Article
Genetics & Heredity
Ahmed Khattab, Ali Torkamani
Summary: This study investigates the genetic basis of diabetic kidney disease (DKD) in type 2 diabetes (T2D) using data from the UK Biobank. The results confirm two loci previously associated with chronic kidney disease and creatinine estimated glomerular filtration rate in T2D, and also identify a novel association between DKD and a variant rs72763500, which is a splicing quantitative trait locus for the nidogen-1 gene.
Review
Urology & Nephrology
Jinfang Song, Jiang Ni, Xiaoxing Yin
Summary: DKD is one of the most common complications of diabetes, and its pathogenesis remains largely unknown. Genetic and environmental factors play important roles in DKD, with familial clustering supporting the critical role of hereditary factors. Exploring and identifying susceptibility genes for DKD can provide insights into its pathogenesis and improve its prevention and treatment.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Zhuo Gao, S. Aishwarya, Xiao-mei Li, Xin-lun Li, Li-na Sui
Summary: This study identified potential key genes and pathways involved in the progression of DKD through integrated bioinformatics analysis. Several differentially expressed genes with roles in DKD progression were identified, along with two drugs that have a validated role in reversing the observed differential gene expression patterns.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hyunwoo Kim, Miyeon Kim, Hwa-Young Lee, Ho-Young Park, Hyunjhung Jhun, Soohyun Kim
Summary: Diabetic nephropathy is a significant microvascular complication in diabetic patients, with current treatment options insufficient to prevent its progression. Recent studies suggest DN is an inflammatory disease, with immune cells potentially playing a role in its development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Khurrum Shahzad, Sameen Fatima, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Hamzah Khawaja, Saira Ambreen, Ahmed Elwakiel, Nora Kloeting, Matthias Blueher, Peter P. Nawroth, Peter R. Mertens, Sven Michel, Frank Jaschinski, Richard Klar, Berend Isermann
Summary: The study demonstrates that an ASO-based approach reducing CHOP expression can ameliorate DKD in mice, providing renal protection on top of ACE inhibition. Inhibition of CHOP not only improves glomerular damage, but also tubular damage. ASO therapies are a potential new approach to target maladaptive ER stress signaling and improve DKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Transplantation
Sok Cin Tye, Petra Denig, Hiddo J. L. Heerspink
Summary: The increasing prevalence of end-stage kidney disease worldwide is closely linked to the rising number of people with diabetes. Early diagnosis of chronic kidney disease in diabetic patients is crucial for slowing down kidney function decline and preventing ESKD. Tailoring individual treatment is necessary due to variation in CKD progression and treatment response among diabetic patients. Biomarker-based approaches show promise in identifying high-risk patients and guiding targeted therapy, potentially leading to a shift towards personalized medicine in diabetic kidney disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Nutrition & Dietetics
Guido Gembillo, Luca Visconti, Alfio Edoardo Giuffrida, Vincenzo Labbozzetta, Luigi Peritore, Antonella Lipari, Vincenzo Calabrese, Giorgina Barbara Piccoli, Massimo Torreggiani, Rossella Siligato, Domenico Santoro
Summary: Zinc plays a potential role in kidney and body homeostasis in diabetic patients and those at a high risk of developing diabetic kidney disease by counteracting diabetes-related risk factors and reducing oxidative stress levels, which can slow down the progression of kidney disease.
Review
Cell Biology
Che-Hao Tseng, Kavya M. Shah, I-Jen Chiu, Li-Li Hsiao
Summary: Diabetic kidney disease is one of the most prevalent complications of type 2 diabetes mellitus, causing a significant burden on patients worldwide. Recent studies have highlighted the relationship between autophagy and diabetic kidney disease, suggesting autophagy as a potential therapeutic target.
Review
Urology & Nephrology
Carmine Zoccali
Summary: The debate on kidney biopsy in diabetic kidney disease (DKD) is multifaceted. One side argues for its broader application, citing precise diagnostic data and personalized treatment plans, while the other side opposes it, pointing out insufficient evidence, resource constraints, and potential risks. Both sides agree on the need for individualized patient care and open discussions between healthcare providers and patients.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri
Summary: Diabetic kidney disease is a global burden that increases the risk of kidney failure and cardiovascular events. There is a need to understand the molecular mechanisms of the disease and find new therapies. Inflammatory and fibrotic mediators play important roles in the pathophysiology of the disease. Recent clinical trials have shown promising drug therapies and dietary strategies for treating diabetic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Vidar T. N. Stefansson, Viji Nair, Toralf Melsom, Helen C. Looker, Laura H. Mariani, Damian Fermin, Felix Eichinger, Rajasree Menon, Lalita Subramanian, Patricia Ladd, Roger Harned, Jennifer L. Harder, Jeffrey B. Hodgin, Petter Bjornstad, Peter J. Nelson, Bjorn O. Eriksen, Robert G. Nelson, Matthias Kretzler
Summary: Hyperfiltration is a characteristic of early diabetic kidney disease that damages glomeruli and increases glomerular load. Our study reveals the molecular pathomechanisms associated with hyperfiltration, involving cellular crosstalk between endothelial and mesangial cells.
