Article
Biochemistry & Molecular Biology
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, Maria Eugenia de la Morena-barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Perez, Henning Kempf, Kathrine S. Asrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Froydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan
Summary: The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoids are characterized by a reliance on extracellular matrices (ECMs), 2D culture patterning, costly growth factors, and a lack of cellular diversity, structure, and organization. However, a new approach has been developed that overcomes these limitations and produces liver-like organoids with high cellular complexity and functionality. These organoids exhibit key liver functions and can be transplanted and maintained long-term. This approach has significant potential in various applications such as cellular therapy, tissue engineering, drug toxicity assessment, and disease modeling.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Chemistry, Medicinal
Xiaolin Zhan, Wei Chen, Jian Chen, Changjiang Lei, Liqin Wei
Summary: This study demonstrated that Telmisartan has protective effects against high glucose-induced injury in human renal glomerular endothelial cells through multiple mechanisms. Telmisartan can improve mitochondrial function, reduce oxidative stress, prevent NADPH oxidase 2 expression, and regulate cell permeability via the MLCK/MLC-2/occludin signaling pathway. Additionally, Telmisartan treatment was shown to ameliorate the reduction of occludin and albuminuria in a diabetic mouse model, suggesting its potential therapeutic role in DN.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Ru Huang, Juan Deng, Chang-Peng Zhu, Shu-Qing Liu, Ya-Lu Cui, Fei Chen, Xin Zhang, Xia Tao, Wei-Fen Xie
Summary: This study aimed to evaluate the therapeutic potential of sulodexide in a mouse model of liver fibrosis and explore its underlying mechanisms. Sulodexide treatment significantly attenuated liver fibrosis induced by thioacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mice. Transcriptome analysis revealed that sulodexide downregulated fibrosis-related genes and liver sinusoidal endothelial cells (LSECs) capillarization-associated genes. Immunohistochemistry confirmed that sulodexide reduced the expression of LSEC capillarization-related genes in fibrotic liver tissues. Scanning electron microscopy showed preserved LSEC fenestrations upon sulodexide treatment. In conclusion, sulodexide attenuated liver fibrosis in mice by restoring differentiated LSECs, suggesting its potential as a therapy for liver fibrosis patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Yan Yang, Ming Ni, Ruobin Zong, Mengxue Yu, Yishuang Sun, Jiahui Li, Pu Chen, Changyong Li
Summary: Liver macrophages have the ability to adjust their phenotype according to signals from the hepatic microenvironment. The study highlights the importance of the Notch1-YAP circuit in regulating macrophage polarization and liver inflammation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Genis Camprecios, Maria Ruart, Aina Anton, Nuria Suarez-Herrera, Carla Montironi, Celia Martinez, Natalia Jimenez, Erica Lafoz, Hector Garcia-Caldero, Marina Vilaseca, Marta Magaz, Mar Coll, Isabel Graupera, Scott L. Friedman, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Research on the use of SPD in two models of liver disease shows that SPD can improve the function of liver endothelial cells, reduce liver oxidative stress, and enhance mitochondrial health. These findings suggest that dietary supplementation with SPD in the early stages of the disease may protect liver endothelial cells, serving as an attractive approach to modify the course of chronic liver disease and halt fibrosis progression.
