4.6 Editorial Material

DIABETES Regional variation in lower limb amputation incidence

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NATURE REVIEWS ENDOCRINOLOGY
Volume 8, Issue 7, Pages 386-388

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NATURE PUBLISHING GROUP
DOI: 10.1038/nrendo.2012.78

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Holman et al. describe regional variation in lower limb amputation rates across England. In addition to confirming a >20-fold increased amputation risk associated with diabetes mellitus, they also report a 10-fold difference in amputation rates in individuals with diabetes mellitus between 151 Primary Care Trusts of the National Health Service.

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