KIDNEY INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Rebekah J. Nicholson, Marcus G. Pezzolesi, Scott A. Summers
Summary: Diabetic kidney disease (DKD) is a prevalent and progressive comorbidity of diabetes mellitus that increases the risk of renal failure. Research suggests that bioactive ceramides may serve as a potential therapeutic target for DKD, as modulation of renal ceramide levels could improve kidney function and ameliorate DKD pathology. Studies have shown that circulating sphingolipid profiles can distinguish DKD patients from diabetic controls, highlighting the potential of ceramide as a central and therapeutically tractable lipid mediator of DKD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Bo Lin, Ying-Yu Ma, Jun-Wei Wang
Summary: Diabetic nephropathy is the leading cause of end-stage renal disease worldwide and its occurrence is likely to reach pandemic proportions. Current treatment strategies neglect the molecular progression mechanism of diabetic nephropathy. Nano-technological techniques offer a new approach for targeted drug delivery and imaging systems in various clinical conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Urology & Nephrology
Karina Haar Jensen, Frederik Persson, Ditte Hansen, Iain Bressendorff, Marie Moller, Peter Rossing, Eva Gravesen, Vanja Kosjerina, Dorte Vistisen, Rikke Borg
Summary: The PRIMETIME 1 study is a large Danish national study that aims to classify kidney disease in diabetes based on registry data. It provides a unique opportunity for future research in diabetic kidney disease.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Shunlai Shang, Shaoyuan Cui, Wenjuan Wang, Chao Wang, Ping Li, Wenge Li, Qinggang Li
Summary: This study analyzed the safety and efficacy of leflunomide combined with low-dose methylprednisolone in the treatment of diabetic kidney disease combined with membranous nephropathy. The combination therapy was found to be more effective than leflunomide monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Clare McKeaveney, Miles Witham, Abrar O. Alamrani, Alexander Peter Maxwell, Robert Mullan, Helen Noble, Joanne Shields, Joanne Reid
Summary: The objective of this study was to report on quality of life and other functional outcomes in patients with advanced chronic kidney disease. The study found that patients receiving hemodialysis had significantly better scores on the Symptoms/Problems List subscale of the KDQoL-36 questionnaire compared to those under conservative management. However, there was no significant difference in the Burden of Kidney Disease subscale scores between the two groups. These findings suggest the use of quality of life assessment tools for clinical prognostication and appropriate management of advanced CKD patients.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Endocrinology & Metabolism
Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu, Emma Ahlqvist, Natalie van Zuydam, Emma H. Dahlstrom, Damian Fermin, Laura J. Smyth, Rany M. Salem, Carol Forsblom, Erkka Valo, Valma Harjutsalo, Eoin P. Brennan, Gareth J. McKay, Darrell Andrews, Ross Doyle, Helen C. Looker, Robert G. Nelson, Colin Palmer, Amy Jayne McKnight, Catherine Godson, Alexander P. Maxwell, Leif Groop, Mark I. McCarthy, Matthias Kretzler, Katalin Susztak, Joel N. Hirschhorn, Jose C. Florez, Per-Henrik Groop
Summary: By performing meta-analysis of previous genome-wide association studies (GWAS) on diabetic kidney disease (DKD) and integrating the results with renal transcriptomics datasets, novel genetic factors and genes contributing to DKD have been identified.
Article
Multidisciplinary Sciences
Carolyn Blair, Joanne Shields, Robert Mullan, William Johnston, Andrew Davenport, Denis Fouque, Kamyar Kalantar-Zadeh, Peter Maxwell, Clare McKeaveney, Helen Noble, Sam Porter, David Seres, Adrian Slee, Ian Swaine, Miles Witham, Joanne Reid
Summary: This study aims to explore the lived experience of individuals with renal cachexia and their carers, in order to inform guidelines and future renal service planning.
Article
Medicine, General & Internal
William G. Herrington, Natalie Staplin, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Jonathan R. Emberson, David Preiss, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K. Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: Empagliflozin therapy reduces the risk of disease progression or cardiovascular death in patients with chronic kidney disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Luke E. Barry, Grainne E. Crealey, Paul Cockwell, Stephen J. Elliman, Matthew D. Griffin, Alexander P. Maxwell, Timothy O'Brien, Norberto Perico, Ciaran O'Neill
Summary: This study simulated the cost-effectiveness of Mesenchymal Stromal Cell therapy compared to other treatments in patients with Diabetic Kidney Disease. The results showed that Mesenchymal Stromal Cell therapy was more cost-effective compared to other treatments. However, sodium/glucose co-transporter 2 inhibitors had the highest cost-effectiveness among all the treatments.
Article
Multidisciplinary Sciences
Laura J. Smyth, Emma H. Dahlstrom, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Summary: This study investigated DNA methylation in 1304 individuals with type 1 diabetes and identified differentially methylated CpG sites associated with diabetic kidney disease. The methylation at 21 of these sites was found to predict the development of kidney failure.
