Autophagy in Brain Tumors: A New Target for Therapeutic Intervention

BH3 Mimetics Reactivate Autophagic Cell Death in Anoxia-Resistant Malignant Glioma Cells

(2015) Holger Hetschko et al.   NEOPLASIA

The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases

(2015) Vinochani Pillay et al.   NEOPLASIA

Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3

(2014) Hiroshi Aoki et al.   Autophagy

Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death

(2011) Sandrine Eimer et al.   CANCER BIOLOGY & THERAPY

Autophagy as a therapeutic target in cancer

(2011) Ning Chen et al.   CANCER BIOLOGY & THERAPY

Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines

(2011) Estefanía Carrasco-García et al.   EXPERIMENTAL CELL RESEARCH

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity

(2011) Wenzhuo Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

(2011) S. Torres et al.   MOLECULAR CANCER THERAPEUTICS

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

(2010) Xin Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

Autophagy and Tumorigenesis

(2010) Srirupa Roy et al.   Seminars in Immunopathology

Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells

(2009) Peng-fei Ge et al.   ACTA PHARMACOLOGICA SINICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways

(2009) Hui-Wen Chiu et al.   Autophagy

The prognostic role of Beclin 1 protein expression in high-grade gliomas

(2009) Luigi Pirtoli et al.   Autophagy

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

(2009) Stephanie L. Lomonaco et al.   INTERNATIONAL JOURNAL OF CANCER

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

(2009) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

(2009) Anne Simonsen et al.   JOURNAL OF CELL BIOLOGY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy

(2009) Khong Kang et al.   Molecular Cancer

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

(2008) Natalia B. Nedelsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PI3K Signaling in Glioma-Animal Models and Therapeutic Challenges

(2008) Christine K. Cheng et al.   BRAIN PATHOLOGY

Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

(2008) M Szybka et al.   BRITISH JOURNAL OF CANCER

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells

(2008) T Yokoyama et al.   GENE THERAPY

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

(2008) Min Sung Kim et al.   HUMAN PATHOLOGY

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Frameshift mutations of autophagy-related genesATG2B, ATG5, ATG9BandATG12in gastric and colorectal cancers with microsatellite instability

(2008) Mi Ran Kang et al.   JOURNAL OF PATHOLOGY

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Delta-24-RGD in Combination With RAD001 Induces Enhanced Anti-glioma Effect via Autophagic Cell Death

(2008) Marta M Alonso et al.   MOLECULAR THERAPY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL