Article
Neurosciences
Xiang-Wen Zhu, Li-Li Zhang, Zong-Ming Zhu, Luo-Yu Wang, Zhong-Xiang Ding, Xiang-Ming Fang
Summary: This study revealed functional abnormalities in unaffected parents of ASD children in ASD-related brain regions using various resting-state fMRI analyzing methods, and found correlations between imaging metric values and the severity of ASD traits.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Linghong Kong, Haijun Li, Yongqiang Shu, Xiang Liu, Panmei Li, Kunyao Li, Wei Xie, Yaping Zeng, Dechang Peng
Summary: The study explored the functional connectivity between insular subregions and other brain areas in patients with obstructive sleep apnea (OSA) and its relationship with clinical symptoms. The results showed that OSA patients exhibited abnormal functional connectivity in the insular subregions, which were related to cognitive, emotional, and sensorimotor networks. These findings provide a new imaging perspective for understanding OSA-related cognitive and affective disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Marlena Duda, Danai Koutra, Chandra Sripada
Summary: This study investigates the presence of dynamic functional connectivity during rest and proposes a data-driven framework for studying cognitive neuroscience questions using connectivity changes. The framework outperforms the traditional sliding window approach in accuracy and computational efficiency when applied to working memory task data. Additionally, when applied to resting state fMRI data, the method consistently identifies five reliable FC states which show significant correlation with behavioral phenotypes.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Gengbiao Zhang, Ni Li, Hongkun Liu, Hongyi Zheng, Wenbin Zheng
Summary: This study investigated the changes in brain functional networks after acute alcohol exposure using sliding window analysis. The results revealed distinctive connectivity patterns under intoxication and provided insights into the alcohol-related mechanisms for neurological damage. The dynamic changes in brain network connectivity were consistent with participants' subjective feelings after drinking, suggesting that dynamic functional network connectivity offers a new approach for studying the effects of alcohol on the brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Yanjiang Wang, Jichao Ma, Xue Chen, Baodi Liu
Summary: This study proposes a spatiotemporal varying hypergraph Laplacian diffusion model to describe the propagation of spontaneous neural activity in the human brain. The research reveals that there exist dynamic functional couplings between brain regions in the form of exponential waves, regulated by the Laplacian of the hypergraph structural connectome. The average statistical dependencies between brain regions, known as functional connectivity, only arise in the moment before the wave reaches steady state.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Neurosciences
A. Iraji, Z. Fu, A. Faghiri, M. Duda, J. Chen, S. Rachakonda, T. DeRamus, P. Kochunov, B. M. Adhikari, A. Belger, J. M. Ford, D. H. Mathalon, G. D. Pearlson, S. G. Potkin, A. Preda, J. A. Turner, T. G. M. van Erp, J. R. Bustillo, K. Yang, K. Ishizuka, A. Faria, A. Sawa, K. Hutchison, E. A. Osuch, J. Theberge, C. Abbott, B. A. Mueller, D. Zhi, C. Zhuo, S. Liu, Y. Xu, M. Salman, J. Liu, Y. Du, J. Sui, T. Adali, V. D. Calhoun
Summary: This study identifies replicable multi-spatial-scale canonical intrinsic connectivity network (ICN) templates using rsfMRI data from over 100k individuals through multi-model-order independent component analysis (ICA). The feasibility of estimating subject-specific ICNs via spatially constrained ICA is also studied. The results show that subject-level ICN estimations vary as a function of the ICN itself, the data length, and the spatial resolution. Longer scans may not always be desirable and spatial smoothness should be considered in optimizing data length.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Mingyan Li, Chai Ji, Weifeng Xuan, Weijun Chen, Ying Lv, Tingting Liu, Yuqing You, Fusheng Gao, Quan Zheng, Jie Shao
Summary: The iron status of preterm infants is associated with motor development and brain structural connectivity. Iron supplementation can improve this relationship. There is a positive correlation between brain structural connectivity and motor development.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Ke Song, Yong Wang, Mei-Xia Ren, Jiao Li, Ting Su, Si-Yi Chen, Yi Shao, Ya-Li Lv
Summary: Using resting-state functional connectivity, this study found abnormal neural activities in specific brain regions of patients with optic neuritis, with significant changes in rsFC, longFCD, and IFCD values, which may help identify the specific mechanism of change in brain function in ON.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Ning Yang, Shuyi Yuan, Chunlong Li, Wenqing Xiao, Shuangcong Xie, Liming Li, Guihua Jiang, Xiaofen Ma
Summary: This study investigated the potential of using amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) features as neurological markers for identifying chronic insomnia (CI). The results showed significant differences in ALFF and FC features between CI patients and healthy controls, and these features were correlated with clinical characteristics. This suggests that ALFF and FC may serve as potential neuromarkers for diagnosing CI.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Janna Marie Bas-Hoogendam, Henk van Steenbergen, Kathrin Cohen Kadosh, P. Michiel Westenberg, Nic J. A. van der Wee
Summary: By studying families genetically enriched for SAD, research found that social anxiety co-segregated with changes in intrinsic functional connectivity within the dorsal attention network and frontoparietal network. Furthermore, these changes in functional connectivity were found to be at least moderately heritable.
