Article
Biochemistry & Molecular Biology
Maureen L. Meister, Rami S. Najjar, Jessica P. Danh, Denise Knapp, Desiree Wanders, Rafaela G. Feresin
Summary: This study investigated the effects of polyphenol-rich blackberry and raspberry on high-fat, high-sucrose (HFHS) diet-induced blood pressure increases. The results showed that blackberry and raspberry reduced the expression of renal and aortic angiotensin type 1 receptor (AT1R), decreased oxidative stress, and improved vascular endothelial function. Additionally, blackberry and raspberry increased the production of nitric oxide, thereby improving vascular function. These findings suggest that the unique polyphenols in blackberry and raspberry may attenuate the detrimental effects of a HFHS diet on blood pressure through multiple pathways.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito
Summary: High-fructose diet induces hypertension and renal damage, which are exaggerated in salt-sensitive Dahl salt-sensitive rats through renal renin-angiotensin system activation. The effects can be controlled by renin-angiotensin system inhibitors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Amanda da Silva Chaves, Nathalia Santos Magalhaes, Daniella Bianchi Reis Insuela, Patricia Machado Rodrigues E Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: This study investigates the role of the renin-angiotensin system (RAS) in the overproduction of corticosterone in diabetic mice. The results suggest that inhibition of angiotensin synthesis and AT(1) receptor activity can reduce corticosterone levels in diabetic mice. Furthermore, the protective effect of Olmesartan on corticosterone overproduction in diabetic mice depends on both AT(1) receptor blockade and AT(2) receptor activation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sam Siljee, Bridget Milne, Helen D. Brasch, Nicholas Bockett, Josie Patel, Paul F. Davis, Andrew Kennedy-Smith, Tinte Itinteang, Swee T. Tan
Summary: This study demonstrated the expression of PRR, ACE2, and AT(2)R by the CSCs within RCCC. Further studies may lead to novel therapeutic targeting of CSCs by manipulation of the RAS in the treatment of this aggressive cancer.
Review
Medicine, Research & Experimental
Chuanxin Su, Jinhua Xue, Chao Ye, Aidong Chen
Summary: Hypertension, present in over one billion adults, is closely related to the disruption of the renin-angiotensin system (RAS). The AT1R receptor is the most important angiotensin II receptor, playing a critical role in vasoconstriction and being associated with multiple signaling pathways, including AT1R/JAK/STAT and Ras/Raf/MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jason D. Vadhan, Robert C. Speth
Summary: This review discusses how activation of the brain RAS following TBI contributes to permanent brain damage, and how drugs that counteract activation of the AT(1)R can potentially ameliorate TBI-induced brain damage.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Nadin Hoffmann, Joerg Peters
Summary: The (pro)renin receptor (P)RR has important roles in the kidney and brain, independently of prorenin, in activating inflammatory and fibrotic responses in renal dysfunction and being linked to hypertension in the brain. By regulating pH and function of v-ATPase, (P) RR plays crucial roles in cellular homeostasis and autophagy in kidney, brain, and heart.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Alper Tuna Guven, Murat Ozdede, Yusuf Ziya Sener, Ali Osman Yildirim, Sabri Engin Altintop, Berkay Yesilyurt, Oguz Abdullah Uyaroglu, Mine Durusu Tanriover
Summary: This study aimed to evaluate the performance of machine learning algorithms in identifying and predicting renal adverse events associated with RAASi. The most important features for predicting these events were found to be index K and glucose levels, as well as uncontrolled diabetes mellitus. kNN, RF, xGB, and NN algorithms showed the highest performance metrics for prediction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Natalia K. S. Lima, Wilka R. A. Farias, Marry A. S. Cirilo, Angelica G. Oliveira, Juliane S. Farias, Regina S. Aires, Humberto Muzi-Filho, Ana D. O. Paixao, Leucio D. Vieira
Summary: Acute renal injury induced by ischemia-reperfusion may lead to changes in proximal tubule ATPases and RAAS components, which are associated with renal Na+ retention and hypertension. NADPH oxidase plays a key role in these alterations.
