PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma

Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival

(2012) Chad R Schultz et al.   Molecular Cancer

Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma

(2011) H. M. McClung et al.   CARCINOGENESIS

Six-month progression-free survival as an alternative primary efficacy endpoint to overall survival in newly diagnosed glioblastoma patients receiving temozolomide

(2011) M.-Y. C. Polley et al.   NEURO-ONCOLOGY

Integrin-linked kinase: Not so ‘pseudo’ after all

(2011) G E Hannigan et al.   ONCOGENE

Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme

(2010) R. Helseth et al.   ACTA NEUROLOGICA SCANDINAVICA

Differential sensitivity of human endometrial carcinoma cells with different PTEN expression to mitogen-activated protein kinase signaling inhibits and implications for therapy

(2010) Lan Xiao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling

(2010) Stacey L. Thomas et al.   NEURO-ONCOLOGY

Secreted protein, acidic and rich in cysteine (SPARC) expression in astrocytic tumour cells negatively correlates with proliferation, while vascular SPARC expression is associated with patient survival

(2010) D. Capper et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein–27

(2010) M E Gonzalez-Mejia et al.   Cell Death & Disease

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide

(2009) Scott B. Widenmaier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPARC: a matricellular regulator of tumorigenesis

(2009) Shanna A. Arnold et al.   Journal of Cell Communication and Signaling

HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion

(2008) William A. Golembieski et al.   GLIA

The Copper Binding Domain of SPARC Mediates Cell Survivalin Vitrovia Interaction with Integrin β1 and Activation of Integrin-linked Kinase

(2008) Matt S. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-linked kinase - essential roles in physiology and cancer biology

(2008) P. C. McDonald et al.   JOURNAL OF CELL SCIENCE

A prototypic matricellular protein in the tumor microenvironment—Where there's SPARC, there's fire

(2008) Clancy J. Clark et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

IFATS Collection: Combinatorial Peptides Identify α5β1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells

(2008) Jing Nie et al.   STEM CELLS