Article
Geriatrics & Gerontology
Ondrej Bezdicek, Josef Mana, Filip Ruzicka, Filip Havlik, Anna Fecikova, Tereza Uhrova, Evzen Ruzicka, Dusan Urgosik, Robert Jech
Summary: STN-DBS is a safe method for improving everyday functioning and IADL in patients with Parkinson's disease. Lower global cognition and LEDD are associated with lower IADL in both pre-surgery and post-surgery examinations.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Maria Antonietta Volonte, Giacomo Clarizio, Sebastiano Galantucci, Pietro Giuseppe Scamarcia, Rosalinda Cardamone, Lina Raffaella Barzaghi, Monica Falautano, Pietro Mortini, Giancarlo Comi, Massimo Filippi
Summary: This study evaluated the long-term effectiveness of STN-DBS treatment on advanced PD patients over a span of 14 years. Results showed significant improvement in tremor, rigidity, and daily dopaminergic dose, but no lasting effect on axial symptoms and cognitive functions. STN-DBS remains an effective therapy for advanced PD patients, extending the period of acceptable quality of life despite disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang
Summary: This study demonstrates that deep brain stimulation can effectively suppress levodopa-induced dyskinesia in Parkinson's disease patients without reducing levodopa dosage. The stimulation sites with good anti-dyskinesia effect are located above the subthalamic nucleus.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Keying Zhu, Sun Peng, Yulun Wu, Yuanyuan Zhao, Zhonglei Lu
Summary: Deep brain stimulation (STN-DBS) improves sleep quality, motor function, and reduces medication usage in Parkinson disease (PD) patients.
Article
Neurosciences
Bernadette C. M. van Wijk, Wolf-Julian Neumann, Daniel Kroneberg, Andreas Horn, Friederike Irmen, Tilmann H. Sander, Qiang Wang, Vladimir Litvak, Andrea A. Kuehn
Summary: This study investigated the structural connectivity profile of the subthalamic nucleus (STN) using local field potential recordings and simultaneous magnetoencephalography. The results suggest the existence of a frequency-specific topography of cortico-STN coherence within the STN, with considerable spatial overlap between functional networks.
Article
Neurosciences
V. S. Witzig, F. Alosaimi, Y. Temel, J. B. Schulz, A. Jahanshahi, S. K. H. Tan
Summary: This study investigated the effects of long-term intermittent bilateral STN-DBS on PPN cholinergic neurons in the MPTP Parkinsonian mouse model. The results showed that STN-DBS improved gait impairments but did not alter the expression or activation of PPN acetylcholine neurons. Therefore, the motor and gait effects of STN-DBS are less likely to be mediated by the STN-PPN connection and PPN cholinergic system.
NEUROSCIENCE LETTERS
(2023)
Article
Engineering, Biomedical
James K. Trevathan, Anders J. Asp, Evan N. Nicolai, Jonathan M. Trevathan, Nicholas A. Kremer, Takashi D. Y. Kozai, David Cheng, Mike J. Schachter, Jonathan J. Nassi, Stephani L. Otte, Jones G. Parker, J. Luis Lujan, Kip A. Ludwig
Summary: This manuscript outlines an approach combining chronic behaving single-photon microendoscope recordings in a pathological mouse model with electrical stimulation of a common deep brain stimulation (DBS) target to study neuromodulation therapy. The authors present detailed steps necessary for this approach and discuss key considerations for extending it to other DBS targets. They also make recommendations based on their experience in implementing and validating the required procedures.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Clinical Neurology
Francesca Mameli, Eleonora Zirone, Roberta Girlando, Elena Scagliotti, Giulia Rigamonti, Edoardo Nicolo Aiello, Barbara Poletti, Roberta Ferrucci, Nicola Ticozzi, Vincenzo Silani, Marco Locatelli, Sergio Barbieri, Fabiana Ruggiero
Summary: Deep brain stimulation (DBS) is an effective treatment for motor symptoms in Parkinson's disease (PD), but patients may experience psychological distress and social maladjustments after surgery. This review examines the role of patients' expectations regarding the outcomes of DBS and highlights the need for intervention to improve pre-operative patient education and post-operative psychosocial adjustment.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Joshua N. Strelow, Till A. Dembek, Juan C. Baldermann, Pablo Andrade, Gereon R. Fink, Veerle Visser-Vandewalle, Michael T. Barbe
Summary: This study aimed to assess the utility of low beta-band suppression as a tool for contact selection in STN-DBS for PD. The results showed that the degree of low beta-band suppression correlated with the clinical efficacy of the respective stimulation contact, indicating its potential as a reliable tool for contact selection in STN-DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Marisa DiMarzio, Radhika Madhavan, Ileana Hancu, Eric Fiveland, Julia Prusik, Suresh Joel, Michael Gillogly, Ilknur Telkes, Michael D. Staudt, Jennifer Durphy, Damian Shin, Julie G. Pilitsis
Summary: This study aimed to investigate the impact of altered frequencies on brain activation in PD patients. It was found that changing the frequency significantly affected the activation levels in regions such as the thalamus, globus pallidum externa, and cerebellum. Additionally, using fMRI signatures may be helpful in determining the optimal frequency for DBS programming.
