Review
Medicine, General & Internal
Gentzon Hall, Christina M. Wyatt
Summary: Proteinuria is common in individuals with HIV infection, reflecting kidney disease, treatment-related nephrotoxicity, and HIV-related glomerular diseases. Recent studies have focused on investigating the mechanisms of podocyte and tubulointerstial injury in HIV-associated nephropathy, showing that injury-induced podocyte dedifferentiation, hyperplasia, and cytoskeletal dysregulation may lead to loss of glomerular filtration barrier integrity.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Jingping Yang, Difei Zhang, Masaru Motojima, Tsutomu Kume, Qing Hou, Yu Pan, Aiping Duan, Mingchao Zhang, Song Jiang, Jinhua Hou, Jingsong Shi, Zhaohui Qin, Zhihong Liu
Summary: This study identified potential TFs in human glomerulus cells through analysis of superenhancer distribution, and elucidated the regulatory roles of FOXC1/2 in podocyte maintenance using transcriptomics and cistromics. The results suggest that FOXC1/2 maintain podocyte differentiation through transcriptional stabilization, with overexpression protecting podocytes from injury. The genome-wide chromatin resources support further investigation of TFs' regulatory roles in glomeruli transcription programs.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Anqun Chen, Lijun Yin, Kyung Lee, John Cijiang He
Summary: Kidney disease is a major complication of viral infections, with both HIV-associated nephropathy (HIVAN) and COVID-19 patients showing similarities in renal issues and underlying mechanisms. The role of local infection and systemic effects in the pathogenesis of these diseases remains an area of ongoing research.
Article
Urology & Nephrology
Rachel K. Y. Hung, Elizabeth Binns-Roemer, John W. Booth, Rachel Hilton, Mark Harber, Beatriz Santana-Suarez, Lucy Campbell, Julie Fox, Andrew Ustianowski, Catherine Cosgrove, James E. Burns, Amanda Clarke, David A. Price, David Chadwick, Denis Onyango, Lisa Hamzah, Kate Bramham, Caroline A. Sabin, Cheryl A. Winkler, Frank A. Post
Summary: APOL1 high-risk genotypes are strongly associated with kidney disease in people of African ancestry with HIV and account for approximately half of ESKD cases in this cohort.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Khurrum Shahzad, Sameen Fatima, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Hamzah Khawaja, Saira Ambreen, Ahmed Elwakiel, Nora Kloeting, Matthias Blueher, Peter P. Nawroth, Peter R. Mertens, Sven Michel, Frank Jaschinski, Richard Klar, Berend Isermann
Summary: The study demonstrates that an ASO-based approach reducing CHOP expression can ameliorate DKD in mice, providing renal protection on top of ACE inhibition. Inhibition of CHOP not only improves glomerular damage, but also tubular damage. ASO therapies are a potential new approach to target maladaptive ER stress signaling and improve DKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Rezzan Eren Sadioglu, Sahin Eyupoglu, Saba Kiremitci, Serhat Birengel, Kenan Keven
Summary: Viral nephropathy refers to kidney damage caused by viruses or virus-induced immune mechanisms, diagnosed mainly through renal biopsy. Various viruses, such as hepatitis B and C, HIV, can affect the kidney. Treatment involves supportive care based on diagnosis.
JOURNAL OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Anika Lucas, Christina M. Wyatt
Summary: Kidney disease remains an important comorbidity in people with HIV, and both HIV infection and treatment may contribute to the progression of chronic kidney disease. Unique considerations for managing chronic kidney disease in HIV-positive individuals include potential drug toxicity and drug-drug interactions due to lifelong antiretroviral therapy. Kidney transplantation and research on HIV-positive donor kidney transplantation have implications for kidney health and HIV cure research.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Rohan Goyal, Pravin C. Singhal
Summary: The APOL1 gene variants G1 and G2, common in African populations, are associated with increased risk of various glomerular diseases, particularly in the context of HIV infection. Mechanisms driving glomerular injury due to APOL1 RRVs have been elucidated, but there are still significant gaps in their application for patient management.
Article
Immunology
Shuai Hu, Runhong Han, Long Chen, Weisong Qin, Xiaodong Xu, Jingsong Shi, Xiaodong Zhu, Mingchao Zhang, Caihong Zeng, Zheng Tang, Hao Bao, Zhihong Liu
Summary: Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes in FSGS, DN, and MN. LRRC55 inhibition may represent a new therapeutic approach for podocyte injury.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, General & Internal
Rachel K. Y. Hung, Beatriz Santana-Suarez, Elizabeth Binns-Roemer, Lucy Campbell, Kate Bramham, Lisa Hamzah, Julie Fox, James E. Burns, Amanda Clarke, Rachel Vincent, Rachael Jones, David A. Price, Denis Onyango, Mark Harber, Rachel Hilton, John W. Booth, Caroline A. Sabin, Cheryl A. Winkler, Frank A. Post
Summary: The study revealed that HIV patients of West African ancestry are at higher risk of kidney disease, including renal impairment and stage 5 CKD, but not significantly associated with proteinuria. West African ancestry is also strongly linked to a diagnosis of HIVAN/FSGS or arterionephrosclerosis on kidney biopsy.
Review
Urology & Nephrology
Bala Waziri, Yakubu Egigogo Raji, Udeme E. Ekrikpo, Saraladevi Naicker
Summary: This systematic review and meta-analysis found a strong association between carrying two risk APOL1 variants and an increased risk of kidney disease in people living with HIV (PLWHIV), including chronic kidney disease (CKD), proteinuria, HIV-associated nephropathy (HIVAN), and progression to end-stage kidney disease (ESKD).
JOURNAL OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Liu, Wei Chen, Chenrui Li, Li Li, Ming Yang, Na Jiang, Shilu Luo, Yiyun Xi, Chongbin Liu, Yachun Han, Hao Zhao, Xuejing Zhu, Shuguang Yuan, Li Xiao, Lin Sun
Summary: DsbA-L plays an important role in ameliorating tubular injury in diabetic nephropathy by improving peroxisomal function.
Article
Cell Biology
Yan Jun Li, Jin Ma, Yik Wen Loh, Steven J. Chadban, Huiling Wu
Summary: The aim of this study was to investigate the impact of short-chain fatty acids on cellular pathways involved in the development of diabetic nephropathy. Short-chain fatty acids were found to provide protection against diabetic nephropathy in mice and exert anti-inflammatory and anti-fibrotic effects through direct effects on kidney cells. GPR43 and GPR109A were identified as critical factors in short-chain fatty acid mediated reno-protection and could be potential therapeutic targets for diabetic nephropathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Xuehong Li, Qinglan Yang, Sirui Liu, Shicong Song, Cheng Wang
Summary: Excessive mitochondrial fission in podocytes is a critical feature of diabetic nephropathy. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are suggested to be related to mitochondrial function, but their role in mitochondrial dynamics disorder in podocytes under diabetic conditions remains unknown.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, General & Internal
Seyoung Yu, Yo Jun Choi, John Hoon Rim, Hye-Youn Kim, Nasim Bekheirnia, Sarah Jane Swartz, Hongzheng Dai, Shen Linda Gu, Soyeon Lee, Ryuichi Nishinakamura, Friedhelm Hildebrandt, Mir Reza Bekheirnia, Heon Yung Gee
Summary: Mutations in the ADAMTS9 gene can cause glomerulotubular nephropathy, and this study provides insights into the functional roles of ADAMTS9 in glomeruli and tubules.
