Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

(2010) Chanseok Shin et al.   MOLECULAR CELL

Target mRNA abundance dilutes microRNA and siRNA activity

(2010) Aaron Arvey et al.   Molecular Systems Biology

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs

(2010) Calvin H. Jan et al.   NATURE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Redefining MicroRNA Targets

(2009) Hervé Seitz   CURRENT BIOLOGY

Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein

(2009) James S. Parker et al.   MOLECULAR CELL

The UCSC Genome Browser database: update 2010

(2009) B. Rhead et al.   NUCLEIC ACIDS RESEARCH

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts

(2008) Molly Hammell et al.   NATURE METHODS

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH

Molecular architecture of a miRNA-regulated 3' UTR

(2008) D. Didiano et al.   RNA

Experimental validation of the importance of seed complement frequency to siRNA specificity

(2008) E. M. Anderson et al.   RNA