Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Review
Cell Biology
Qian Ren, Jiongcheng Chen, Youhua Liu
Summary: LRP5 and LRP6 are crucial in mediating Wnt signaling, with similar functions but also distinct characteristics, as they interact with different protein partners, each possessing its own unique functions. Understanding the precise roles of LRP5 and LRP6 may help in identifying and refining therapeutic targets for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Xiaoming Huang, Tong Wu
Summary: This study demonstrates that downregulation of SOST promotes the malignant progression of uveal melanoma by activating the Wnt/beta-catenin signaling pathway. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Hong-He Xiao, Ji-Cong Chen, He Li, Rui-Hai Li, Hai-Bo Wang, Hui-Peng Song, Hong-Yan Li, Guo-Shun Shan, Yu Tian, Yu-Meng Zhao, Jin-Ming Tian, Jing-Xian Yang
Summary: The study demonstrated that ICS II could improve neurogenesis dysfunction and inhibit mitochondrial fission by activating the Wnt/beta-catenin signaling pathway, thereby promoting the restoration of cognitive function in APP/PS1 mice.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Huifang Zhu, Zijie Su, Jiong Ning, Liang Zhou, Lifeng Tan, Sapna Sayed, Jiaxing Song, Zhongyuan Wang, Huan Li, Qi Sun, Shanshan Liu, Ou Sha, Feng Leng, Xianxiong Chen, Desheng Lu
Summary: TMEM97 upregulation is associated with poor outcome in multiple human cancers, including breast cancer, by enhancing LRP6-mediated Wnt signaling. TMEM97 interacts with LRP6 to promote CK1 delta/epsilon-dependent phosphorylation of LRP6, leading to stabilization of beta-catenin. In breast cancer cells, TMEM97 deficiency attenuated Wnt/beta-catenin signaling and suppressed tumorigenic properties, suggesting that targeting TMEM97 could be a promising therapeutic strategy for breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Gozal Bahlakeh, Reza Rahbarghazi, Ali Abedelahi, Saeed Sadigh-Eteghad, Mohammad Karimipour
Summary: This study investigates the impact of NTF-SCs on hippocampal neurogenesis mediated by the Wnt/β-catenin signaling cascade in AD-like mouse brain. The results suggest that activating the Wnt/β-catenin pathway through NTF-SCs may be a potential therapeutic approach to restore neurogenesis in AD.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Behavioral Sciences
Li Yao, Xuemin Xu, Yukun Xu, Chunyan Li, Fang Xie, Minghao Guo, Zhaoyang Liu, Xiaoming Liu
Summary: The study confirmed the downregulation of OGDHL expression in the brain of Alzheimer's disease mice and found that upregulation of OGDHL could improve memory deficits, reduce neuroinflammation, amyloid plaque load, and tau phosphorylation, as well as activate the Wnt/beta-catenin signaling pathway.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Oncology
Wei-Tao Zhang, Ji-Jun Zhang, Quan Shao, Ying-Kai Wang, Jie-Peng Jia, Bo Qian, Xiao-Wen Tian, Wen-Ji Yan
Summary: This study reveals that the upregulated expression of FGD5-AS1 in pancreatic cancer activates the Wnt/β-catenin signaling pathway and promotes cancer cell proliferation, migration, and invasion by suppressing miR-577.
Article
Cell Biology
Prameet Kaur, Ellora Hui Zhen Chua, Wen Kin Lim, Jiarui Liu, Nathan Harmston, Nicholas S. Tolwinski
Summary: In this study, the researchers used an optogenetic model to investigate the effect of Wnt signaling on amyloid-beta in patients with Alzheimer's disease. They found that Wnt activation can rescue the detrimental effects of amyloid expression and oligomerization, and identified changes in gene expression related to aging, protein misfolding, metabolism, and inflammation. They proposed that Wnt expression reduces inflammation through repression of Toll activating factors.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Pharmacology & Pharmacy
Sapna Sayed, Jiaxing Song, Ling Wang, Tobias Achu Muluh, Boxin Liu, Zhixian Lin, Yun Tang, Zijie Su, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guangqian Zhou, Qi Sun, Desheng Lu
Summary: In this study, ISX9 was identified as a novel agonist of the Wnt/beta-catenin pathway, which activates hair regrowth and may be a potential treatment for alopecia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Hong-He Xiao, Ming-Bo Zhang, Jun-Ting Xu, Yan Deng, Ning Li, Peng Gao, Yan Li, Liang Kong, Wan-yi Li, Ji-Cong Chen, Hong-Yan Li, Guo-Shun Shan, He Tai, Jing-Xian Yang
Summary: Adult neurogenesis is crucial for cognitive function maintenance in mammals and humans, and it is seen as a potential therapeutic strategy for neurodegenerative diseases like Alzheimer's disease. Icarisid II (ICS II), derived from Epimedii Folium, has been shown to have neuroprotective effects, including promoting proliferation and differentiation of neural stem cells (NSCs). The study demonstrates that ICS II promotes NSCs proliferation and neuronal differentiation by activating the Wnt/beta-catenin signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Angela Inzulza-Tapia, Marcelo Alarcon
Summary: Cardiovascular diseases are the leading cause of death worldwide. Platelet-secreted non-coding RNA (ncRNA) play a crucial regulatory role in the occurrence and development of these diseases, and have potential value in identifying and treating cardiovascular diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Volkan Uzungil, Harvey Tran, Connor Aitken, Carey Wilson, Carlos M. Opazo, Shanshan Li, Jennyfer M. Payet, Celeste H. Mawal, Ashley Bush, Matthew W. Hale, Anthony J. Hannan, Thibault Renoir
Summary: In this study, the potential antidepressant properties of the iron chelator deferiprone were explored using the 5-HTT KO mouse model. Deferiprone showed potential antidepressant-like effects by reducing immobility time and latency to feed, potentially acting through an iron-independent mechanism. Additionally, deferiprone reversed swim stress-induced changes in neuronal activity and activated specific brain regions in mice. These findings suggest that deferiprone could be a potential candidate for antidepressant medications.
Article
Clinical Neurology
Tobias Brunger, Eduardo Perez-Palma, Ludovica Montanucci, Michael Nothnagel, Rikke S. Moller, Stephanie Schorge, Sameer Zuberi, Joseph Symonds, Johannes R. Lemke, Andreas Brunklaus, Stephen F. Traynelis, Patrick May, Dennis Lal
Summary: This study aimed to systematically identify biological features associated with variant pathogenicity in ion-channel genes and found that these features are correlated with clinical phenotypes and molecular measurements in patients with neurodevelopmental disorders. The results suggest the feasibility of clinical decision support algorithms that can predict variant pathogenicity and function in the future.
Article
Clinical Neurology
Sumaiya Iqbal, Tobias Bruenger, Eduardo Perez-Palma, Marie Macnee, Andreas Brunklaus, Mark J. Daly, Arthur J. Campbell, David Hoksza, Patrick May, Dennis Lal
Summary: Neurodevelopmental disorders (NDDs) are heterogeneous conditions, and genetic testing can identify pathogenic variants. However, the significance of most identified variants is still uncertain. We developed a consensus approach to identify essential sites on NDD-associated proteins and found that missense variants at these sites are enriched in patients. Our findings provide valuable insights for variant interpretation and drug target development.
Article
Clinical Neurology
Javier A. Lopez-Rivera, Costin Leu, Marie Macnee, Jean Khoury, Lucas Hoffmann, Roland Coras, Katja Kobow, Nisha Bhattarai, Eduardo Perez-Palma, Hajo Hamer, Sebastian Brandner, Karl Roessler, Christian G. Bien, Thilo Kalbhenn, Tom Pieper, Till Hartlieb, Elizabeth Butler, Giulio Genovese, Kerstin Becker, Janine Altmueller, Lisa-Marie Niestroj, Lisa Ferguson, Robyn M. Busch, Peter Nuernberg, Imad Najm, Ingmar Bluemcke, Dennis Lal
Summary: Lopez-Rivera et al. conducted a study on the genetic architecture of different types of epileptic brain lesions. They discovered novel somatic chromosomal alterations, identified new genes and genotype-phenotype associations, and supported the role of genetics in the histopathological diagnosis of epileptic lesions. The findings provide valuable insights for improving treatment of drug-resistant focal epilepsy.
Article
Clinical Neurology
Bernabe Bustos, Kimberley Billingsley, Cornelis Blauwendraat, J. Raphael Gibbs, Ziv Gan-Or, Dimitri Krainc, Andrew B. Singleton, Steven J. Lubbe
Summary: Bustos et al. conducted the first genome-wide meta-analysis of common short tandem repeats (STRs) in Parkinson's disease and identified four new independent risk factors. They found that STRs contribute to the heritability of Parkinson's disease and that STR-associated genes are enriched in Parkinson's disease-relevant tissues and pathways.
