Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

ATR maintains select progenitors during nervous system development

(2012) Youngsoo Lee et al.   EMBO JOURNAL

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

(2011) C. Cotta-Ramusino et al.   SCIENCE

Neural stem and progenitor cells shorten S-phase on commitment to neuron production

(2011) Yoko Arai et al.   Nature Communications

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication

(2010) Akiko Kumagai et al.   CELL

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator

(2010) C. L. Sansam et al.   GENES & DEVELOPMENT

Molecular Basis of BACH1/FANCJ Recognition by TopBP1 in DNA Replication Checkpoint Control

(2010) Charles Chung Yun Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TopBP1 Deficiency Causes an Early Embryonic Lethality and Induces Cellular Senescence in Primary Cells

(2010) Yoon Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks

(2010) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

(2010) Zihua Gong et al.   MOLECULAR CELL

GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication

(2010) Alessia Balestrini et al.   NATURE CELL BIOLOGY

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Eukaryotic DNA replication control: Lock and load, then fire

(2009) Dirk Remus et al.   CURRENT OPINION IN CELL BIOLOGY

Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors

(2009) J. N. Pulvers et al.   DEVELOPMENT

A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

(2009) Vasundhara M. Navadgi-Patil et al.   DNA REPAIR

DNA replication as a target of the DNA damage checkpoint

(2009) Philip Zegerman et al.   DNA REPAIR

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

(2009) E. R.P. Shull et al.   GENES & DEVELOPMENT

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

(2009) Yaroslava Ruzankina et al.   NATURE GENETICS

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex

(2009) Shen-Ju Chou et al.   NATURE NEUROSCIENCE

The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1

(2009) Youngsoo Lee et al.   NATURE NEUROSCIENCE

DNA repair deficiency and neurological disease

(2009) Peter J. McKinnon   NATURE REVIEWS NEUROSCIENCE

Neocortical neurogenesis: morphogenetic gradients and beyond

(2009) Verne S. Caviness et al.   TRENDS IN NEUROSCIENCES

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY