Article
Multidisciplinary Sciences
Wanna Sa-nongdej, Sukumal Chongthammakun, Chanchai Songthaveesin
Summary: Glioma stem-like cells (GSCs) are highly resistant to treatment, and nutrient starvation could potentially improve treatment outcomes by triggering apoptotic and autophagic metabolic reprogramming in cancer cells.
Review
Cell Biology
Karina Biserova, Arvids Jakovlevs, Romans Uljanovs, Ilze Strumfa
Summary: Cancer stem cells, particularly in glioblastoma, play a crucial role in tumor resistance to treatment and recurrence. The regulatory mechanisms of glioma stem cells include tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics, which serve as potential targets for future treatments.Understanding the molecular markers and treatment resistance of GSCs in glioblastoma may lead to more effective therapeutic strategies in the future.
Review
Immunology
Kouminin Kanwore, Konimpo Kanwore, Gabriel Komla Adzika, Ayanlaja Abdulrahman Abiola, Xiaoxiao Guo, Piniel Alphayo Kambey, Ying Xia, Dianshuai Gao
Summary: This review examines the underlying mechanisms of glioma initiation and metabolism activation, as well as the tumor microenvironment changes that affect epigenetic modifications in immune cells, from an oncological and immunological perspective. The potential for therapeutic intervention is also highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiangyu Li, Ming Liu, Junfeng Zhao, Tong Ren, Xin Yan, Lijun Zhang, Xun Wang
Summary: Glioma stem cells play a crucial role in the immune microenvironment of glioma, becoming a focus of research. Immunotherapeutic strategies targeting glioma stem cells have gained increasing attention, providing new perspectives for the immunotherapy of glioma.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Maoyu Wang, Sen Shen, Feng Hou, Yaohua Yan
Summary: This article reviews the feasibility of treating gliomas by targeting integrins on glioma stem cells, elucidating the functions and mechanisms of integrins in glioma stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Inka Berglar, Stephanie Hehlgans, Andrej Wehle, Caterina Roth, Christel Herold-Mende, Franz Roedel, Donat Koegel, Benedikt Linder
Summary: In this study, we investigated the role of CHRDL1 in glioma stem-like cells and found that depletion of CHRDL1 reduces stemness and enhances radiation sensitivity. Additionally, high expression of CHRDL1 may also serve as a marker protein for determining BMP4 susceptibility.
Article
Biochemistry & Molecular Biology
Patricia Torres-Barrera, Dafne Moreno-Lorenzana, Jose Antonio Alvarado-Moreno, Elena Garcia-Ruiz, Cesar Lagunas, Hector Mayani, Antonieta Chavez-Gonzalez
Summary: The bone marrow microenvironment in chronic myeloid leukemia plays a role in regulating the proliferation and quiescence of stem and progenitor cells. A co-culture model of primitive CML cells and endothelial colony forming cells has been used to study this interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yingying Liu, Peisheng Chen, Liufei Xu, Bo Wang, Shengping Zhang, Xiangpeng Wang
Summary: In this study, researchers found that the expression level of GALNT2 is elevated in GBM, IDH1 wildtype glioma, and GSCs. GALNT2 expression is correlated with unfavorable clinical outcomes in GBM patients. Targeting GALNT2 can block GSCs cell proliferation, self-renewal, and malignant invasion through repressing CD44 expression.
Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Marc-Antoine Da-Veiga, Bernard Rogister, Arnaud Lombard, Virginie Neirinckx, Caroline Piette
Summary: Pediatric high-grade glioma (pHGG) has a poor prognosis, especially in younger patients. The highly malignant glioma stem cells (GSCs) remain poorly investigated in pediatric cases, despite being well described in adult brain tumors. Understanding the role of GSCs in pediatric tumors could lead to targeted treatments for better outcomes.
