Article
Behavioral Sciences
Yu Hu, Haixia Li, Cheng Zhou, Ying Liu, Zhen Ma
Summary: The study investigated the effects of different concentrations of the serotonin receptor agonist on aggressive behavior in juvenile pufferfish, showing that activation of the serotonergic system can suppress both aggressive behavior and locomotor activity in the fish.
AGGRESSIVE BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Pragathi Balakrishna, Sagila George, Hassan Hatoum, Sarbajit Mukherjee
Summary: Serotonin plays a significant role as a neurotransmitter in the central nervous system and a motility mediator in the gastrointestinal tract, with ongoing research into its role in tumorigenesis in various cancers. Drugs like octreotide and telotristat are being investigated for their potential in treating neuroendocrine cancers, with serotonin receptor antagonists showing anticancer effects in in vitro studies across different cancer types. Further in vivo studies are needed to fully understand serotonin's role in cancer and its potential as an anticancer therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Aqeela Imamdin, Emiel P. C. van der Vorst
Summary: Serotonin, a well-known neurotransmitter in the central nervous system, has also been found to have a significant impact on peripheral tissues. It has been shown to influence immune cell responses and contribute to the development of diseases such as atherosclerosis that are caused by immune hyperactivity. This review focuses on the differences in serotonin production between the central nervous system and the periphery, and outlines the role of serotonin in peripheral tissues, particularly its effects on immune cells related to atherosclerosis. Important considerations for future research are also identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ria Gupta, Sidharth Mehan, Pranshul Sethi, Aradhana Prajapati, Abdulrahman Alshammari, Metab Alharbi, Haneen A. Al-Mazroua, Acharan S. Narula
Summary: This study investigated the neuroprotective effects of Purmorphamine, a smoothened-sonic-hedgehog agonist, in a rat model of obsessive-compulsive disorder (OCD). The results demonstrated that Purmorphamine attenuated OCD-like behaviors, oxidative stress, inflammation, apoptosis, and neurotransmitter imbalance induced by 8-hydroxy-2-(di-n-propylamino)-tetralin injection. The neuroprotective effect of Purmorphamine was comparable to the standard drug for OCD, fluvoxamine, and the combination of Purmorphamine and fluvoxamine showed a more significant restoration of these pathological changes.
Review
Biochemistry & Molecular Biology
Tomasz Guzel, Dagmara Mirowska-Guzel
Summary: Serotonin is a neurotransmitter that acts in both the central nervous system and peripheral structures, also functioning as a hormone in platelets. It modulates CNS neurons, pain transmission, and platelet aggregation. Serotonin also influences muscle motility in the gut, bronchi, uterus, and vessels. Its synthesis starts with hydroxylation and decarboxylation of tryptophan. 5-HT receptors in the brain and gut are targets for drugs that modify serotonin neurotransmission.
Article
Biochemistry & Molecular Biology
Xi Zhao, Xinyu Lian, Jianlan Xie, Guoquan Liu
Summary: Tumor cells can use accumulated cholesterol to inhibit lipid peroxidation (LPO) and ferroptosis, providing a new strategy for tumor treatment.
Article
Plant Sciences
Shuo Zhang, Ya-Ning Shi, Jia Gu, Peng He, Qi-Di Ai, Xu-Dong Zhou, Wei Wang, Li Qin
Summary: This study investigates the mechanism of DMY against hepatocellular carcinoma (HCC), revealing that it inhibits the proliferation, migration, and invasion of HCC cells by reducing cholesterol to disrupt lipid rafts.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sugandha Gupta, Mengya Wang, Yoshiaki Azuma, Nancy A. Muma
Summary: This study reveals two mechanisms regulating SUMOylation of 5-HT1ARs, by agonists and EB, and two key enzymes, PIASx alpha and SENP2, involved in this process. The findings demonstrate that these mechanisms differ based on treatment with agonists and EB. Targeting the SUMOylation of 5-HT1ARs could have important clinical relevance for the therapy of several neuropsychiatric disorders involving 5-HT1ARs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michela Codini, Mercedes Garcia-Gil, Elisabetta Albi
Summary: Lipid rafts are critical cell membrane platforms enriched in sphingolipids and cholesterol, playing roles in various cellular processes, including cancer. Recent findings on cholesterol, sphingolipids, and lipid rafts in cellular and nuclear membranes provide insights into using lipid rafts as biomolecular targets for developing innovative therapeutic strategies in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Carmen M. Deveau, Eric Rodriguez, Allen Schroering, Bryan K. Yamamoto
Summary: This study found that statins and lipid signaling intermediates can modulate serotonin uptake in serotonergic neurons through regulation of the serotonin transporter, independently of cholesterol.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martina Janikova, Karolina Mainerova, Iveta Vojtechova, Tomas Petrasek, Jan Svoboda, Ales Stuchlik
Summary: The study examined the impact of using 8-OH-DPAT to simulate OCD behavior on spatial learning, as well as the effects of memantine and riluzole in this model. The results showed that monotherapy with glutamate-modulating agents in the model group did not reduce cognitive symptoms but may exacerbate them.
