Article
Neurosciences
Jose Tiago Costa-Pereira, Paula Serrao, Isabel Martins, Isaura Tavares
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Jose Tiago Costa-Pereira, Joana Ribeiro, Isabel Martins, Isaura Tavares
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Anesthesiology
Ana Rita Costa, Marilia Sousa, Steven P. Wilson, Carlos Reguenga, Armando Teixeira-Pinto, Isaura Tavares, Isabel Martins
Article
Neurosciences
Joana Reis Pedro, Liane I. F. Moura, Angela Valerio-Fernandes, Filipa Baptista, Joana M. Gaspar, Barbara S. Pinheiro, Cristina Lemos, Fernanda Neutzling Kaufmann, Carla Morgado, Carla S. da Silva-Santos, Isaura Tavares, Samira G. Ferreira, Eugenia Carvalho, Antonio F. Ambrosio, Rodrigo A. Cunha, Joao M. N. Duarte, Attila Kofalvi
BRAIN RESEARCH BULLETIN
(2020)
Review
Physiology
Silvia S. Chambel, Isaura Tavares, Celia D. Cruz
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Neurosciences
Margarida Martins-Oliveira, Isaura Tavares, Peter J. Goadsby
Summary: Studies have shown that migraine attacks may be related to changes in appetite, with fasting or skipping meals often considered common triggers in susceptible individuals, and hunger or abnormal appetite reported in the premonitory phase. Over the past decade, research into overlapping fields of neuroscience has become increasingly important, leading to novel findings. Data suggest that further research is needed to uncover the key neurobiological mechanisms underlying the interaction between migraine and appetite.
Review
Physiology
Marta Reina-Couto, Patricia Pereira-Terra, Janete Quelhas-Santos, Carolina Silva-Pereira, Antonio Albino-Teixeira, Teresa Sousa
Summary: Inflammation is a major contributor to different types of heart failure, but trials of anti-inflammatory strategies in HF patients have shown inconsistent results. Future therapeutic advances may involve tailored anti-inflammatory treatments based on individual inflammatory profiles and the development of resolution pharmacology targeting inflammation pathways in HF.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Loucano, Joana Oliveira, Isabel Martins, Rui Vaz, Isaura Tavares
Summary: Hydrocephalus leads to increased noradrenergic expression in the locus coeruleus, accompanied by oxidative stress damage, resulting in alterations in pain modulation. The oxidative stress in LC neurons may contribute to the elevation of NA levels, while decreased activation of spinal neurons may lead to reduced pain responses in hydrocephalic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Behavioral Sciences
Salome Leca, Isaura Tavares
Summary: Fibromyalgia is a common cause of chronic pain that greatly affects quality of life. Cognitive-behavioral therapy and mindfulness-based interventions have shown promising results in reducing the negative aspects of the disease, but further research is needed to confirm their effectiveness and critically discuss study designs.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Jose Tiago Costa-Pereira, Rita Oliveira, Irene Guadilla, Maria Jose Guillen, Isaura Tavares, Pilar Lopez-Larrubia
Summary: Chemotherapy-induced neuropathy is a common complication of cancer treatment. This study found that neuronal function and metabolic profiles in specific brain regions are altered during chemotherapy-induced neuropathy, suggesting their involvement in pain processing and modulation.
BRAIN RESEARCH BULLETIN
(2023)
Article
Clinical Neurology
Margarida Martins-Oliveira, Simon Akerman, Philip R. Holland, Isaura Tavares, Peter J. Goadsby
Summary: Research findings suggest that pharmacological modulation of ventral tegmental area parabrachial pigmented nucleus neurons can influence trigeminovascular sensory processing and consequently reduce circulating glucose levels. This is relevant for understanding the associated sensory and homeostatic symptoms in susceptible migraine patients.
Review
Education & Educational Research
Bruno Daniel Carneiro, Daniel Humberto Pozza, Isaura Tavares
Summary: This study explores the importance of Histology and Embryology in medical education and the perspectives of medical students towards teaching methods. The results show that students in clinical years are more likely to recognize the clinical relevance of these subjects. Most students suggest a clinical-oriented approach and the integration of Histology and Biopathology in the curriculum.
BMC MEDICAL EDUCATION
(2023)
Review
Biochemistry & Molecular Biology
Daniel H. H. Pozza, Isaura Tavares, Celia Duarte Cruz, Sara Fonseca
Summary: This systematic review aimed to identify high-risk patients and summarise the causes, consequences, and management/recommendations of spinal cord injuries (SCI) due to neuraxial techniques in anaesthesia. The main risk factors reported were extremes of age, obesity, and diabetes. Anaes-SCI was reported as a consequence of various factors and mainly resulted in motor deficits, sensory loss, and pain. Despite potential complications, neuraxial techniques are still a beneficial option for pain prevention and management, but careful patient management and close monitoring are crucial to minimize the risk of SCI and complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Isaura Tavares, Jose Tiago Costa-Pereira, Isabel Martins
Summary: The treatment of neuropathic pain is challenging, with recent research indicating the dual action of noradrenergic modulation in brainstem pain modulatory circuits. The serotoninergic system also plays a role in neuropathic pain models, with opioids involved in the modulation of descending modulatory circuits.
FRONTIERS IN PAIN RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Solida Long, Diana I. S. P. Resende, Andreia Palmeira, Anake Kijjoa, Artur M. S. Silva, Maria Elizabeth Tiritan, Patricia Pereira-Terra, Joana Freitas-Silva, Sandra Barreiro, Renata Silva, Fernando Remiao, Eugenia Pinto, Paulo Martins da Costa, Emilia Sousa, Madalena M. M. Pinto
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)