Article
Clinical Neurology
Marie Macnee, Eduardo Perez-Palma, Javier A. Lopez-Rivera, Alina Ivaniuk, Patrick May, Rikke S. Moller, Dennis Lal
Summary: A computational analysis of the scientific literature in PubMed revealed a total of 738 epilepsy-associated genes, with 143 genes classified as primary. These genes predominantly belong to the ion channel category and have been extensively reported in the past decade, warranting further research.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Alessia Nasca, Niccolo E. Mencacci, Federica Invernizzi, Michael Zech, Ignacio J. Keller Sarmiento, Andrea Legati, Chiara Frascarelli, Bernabe Bustos, Luigi M. Romito, Dimitri Krainc, Juliane Winkelmann, Miryam Carecchio, Nardo Nardocci, Giovanna Zorzi, Holger Prokisch, Steven J. Lubbe, Barbara Garavaglia, Daniele Ghezzi
Summary: Nasca et al. have discovered a new candidate gene for dystonia, ATP5F1B, which encodes a subunit of the mitochondrial ATP synthase. This gene is associated with early-onset isolated dystonia in two families with autosomal dominant inheritance and incomplete penetrance. Functional studies showed a dominant-negative effect of the identified ATP5F1B variants, leading to reduced activity of complex V and impaired mitochondrial function.
Article
Biochemistry & Molecular Biology
Andres Trostchansky, Marcelo Alarcon
Summary: Oxidative stress is involved in various non-communicable diseases, such as cardiovascular diseases. Excessive reactive oxygen species (ROS) formation can lead to the undesirable effects of oxidative stress. Platelets play a crucial role in arterial thrombosis, and excessive ROS formation stimulates platelet activation and aggregation. The proteins Protein Disulphide Isomerase (PDI) and NADPH oxidase (NOX) isoforms are involved in these processes. A bioinformatic analysis of their roles and interactions in platelets, as well as the signaling pathways involved, was performed. The data support the potential use of specific enzyme inhibitors or dual inhibition of these enzymes for treating diseases involving platelet dysfunction.
Correction
Neurosciences
Hampton. L. Leonard, Ruqaya Murtadha, Alejandro Martinez-Carrasco, Alina Jama, Amica Corda Mueller-Nedebock, Ana-Luisa Gil-Martinez, Anastasia Illarionova, Anni Moore, Bernabe. Bustos, Bharati Jadhav, Brook Huxford, Catherine Storm, Clodagh Towns, Dan Vitale, Devina Chetty, Eric Yu, Francis. P. Grenn, Gabriela Salazar, Geoffrey Rateau, Hirotaka Iwaki, Inas Elsayed, Isabelle Francesca Foote, Zune Jansen van Rensburg, Jonggeol Jeff Kim, Jie Yuan, Julie Lake, Kajsa Brolin, Konstantin Senkevich, Lesley Wu, Manuela M. X. Tan, Maria Teresa Perinan, Mary. B. Makarious, Michael Ta, Nikita Simone Pillay, Oswaldo Lorenzo Betancor, Paula R. Reyes-Perez, Pilar Alvarez Jerez, Prabhjyot Saini, Rami al-Ouran, Ramiya Sivakumar, Raquel Real, Regina. H. Reynolds, Ruifneg Hu, Shameemah Abrahams, Shilpa. L. Rao, Tarek Antar, Thiago Peixoto Leal, Vassilena Iankova, William J. Scotton, Yeajin Song, Andrew Singleton, Mike. A. Nalls, Sumit Dey, Sara Bandres-Ciga, Cornelis Blauwendraat, Alastair. J. Noyce
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Hampton L. Leonard, Ruqaya Murtadha, Alejandro Martinez-Carrasco, Alina Jama, Amica Corda Mueller-Nedebock, Ana-Luisa Gil-Martinez, Anastasia Illarionova, Anni Moore, Bernabe I. Bustos, Bharati Jadhav, Brook Huxford, Catherine Storm, Clodagh Towns, Dan Vitale, Devina Chetty, Eric Yu, Francis P. Grenn, Gabriela Salazar, Geoffrey Rateau, Hirotaka Iwaki, Inas Elsayed, Isabelle Francesca Foote, Zune Jansen van Rensburg, Jonggeol Jeff Kim, Jie Yuan, Julie Lake, Kajsa Brolin, Konstantin Senkevich, Lesley Wu, Manuela M. X. Tan, Maria Teresa Perinan, Mary B. Makarious, Michael Ta, Nikita Simone Pillay, Oswaldo Lorenzo Betancor, Paula R. Reyes-Perez, Pilar Alvarez Jerez, Prabhjyot Saini, Rami al-Ouran, Ramiya Sivakumar, Raquel Real, Regina H. Reynolds, Ruifneg Hu, Shameemah Abrahams, Shilpa C. Rao, Tarek Antar, Thiago Peixoto Leal, Vassilena Iankova, William J. Scotton, Yeajin Song, Andrew Singleton, Mike A. Nalls, Sumit Dey, Sara Bandres-Ciga, Cornelis Blauwendraat, Alastair J. Noyce
Summary: Open science and collaboration are essential for Parkinson's disease (PD) research progress. Hackathons bring together people with diverse skills and backgrounds to generate resources and creative solutions. A virtual 3-day hackathon was organized, involving 49 early-career scientists from 12 countries who built PD-focused tools and pipelines. The goal was to provide scientists with access to necessary code and tools, accelerating their research. Hackathons inspire creative thinking, supplement data science training, and foster collaboration, benefiting early-career researchers. The generated resources can accelerate PD genetics research.
