Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Yunxing Ma, Julia Brettschneider, Joanna F. Collingwood
Summary: Levels of amyloid-beta and tau in human cerebrospinal fluid were evaluated to predict the transition from Mild Cognitive Impairment to Alzheimer's disease. The results support the value of amyloid-beta and tau as markers of patient outcome.
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Patricia Diaz-Galvan, Scott A. Przybelski, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunter, Clifford R. Jack, Hoon-Ki Paul Min, Manoj Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St Louis, David S. Knopman, Vijay K. Ramanan, Owen Ross, Neill Graff-Radford, Gregory S. Day, Dennis W. Dickson, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe, Brad F. Boeve, Kejal Kantarci
Summary: Aβ load increases throughout the DLB continuum, with significant elevation in the prodromal stage of MCI-LB and in DLB. APOE ε4 carriers have higher Aβ levels compared to noncarriers in MCI-LB and DLB groups. Women tend to have higher Aβ levels than men as they get older.
Article
Clinical Neurology
Pavel Katsel, Peter Fam, Weilun Tan, Sonia Khan, Miguel Gama-Sosa, Rita De Gasperi, Panos Roussos, Ari Robinson, Itzik Cooper, Michal Schnaider-Beeri, Vahram Haroutunian
Summary: The study found that subsets of vascular genes related to early response to hypoxia were upregulated in MCI patients before the accumulation of AD neuropathology, suggesting that cerebrovascular remodeling is an important antecedent to the development of dementia and a component of the homeostatic response to reduced oxygen tension in aging prior to the onset of AD. The early activation of pro-angiogenic hypoxia-inducible factor signaling in response to mild hypoxia was also detected in mouse brains similar to those that were altered in MCI. Protracted responses to hypoxia were characterized by activation of phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt)-the mammalian target of rapamycin (mTOR) pathways in brain microvessel isolates.
ALZHEIMERS & DEMENTIA
(2022)
Article
Food Science & Technology
Zhipeng Kan, Yijun Wang, Qian Chen, Xiaoyu Tang, Henry J. Thompson, Jinbao Huang, Jinsong Zhang, Feng Gao, Yong Shen, Xiaochun Wan
Summary: In this study, it was found that green tea extract treatment significantly improved spatial learning and memory ability in 5XFAD mice, reduced the formation of A beta, and decreased the levels of related proteins. GTE also suppressed glial cell activation and inflammatory responses, while increasing synaptic protein levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Clinical Neurology
Santiago Bullich, Andre Mueller, Susan De Santi, Norman Koglin, Stephen Krause, June Kaplow, Michio Kanekiyo, Nuria Roe-Vellve, Audrey Perrotin, Aleksandar Jovalekic, David Scott, Michelle Gee, Andrew Stephens, Michael Irizarry
Summary: This study aimed to evaluate tau deposition using F-18-PI-2620 PET in beta-amyloid positive subjects with mild cognitive impairment (MCI) or mild AD dementia, and investigate its correlation with amyloid deposition, CSF assessment, hippocampal volume, and cognition. The results showed significant associations between tau deposition and hippocampal volume, CSF biomarkers, and amyloid-beta load. The quantifiable increases in F-18-PI-2620 SUVR in regions with early tau deposition support the hypothesis that cortical tau is associated with cognitive impairment in AD. The study highlights the utility of F-18-PI-2620 PET in assessing tau deposits in early AD cases.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Samar O. El-Ganainy, Omar A. Soliman, Aya A. Ghazy, Maram Allam, Aya I. Elbahnasi, Amira M. Mansour, Mennatallah A. Gowayed
Summary: Oxytocin has neuroprotective potential in Alzheimer's disease, restoring cognition and suppressing beta-amyloid, Tau accumulation, and neuronal death. Combined treatment with galantamine and oxytocin shows better biochemical and histopathological profiles.
NEUROCHEMICAL RESEARCH
(2022)
Article
Clinical Neurology
Federico Verde, Edoardo Nicolo Aiello, Ilaria Milone, Eleonora Giacopuzzi Grigoli, Antonella Dubini, Antonia Ratti, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani
Summary: This study compared the distribution of T +/- profiles among A+patients with MCI and dementia. The results showed that A+T+ profiles were predominant in both groups, contradicting the common notion of A+T- profiles being more prevalent in MCI patients.
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Aonan Zhao, Yang Jiao, Guanyu Ye, Wenyan Kang, Lan Tan, Yuanyuan Li, Yulei Deng, Jun Liu
Summary: This study found that sTREM2 may serve as a potential predictive biomarker of the conversion from MCI to AD. Low levels of CSF sTREM2 and Aβ1-42 were associated with an increased risk of MCI-to-AD conversion, while elevated CSF sTREM2 levels were associated with a decreased risk. In the NRHAD cohort, individuals in the MCI group with high plasma sTREM2 levels were more likely to progress to AD, and those with low Aβ1-42 and high plasma sTREM2 levels had a faster cognitive decline. CSF sTREM2 levels were highly correlated with plasma sTREM2 levels in the CABLE database.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Clinical Neurology
Michael W. Weiner, Dallas P. Veitch, Melanie J. Miller, Paul S. Aisen, Bruce Albala, Laurel A. Beckett, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Susan M. Landau, John C. Morris, Rachel Nosheny, Ozioma C. Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera-Mindt, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun, John Q. Trojanowski
Summary: ADNI4 aims to improve the validation of biomarkers for Alzheimer's disease clinical trials using new technologies and community-engaged approaches to recruit participants from underrepresented populations. The study will utilize an online portal for screening and conduct blood and digital cognitive testing. Additionally, MRI sequences and new PET tracers will be added to the project.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Zahinoor Ismail, Rebeca Leon, Byron Creese, Clive Ballard, Philippe Robert, Eric E. Smith
Summary: This study investigated the association between mild behavioral impairment (MBI) in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and found that adding MBI to MCI can better identify AD and improve dementia prognostication. Therefore, the addition of MBI is important for the detection of AD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Geriatrics & Gerontology
Wataru Araki, Kazutomi Kanemaru, Kotaro Hattori, Tadashi Tsukamoto, Yuko Saito, Sumiko Yoshida, Harumasa Takano, Masuhiro Sakata, Yuma Yokoi, Yoshie Omachi, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Hisateru Tachimori, Shigeo Murayama, Hidehiro Mizusawa
Summary: The study found that concentrations of sAPPα and sAPPβ in the CSF of MCI-AD patients were significantly higher than in MCI patients due to other causes, and these sAPP concentrations were highly correlated with p-tau levels, indicating a potential role for these proteins in the precise diagnosis of MCI.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jun Pyo Kim, Jonghoon Kim, Hyemin Jang, Jaeho Kim, Sung Hoon Kang, Ji Sun Kim, Jongmin Lee, Duk L. Na, Hee Jin Kim, Sang Won Seo, Hyunjin Park
Summary: Predicting amyloid positivity in MCI patients is crucial, and in this study, radiomics features derived from structural MRI were found to have predictive value. Combining T1 and T2 FLAIR radiomics models with baseline features resulted in the best predictive performance for amyloid positivity.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri
Summary: This study investigated the association between the severity of neuropsychiatric symptoms (NPS) and Alzheimer's disease (AD) biomarkers (Aβ, p-tau, and HR) in order to characterize MCI patients with a poor prognosis. The results showed that only MCI patients with severe NPS had a lower hippocampal volume ratio (HR), indicating more pronounced medio-temporal atrophy. Future longitudinal studies are needed to further understand the relevance of this finding.