NATURE COMMUNICATIONS
(2022)
Article
Urology & Nephrology
Laura J. Smyth, Katie R. Kerr, Jill Kilner, Aine E. McGill, Alexander P. Maxwell, Amy Jayne McKnight
Summary: This study analyzed the DNA methylation of kidney transplant recipients and identified markers associated with the risk of transplant complications. The findings provide an important reference for future epigenetic studies on posttransplant complications.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Multidisciplinary Sciences
Wael Osman, Mira Mousa, Mohammed Albreiki, Zahrah Baalfaqih, Hinda Daggag, Claire Hill, Amy Jayne McKnight, Alexander P. Maxwell, Habiba Al Safar
Summary: Diabetic kidney disease (DKD), or diabetic nephropathy, is a major cause of renal impairment and end-stage renal disease. This study conducted a genome-wide association study to investigate genetic factors associated with the development and progression of DKD in the Emirati population. The CNR2 gene was found to be significantly associated with the development of DKD in individuals with type 2 diabetes mellitus (T2DM).
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Claire Hill, Seamus M. Duffy, Laura Kettyle, Liane McGlynn, Niina M. Sandholm, Rany Salem, Alex J. Thompson, Elizabeth Swan, Jill Kilner, Peter G. Rossing, Paul Shiels, Maria Lajer, Per-Henrik Groop, Alexander Peter Maxwell, Amy Jayne McKnight, GENIE Consortium
Summary: Diabetic kidney disease (DKD) is a major global health problem characterized by accelerated aging. This study explored features affecting telomere biology and methylation dysregulation in DKD using multi-omics approaches, which may provide useful biomarkers or therapeutic targets.
Review
Genetics & Heredity
Claire Hill, Seamus Duffy, Tiernan Coulter, Alexander Peter Maxwell, Amy Jayne McKnight
Summary: The global prevalence of diabetes is increasing and research is needed to find new ways to manage it. Diabetes can lead to kidney disease, which is a burden to patients and healthcare services. This review highlights studies on genomic and functional prediction tools that have identified genes and pathways associated with diabetic kidney disease, particularly focusing on the regulation of telomere length. The potential to use therapeutics that modulate telomere length for the treatment of diabetic kidney disease is discussed in the review.
Article
Urology & Nephrology
Norberto Perico, Giuseppe Remuzzi, Matthew D. Griffin, Paul Cockwell, Alexander P. Maxwell, Federica Casiraghi, Nadia Rubis, Tobia Peracchi, Alessandro Villa, Marta Todeschini, Fabiola Carrara, Bernadette A. Magee, Piero L. Ruggenenti, Stefano Rota, Laura Cappelletti, Veronica Mcinerney, Tomas P. Griffin, Md Nahidul Islam, Martino Introna, Olga Pedrini, Josee Golay, Andrew A. Finnerty, Jon Smythe, Willem E. Fibbe, Stephen J. Elliman, Timothy O'Brien, NEPHSTROM Trial Consortium
Summary: The NEPHSTROM study evaluates the safety, tolerability, and preliminary efficacy of ORBCEL-M cell therapy in adults with type 2 diabetes and progressive diabetic kidney disease. The results show that ORBCEL-M cell therapy is safe and well-tolerated in the lowest dose cohort, and significantly reduces the decline rate of eGFR over 18 months.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Nga T. Q. Nguyen, Aisling E. E. Courtney, Hoa Q. Q. Nguyen, Michael Quinn, Alexander P. P. Maxwell, Ciaran O'Neill
Summary: This study aimed to assign expanded criteria and non-expanded criteria donation status and examine early clinical and economic outcomes among expanded criteria and non-expanded criteria living kidney donor (LKD) hospitalizations in the US.
JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Anna Rainey, Gareth J. Mckay, Jane English, Ammarin Thakkinstian, Alexander Peter Maxwell, Michael Corr
Summary: Kidney transplantation is the optimal treatment for most patients with end-stage kidney disease, but rejection and graft failure remain common. The development of non-invasive biomarkers to monitor graft function and predict transplant outcomes is still needed. Proteomic investigation has identified potential biomarkers, but their clinical translation and adoption are limited and require further evaluation in larger trials.
Article
Health Care Sciences & Services
Carolyn Blair, Adrian Slee, Andrew Davenport, Denis Fouque, William Johnston, Kamyar Kalantar-Zadeh, Peter Maxwell, Clare McKeaveney, Robert Mullan, Helen Noble, Sam Porter, David Seres, Joanne Shields, Ian Swaine, Miles Witham, Joanne Reid
Summary: This study aimed to develop a theoretical framework for a multimodal intervention for patients with renal cachexia. The researchers used a Theory of Change approach to guide the development of the framework and provide evidence for the effectiveness of the intervention.
Article
Health Care Sciences & Services
Clare McKeaveney, Helen Noble, Aisling E. Courtney, Sian Griffin, Paul Gill, William Johnston, Alexander P. Maxwell, Francesca Teasdale, Joanne Reid
Summary: This study aims to gain an in-depth understanding of the lived experiences of kidney transplant recipients. The results revealed that the participants continue to manage ongoing fears of dialysis, distress, and the impact of COVID-19, as well as dealing with difficult conversations. Renal healthcare professionals need to recognize the holistic and multidomain experiences of kidney patients to provide responsive psychosocial care.