NPJ PARKINSONS DISEASE
(2023)
Article
Oncology
Linda Zollner, Felix Boekstegers, Carol Barahona Ponce, Dominique Scherer, Katherine Marcelain, Valentina Garate-Calderon, Melanie Waldenberger, Erik Morales, Armando Rojas, Cesar Munoz, Javier Retamales, Gonzalo De Toro, Allan Vera Kortmann, Olga Barajas, Maria Teresa Rivera, Analia Cortes, Denisse Loader, Javiera Saavedra, Lorena Gutierrez, Alejandro Ortega, Maria Enriqueta Bertran, Leonardo Bartolotti, Fernando Gabler, Monica Campos, Juan Alvarado, Fabricio Moisan, Loreto Spencer, Bruno Nervi, Daniel Carvajal, Hector Losada, Mauricio Almau, Plinio Fernandez, Jordi Olloquequi, Alice R. Carter, Juan Francisco Miquel Poblete, Bernabe Ignacio Bustos, Macarena Fuentes Guajardo, Rolando Gonzalez-Jose, Maria Catira Bortolini, Victor Acuna-Alonzo, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer, Justo Lorenzo Bermejo
Summary: There is a strong association between the proportion of Mapuche ancestry and the risk of gallbladder cancer (GBC). Mapuche ancestry has a putatively causal effect on GBC risk and gallstone disease, while showing a negative effect on BMI. These findings have significant implications for GBC prevention and future admixture mapping studies.
Article
Biochemical Research Methods
Marie Macnee, Eduardo Perez-Palma, Tobias Bruenger, Chiara Kloeckner, Konrad Platzer, Arthur Stefanski, Ludovica Montanucci, Allan Bayat, Maximilian Radtke, Ryan L. Collins, Michael Talkowski, Daniel Blankenberg, Rikke S. Moller, Johannes R. Lemke, Michael Nothnagel, Patrick May, Dennis Lal
Summary: CNV-ClinViewer is an open-source web application for clinical evaluation and visual exploration of CNVs. It allows real-time interactive exploration of large CNV datasets and facilitates semi-automated clinical CNV interpretation. It enhances patient care for clinical investigators and translational genomic research for basic scientists.
Article
Genetics & Heredity
Yuri A. Zarate, Katherine Bosanko, Amrit Kannan, Ashlen Thomason, Beth Nutt, Nihit Kumar, Kirt Simmons, Aaron Hiegert, Larry Hartzell, Adam Johnson, Tabitha Prater, Eduardo Perez-Palma, Tobias Bruenger, Arthur Stefanski, Dennis Lal, Aisling R. Caffrey
Summary: Characterized by developmental delay with severe speech delay, dental anomalies, cleft palate, skeletal abnormalities, and behavioral difficulties, SATB2-associated syndrome (SAS) is caused by pathogenic variants in SATB2. The SAS severity score, based on data from the SAS registry, is a comprehensive scoring rubric that encompasses 15 different individual neurodevelopmental and systemic features. The score allows quantitative description of phenotype morbidity and can be used in routine clinical counseling.
Article
Psychiatry
Parsa Ravanfar, Warda T. Syeda, Mahesh Jayaram, R. Jarrett Rushmore, Bradford Moffat, Alexander P. Lin, Amanda E. Lyall, Antonia H. Merritt, Negin Yaghmaie, Liliana Laskaris, Sandra Luza, Carlos M. Opazo, Benny Liberg, M. Mallar Chakravarty, Gabriel A. Devenyi, Patricia Desmond, Vanessa L. Cropley, Nikos Makris, Martha E. Shenton, Ashley Bush, Dennis Velakoulis, Christos Pantelis
Summary: This study found increased iron in the putamen in schizophrenia, as well as network-wide disturbances of iron and metabolic status.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
