Review
Oncology
Vivek Subbiah, Howard A. Burris III, Razelle Kurzrock
Summary: Advances in next-generation sequencing, targeted therapies, and immunotherapies have transformed cancer therapy. Basket trials, an effective clinical trial design, evaluate the efficacy of therapies based on specific molecular alterations across multiple cancer types, offering potential for personalized treatments and revolutionizing cancer care.
Review
Chemistry, Multidisciplinary
C. Bastiancich, E. Bozzato, I. Henley, B. Newland
Summary: A systematic analysis of studies shows that local drug delivery is more effective in treating glioblastoma compared to systemic administration, with benefits in terms of median survival, tumor volume, and adverse events. The evidence supports the further development of drug delivery systems for local therapeutic delivery to brain cancers like GBM.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Oncology
Chiara Corti, Gabriele Antonarelli, Carmine Valenza, Eleonora Nicolo, Hope Rugo, Javier Cortes, Nadia Harbeck, Lisa A. Carey, Carmen Criscitiello, Giuseppe Curigliano
Summary: This review discusses the challenges and opportunities of pan-histological expansion of ADCs in solid tumors. It covers technological and manufacturing advancements, current evidence from clinical trials, and the need for predictive biomarkers and methodological, statistical, and regulatory considerations in a biomarker-driven histology-agnostic approach.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Chemistry, Medicinal
Shuo Yuan, Dan-Dan Shen, Rui Jia, Ju-Shan Sun, Jian Song, Hong-Min Liu
Summary: The U.S. FDA approved a total of 37 new drugs in 2022, including 20 chemical entities and 17 biologics. Among them, 17 small molecule drugs, 1 radiotherapy, and 2 diagnostic agents provide unique scaffolds, breakthrough clinical benefits, and new mechanisms of action for the discovery of more effective clinical candidates. Structure-based drug development and fragment-based drug development have always been important modules in drug discovery, allowing bypassing patent protection and enhancing biological activity. Therefore, we summarized valuable information on the clinical application, mechanism of action, and chemical synthesis of 17 newly approved small molecule drugs in 2022. We hope this timely and comprehensive review will inspire creative and elegant approaches in synthetic methodologies and mechanisms of action for the discovery of new drugs with novel chemical scaffolds and expanded clinical indications.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Oncology
Shaily Arora, Preeti Narayan, Christy L. Osgood, Suparna Wedam, Tatiana M. Prowell, Jennifer J. Gao, Mirat Shah, Danielle Krol, Sakar Wahby, Melanie Royce, Soma Ghosh, Reena Philip, Gwynn Ison, Tara Berman, Christina Brus, Erik W. Bloomquist, Mallorie H. Fiero, Shenghui Tang, Richard Pazdur, Amna Ibrahim, Laleh Amiri-Kordestani, Julia A. Beaver
Summary: The treatment of patients with breast cancer has been greatly influenced by the approval of various drugs and indications in the past decade. This article summarizes the FDA approvals of 30 treatments for breast cancer from 2010 to 2020, including trial design, results, and regulatory considerations. The majority of approvals were for metastatic breast cancer, with a smaller number for early breast cancer. These approvals were primarily based on progression-free survival, overall survival, or objective response rate, and also involved other review initiatives and designations.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Viktoria Gloy, Andreas M. Schmitt, Pascal Dueblin, Julian Hirt, Cathrin Axfors, Hanna Kuk, Tiago V. Pereira, Clara Locher, Laura Caquelin, Martin Walter-Claudi, Mark P. Lythgoe, Amanda Herbrand, Benjamin Kasenda, Lars G. Hemkens
Summary: We analyzed all cancer drugs approved by the FDA between 2000 and 2020 and found that 49% of drugs were approved without randomized controlled trials, and 82% had only one clinical trial. Although some drugs showed benefits in overall survival, there were limited improvements in quality of life.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Vageesha W. Liyana W. Gunawardana, Carson Ward, Han Wang, Joseph H. Holbrook, Emily R. Sekera, Honggang Cui, Amanda B. Hummon, Jovica D. Badjic
Summary: In this study, a novel covalent basket cage CBC-11 was prepared and characterized. The cage exhibited tetrahedral shape and could form crystalline nanoparticles when assembled. It was capable of trapping anticancer drugs in a non-cooperative manner. The biocompatibility of CBC-11 was demonstrated and it showed potential as a polyvalent binder for drug sequestration or delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
News Item
Oncology
Mary Beth Nierengarten
Summary: This news section provides timely information for cancer readers, covering events, public policy analysis, topical issues, and personalities. This issue explores the use of single-arm studies for accelerated drug approvals, the impact of evidence-based surgical metrics on early-stage lung cancer patients, and the cost-effectiveness of lung cancer screening based on personal risk factors.