Review
Oncology
Arnaud Lombard, Marina Digregorio, Clement Delcamp, Bernard Rogister, Caroline Piette, Natacha Coppieters
Summary: High-grade gliomas account for a high proportion of cancer-related deaths in both adults and children, with poor prognosis due to tumor recurrences. Glioma stem cells (GSCs) play a crucial role in tumor recurrences by migrating to the SVZ and resisting treatments. Targeting the neurogenic region of the SVZ could hold therapeutic advantages in treating both adult GBM and pediatric HGG.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Qing Zhang, Jialin Wang, Junwen Zhang, Fusheng Liu
Summary: Mesenchymal stem cells (MSCs) play crucial roles in the tumor microenvironment (TME), contributing to tumor progression and therapeutic resistance. Glioma-resident MSCs (GR-MSCs) enhance the tumorigenicity of glioma stem cells (GSCs) through the IL-6/gp130/STAT3 pathway. Higher percentage of GR-MSCs in the TME leads to poor prognosis of glioma patients and their secretion of specific miRNA promotes tumor growth. Novel therapeutic strategies targeting GR-MSCs are urgently needed for GBM patients.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Retraction
Cell & Tissue Engineering
Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang, Xuexi Wang
Summary: The article has been retracted. More details can be found in the Retraction Notice at https://doi.org/10.1186/s13287-019-1149-5.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Xingliang Dai, Yuxuan Shao, Xuefeng Tian, Xiaoyan Cao, Lei Ye, Peng Gao, Hongwei Cheng, Xianwen Wang
Summary: Cell fusion between GSCs and MSCs in 3D-bioprinted models promotes the progression of glioma by enhancing the malignant properties of the fused cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell & Tissue Engineering
Bing-zhou Xue, Wei Xiang, Qing Zhang, Hao-fei Wang, Yu-jie Zhou, Han Tian, Ahmed Abdelmaksou, Jian Xue, Min-xuan Sun, Dong-ye Yi, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao, Peng Fu
Summary: The study found that CD90(low) gaMSCs increased FOXS1 expression in glioma cells by secreting IL-6, leading to the activation of epithelial-mesenchymal transition and resistance to TMZ in these cells. These results reveal a new role of gaMSCs in promoting chemotherapy resistance.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Hematology
Noemi Andor, Erin F. Simonds, Debra K. Czerwinski, Jiamin Chen, Susan M. Grimes, Christina Wood-Bouwens, Grace X. Y. Zheng, Matthew A. Kubit, Stephanie Greer, William A. Weiss, Ronald Levy, Hanlee P. Ji
Article
Oncology
Jezabel Rodriguez-Blanco, Bin Li, Jun Long, Chen Shen, Fan Yang, Darren Orton, Sara Collins, Noriyuki Kasahara, Nagi G. Ayad, Heather J. McCrea, Martine F. Roussel, William A. Weiss, Anthony J. Capobianco, David J. Robbins
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Andrew McKinney, Olle R. Lindberg, Jane R. Engler, Katharine Y. Chen, Anupam Kumar, Henry Gong, Kan V. Lu, Erin F. Simonds, Timothy F. Cloughesy, Linda M. Liau, Michael Prados, Andrew W. Bollen, Mitchel S. Berger, Joseph T. C. Shieh, C. David James, Theodore P. Nicolaides, William H. Yong, Albert Lai, Monika E. Hegi, William A. Weiss, Joanna J. Phillips
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Zhenyi An, William A. Weiss
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Oncology
