ibarra-Lecue, Igor Horrillo, Aitor Villate, Maria Recio, J. Javier Meana, Rebeca Diez-Alarcia, Oihane Mentxaka, Rafael Segarra, Nestor Etxebarria, Luis F. Callado, Leyre Urigun
Summary: The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. The olfactory epithelium, with its regenerative capabilities and ability to differentiate into multiple cell types, provides a unique resource for investigating neuronal molecular markers of neuropsychiatric and neurological diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sheng Chen, Tailin He, Yiming Zhong, Mingjue Chen, Qing Yao, Di Chen, Zengwu Shao, Guozhi Xiao
Summary: The skeletal system plays crucial roles in body shaping, support and movement, protection of internal organs, production of blood cells, and regulation of calcium and phosphate metabolism. Skeletal diseases and disorders such as osteoporosis, arthritis, and intervertebral disc degeneration are becoming increasingly common and have significant social and economic impacts. This review focuses on the molecular mechanisms and therapeutic targets of focal adhesion proteins in skeletal diseases.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Physical
Zuoxian Xiang, Chuanxiang Tang, Chao Chang, Guozhi Liu
Summary: Based on our previous research, a preliminary model of neural signal generation and transmission was established to study signal transmission on unmyelinated nerves. The model showed that the neural system exhibited THz and infrared electromagnetic oscillations on a short time scale, while the energy envelope curve of the rapidly oscillating signal varied slowly. The effects of temperature on signal transmission were also explored, revealing that overly high and overly low temperatures were not conducive to the transmission of neural signals.
Review
Biochemistry & Molecular Biology
Matilde Contardo, Roberta De Gioia, Delia Gagliardi, Giacomo Pietro Comi, Linda Ottoboni, Monica Nizzardo, Stefania Corti
Summary: In vivo cell reprogramming offers a promising approach to generate new neurons in the adult mammalian nervous system, with the successful conversion of glial cells into neurons through the repression of a single gene Ptbp1. However, concerns about the reliability of this strategy, particularly regarding the nature of converted neurons in vivo, necessitate further investigation with stringent lineage tracing methods.
Review
Biochemistry & Molecular Biology
Roberta Piovesana, Adam J. Reid, Ada Maria Tata
Summary: The communication between neurons and glial cells has been well-documented in various stages of development and disease. Neurotransmitters, especially acetylcholine, play a significant role in regulating the development and physiology of glial cells. This review focuses on the contribution of neurotransmitter receptors, particularly the M2 muscarinic receptor and the alpha 7 nicotinic receptor, in influencing the phenotype and functioning of Schwann cells. Understanding these interactions can help identify potential therapeutic targets for pathological conditions involving glial cells.
Review
Biochemistry & Molecular Biology
Alfredo Ulloa-Aguirre, Teresa Zarinan, Eduardo Jardon-Valadez
Summary: This review discusses the mechanisms by which mutations in GPCRs involved in endocrine function in humans lead to misfolding, decreased plasma membrane expression of the receptor protein, and loss-of-function diseases. Special attention is given to misfolded GPCRs that regulate reproductive function, and promising therapeutic interventions targeting trafficking of these defective proteins to rescue their normal function are also described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
E. A. Zubkov, Ya. A. Zorkina, E. V. Orshanskaya, N. N. Khlebnikova, N. A. Krupina, V. P. Chekhonin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Medicine, Research & Experimental
Xu Guo, Yao Xu, Xin Wang, Feng Lin, Haixiao Wu, Jincai Duan, Yuqing Xiong, Xiuxin Han, Vladimir P. Baklaushev, Shunbin Xiong, Vladimir P. Chekhonin, Karl Peltzer, Guowen Wang, Chao Zhang
MEDICAL SCIENCE MONITOR
(2019)
Article
Gastroenterology & Hepatology
Xin Wang, Min Mao, Guijun Xu, Feng Lin, Peng Sun, Vladimir P. Baklaushev, Vladimir P. Chekhonin, Karl Peltzer, Jin Zhang, Chao Zhang
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Materials Science, Multidisciplinary