Article
Neurosciences
Charles J. Frazier, Scott W. Harden, Amy R. Alleyne, Mazher Mohammed, Wanhui Sheng, Justin A. Smith, Khalid Elsaafien, Eliot A. Spector, Dominique N. Johnson, Karen A. Scott, Eric G. Krause, Annette D. de Kloet
Summary: The study shows that AT1aR neurons in the lamina terminalis play a crucial role in blood pressure control by influencing cardiovascular parameters and fluid intake through optogenetic stimulation. Additionally, activation of these neurons leads to neuroendocrine and behavioral responses that increase blood pressure.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Article
Environmental Sciences
Md Shiblur Rahaman, Nathan Mise, Akihiko Ikegami, Cai Zong, Gaku Ichihara, Sahoko Ichihara
Summary: It has been established that arsenic exposure leads to hypertension in humans, but the underlying molecular mechanisms are not fully understood. This study explored the potential mechanisms by investigating the renin-angiotensin system (RAS). The findings suggest that arsenic-induced hypertension is mediated by oxidative stress-mediated inhibition of ACE2 and suppression of the vasoprotective axes of RAS.
Review
Biochemistry & Molecular Biology
Raul Loera-Valencia, Francesca Eroli, Sara Garcia-Ptacek, Silvia Maioli
Summary: The article explores the role of the brain renin-angiotensin system in cognition and Alzheimer's disease pathogenesis, as well as its relationship with risk factors such as hypercholesterolemia. Current RAS inhibition therapy's efficacy in improving cognition in AD patients is uncertain, with only one therapy under consideration in clinical trials. Additionally, research on novel drugs may offer potential for highly specific treatments targeting the brain RAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
V. H. G. Rizzi, L. d. B. Sene, C. D. B. Fernandez, J. A. R. Gontijo, P. A. Boer
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2017)
Article
Pathology
Paula Aiello Tome de Souza Castro, Ludimila Canuto Faccioni, Patricia Aline Boer, Robson Francisco Carvalho, Selma Maria Michelin Matheus, Maeli Dal-Pai-Silva
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2017)
Article
Biology
Leticia B. Sene, Victor Hugo Goncalves Rizzi, Jose A. R. Gontijo, Patricia A. Boer
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
D. B. Torres, A. Lopes, A. J. Rodrigues, J. J. Cerqueira, N. Sousa, J. A. R. Gontijo, P. A. Boer
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
Article
Biology
Barbara Vaccari Cardoso, Augusto Henrique Custedio, Patricia Aline Boer, Jose Antonio Rocha Gontijo
Article
Engineering, Biomedical
Helcio R. B. Orlande, Nelson Afonso Lutaif, Jose Antonio Rocha Gontijo
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2019)
Article
Multidisciplinary Sciences
Heloisa Balan Assalin, Jose Antonio Rocha Gontijo, Patricia Aline Boer
Article
Multidisciplinary Sciences
Leticia de Barros Sene, Wellerson Rodrigo Scarano, Adriana Zapparoli, Jose Antonio Rocha Gontijo, Patricia Aline Boer
Summary: This study found that gestational low-protein intake can affect renal development in offspring by altering miRNA and predicted target gene expression levels in the kidney, leading to a reduction in nephron number. Specifically, there were decreased cell numbers and changes in immunoreactivity of related proteins observed in the metanephros.
Article
Physiology
Gabriela Leme Lamana, Ana Leticia Luchiari Ferrari, Jose Antonio Rocha Gontijo, Patricia Aline Boer
Summary: The study indicates that protein restriction during gestational and breastfeeding periods can lead to significant changes in renal function and structure in offspring, including decreased nephron number, increased glomerular volume, and early glomerulosclerosis. These findings highlight the important impact of maternal protein restriction on renal development in fetal-programmed adult offspring.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Leticia de Barros Sene, Gabriela Leme Lamana, Andre Schwambach Vieira, Wellerson Rodrigo Scarano, Jose Antonio Rocha Gontijo, Patricia Aline Boer
Summary: The research revealed miRNA and molecular pathway changes in the kidneys affected by protein restriction during fetal development, which may lead to reduced nephron numbers and other related dysfunctions. Further data analysis indicated the involvement of multiple miRNAs in regulating kidney development.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Julia Seva Gomes, Leticia Barros Sene, Gabriela Leme Lamana, Patricia Aline Boer, Jose Antonio Rocha Gontijo
Summary: This study investigated molecular modulations in the HIF-1 signaling pathway in the kidneys of 17-GD LP offspring. The results showed increased expression of elF4, HSP90, p53, p300, NF kappa beta, and AT2 genes in the low protein group. Additionally, increased labeling of HIF-1 alpha in LP offspring was associated with reduced elF4 expression. These findings suggest that changes in the HIF-1 pathway may be related to the programmed reduction in nephron number in LP offspring.