Liguo Zhang, Xuelian He, Xuezhao Liu, Feng Zhang, L. Frank Huang, Andrew S. Potter, Lingli Xu, Wenhao Zhou, Tao Zheng, Zaili Luo, Kalen P. Berry, Allison Pribnow, Stephanie M. Smith, Christine Fuller, Blaise Jones, Maryam Fouladi, Rachid Drissi, Zeng-Jie Yang, W. Clay Gustafson, Marc Remke, Scott L. Pomeroy, Emily J. Girard, James M. Olson, A. Sorana Morrissy, Maria C. Vladoiu, Jiao Zhang, Weidong Tian, Mei Xin, Michael D. Taylor, S. Steven Potter, Martine F. Roussel, William A. Weiss, Q. Richard Lu
Article
Cell Biology
Nilanjana Chatterjee, Evangelos Pazarentzos, Manasi K. Mayekar, Philippe Gui, David V. Allegakoen, Gorjan Hrustanovic, Victor Olivas, Luping Lin, Erik Verschueren, Jeffrey R. Johnson, Matan Hofree, Jenny J. Yan, Billy W. Newton, John V. Dollen, Charles H. Earnshaw, Jennifer Flanagan, Elton Chan, Saurabh Asthana, Trey Ideker, Wei Wu, Junji Suzuki, Benjamin A. Barad, Yuriy Kirichok, James S. Fraser, William A. Weiss, Nevan J. Krogan, Asmin Tulpule, Amit J. Sabnis, Trever G. Bivona
Article
Cell Biology
Hanna Sabelstrom, Rebecca Petri, Ksenya Shchors, Rahul Jandial, Christin Schmidt, Rohit Sacheva, Selma Masic, Edith Yuan, Trenten Fenster, Michael Martinez, Supna Saxena, Theodore P. Nicolaides, Shirin Ilkhanizadeh, Mitchel S. Berger, Evan Y. Snyder, William A. Weiss, Johan Jakobsson, Anders Persson
Article
Oncology
Caroline von Achenbach, Manuela Silginer, Vincent Blot, William A. Weiss, Michael Weller
MOLECULAR CANCER THERAPEUTICS
(2020)
Editorial Material
Oncology
Xujun Luo, William A. Weiss
Editorial Material
Immunology
Zulekha A. Qadeer, William A. Weiss
Summary: The study reveals that bone morphogenetic proteins and Sox9 promote the transdifferentiation of tumor cells into tumor-derived astrocytes, which can be targeted by BMP inhibitors.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Editorial Material
Immunology
Robert A. Lindquist, William A. Weiss
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Editorial Material
Cell Biology
Mary Clare Beytagh, William A. Weiss
Summary: EGFR plays a tumour-suppressive role in EGFR-amplified glioblastoma, regulated by ligand abundance. Increased EGFR ligand suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.
NATURE CELL BIOLOGY
(2022)
Review
Oncology
Megan L. Tigue, Matthew A. Loberg, Jeremy A. Goettel, William A. Weiss, Ethan Lee, Vivian L. Weiss
Summary: Tumor-associated macrophages (TAM) have a significant impact on tumor growth and immune responses, with TAM infiltration being linked to poor prognosis in various cancers. TAMs can be categorized as pro-inflammatory, M1-like, or anti-inflammatory, M2-like. Recent evidence suggests that Wnt signaling plays a crucial role in promoting an immunosuppressive, M2-like phenotype in TAMs, facilitating cancer cell proliferation, invasion, and metastasis. Targeting TAM polarization and their protumorigenic functions through Wnt signaling inhibitors could potentially be an effective treatment strategy in cancers with a high presence of macrophages in the microenvironment.
Article
Multidisciplinary Sciences
Ziyang Zhang, Qiwen Fan, Xujun Luo, Kevin Lou, William A. Weiss, Kevan M. Shokat
Summary: This study presents a strategy to achieve brain-specific treatment of central nervous system diseases by combining brain-permeable and brain-impermeable drugs. The design of cell-permeable FKBP12-dependent kinase inhibitors enables brain-restricted inhibition of specific kinase targets.
Editorial Material
Oncology
Mary Clare Beytagh, William A. Weiss
Summary: Epigenetic reprogramming plays a role in tumorigenesis in pediatric H3K27M glioma by altering the functions of chromatin remodeling complexes. BRG1 is identified as a novel dependency in this type of tumor and its recruitment to regulatory elements drives tumor progression.
