Correction
Cell Biology
Nikolaus Pfanner, Bettina Warscheid, Nils Wiedemann
Summary: A correction to the paper has been published, and more information can be found at the provided link.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Review
Cell Biology
Shintaro Komatsu, Hiroki Kitai, Hiroshi I. Suzuki
Summary: MicroRNAs (miRNAs) act as versatile regulators of gene expression at the post-transcriptional level. Recent studies have uncovered the mechanisms involved in miRNA biogenesis, including the processing of both canonical and non-canonical miRNAs. Additionally, the complex interactions between miRNAs and their targets have been explored, revealing target-mediated miRNA degradation and cooperative regulation by multiple miRNAs. These findings highlight the coordinated regulation of miRNA biogenesis and miRNA-target interaction in miRNA biology.
Review
Agronomy
Beatriz Val-Torregrosa, Mireia Bundo, Blanca San Segundo
Summary: Rice production is affected by various stresses, including nutrient stress. Improper use of pesticides can have harmful effects on the environment and human health. Understanding the interaction between nutrient stress and disease resistance is essential for optimizing fertilizer and pesticide use in rice production.
Review
Physiology
Chiara Giordani, Andrea Silvestrini, Angelica Giuliani, Fabiola Olivieri, Maria Rita Rippo
Summary: Mitochondria are organelles that generate energy for the cell, regulating cell homeostasis. They communicate bidirectionally with the nucleus, with non-coding RNAs potentially playing a central role in this communication. MitomiRs, a type of miRNA found in mitochondria, may mediate crosstalk between the nucleus and mitochondria, impacting mitochondrial homeostasis.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Izabela Suster, Yue Feng
Summary: miRNAs, small non-coding RNAs that silence genes, have been extensively studied in brain development, with focus on their regulation at transcriptional and posttranscriptional levels. Imbalance of miRNAs in neuronal and glial cells is associated with developmental brain disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Weiping Lin, Shuxun Chen, Yan Wang, Ming Wang, Wayne Yuk-Wai Lee, Xiaohua Jiang, Gang Li
Summary: Cellular therapy shows potential for curing various diseases. Adult stem cells in dynamic niches play a crucial role in tissue homeostasis, with mitochondrial-mediated mechanisms responsible for their diversity and tissue repair abilities. Understanding mitochondrial dynamics in stem cells could lead to novel strategies for anti-aging interventions and healthy aging.
CELL DEATH & DISEASE
(2021)
Review
Biology
Annette Graham
Summary: High-density lipoproteins (HDL) play a crucial role in protecting cellular functions and can modulate the expression of microRNA to achieve this protective effect. Understanding the contribution of microRNA in sustaining cellular function offers new possibilities for therapeutic interventions.
Review
Cell Biology
Monika Vilimova, Sebastien Pfeffer
Summary: A significant portion of miRNA genes in animal genomes tend to cluster together. These miRNA clusters are transcribed as polycistronic transcripts, benefiting from common transcriptional regulation. However, there are discrepancies in the accumulation of mature miRNAs produced from the same cluster, suggesting unforeseen post-transcriptional regulatory mechanisms.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Medicine, Research & Experimental
Rinki Doloi, Sadhana M. Gupta
Summary: Breast cancer, the most burdensome disease in females worldwide, is expected to increase significantly due to lifestyle factors, genetic mutations, and an aging population. The Hippo and Wnt signaling pathways play important roles in organ development, tissue homeostasis, cell proliferation, and apoptosis. microRNAs, short nucleotide sequences, act as regulatory components in most cancers and can be used as diagnostic and prognostic markers. Recent studies suggest that deregulated Hippo and Wnt signaling pathways, mediated by miRNAs, contribute to tumorigenesis, metastasis, and chemoresistance in breast cancer. This review discusses the crosstalk between Hippo and Wnt signaling pathways and potential miRNAs involved in regulating the interplay between these two pathways in breast cancer, a topic that has not been explored before.
Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Haithem Barbour, Nadine Sen Nkwe, Benjamin Estavoyer, Clemence Messmer, Mila Gushul-Leclaire, Romain Villot, Maxime Uriarte, Karine Boulay, Sari Hlayhel, Bassel Farhat, Eric Milot, Frederick A. Mallette, Salima Daou, El Bachir Affar
Summary: Ubiquitination is an important post-translational modification (PTM) that regulates various cellular processes in eukaryotes. Abnormalities in ubiquitin signaling play a role in human pathologies such as cancer and neurodegeneration. Progress has been made in understanding how ubiquitin ligases recognize their substrates and how ubiquitination is regulated. This study explores the coordination of E3 ligases and provides a comprehensive inventory of ubiquitination crosstalk with multiple PTMs, discussing the molecular mechanisms by which PTMs orchestrate ubiquitination to ensure cell homeostasis.
Article
Biochemistry & Molecular Biology
Mark Ziemann, Sze Chern Lim, Yilin Kang, Sona Samuel, Isabel Lopez Sanchez, Michael Gantier, Diana Stojanovski, Matthew McKenzie
Summary: MiR-101-3p acts as a tumor suppressor that regulates cancer proliferation and apoptotic signaling. It downregulates multiple mitochondrial processes, disrupts mitochondrial function, and modulates mitochondrial metabolism by regulating mtDNA transcription and complex II biogenesis.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Neurosciences
Ziyu Li, Shuisheng Yu, Xuyang Hu, Yiteng Li, Xingyu You, Dasheng Tian, Li Cheng, Meige Zheng, Juehua Jing
Summary: This study reviews recent advances in fibrotic scar formation after SCI, exploring its interactions with other main cellular components and its potential role as a treatment target for SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Joanna Kalafut, Arkadiusz Czerwonka, Karolina Czapla, Alicja Przybyszewska-Podstawka, Justyna Magdalena Hermanowicz, Adolfo Rivero-Muller, Lidia Borkiewicz
Summary: Notch1 signaling plays a diverse role in tissue development and homeostasis. The relationship between NOTCH1 expression and the development of health disorders, especially cancers, is intensively studied. Control of Notch1 signaling involves not only transcriptional regulation but also various post-translational events, including ligand-dependent mechanical activation and interaction with other signaling molecules, such as long non-coding RNAs (lncRNAs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Julie A. Hicks, Hsiao-Ching Liu
Summary: MiRNA, a class of small noncoding RNAs, regulate the majority of protein-coding genes in organisms. Disruption of miRNA function can lead to pathological conditions, with metabolism being one physiological system under tight miRNA regulation.