Review
Endocrinology & Metabolism
Anson C. M. Chau, Ashleigh E. Smith, Brenton Hordacre, Saravana Kumar, Eva Y. W. Cheung, Henry K. F. Mak
Summary: This review explores the application of rs-fMRI in studying brain functional connectivity alterations in T2DM patients over the past decade, focusing on the importance of graph theory as a contemporary rsfMRI analysis method. These techniques can reveal changes in brain topological structures in T2DM patients and their correlation with cognitive performance.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Nelly Padilla, Anira Escrichs, Elvira del Agua, Morten Kringelbach, Antonio Donaire, Gustavo Deco, Ulrika Aden
Summary: The brain in extremely preterm (EPT) children has difficulties in adapting and developing after birth. Resting-state functional magnetic resonance imaging revealed reduced neural information propagation and variability in certain brain networks, which were associated with cognitive performance. This study suggests that interventions targeting these resting-state networks could help improve brain function in EPT children.
Article
Neurosciences
Anees Abrol, Zening Fu, Yuhui Du, Tony W. W. Wilson, Yu-Ping Wang, Julia M. M. Stephen, Vince D. D. Calhoun
Summary: The brain's functional architecture and organization undergo continuous development and modification throughout adolescence. This study systematically evaluated over 47,000 youth and adult brains to examine time-resolved functional connectivity patterns and found distinct differences between the two life stages, indicating an overall inverted U-shaped trajectory in the strengthening and modularization of functional coupling. These findings suggest greater synchrony and integration of the brain's functional connections beyond adolescence, with a gradual decline during healthy aging.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Seh Hyun Kim, Seung Han Shin, Hyo Ju Yang, Seul Gi Park, Soo Yeon Lim, Young Hun Choi, Ee-Kyung Kim, Han-Suk Kim
Summary: Isolated cerebellar hemorrhage (CBH) is associated with abnormal motor development in preterm infants, and this study found it to be related to PCO2 fluctuation within 72 hours after birth. Isolated CBH accompanied by adverse neurodevelopmental outcomes is associated with a smaller ventral diencephalon and midbrain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Z. Moradimanesh, R. Khosrowabadi, M. Eshaghi Gordji, G. R. Jafari
Summary: The complexity of a network is determined not only by its size but also by the interactions between elements. The complexity of brain networks also arises from interactions beyond pair connections, particularly in genetically complex brain impairments like ASD. By analyzing ASD and control networks using structural balance theory, it was found that balanced triads are overrepresented in the ASD networks, providing empirical evidence for the concept of structural balance on brain networks.
SCIENTIFIC REPORTS
(2021)
Article
Statistics & Probability
Kuang-Yao Lee, Dingjue Ji, Lexin Li, Todd Constable, Hongyu Zhao
Summary: Graphical modeling of multivariate functional data is important in various applications. In this article, we propose a new conditional graphical model that takes into account the effects of external variables on graph structure, and introduce new linear operators to extend existing methods.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Neurosciences
Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernandez, Kristian Haendler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, Andre M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle
Summary: This study reveals a neuroprogenitor-based genetic subtype of human hydrocephalus with defective neurogenesis and altered brain-fluid biomechanics. By analyzing genomic and transcriptomic data of 483 patients with congenital hydrocephalus, the study identifies a group of risk genes that converge in embryonic neuroepithelial stem cells. Mutations in these genes lead to premature neuroepithelial cell differentiation and reduced neurogenesis, resulting in the development of hydrocephalus. This research highlights the importance of precisely regulated neuroepithelial cell fate for normal brain-CSF biomechanics and provides insights into the genetic mechanisms behind hydrocephalus.
NATURE NEUROSCIENCE
(2022)
Article
Psychology, Biological
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Qi Lin, Emily W. Avery, Dustin Sheinost, R. Todd Constable, Marvin M. Chun
Summary: This study introduces a model that predicts a person's overall attentional functioning using functional magnetic resonance imaging data and demonstrates its generalization across multiple datasets.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Neurosciences
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Dustin Scheinost, R. Todd Constable, Marvin M. Chun
Summary: This study presents a novel method that models the brain's functional reorganization in response to specific task goals. The method accurately generates task-related connectomes from task-free connectomes and amplifies behaviorally relevant individual differences. Additionally, the study reveals how the brain reorganizes between different cognitive states.
