Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biology
Kelvin W. Pond, Julia M. Morris, Olga Alkhimenok, Reeba P. Varghese, Carly R. Cabel, Nathan A. Ellis, Jayati Chakrabarti, Yana Zavros, Juanita L. Merchant, Curtis A. Thorne, Andrew L. Paek
Summary: The establishment and maintenance of different cellular compartments in tissues is crucial for all metazoans, especially in the human colon. This study reveals the critical role of wave-like ERK signaling induced by apoptotic cells in maintaining tissue patterning and homeostasis.
Article
Biochemistry & Molecular Biology
Rita Hargitai, David Kis, Eszter Persa, Tunde Szatmari, Geza Safrany, Katalin Lumniczky
Summary: The study shows that extracellular vesicles (EVs) from irradiated mice can affect the redox status and expression of radiation-response genes in bystander mice. Irradiation with 2 Gy leads to increased lipid peroxidation and altered gene expression. EVs cause decreased expression of antioxidant enzyme genes and iNOS2 in bystander mice.
Article
Ophthalmology
Xinye Qian, Hehe Liu, Shangyi Fu, Jiaxiong Lu, Yu-Ting Hung, Cassidy Turner, Haiwei Gu, Rui Chen
Summary: This study aims to assess the therapeutic efficacy of gene therapy in Tlcd3b mutant retina and validate the role of TLCD3B as a ceramide synthase in vivo. The findings show that overexpression of Tlcd3b can rescue retinal degeneration in mutant mice, indicating its primary function in photoreceptor cells. This research lays the foundation for developing future therapy for TLCD3B retinopathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Plant Sciences
Muhammad Ahsan Altaf, Nitin Sharma, Dipali Srivastava, Sayanti Mandal, Sandeep Adavi, Rupak Jena, Rakesh Kumar Bairwa, Abilash Valsala Gopalakrishnan, Awadhesh Kumar, Abhijit Dey, Milan Kumar Lal, Rahul Kumar Tiwari, Ravinder Kumar, Parvaiz Ahmed
Summary: Melatonin protects plants from heavy metal stress by immobilizing the metals in cell walls and storing them in root cell vacuoles, reducing their translocation to shoots. It enhances osmolyte production, increases antioxidant enzyme activity, and improves photosynthesis, thereby improving cellular functions. Understanding melatonin-mediated response and signaling is important for sustaining crop production in heavy metal-stressed soils.
Article
Multidisciplinary Sciences
Kumari Alka, Ghulam Mohammad, Renu A. Kowluru
Summary: Hyperlipidemia is a major systemic factor in diabetic retinopathy development, exacerbating cytosolic ROS production and mitochondrial damage. Inhibiting the rate limiting enzyme of ceramide biosynthesis, SPT, regulates activation of DNA methylation-hydroxymethylation machinery and prevents increased Rac1 transcription.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Megan Sheridan, Besim Ogretmen
Summary: Sphingolipids are membrane-associated lipids that play crucial roles in regulating cell functions such as proliferation, migration, senescence, and death. In cancer cells, sphingolipids are involved in pathways relevant to cancer therapy, including invasion, metastasis, apoptosis, and lethal mitophagy. Notable sphingolipids like ceramide and sphingosine-1 phosphate have contrasting effects on cell survival and chemotherapeutic resistance, with ceramide inducing death and lethal mitophagy, and sphingosine-1 phosphate promoting survival. These lipids are characterized by a long-chain sphingosine backbone linked to a fatty acyl chain with variable length, and alterations in ceramide synthases and sphingolipid regulation of mitophagy have important implications for cancer therapy.
Article
Environmental Sciences
Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Min Ju Kim, Soo-Hyun Park, Bong-Seok Song, Bo-Woong Sim, Sun-Uk Kim
Summary: The study showed that inhibition of ceramide generation can attenuate the effects of heat stress-induced apoptosis in porcine cumulus-oocyte complexes (COCs).