Article
Cell Biology
Hiroshi Tachibana, Kodai Minoura, Tomohiro Omachi, Kohjiro Nagao, Takafumi Ichikawa, Yasuhisa Kimura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Kazumitsu Ueda, Noriyuki Kioka
Summary: This study reveals that the lipid composition of the plasma membrane at FAs is locally distinct, with an enrichment of cholesterol and phosphatidylcholine with saturated fatty acid chains.
JOURNAL OF CELL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Daniel Maia Nogueira de Oliveira, Carlos Alberto Oliveira-Silva, Camila Gadelha Pinheiro, Emanuella Feitosa de Carvalho, Kalinne Kelly Lima Gadelha, Karine Lima-Silva, Ana Karolina Martins Cavalcante, Monica de Oliveira Belem, Suliana Mesquita Paula, Armenio Aguiar dos Santos, Pedro Jorge Caldas Magalhaes
Summary: 8-MPEA and octopamine have different effects on the rat gastrointestinal tract, with the excitatory effects of 8-MPEA involving 5-HT receptors, while octopamine likely inhibits rat gut contractility through the involvement of 5-HT4 and TA receptors. Overall, octopamine effectively inhibits rat gastrointestinal transit.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
N. V. Kudryashov, A. V. Volkova, A. A. Shimshirt, P. L. Naplekova, T. A. Voronina, S. B. Seredenin
Summary: The study investigated the effect of 5-HT1A receptor agonist 8-OH-DPAT on the spontaneous alternation behavior of mice in Y-maze. The results showed that administration of 8-OH-DPAT decreased spontaneous alternation and locomotor activity in mice without habituation and food reward. However, treatment with 8-OH-DPAT after habituation and food deprivation increased repeated choices of goal arms without affecting locomotor activity, indicating perseverative behavior. Therefore, the 8-OH-DPAT-induced decrease in spontaneous alternation behavior in Y-maze in mice with habituation and food reward is a suitable procedure for experimental modeling of perseverative behavior and studying the anticompulsive activity of new substances.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hoa T. N. Phan, Benita Sjogren, Richard R. Neubig
MOLECULAR PHARMACOLOGY
(2017)
Article
Clinical Neurology
Huijie Feng, Benita Sjogren, Behirda Karaj, Vincent Shaw, Aysegul Gezer, Richard R. Neubig
Article
Pharmacology & Pharmacy
David J. Ferland, Emma S. Darios, Richard R. Neubig, Benita Sjogren, Nguyen Truong, Rosa Torres, Thomas S. Dexheimer, Janice M. Thompson, Stephanie W. Watts
VASCULAR PHARMACOLOGY
(2017)
Review
Oncology
Karl Bjork, Benita Sjogren, Per Svenningsson
EXPERIMENTAL CELL RESEARCH
(2010)
Article
Biochemical Research Methods
Alexandra Madeira, Elisabet Ohman, Anna Nilsson, Benita Sjogren, Per E. Andren, Per Svenningsson
Article
Neurosciences
Therese M. Eriksson, Sarah Holst, Tiberiu L. Stan, Torben Hager, Benita Sjogren, Sven Ove Ogren, Per Svenningsson, Oliver Stiedl
Article
Multidisciplinary Sciences
Benita Sjoegren, Steven Swaney, Richard R. Neubig
Article
Biochemistry & Molecular Biology
Corey L. Jones, Evert Njomen, Benita Sjogren, Thomas S. Dexheimer, Jetze J. Tepe
ACS CHEMICAL BIOLOGY
(2017)
Article
Biochemical Research Methods
Karl Skold, Marcus Svensson, Mathias Norrman, Benita Sjogren, Per Svenningsson, Per E. Andren
Article
Biochemistry & Molecular Biology
Benita Sjögren, Per Svenningsson
Article
Pharmacology & Pharmacy
Benita Sjogren, Mark W. Hamblin, Per Svenningsson
EUROPEAN JOURNAL OF PHARMACOLOGY
(2006)