Article
Clinical Neurology
Lejla Colic, Alexis Clark, Anjali Sankar, Durga J. Rathi, Danielle A. Goldman, Jihoon A. Kim, Luca M. Villa, E. Kale Edmiston, Elizabeth T. C. Lippard, Brian Pittman, R. Todd Constable, Carolyn M. Mazure, Hilary P. Blumberg
Summary: This study investigated the relationships among gender, childhood maltreatment, hippocampus and prefrontal gray matter structure, and clinical features in bipolar disorder (BD). The findings demonstrated significant gender-related effects of childhood maltreatment on frontotemporal structure and clinical features of BD, providing novel perspectives on the gendered effects of childhood maltreatment in BD.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Kangjoo Lee, Corey Horien, David O'Connor, Bronwen Garand-Sheridan, Fuyuze Tokoglu, Dustin Scheinost, Evelyn M. R. Lake, R. Todd Constable
Summary: This study investigates the impact of arousal levels indexed by pupil area on the integration of large-scale brain networks using simultaneous resting state functional magnetic resonance imaging (fMRI) and pupillometry. The results show a decrease in between-network integration and inter-subject variability at low arousal compared to high arousal, with differences occurring across regions of multiple brain networks. State-dependent changes in network integration within hub regions suggest a brain state transition characterized by global synchronization and reduced network overlaps. Arousal modulation has a brain-wide impact on high-level between-network communications. Additionally, changes in fMRI signal correlation structures and the choice of global signal regression can influence conclusions when studying arousal modulations.
Article
Multidisciplinary Sciences
Yonghyun Ha, Kartiga Selvaganesan, Baosong Wu, Kasey Hancock, Charles Rogers, Sajad Hosseinnezhadian, Gigi Galiana, R. Todd Constable
Summary: At low field MRI, the long recovery time of the RF coil results in long rising and ring-down times for the square pulse, causing distortion of the applied sinc pulse. By using the Q-factor to calculate the rising and ring-down times, the RF square pulse can be compensated with additional square pulses. A series of square pulses are applied to continuously changing amplitude of the sinc pulse. The number and amplitude of the square pulses are calculated. Experimental results show that sinc pulses can be compensated using a series of square pulses, with smoother application to the RF coil with more pulses.
Article
Neurosciences
John Bero, Yang Li, Aviral Kumar, Colin Humphries, Snehesh Nag, Heungyeol Lee, Woo Young Ahn, Sowon Hahn, Robert Todd Constable, Hackjin Kim, Daeyeol Lee
Summary: This study examined the interaction between myelination, cortical thickness, and resting-state functional connectivity in children aged 10 to 15. The results showed higher correlations among these measures in sensory-motor cortical areas compared to association cortical areas. These correlations were stable and not influenced by age-related changes in each measure, and regional variations reflected the hierarchy of cortical information processing.
HUMAN BRAIN MAPPING
(2023)
Meeting Abstract
Clinical Neurology
Ece Eldem, Shubham Misra, Terence Quinn, Lucas Driskell, Alice Perez, Carmen Carrion, Todd Constable, Joseph Schindler, Yize Zhao, Jason Sico, Jason D. Hinman, Heather Allore, Swathi Kiran, Jubin Abutalebi, Jean-Marie Annoni, Nishant K. Mishra
Article
Chemistry, Multidisciplinary
Sandeep K. Mishra, Peter Herman, Michael Crair, R. Todd Constable, John J. Walsh, Adil Akif, Justus V. Verhagen, Fahmeed Hyder
Summary: In this study, magnetic protein nanoparticles (MPNPs) with fluorescent dye (f-MPNPs) were successfully synthesized for optical cerebrovascular imaging without losing the properties of positive magnetic resonance imaging (MRI) contrast. In vivo experiments on mice showed that f-MPNPs provided detailed microvascular contrast enhancement with fast clearance and no toxic effects.
Article
Multidisciplinary Sciences
Abigail S. Greene, Xilin Shen, Stephanie Noble, Corey Horien, C. Alice Hahn, Jagriti Arora, Fuyuze Tokoglu, Marisa N. Spann, Carmen Carrion, Daniel S. Barron, Gerard Sanacora, Vinod H. Srihari, Scott W. Woods, Dustin Scheinost, R. Todd Constable
Summary: Individual differences in brain functional organization manifest a range of traits, symptoms, and behaviors. Predictive models linking brain activity to phenotype highlight the failure of models in different individuals, showing reliable and phenotype-specific failures that generalize across datasets.
Article
Clinical Neurology
Mubbahsir Sheikh, Mohamad Koubeissi, R. Todd Constable, Dennis D. Spencer, Rafeed Alkawadri
Summary: This is the first known case of profound illusionary time dilation caused by electrical cortical stimulation. The study found that stimulation of certain brain regions can alter time perception. This finding may have potential benefits for conditions involving impaired time perception.
EPILEPTIC DISORDERS
(2022)
Meeting Abstract
Neurosciences
Yihong Zhao, Martin Paulus, Kara Bagot, R. Todd Constable, Marc Potenza
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Danielle Goldman, Anjali Sankar, Lejla Colic, Luca M. Villa, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Corey Horien, Kangjoo Lee, Margaret L. Westwater, Stephanie Noble, Link Tejavibulya, Teimur Kayani, R. Todd Constable, Dustin Scheinost
Summary: Large, publicly available neuroimaging datasets are increasingly common, but there are challenges related to tool options for data processing and organization. This article presents a protocol to address these barriers, with steps for dataset search and download, proper data management, practical data analysis guidelines, and instructions for data and result sharing.