FRONTIERS IN MEDICINE
(2023)
Article
Pathology
Vinod Kumar, Himanshu Vashistha, Xiqian Lan, Nirupama Chandel, Kamesh Ayasolla, Seyedeh Shadafarin Marashi Shoshtari, Rukhsana Aslam, Nitpriya Paliwal, Frank Abbruscato, Joanna Mikulak, Waldemar Popik, Mohamed G. Atta, Praveen N. Chander, Ashwani Malhotra, Catherine Meyer-Schwesinger, Karl Skorecki, Pravin C. Singhal
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Immunology
Jolanda Brummelman, Emilia M. C. Mazza, Giorgia Alvisi, Federico S. Colombo, Andrea Grilli, Joanna Mikulak, Domenico Mavilio, Marco Alloisio, Francesco Ferrari, Egesta Lopci, Pierluigi Novellis, Giulia Veronesi, Enrico Lugli
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Cell Biology
Vinod Kumar, Kamesh Ayasolla, Alok Jha, Abheepsa Mishra, Himanshu Vashistha, Xiqian Lan, Maleeha Qayyum, Sushma Chinnapaka, Richa Purohit, Joanna Mikulak, Moin A. Saleem, Ashwani Malhotra, Karl Skorecki, Pravin C. Singhal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Review
Immunology
Clara Di Vito, Joanna Mikulak, Elisa Zaghi, Silvia Pesce, Emanuela Marcenaro, Domenico Mavilio
SEMINARS IN IMMUNOLOGY
(2019)
Letter
Medicine, General & Internal
Joanna Mikulak, Francesco Dieli, Domenico Mavilio
Review
Immunology
Joanna Mikulak, Elena Bruni, Ferdinando Oriolo, Clara Di Vito, Domenico Mavilio
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Immunology
Clara Di Vito, Joanna Mikulak, Domenico Mavilio
FRONTIERS IN IMMUNOLOGY
(2019)
Editorial Material
Immunology
Joanna Mikulak, Clara Di Vito, Domenico Mavilio
Article
Oncology
Elena Bruni, Valentina Cazzetta, Matteo Donadon, Matteo Cimino, Guido Torzilli, Gianmarco Spata, Gloria Leonardi, Francesco Dieli, Joanna Mikulak, Domenico Mavilio
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Manuela Valsecchi, Valentina Cazzetta, Ferdinando Oriolo, Xiqian Lan, Rocco Piazza, Moin A. Saleem, Pravin C. Singhal, Domenico Mavilio, Joanna Mikulak, Massimo Aureli
GLYCOCONJUGATE JOURNAL
(2020)
Review
Gastroenterology & Hepatology
Michela Anna Polidoro, Joanna Mikulak, Valentina Cazzetta, Ana Lleo, Domenico Mavilio, Guido Torzilli, Matteo Donadon
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Review
Oncology
Valentina Cazzetta, Sara Franzese, Claudia Carenza, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Summary: The reciprocal crosstalk between dendritic cells (DCs) and natural killer (NK) cells plays a crucial role in regulating immune defense against viruses and tumors, with potential therapeutic implications in liver malignancies. NK cells and DCs are innate immune cells that interact to control activation and immune responses, particularly in the context of liver cancer.
Article
Cell Biology
Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico S. Colombo, Enrico Lugli, Emanuela Marcenaro, Eric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Summary: NKG2A expression identifies a subset of V delta 2 T cells with intrinsic hyper-responsiveness against cancer, which is counterbalanced by the inhibitory signaling delivered by HLA-E expressed on malignant cells. Removal of NKG2A restores the effector functions of V delta 2 T cells.
Article
Medicine, Research & Experimental
Joanna Mikulak, Ferdinando Oriolo, Elena Bruni, Alessandra Roberto, Federico S. Colombo, Anna Villa, Marita Bosticardo, Ileana Bortolomai, Elena Lo Presti, Serena Meraviglia, Francesco Dieli, Stefania Vetrano, Silvio Danese, Silvia Della Bella, Michele M. Carvello, Matteo Sacchi, Giovanni Cugini, Giovanni Colombo, Marco Klinger, Paola Spaggiari, Massimo Roncalli, Immo Prinz, Sarina Ravens, Biagio di Lorenzo, Emanuela Marcenaro, Bruno Silva-Santos, Antonino Spinelli, Domenico Mavilio
Meeting Abstract
Biochemistry & Molecular Biology
Domenico Mavilio, Joanna Mikulak, Ferdinando Oriolo, Alessandra Roberto, Elena Bruni, Paolo Tentorio, Federico Colombo, Michele Carvello, Antonino Spinelli, Bruno Silva-Santoss