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Ruijiao Liu, Tengfei Duan, Li Yu, Yongzhong Tang, Shikun Liu, Chunjiang Wang, Wei-Jin Fang
Summary: This study found that high-fat diet leads to activation of cardiomyocyte ASMase, which increases NOX4 expression and thereby increases oxidative stress and apoptosis, ultimately causing metabolic cardiomyopathy.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cell Biology
Yolanda Leon, Marta Magarinos, Isabel Varela-Nieto
Summary: Sphingolipids play a crucial role in cell membrane structure and function, with ceramide being an essential component for sphingolipid biosynthesis. Ceramide kinase (CERK) phosphorylates ceramide to generate ceramide-1-phosphate, which is a cytoprotective signaling molecule widely studied in various tissues. In the context of inner ear development, CERK is crucial for cell proliferation, apoptosis, and neurogenesis, and is a key component in the pro-survival pathways elicited by insulin-like growth factor-1 (IGF-1).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ragini Singh, Mohit Rajput, Rana P. Singh
Summary: Simulated microgravity (SMG) results in decreased cell proliferation and viability, increased DNA damage and apoptosis, and altered expression of DNA repair genes, leading to changes in DNA repair capacity. These effects may activate apoptotic cell death pathways mediated by ATM/ATR-Chk1/2 and Ku70/80 and DNA-PK.
Article
Biochemistry & Molecular Biology
Sathisaran Umamaheswari, Sheela Priyadarshinee, Krishna Kadirvelu, Mathan Ramesh
Summary: The study elucidates the molecular events underlying apoptosis in the gills of zebrafish exposed to polystyrene microplastics, demonstrating that the exposure induces dose-and time-dependent ROS mediated apoptotic responses. The physiological responses observed in the gills correlate with the molecular mechanisms underpinning the toxicity of PS-MPs in zebrafish.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Organic
Chander Shekhar, Gedu Satyanarayana
Summary: In this study, a triflic acid-driven dual cyclization pathway was developed to produce functionalized molecules from readily available starting materials under metal-free conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Oncology
Ru-Tsun Mai, Chi-Hong Chao, Yao-Wen Chang, Yu-Ching Kao, Yi Cheng, Hsiang -Yu Hsu, Yi-Yuan Su, Chen-Yun Wang, Bo-Ying Lai
Summary: Numerous reports indicate that enhanced expression of Y-box binding protein-1 (YB-1) is strongly associated with tumorigenesis, aggressiveness, drug resistance, as well as poor prognosis in several types of cancers. This study reveals the sumoylation of YB-1 and its crucial role in DNA mismatch repair deficiency and alkylator tolerance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Zhong-Xuan Wang, Yao-Lin Li, Jia-Li Pu, Bao-Rong Zhang
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, and the role of DNA damage and repair deficiency in its pathogenesis has been increasingly recognized. This review provides an overview of the current understanding of DNA damage and repair in PD, including the evidence and causes of DNA damage, the potential pathways linking DNA damage to neurotoxicity, and possible interventions targeting DNA damage and repair. Future research should focus on addressing key issues to further elucidate the role of DNA damage in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Amey Bandekar, Shrirang Karve, Min-Yuan Chang, Qingshan Mu, Jimmy Rotolo, Stavroula Sofou
Article
Biology
Kamal Datta, Shubhankar Suman, Daniela Trani, Kathryn Doiron, Jimmy A. Rotolo, Bhaskar V. S. Kallakury, Richard Kolesnick, Michael F. Cole, Albert J. Fornace
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2012)
Article
Medicine, Research & Experimental
Jimmy Rotolo, Branka Stancevic, Jianjun Zhang, Guoqiang Hua, John Fuller, Xianglei Yin, Adriana Haimovitz-Friedman, Kisu Kim, Ming Qian, Marina Cardo-Vila, Zvi Fuks, Renata Pasqualini, Wadih Arap, Richard Kolesnick
JOURNAL OF CLINICAL INVESTIGATION
(2012)
Article
Immunology