Petr Ostroverkhov, Alevtina Semkina, Aleksey Nikitin, Alexander Smirnov, Daria Vedenyapina, Kseniya Vlasova, Igor Kireev, Mikhail Grin, Vladimir Chekhonin, Alexander Majouga, Maxim Abakumov
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2019)
Article
Biochemistry & Molecular Biology
Maxim Abakumov, Athina Kilpelainen, Stefan Petkov, Sergey Belikov, Nataliya Klyachko, Vladimir Chekhonin, Maria Isaguliants
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Medicine, Research & Experimental
A. O. Sosnovtseva, A. O. Zheltukhin, A. V. Lipatova, P. M. Chumakov, V. P. Chekhonin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Medicine, Research & Experimental
V. P. Chekhonin, M. A. Abakumov, A. G. Mazhuga, A. N. Bagdinova, E. I. Demikhov, T. E. Demikhov, B. Ya. Mishkinis, M. V. Konstantinov, V. P. Tarasov, B. A. Shumm, A. A. Gippius, N. V. Gervits, A. B. Shumm
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Medicine, Research & Experimental
S. S. Vodopyanov, M. A. Kunin, A. S. Garanina, N. F. Grinenko, K. Yu. Vlasova, P. A. Mel'nikov, V. P. Chekhonin, K. K. Sukhinich, A. V. Makarov, V. A. Naumenko, M. A. Abakumov, A. G. Majouga
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Review
Neurosciences
Alexey A. Murashko, Konstantin A. Pavlov, Olga V. Pavlova, Olga I. Gurina, Alexander Shmukler
Summary: The study found that different detection methods led to variations in the prevalence of NMDAR antibodies, with live cell-based assays potentially being more sensitive but with poorer specificity. Additionally, there may be links between AB-positive status and acute symptoms, and immunotherapy could be effective in AB-positive patients but further research is needed.
NEUROPSYCHOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Abramova, Yana Zorkina, Timur Syunyakov, Eugene Zubkov, Valeria Ushakova, Artemiy Silantyev, Kristina Soloveva, Olga Gurina, Alexander Majouga, Anna Morozova, Vladimir Chekhonin
Summary: The study found that ultrasound stress can lead rats to exhibit depressive-like behavior, while treatment with clomipramine can have an antidepressant effect. Different routes of drug administration can influence the drug's impact on the metabolic profiles in the frontal cortex and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anna Morozova, Yana Zorkina, Olga Abramova, Olga Pavlova, Konstantin Pavlov, Kristina Soloveva, Maria Volkova, Polina Alekseeva, Alisa Andryshchenko, Georgiy Kostyuk, Olga Gurina, Vladimir Chekhonin
Summary: This review focuses on the cognitive impairment as a significant component in various psychiatric disorders and its impact on the quality of life. It summarizes the current understanding of the underlying neurobiological mechanisms of cognitive impairment in individuals with schizophrenia, depression, mild cognitive impairment, and dementia (including Alzheimer's disease). The review also provides data on the prevalence of cognitive impairment in individuals with mental illness and the associated biological markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Artemiy S. Silantyev, Olga N. Bukato, Ivan O. Butenko, Anastasia A. Chernysheva, Olga Pobeguts, Alexander E. Nosyrev, Olga Gurina
Summary: Human multiforme glioblastoma is known for its unfavorable prognosis, low survival rate, and limited therapy possibilities. Rat C6 glioma serves as an experimental model for studying the growth and invasion of glioblastoma, showing changes in surrounding tissues that create a favorable environment for tumor development. Understanding the changes in normotypic cells upon contact with tumor cells is of great interest, and analysis of these interactions using LC-MS has been conducted in this study.
Article
Engineering, Electrical & Electronic
Yulia S. Maklygina, Alexei S. Skobeltsin, Tatiana A. Savelieva, Galina Pavlova, Ivan Chekhonin, Olga Gurina, Anastasiya A. Chernysheva, Sergey A. Cherepanov, Victor B. Loschenov
FRONTIERS OF OPTOELECTRONICS
(2020)
Article
Oncology
Chao Zhang, Xu Guo, Karl Peltzer, Wenjuan Ma, Lisha Qi, Yanting Zhang, Xiuxin Han, Vladimir P. Baklaushev, Yueliang Yao, Guowen Wang, Vladimir P. Chekhonin, Xin Wang, Yulin Ma
Meeting Abstract
Pediatrics
Valeria Novikova, Margarita Gurova, Olga Gurina, Olga Varlamova, Aleksey Blinov, Irina Burnysheva
ARCHIVES OF DISEASE IN CHILDHOOD
(2019)
