Looking under the skin: the first steps in malarial infection and immunity

Role of host cell traversal by the malaria sporozoite during liver infection

(2013) Joana Tavares et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure

(2013) Ally Olotu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity

(2013) E. M. Bijker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations

(2013) S. C. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages

(2013) I. A. Cockburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver or blood-stage arrest during malaria sporozoite immunization: the later the better?

(2013) Krystelle Nganou-Makamdop et al.   TRENDS IN PARASITOLOGY

Suppression of Host p53 Is Critical for Plasmodium Liver-Stage Infection

(2013) Alexis Kaushansky et al.   Cell Reports

Uncovering Common Principles in Protein Export of Malaria Parasites

(2012) Christof Grüring et al.   Cell Host & Microbe

Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria

(2012) Michel Obeid et al.   EMBO Molecular Medicine

Extrahepatic Exoerythrocytic Forms of Rodent Malaria Parasites at the Site of Inoculation: Clearance after Immunization, Susceptibility to Primaquine, and Contribution to Blood-Stage Infection

(2012) Tatiana Voza et al.   INFECTION AND IMMUNITY

Naturally acquired immune responses against Plasmodium falciparum sporozoites and liver infection

(2012) Vittoria Offeddu et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Molecular make-up of the Plasmodium parasitophorous vacuolar membrane

(2012) Tobias Spielmann et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

(2012) Ashley M. Vaughan et al.   JOURNAL OF CLINICAL INVESTIGATION

ReducedPlasmodium bergheisporozoite liver load associates with low protective efficacy after intradermal immunization

(2012) K. NGANOU-MAKAMDOP et al.   PARASITE IMMUNOLOGY

Plasmodium liver load following parenteral sporozoite administration in rodents

(2012) Ivo H. Ploemen et al.   VACCINE

Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

(2011) Noah S. Butler et al.   Cell Host & Microbe

The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

(2011) Alida Coppi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmodium-Host Interactions Directly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity

(2011) N. W. Schmidt et al.   JOURNAL OF IMMUNOLOGY

CD8+ T Effector Memory Cells Protect against Liver-Stage Malaria

(2011) A. Reyes-Sandoval et al.   JOURNAL OF IMMUNOLOGY

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

(2011) Meta Roestenberg et al.   LANCET

Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity

(2011) Tatiana Voza et al.   MALARIA JOURNAL

Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites

(2011) Joana M. Haussig et al.   MOLECULAR MICROBIOLOGY

Mixed results for a malaria vaccine

(2011)   NATURE MEDICINE

The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species

(2011) Alexis Kaushansky et al.   NATURE MEDICINE

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

(2011) J. E. Epstein et al.   SCIENCE

Dormancy in mammalian malaria

(2011) Miles B. Markus   TRENDS IN PARASITOLOGY

Comparative efficacy of pre-erythrocytic whole organism vaccine strategies against the malaria parasite

(2011) Johannes Friesen et al.   VACCINE

Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage Egress

(2011) Stefanie Graewe et al.   PLoS Pathogens

Dendritic Cells and Hepatocytes Use Distinct Pathways to Process Protective Antigen from Plasmodium in vivo

(2011) Ian A. Cockburn et al.   PLoS Pathogens

Plasmodium yoelii: Influence of immune modulators on the development of the liver stage

(2010) Xu Wen-yue et al.   EXPERIMENTAL PARASITOLOGY

From the circumsporozoite protein to the RTS,S/AS candidate vaccine

(2010) Joe Cohen et al.   Human vaccines & immunotherapeutics

Prime-boost vectored malaria vaccines: Progress and prospects

(2010) Adrian V. S. Hill et al.   Human vaccines & immunotherapeutics

Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

(2010) M. Mauduit et al.   INFECTION AND IMMUNITY

Differential Effector Pathways Regulate Memory CD8 T Cell Immunity against Plasmodium berghei versus P . yoelii Sporozoites

(2010) Noah S. Butler et al.   JOURNAL OF IMMUNOLOGY

Plasmodiumpyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection

(2010) Ying Pei et al.   MOLECULAR MICROBIOLOGY

The intradermal route for inoculation of sporozoites of rodent malaria parasites for immunological studies

(2010) M. INOUE et al.   PARASITE IMMUNOLOGY

The hypnozoite concept, with particular reference to malaria

(2010) Miles B. Markus   PARASITOLOGY RESEARCH

The evolution, metabolism and functions of the apicoplast

(2010) L. Lim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

(2010) D. Lys Guilbride et al.   PLoS One

Development of the malaria parasite in the skin of the mammalian host

(2010) P. Gueirard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Immunization Against Malaria: Causal Prophylaxis with Antibiotics

(2010) J. Friesen et al.   Science Translational Medicine

An update on the rapid advances in malaria parasite cell biology

(2010) Isabelle Coppens et al.   TRENDS IN PARASITOLOGY

Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes

(2010) Annika Rennenberg et al.   PLoS Pathogens

Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

(2010) Ian A. Cockburn et al.   PLoS Pathogens

Role of Plasmodium berghei cGMP-dependent Protein Kinase in Late Liver Stage Development

(2009) Adebola Falae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Protection against a Malaria Challenge by Sporozoite Inoculation

(2009) Meta Roestenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

(2009) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Host Cell Traversal Is Important for Progression of the Malaria Parasite through the Dermis to the Liver

(2008) Rogerio Amino et al.   Cell Host & Microbe

Expression and processing ofPlasmodium bergheiSERA3 during liver stages

(2008) Anja Schmidt-Christensen et al.   CELLULAR MICROBIOLOGY

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

Effector CD8+ T Lymphocytes against Liver Stages of Plasmodium yoelii Do Not Require Gamma Interferon for Antiparasite Activity

(2008) S. Chakravarty et al.   INFECTION AND IMMUNITY

A combined transcriptome and proteome survey of malaria parasite liver stages

(2008) A. S. Tarun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of the Parasite Plasma Membrane and the Parasitophorous Vacuole Membrane during Exo-Erythrocytic Development of Malaria Parasites

(2008) Angelika Sturm et al.   PROTIST

Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge

(2008) Lisa A. Purcell et al.   VACCINE

Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

(2008) Kent E. Kester et al.   VACCINE

Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity

(2008) Edwin Lasonder et al.   PLoS Pathogens

Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken

(2007) Ute Frevert et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY