Recent Advances in the Development of Dopamine D3 Receptor Antagonists: a Medicinal Chemistry Perspective

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders

(2010) Christian A. Heidbreder et al.   Annals of the New York Academy of Sciences

Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist

(2010) Graham Searle et al.   BIOLOGICAL PSYCHIATRY

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

(2010) Ian P. Holmes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

[3-Azabicyclo[3.1.0]hex-1-yl]phenyl-benzenesulfonamides as selective dopamine D3 antagonists

(2010) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Triazolyl Azabicyclo[3.1.0]hexanes: a Class of Potent and Selective Dopamine D3 Receptor Antagonists

(2010) Giorgio Bonanomi et al.   ChemMedChem

A Series of 18F-Labelled Pyridinylphenyl Amides as Subtype-Selective Radioligands for the Dopamine D3 Receptor

(2010) Carsten Hocke et al.   ChemMedChem

The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures

(2010) Mark J. Millan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploration of the Amine Terminus in a Novel Series of 1,2,4-Triazolo-3-yl-azabicyclo[3.1.0]hexanes as Selective Dopamine D3Receptor Antagonists

(2010) Fabrizio Micheli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the Transport, Metabolism, and Pharmacokinetics of the Dopamine D3 Receptor-Selective Fluorenyl- and 2-Pyridylphenyl Amides Developed for Treatment of Psychostimulant Abuse

(2010) C. W. Mason et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists

(2010) Ji-Kyung Choi et al.   PSYCHOPHARMACOLOGY

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

(2009) Paul Gleeson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies

(2009) Idriss Bennacef et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization

(2009) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part one: Lead identification

(2009) Ian P. Holmes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The selective dopamine D3 receptor antagonist SB 277011-A, but not the partial agonist BP 897, blocks cue-induced reinstatement of nicotine-seeking

(2009) Maram A. T. M. Khaled et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

1,1′-Disubstituted Ferrocenes as Molecular Hinges in Mono- and Bivalent Dopamine Receptor Ligands

(2009) Daniela Huber et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with Functionalized Linking Chains as High Affinity and Enantioselective D3 Receptor Antagonists∥⊥

(2009) Amy Hauck Newman et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,2,4-Triazolyl Azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Dopamine D3Receptor Antagonists

(2009) Fabrizio Micheli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Delay of Ejaculation Induced by SB-277011, a Selective Dopamine D3 Receptor Antagonist, in the Rat

(2009) Pierre Clément et al.   Journal of Sexual Medicine

Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in rats

(2009) Rakesh Kumar et al.   NEUROPHARMACOLOGY

Synthesis of new carbon-11-labeled carboxamide derivatives as potential PET dopamine D3 receptor radioligands

(2008) Mingzhang Gao et al.   APPLIED RADIATION AND ISOTOPES

Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II

(2008) Marcello Leopoldo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-Fused and hetero-fused systems

(2008) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems

(2008) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

18F-Labeled FAUC 346 and BP 897 Derivatives as Subtype-Selective Potential PET Radioligands for the Dopamine D3 Receptor

(2008) Carsten Hocke et al.   ChemMedChem

Selective dopamine D3receptor antagonists. A decade of progress: 1997 – 2007

(2008) Fabrizio Micheli et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY