Article
Chemistry, Medicinal
Jessica Poole, Lauren E. Hartley-Tassell, Christopher J. Day, Danielle Stanisic, Penny L. Groves, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Joe Tiralongo, Nicolai Bovin, Denise L. Doolan, Michael P. Jennings
Summary: The transmission of Plasmodium spp. sporozoites to the mammalian host is crucial for the development of malaria, yet the exact route of transmission and the host glycan structures involved are not fully understood. By analyzing the glycan structures recognized and bound by sporozoites from P. falciparum and P. yoelii, this study identified key host glycan structures for human and rodent Plasmodium spp. sporozoites. Understanding how these sporozoites interact with specific glycan structures could offer insight into the infectious disease and aid in the development of effective therapeutics.
ACS INFECTIOUS DISEASES
(2021)
Review
Microbiology
Carola Schafer, Gigliola Zanghi, Ashley M. Vaughan, Stefan H. I. Kappe
Summary: Plasmodium vivax, the most widespread human malaria parasite, can form latent liver stages known as hypnozoites which can activate weeks, months, or even years after the primary infection, causing relapses of blood stage infection. Eliminating hypnozoites is a major obstacle for malaria treatment and eradication as they are undetectable and unaffected by most antimalarial drugs.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Article
Immunology
Elizabeth K. K. Glennon, Tinotenda Tongogara, Veronica I. Primavera, Sophia M. Reeder, Ling Wei, Alexis Kaushansky
Summary: Using digital spatial profiling, changes in host signaling during Plasmodium yoelii infection were characterized without disrupting the liver tissue. Insights into the heterogeneous microenvironment surrounding the infected hepatocyte were obtained, and a subset of CD163(+) Kupffer cells migrating towards infected cells during infection was identified.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sittinont Chainarin, Ubonwan Jaihan, Parsakorn Tapaopong, Pinyapat Kongngen, Nawapol Kunkeaw, Liwang Cui, Jetsumon Sattabongkot, Wang Nguitragool, Wanlapa Roobsoong
Summary: The role of EphA2 in Plasmodium vivax infection was investigated, and it was found that EphA2 enhances the parasite infection rate. A new cell line expressing the whole extracellular domain of EphA2 was generated, which supports a higher rate of P. vivax infection and is a valuable tool for P. vivax liver-stage research.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Mohd Kamil, Umit Y. Kina, Gozde Deveci, Sevim N. Akyuz, Ilknur Yilmaz, Ahmed S. I. Aly
Summary: Positively-charged polyamines are essential for the replication of eukaryotic cells, including parasitic protozoa and cancer cells. This study identifies SpdS as an essential enzyme for the blood-stage growth of malaria parasite, with a specific mitochondrial localization. SpdS could be a potential drug target against malaria.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
Minami Baba, Mamoru Nozaki, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino
Summary: The protein RON4 plays a crucial role in the infection of liver by Plasmodium parasites. It is involved in the crossing of sinusoidal cells and invasion of hepatocytes, contributing to the sporozoite's ability to adhere and move. This finding provides important insights into the invasion mechanisms of Apicomplexa parasites.
Article
Parasitology
Xueyan Hu, Jie Zhao, Junhui Zhao, Ence Yang, Mozhi Jia
Summary: The study found that during the blood stage of the parasite, patients with malaria exhibit activated immune responses, aberrant metabolic processes, and tissue remodeling changes in the liver, providing a systematic outline of liver responses during Plasmodium infection.
PARASITES & VECTORS
(2023)
Article
Immunology
Takaaki Yuguchi, Bernard N. Kanoi, Hikaru Nagaoka, Toyokazu Miura, Daisuke Ito, Hiroyuki Takeda, Takafumi Tsuboi, Eizo Takashima, Hitoshi Otsuki
Summary: Erythrocyte recognition and invasion play a critical role in the intra-erythrocytic development of Plasmodium spp. parasites, with EBL proteins involved in tight junction formation. PyEBL was found to specifically interact with basigin, shedding light on its role in modulating the virulence of P. yoelii. This discovery offers new insights into the mechanisms of malaria infection and potential interventions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biology
Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F. Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A. Elias, William M. Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju
Summary: The study uncovered the critical role of Chi3I1 in mediating APAP-induced hepatic platelet recruitment, signaling through CD44 and C-type lectin-like receptor 2. Inhibiting Chi3I1 effectively attenuated liver injury induced by APAP.
Article
Agriculture, Dairy & Animal Science
Meihong Gao, Chunjiang Cai, Xu Han, Luyu Wang, Weifeng Zhang, Leying Zhang, Ling Yang
Summary: The study revealed that in early pregnancy, the expression levels of TLR2, TLR3, TLR5, TLR9, and TRAF6 increased in sheep liver, while the levels of TLR4 and TLR7 decreased. Additionally, the highest expression levels of MyD88 and IRAK1 were observed on days 13 and 16 of pregnancy, respectively, with MyD88 protein located in endothelial cells of proper hepatic arteries and portal veins as well as in hepatocytes.
JOURNAL OF APPLIED ANIMAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Bingxin Li, Longsheng Hong, Yindan Luo, Bingqi Zhang, Ziyu Yu, Wanyan Li, Nan Cao, Yunmao Huang, Danning Xu, Yugu Li, Yunbo Tian
Summary: LPS is a virulence factor of Gram-negative bacteria and its excessive concentration in geese can induce liver damage and reduce production performance. In this study, transcriptome sequencing analysis identified 727 differentially expressed genes related to LPS-induced liver injury and enrichment analysis showed the involvement of Toll-like receptor, MAPK, NOD-like receptor, FoxO, and PPAR signaling pathways. The TLR7-mediated MAPK signaling pathway played a major role in LPS-induced liver injury in geese.
Article
Medicine, General & Internal
Wen Zhang, Lei Wang, Xue-Hua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Guang-Ming Ren, Rong-Hua Yin, Xiao-Ming Yang
Summary: TLR5 activation plays a promoting role in the initial events of liver regeneration after partial hepatectomy. The TLR5 signaling positively regulates liver regeneration, suggesting the potential of TLR5 agonists to promote liver regeneration.
MILITARY MEDICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Moritz Peiseler, Bruna Araujo David, Joel Zindel, Bas G. J. Surewaard, Woo-Yong Lee, Felix Heymann, Ysbrand Nusse, Fernanda V. S. Castanheira, Raymond Shim, Adrien Guillot, Alix Bruneau, Jawairia Atif, Catia Perciani, Christina Ohland, Priyanka Ganguli Mukherjee, Annika Niehrs, Roland Thuenauer, Marcus Altfeld, Mathias Amrein, Zhaoyuan Liu, Paul M. K. Gordon, Kathy McCoy, Justin Deniset, Sonya MacParland, Florent Ginhoux, Frank Tacke, Paul Kubes
Summary: Liver fibrosis disrupts the interaction between Kupffer cells and parenchymal cells, leading to a decrease in bacterial clearance ability. Commensal bacteria stimulate the recruitment of monocytes through CD44 to form multinucleated cell aggregates (syncytia) in a distinct vascular compartment. These syncytia display enhanced bacterial capture ability and may represent an antimicrobial defense mechanism that evolved with fibrosis.
Article
Immunology
Jing Zhao, Hyuneui Jeong, Daram Yang, Weishun Tian, Jong-Won Kim, Chae Woong Lim, Bumseok Kim
Summary: TLR7 plays a critical role in ConA-induced liver injury, and its deficiency attenuates liver damage and reduces the release of hepatic pro-inflammatory cytokines. TLR7 deficiency also inhibits the proliferation of CD4+ T cells stimulated by ConA and specifically suppresses the expression of TNF-alpha in liver Kupffer cells. Depletion of Kupffer cells abolishes the detrimental role of TLR7 in ConA-induced liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carolina Medina-Montano, Maximiliano Luis Cacicedo, Malin Svensson, Maria Jose Limeres, Yanira Zeyn, Jean Emiro Chaves-Giraldo, Nadine Roehrig, Stephan Grabbe, Stephan Gehring, Matthias Bros
Summary: This study compared two isolation methods for murine liver non-parenchymal cells (NPCs), and found that both methods were comparable in terms of yield, purity, and composition of liver NPCs. However, NPCs enriched by the liver dissociation (LD) method showed a lower degree of activation and responsiveness to stimulation, making it less suitable for certain applications such as nano-vaccines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Julio Gallego-Delgado, Upal Basu-Roy, Maureen Ty, Matilde Alique, Cristina Fernandez-Arias, Alexandru Movila, Pollyanna Gomes, Ada Weinstock, Wenyue Xu, Innocent Edagha, Samuel C. Wassmer, Thomas Walther, Marta Ruiz-Ortega, Ana Rodriguez
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Immunology
Feng Zhu, Taiping Liu, Chenhao Zhao, Xiao Lu, Jian Zhang, Wenyue Xu
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
X. Lu, T. Liu, F. Zhu, L. Chen, W. Xu
PARASITE IMMUNOLOGY
(2017)
Article
Public, Environmental & Occupational Health
Yijing Zhang, Yi Yao, Weixing Du, Kai Wu, Wenyue Xu, Min Lin, Huabing Tan, Jian Li
PATHOGENS AND GLOBAL HEALTH
(2017)
Article
Parasitology
Taiping Liu, Xiangyun Cheng, Yan Ding, Feng Zhu, Yong Fu, Xiaohong Peng, Wenyue Xu
PARASITES & VECTORS
(2018)
Article
Immunology
Yong Fu, Xiao Lu, Feng Zhu, Yunxiang Zhao, Yan Ding, Lilin Ye, Bo Guo, Taiping Liu, Wenyue Xu
PARASITE IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Yong Fu, Yan Ding, Qinghui Wang, Feng Zhu, Yulong Tan, Xiao Lu, Bo Guo, Qingfeng Zhang, Yaming Cao, Taiping Liu, Liwang Cui, Wenyue Xu
Article
Cell Biology
Zhenghui Huang, Ruoxi Li, Tongke Tang, Dazheng Ling, Manjiong Wang, Dandan Xu, Maoxin Sun, Lulu Zheng, Feng Zhu, Hui Min, Rachasak Boonhok, Yan Ding, Yuhao Wen, Yicong Chen, Xiaokang Li, Yuxi Chen, Taiping Liu, Jiping Han, Jun Miao, Qiang Fang, Yaming Cao, Yun Tang, Jie Cui, Wenyue Xu, Liwang Cui, Jin Zhu, Gary Wong, Jian Li, Lubin Jiang
Article
Chemistry, Medicinal
Ruoxi Li, Dazheng Ling, Tongke Tang, Zhenghui Huang, Manjiong Wang, Yan Ding, Taiping Liu, Hanwen Wei, Wenyue Xu, Fei Mao, Jin Zhu, Xiaokang Li, Lubin Jiang, Jian Li
Summary: In this study, a total of 31 novel spirocyclic hydroxamic acid derivatives were synthesized based on the structure of the clinical anticancer drug candidate quisinostat, with compound 11 displaying broad potency against various multidrug-resistant malarial parasites both in vitro and in vivo. The compound showed specific efficacy against schizonts, acceptable metabolic stability, and pharmacokinetic properties, making it a promising PfHDAC1 inhibitor for malaria treatment and research.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Microbiology
Jingjing Cai, Suilin Chen, Feng Zhu, Xiao Lu, Taiping Liu, Wenyue Xu
Summary: Whole-parasite vaccines have regained attention due to challenges faced in developing highly efficient subunit malaria vaccines. The whole-killed blood-stage vaccine is advantageous in inducing protective immunity but raises concerns due to the high dose of parasitized red blood cell lysate required. Understanding the major components of the vaccine and developing suitable human-compatible adjuvants will be crucial for optimizing its effectiveness.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Zong Yawen, Cheng Xiangyun, Liao Binyou, Ye Xingchen, Liu Taiping, Zhou Xuedong, Li Jiyao, Cheng Lei, Xu Wenyue, Ren Biao
Summary: Our study revealed a complex and important relationship between intestinal microbiota and host immunity during Plasmodium infection, highlighting the crucial regulatory role of intestinal microbiome in modulating host immunity against the parasite.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Microbiology
Suilin Chen, Yuanli Gao, Yongling Fan, Shuai Guo, Jian Zhou, Taiping Liu, Wenyue Xu
Summary: This study used single-cell RNA sequencing to reveal the different roles of adaptive and innate immune responses in controlling malaria recrudescence. The number of Th1 cells and plasma cells decreased, while the number of red pulp macrophages, γδT cells, and dendritic cells increased during the recurrence stage. These findings have important implications for the development of immune interventions against malaria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Feng Zhu, Hong Zheng, Suilin Chen, Kun Zhang, Xin Qin, Jingru Zhang, Taiping Liu, Yongling Fan, Liting Wang, Xiaoxu Li, Jian Zhang, Wenyue Xu
Summary: A study showed that malaria parasite oocysts evade mosquito immune responses by inducing hemocyte nitration. This finding is important for understanding the immune evasion mechanisms of oocysts and highlights the unknown role of CSP in this process.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Shiming Jiao, Nie Tan, Chengyu Zhu, Yong Fu, Kun Zhang, Yan Ding, Wenyue Xu
Summary: A study found that mFGL2 expression increases during malaria infection, but has no significant impact on immune coagulation. However, FGL2 deficiency does not significantly affect the development of malaria parasites or the pathology of the infected liver. This study reveals the unique features of mFGL2 in liver-stage malaria infections.
PARASITE IMMUNOLOGY
(2023)
Article
Oncology
Dong Zhou, Hong Zheng, Quanxing Liu, Xiao Lu, Xufeng Deng, Li Jiang, Bing Hou, Yong Fu, Feng Zhu, Yan Ding, Wenyue Xu, Jigang Dai
CANCER BIOLOGY & MEDICINE
(2019)