Article
Oncology
Bram De Wilde, Elly Barry, Elizabeth Fox, Dominik Karres, Mark Kieran, John Manlay, Donna Ludwinski, Gregory Reaman, Pamela Kearns
Summary: This article discusses how academic-sponsored trials can directly contribute to the licensing of new medicines. It identifies critical gaps in knowledge, standard procedures, and resources within academic consortia that hinder the trial data from contributing to marketing authorization applications. Through a suite of recommendations focusing on essential documents, data, management, and resources, academic-industry partnerships are enabled to deliver trials that meet regulatory requirements.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Sara Reardon
Summary: The FDA's decision, which is expected to be announced this month, has been delayed multiple times, causing difficulties for families of children with Duchenne muscular dystrophy.
Review
Oncology
Shawn M. Sweeney, Hisham K. Hamadeh, Natalie Abrams, Stacey J. Adam, Sara Brenner, Dana E. Connors, Gerard J. Davis, Louis D. Fiore, Susan H. Gawel, Robert L. Grossman, Sean E. Hanlon, Karl Hsu, Gary J. Kelloff, Ilan R. Kirsch, Bill Louv, Deven McGraw, Frank Meng, Daniel Milgram, Robert S. Miller, Emily Morgan, Lata Mukundam, Thoma O'Brien, Paul Robbins, Eric H. Rubin, Wendy S. Rubinstein, Liz Salmi, Teilo H. Schaller, George Shi, Caroline C. Sigman, Sudhir Srivastava
Summary: The analysis of big healthcare data has great potential in advancing oncology drug development and patient treatment in precision medicine. However, challenges exist in organizing, sharing, integrating, and making data accessible. This review presents five case studies showcasing successful approaches to addressing these challenges and emphasizes the need for data sharing and utilization to advance cancer research and treatment.
Article
Engineering, Industrial
Haytham Omar, Walid Klibi, M. Zied Babai, Yves Ducq
Summary: Omnichannel retailing has increased the complexity of supply chain demand forecasting, as customers now purchase diverse products through various channels. This study proposes a new approach using customer shopping basket data to forecast demand and improve accuracy and stock control in omnichannel retailing. By utilizing network graph theory and marketing literature, four attributes are identified to promote connectivity between products in shopping baskets. Empirical analysis conducted on a major cosmetics retailer in France demonstrates the effectiveness of the proposed forecasting methods, showcasing the benefits of joint forecasting and shared inventory between online and store channels in reducing shortages.
INTERNATIONAL JOURNAL OF PRODUCTION ECONOMICS
(2023)
Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Mamdouh S. Masoud, Mohamed M. Ibrahim, Mohamed S. Ramadan, Gaber A. M. Mersal, Ibrahim M. El-Mehasseb
Summary: This study focuses on improving the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by combining it with beta-cyclodextrin (beta CD) basket to form a novel self-assembly beta CD-SOF. The drug is then loaded onto chitosan nanoparticles (Cs NPs) to create a hybrid composite named Cs@beta CD-SOF. Through various characterization methods, it is confirmed that Cs@beta CD-SOF has a loading efficiency of 94.54% and exhibits high release efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ruby Lieshout, Alessandra V. S. Faria, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Monique M. A. Verstegen, Gwenny M. Fuhler
Summary: Kinome profiling is a feasible method to identify druggable targets for cholangiocarcinoma. Growth factor signaling and downstream effectors are more active in cholangiocarcinoma organoids, which could potentially provide targets for treatment. Screening of kinase inhibitors revealed several potential effective inhibitors and compounds with patient-specific efficacy. The sensitivity of kinase inhibitors correlated with the activity of their target kinases, signifying them as potential predictors of response. Furthermore, correlations were found between drug response and kinases not targeted directly by the drugs.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mijin Lee, Ji Min Han, Jaeyeon Lee, Ju Young Oh, Jung Sun Kim, Hye Sun Gwak, Kyung Hee Choi
Summary: Pharmacogenomics involves studying DNA and RNA changes associated with drug response, enabling the prediction of drug efficacy and adverse effects based on patients' genetic mutations. Accessible pharmacogenomic information is crucial for safe and effective drug use. This study examined pharmacogenomic information on drug labels in Korea, Europe, Japan, and the US. Differences in drug labeling information were found among these countries, attributed to variations in mutant alleles, update frequencies of drug lists, and pharmacogenomics guidelines. Continuous efforts are needed to identify and report mutations that explain drug efficacy and side effects for safe drug use.
FRONTIERS IN PHARMACOLOGY
(2023)
