Rationale in support of the use of selective dopamine D3 receptor antagonists for the pharmacotherapeutic management of substance use disorders

Higher Binding of the Dopamine D3 Receptor-Preferring Ligand [11C]-(+)-Propyl-Hexahydro-Naphtho-Oxazin in Methamphetamine Polydrug Users: A Positron Emission Tomography Study

(2012) I. Boileau et al.   JOURNAL OF NEUROSCIENCE

Cognitive enhancement as a treatment for drug addictions

(2012) Mehmet Sofuoglu et al.   NEUROPHARMACOLOGY

Occupancy of Brain Dopamine D3 Receptors and Drug Craving: A Translational Approach

(2012) Manolo Mugnaini et al.   NEUROPSYCHOPHARMACOLOGY

The effects of the preferential dopamine D3 receptor antagonist S33138 on ethanol binge drinking in C57BL/6J mice

(2012) Onarae V. Rice et al.   SYNAPSE

YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice

(2011) Rui Song et al.   ADDICTION BIOLOGY

Orbitofrontal Connectivity with Resting-State Networks Is Associated with Midbrain Dopamine D3 Receptor Availability

(2011) David M. Cole et al.   CEREBRAL CORTEX

Recent Advances in the Development of Dopamine D3 Receptor Antagonists: a Medicinal Chemistry Perspective

(2011) Fabrizio Micheli   ChemMedChem

Dopamine D3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats

(2011) Amanda E. Higley et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment

(2011) David J. G. Watson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

(2011) David JG Watson et al.   NEUROPSYCHOPHARMACOLOGY

The acute administration of the selective dopamine D3 receptor antagonist SB-277011A reverses conditioned place aversion produced by naloxone precipitated withdrawal from acute morphine administration in rats

(2011) Onarae V. Rice et al.   SYNAPSE

Affinity and selectivity of [11C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo

(2011) Jean-Dominique Gallezot et al.   SYNAPSE

The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access

(2010) Laura Orio et al.   ADDICTION BIOLOGY

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders

(2010) Christian A. Heidbreder et al.   Annals of the New York Academy of Sciences

Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist

(2010) Graham Searle et al.   BIOLOGICAL PSYCHIATRY

D3 receptor target engagement in humans with ABT-925 using [11C](+)-PHNO PET

(2010) Mark Day et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET)

(2010) Eugenii A. Rabiner et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures

(2010) Mark J. Millan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

(2010) C. Achat-Mendes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats

(2010) Amanda E Higley et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy

(2010) Andri C. Tziortzi et al.   NEUROIMAGE

Influence of dopamine D3 receptor knockout on age-related decline of spatial memory

(2010) Bo Xing et al.   NEUROSCIENCE LETTERS

Enhanced cognitive performance of dopamine D3 receptor “knock-out” mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems

(2010) Vincenzo Micale et al.   PHARMACOLOGICAL RESEARCH

In vitro and in vivo comparison of [3H](+)-PHNO and [3H]raclopride binding to rat striatum and lobes 9 and 10 of the cerebellum: A method to distinguish dopamine D3 from D2 receptor sites: A method to distinguish dopamine D3 from D2 receptor sites

(2010) Béla Kiss et al.   SYNAPSE

Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925

(2009) Ariel Graff-Guerrero et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking

(2009) Maram A. T. M. Khaled et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Delay of Ejaculation Induced by SB-277011, a Selective Dopamine D3 Receptor Antagonist, in the Rat

(2009) Pierre Clément et al.   Journal of Sexual Medicine

Positron emission tomography imaging of D2/3agonist binding in healthy human subjects with the radiotracer [11C]-N-propyl-norapomorphine: Preliminary evaluation and reproducibility studies

(2009) Rajesh Narendran et al.   SYNAPSE

In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice

(2009) Eugenii A. Rabiner et al.   SYNAPSE

Drug seeking under a second-order schedule of reinforcement depends on dopamine D₃ receptors in the basolateral amygdala.

(2008) Patricia Di Ciano   BEHAVIORAL NEUROSCIENCE

Attentional bias in addictive behaviors: A review of its development, causes, and consequences

(2008) M FIELD et al.   DRUG AND ALCOHOL DEPENDENCE

Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D1 receptor agonists, but not of D2 antagonists

(2008) Florence Loiseau et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats

(2008) Xiao-Qing Peng et al.   NEUROPHARMACOLOGY

Dopamine receptor 3 (D3) knockout mice show regular emotional behaviour

(2008) S CHOURBAJI et al.   PHARMACOLOGICAL RESEARCH

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity

(2008) Panayotis K. Thanos et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Role of dopamine D3 receptors in the expression of conditioned fear in rats

(2007) Shelley N. Swain et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans

(2007) Ariel Graff-Guerrero et al.   HUMAN BRAIN MAPPING