Raymond Schuch, Han M. Lee, Brent C. Schneider, Karen L. Sauve, Christina Law, Babar K. Khan, Jimmy A. Rotolo, Yuki Horiuchi, Daniel E. Couto, Assaf Raz, Vincent A. Fischetti, David B. Huang, Robert C. Nowinski, Michael Wittekind
JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Multidisciplinary Sciences
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
Article
Multidisciplinary Sciences
Sydney X. Lu, Lucy W. Kappel, Anne-Marie Charbonneau-Allard, Renee Atallah, Amanda M. Holland, Claire Turbide, Vanessa M. Hubbard, Jimmy A. Rotolo, Marsinay Smith, David Suh, Christopher King, Uttam K. Rao, Nury Yim, Johanne L. Bautista, Robert R. Jenq, Olaf Penack, Il-Kang Na, Chen Liu, George Murphy, Onder Alpdogan, Richard S. Blumberg, Fernando Macian, Kathryn V. Holmes, Nicole Beauchemin, Marcel R. M. van den Brink
Article
Multidisciplinary Sciences
Branka Stancevic, Nira Varda-Bloom, Jin Cheng, John D. Fuller, Jimmy A. Rotolo, Monica Garcia-Barros, Regina Feldman, Shyam Rao, Ralph R. Weichselbaum, Dror Harats, Adriana Haimovitz-Friedman, Zvi Fuks, Michel Sadelain, Richard Kolesnick
Correction
Multidisciplinary Sciences
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
Article
Oncology
Maria Laura Martin, Mohammad Adileh, Kuo-Shun Hsu, Guoqiang Hua, Sang Gyu Lee, Christy Li, John D. Fuller, Jimmy A. Rotolo, Sahra Bodo, Stefan Klingler, Adriana Haimovitz-Friedman, Joseph O. Deasy, Zvi Fuks, Philip B. Paty, Richard N. Kolesnick
Article
Cell Biology
Charles S. Ferranti, Jin Cheng, Chris Thompson, Jianjun Zhang, Jimmy A. Rotolo, Saha Buddaseth, Zvi Fuks, Richard N. Kolesnick
JOURNAL OF CELL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Jimmy A. Rotolo, Chii Shyang Fong, Sahra Bodo, Prashanth Kb Nagesh, John Fuller, Thivashnee Sharma, Alessandra Piersigilli, Zhigang Zhang, Zvi Fuks, Vijay K. Singh, Richard Kolesnick
Summary: This study identified an anti-ceramide 6B5 single-chain variable fragment (scFv) that mitigated mouse lethality after nuclear attack, initiating tissue repair and promoting survival. Successful preclinical development may lead to inclusion of anticeramide 6B5 scFv in the Strategic National Stockpile for distribution after radiation catastrophe.
Article
Oncology
Emad Darvishi, Lila Ghamsari, Siok F. Leong, Ricardo Ramirez, Mark Koester, Erin Gallagher, Miao Yu, Jody M. Mason, Gene Merutka, Barry J. Kappel, Jim A. Rotolo
Summary: The study reveals the mechanism of action and antitumor activity of ST101, a novel peptide antagonist of C/EBP beta. ST101 inhibits dimerization of C/EBP beta and enhances its degradation, resulting in attenuation of transcription of C/EBP beta target genes and potent tumor-specific cytotoxic activity in various cancer cell lines. In mouse xenograft models, ST101 shows strong inhibition or regression of tumor growth, both as a single agent and in combination studies.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Miao Yu, Lila Ghamsari, Jim A. Rotolo, Barry J. Kappel, Jody M. Mason
Summary: The study focused on developing an antagonist selective for the Fra1 oncogenic transcriptional regulator using library design, computational screening, and intracellular screening. By reducing the library size and enriching for binders with specific criteria, the researchers identified a peptide (Fra1W) that exhibited specificity through a combination of hydrophobic and electrostatic contacts, showing high Fra1 affinity and selective binding. The multidisciplinary approach demonstrated a robust screening pipeline for generating target-specific hits and provided new insights into rational peptide design for novel bZIP family inhibitors.
RSC CHEMICAL BIOLOGY
(2021)
Article
Microbiology
Raymond Schuch, Babar K. Khan, Assaf Raz, Jimmy A. Rotolo, Michael Wittekind
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Cell Biology
Jeanna Jacobi, Monica Garcia-Barros, Shyam Rao, Jimmy A. Rotolo, Chris Thompson, Aviram Mizrachi, Regina Feldman, Katia Manova, Alicja Bielawska, Jacek Bielawska, Zvi Fuks, Richard Kolesnick, Adriana Haimovitz-Friedman
CELLULAR SIGNALLING
(2017)