Article
Clinical Neurology
Maidinamu Yakufujiang, Yoshinori Higuchi, Kyoko Aoyagi, Tatsuya Yamamoto, Toru Sakurai, Midori Abe, Yoji Okahara, Masaki Izumi, Osamu Nagano, Yoshitaka Yamanaka, Shigeki Hirano, Akihiro Shiina, Atsushi Murata, Yasuo Iwadate
Summary: This study found that preoperative evaluation using the Similarities and Object Assembly subtests in patients undergoing STN-DBS surgery may help predict cognitive declines postoperatively, especially in visuospatial functioning. A low score on the Similarities subtest may also predict future global cognitive deterioration.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Andreas Nowacki, Sabry Barlatey, Bassam Al-Fatly, Till Dembek, Maarten Bot, Alexander L. Green, Dorothee Kubler, M. Lenard Lachenmayer, Ines Debove, Alba Segura-Amil, Andreas Horn, Veerle Visser-Vandewalle, Rick Schuurman, Michael Barbe, Tipu Z. Aziz, Andrea A. Kuhn, T. A. Khoa Nguyen, Claudio Pollo
Summary: The objective of this study was to analyze individual clinical and neuroimaging data of patients undergoing deep brain stimulation for essential tremor and identify predictors of outcome and an optimal stimulation site. The results showed a cluster of optimal stimulation that significantly improved tremor and coincided with a normative structural connectivity-based cerebellothalamic tract.
ANNALS OF NEUROLOGY
(2022)
Article
Neurosciences
Maddalena Brunetti, Nadine Morkisch, Claire Fritzsch, Jan Mehnert, Jens Steinbrink, Michael Niedeggen, Christian Dohle
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2015)
Review
Engineering, Biomedical
Luara Ferreira dos Santos, Oliver Christ, Kedar Mate, Henning Schmidt, Joerg Krueger, Christian Dohle
BIOMEDICAL ENGINEERING ONLINE
(2016)
Review
Clinical Neurology
Holm Thieme, Nadine Morkisch, Christian Rietz, Christian Dohle, Bernhard Borgetto
Article
Clinical Neurology
C. Dohle, R. Tholen, H. Wittenberg, J. Quintern, S. Saal, K. M. Stephan
Article
Neurosciences
Thomas Schick, Hans-Peter Schlake, Juliane Kallusky, Guenter Hohlfeld, Maria Steinmetz, Florian Tripp, Karsten Krakow, Michaela Pinter, Christian Dohle
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2017)
Article
Public, Environmental & Occupational Health
Christian Dohle, Gerit Korr, Michael Friedrichs, Volker Kullmann, Mei-Lin Tung, Martin Kaase, Holger Ruessmann, Dagmar Sissolak, Dirk Werber, Laura Becker, Stephan Fuchs, Yvonne Pfeifer, Torsten Semmler, Gudrun Widders, Tim Eckmanns, Guido Werner, Edith Zill, Sebastian Haller
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ
(2018)
Article
Anesthesiology
Maria-Dorothea Heidler, Annett Salzwedel, Michael Joebges, Olaf Lueck, Christian Dohle, Michael Seifert, Andrea von Helden, Wibke Hollweg, Heinz Voeller
BMC ANESTHESIOLOGY
(2018)
Article
Microbiology
Laura Becker, Stephan Fuchs, Yvonne Pfeifer, Torsten Semmler, Tim Eckmanns, Gerit Korr, Dagmar Sissolak, Michael Friedrichs, Edith Zill, Mei-Lin Tung, Christian Dohle, Martin Kaase, Soeren Gatermann, Holger Ruessmann, Matthias Steglich, Sebastian Haller, Guido Werner
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Medicine, Research & Experimental
Agnes Floeel, Cordula Werner, Ulrike Grittner, Stefan Hesse, Michael Joebges, Janet Knauss, Michael Seifert, Elisabeth Steinhagen-Thiessen, Mehmet Goevercin, Christian Dohle, Wolfgang Fischer, Regina Schlieder, Alexander Heinrich Nave, Andreas Meisel, Martin Ebinger, Ian Wellwood
Editorial Material
Clinical Neurology
Holm Thieme, Nadine Morkisch, Jan Mehrholz, Marcus Pohl, Johann Behrens, Bernhard Borgetto, Christian Dohle
Article
Neurosciences
Nadine Morkisch, Holm Thieme, Christian Dohle
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2019)
Letter
Clinical Neurology
Thomas Platz, Andreas Bender, Christian Dohle, Anna Gorsler, Stefan Knecht, Joachim Liepert, Thomas Mokrusch, Michael Sailer
NEUROLOGICAL RESEARCH AND PRACTICE
(2020)
Article
Clinical Neurology
Christian Dohle, Friedemann Mueller, Klaus Martin Stephan
AKTUELLE NEUROLOGIE
(2017)
Article
Rehabilitation
Simon Hoermann, Luara Ferreira dos Santos, Nadine Morkisch, Katrin Jettkowski, Moran Sillis, Hemakumar Devan, Parimala S. Kanagasabai, Henning Schmidt, Joerg Krueger, Christian Dohle, Holger Regenbrecht, Leigh Hale, Nicholas J. Cutfield
DISABILITY AND REHABILITATION
(2017)
Article
Neurosciences
Claire Fritzsch, Jing Wang, Luara Ferreira dos Santos, Karl-Heinz Mauritz, Maddalena Brunetti, Christian Dohle
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2014)