Article
Geriatrics & Gerontology
Nazaneen Saleh, Caglar Cosarderelioglu, Ramya Vajapey, Jeremy Walston, Peter M. Abadir
Summary: Chronic inflammation, oxidative stress, and dysregulation of the renin-angiotensin system commonly contribute to age-related decline. Oral Losartan treatment has a positive impact on brain-specific angiotensin system and reduces protein levels and oxidative stress damage in a frailty mouse model.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Juan-Li Duan, Zi-Yi Zhou, Bai Ruan, Zhi-Qiang Fang, Jian Ding, Jing-Jing Liu, Ping Song, Hao Xu, Chen Xu, Zhen-Sheng Yue, Hua Han, Guo-Rui Dou, Lin Wang
Summary: c-Kit-positive liver sinusoidal endothelial cells play a role in promoting hepatocyte proliferation and reducing liver injuries. Mutation in the Notch pathway affects the distribution of these cells and liver zonation. Activation of Notch signaling impedes liver regeneration and weakens the positive regulatory effects of c-Kit-positive liver sinusoidal endothelial cells on hepatocytes.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Chemistry, Medicinal
Jiehan Zhang, Hongrong Li, Dandong Wang, Jiaojiao Gu, Yunlong Hou, Yiling Wu
Summary: The purpose of this study was to investigate the mechanism by which the Chinese compound Shensong Yangxin Capsule (SSYX) reduces susceptibility to arrhythmia in db/db mice. The results showed that SSYX decreased the susceptibility of db/db mice to arrhythmia and improved abnormal electrocardiogram parameters. In addition, SSYX exerted its effects by inhibiting inflammatory response and macrophage polarization, and by protecting endothelial cell function to alleviate arrhythmia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Engineering, Biomedical
Camille Le Guilcher, Gregory Merlen, Alessandra Dellaquila, Marie-Noeurolle Labour, Rachida Aid, Thierry Tordjmann, Didier Letourneur, Teresa Simon-Yarza
Summary: Porous pullulan-dextran hydrogel can be used to self-assemble hepatocytes and biliary-like cells into functional 3D microtissues, showing potential value in clinical applications.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Xin Ouyang, Zhengjia Wang, Mei Luo, Maozhou Wang, Xing Liu, Jiaxin Chen, JianGuo Feng, Jing Jia, Xiaobin Wang
Summary: The study found that ketamine can mitigate depressive-like behaviors in female mice by activating the ERK/GLUT3 signal pathway and increasing glucose uptake in the prefrontal cortex.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Simon Klepper, Susan Jung, Lara Dittmann, Carol Geppert, Arnd Hartmann, Nicole Beier, Regina Trollmann
Summary: Experimental data indicate that rhGH and rhEPO have complementary neuroprotective actions in neonatal hypoxic brain injury. The study also suggests that rhGH and rhEPO mediate stabilization of the blood-brain barrier and promote regenerative vascular effects in the injured brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tingting Liu, Jin Li, Qian Li, Yiyi Liang, Jian Gao, Zihong Meng, Peiying Li, Ming Yao, Jinyang Gu, Hong Tu, Yu Gan
Summary: The study demonstrates that environment-induced eustress enhances liver regeneration through the sympathetic nerve/ILC1/IL-22 axis. This finding supports the brain-liver axis and emphasizes the importance of positive psychological stress in promoting liver regeneration.
Article
Environmental Sciences
Yanchao Hu, Xu Gu, Yan Zhang, Weidong Ma, Lijun Sun, Congxia Wang, Bincheng Ren
Summary: This study investigated the function and mechanism of Vitamin D receptor (VDR) in improving Human Umbilical Vein Endothelial Cell (HUVEC) functions. The results showed that VDR inhibits ox-LDL-induced endothelial dysfunction and ferroptosis by regulating ADM transcription and acting on AMPK signaling pathway. Overexpression of VDR in Apoe-/- mice reduces lipid deposition and plaque area in atherosclerotic mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
D. Vacondio, H. Nogueira Pinto, L. Coenen, I. A. Mulder, R. Fontijn, B. van het Hof, W. K. Fung, A. Jongejan, G. Kooij, N. Zelcer, A. J. Rozemueller, H. E. de Vries, N. M. de Wit
Summary: In Alzheimer's disease, capillary cerebral amyloid-angiopathy (capCAA) affects more than 50% of the patients, resulting in localized hypoxia, neuro-inflammation, and blood-brain barrier dysfunction. LXR alpha is essential for maintaining blood-brain barrier integrity by inhibiting the transcription factor SNAI2. Hypoxia leads to decreased LXR alpha expression and increased SNAI2 expression, causing dedifferentiation and sprouting of brain endothelial cells.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Eun S. Park, Sehee Kim, Shuning Huang, Ji Young Yoo, Jakob Korbelin, Tae Jin Lee, Balveen Kaur, Pramod K. Dash, Peng R. Chen, Eunhee Kim
Summary: Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke and neurological deficits in children and young adults, with no pharmacological intervention available. KRAS mutations, commonly seen in cancer, have been found in human sporadic bAVMs, leading to a new direction in research. Using AAV-BR1, the study demonstrated that endothelial KRAS(G12V) mutation induces bAVMs in mice, and MEK/ERK inhibition can suppress bAVM growth.
ANNALS OF NEUROLOGY
(2021)