Editorial Material
Multidisciplinary Sciences
Emma Marris
Summary: This study is one of the few to uncover the behavioral effects of Toxoplasma gondii in wild animals.
Editorial Material
Microbiology
Andrea Du Toit
Summary: During archaeal cell division, FtsZ1 and FtsZ2 have distinct functions.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Education & Educational Research
Eman Naama, Shiri Lavy
Summary: The sense of meaning and self-efficacy of teachers contribute to teacher caring, which in turn affects job satisfaction and burnout levels.
TEACHING AND TEACHER EDUCATION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nuno Raimundo
Summary: Refeeding activates lipophagy in the intestine, facilitating the processing of dietary fats.
Editorial Material
Immunology
Emily E. Thornton, Tal I. Arnon
Summary: Unconventional T cells play important roles in protecting barrier tissues, and they also have the ability to adjust lymph nodes function and influence immune responses.
Article
Cardiac & Cardiovascular Systems
Denuja Karunakaran, My-Anh Nguyen, Michele Geoffrion, Dianne Vreeken, Zachary Lister, Henry S. Cheng, Nicola Otte, Patricia Essebier, Hailey Wyatt, Joshua W. Kandiah, Richard Jung, Francis J. Alenghat, Ana Mompeon, Richard Lee, Calvin Pan, Emma Gordon, Adil Rasheed, Aldons J. Lusis, Peter Liu, Ljubica Perisic Matic, Ulf Hedin, Jason E. Fish, Liang Guo, Frank Kolodgie, Renu Virmani, Janine M. van Gils, Katey J. Rayner
Summary: The study indicates that RIPK1 plays a central role in driving inflammation in atherosclerosis by activating the NF-kappa B pathway and promoting the release of inflammatory cytokines. Knockdown of RIPK1 reduces inflammatory cell activation and protects against the progression of atherosclerosis. These findings suggest RIPK1 as a potential therapeutic target to reduce residual inflammation in patients at high risk of coronary artery disease.
Editorial Material
Plant Sciences
Lena Vlaminck, Birgit Vanden Berghen, Liesbet Vranken, Sofie Goormachtig
Summary: Citizen science is an underappreciated tool that can enhance both fundamental and applied science by going beyond basic data collection. We advocate for the integration of these three disciplines to promote sustainable and adaptive agriculture, using Northwestern European soybean cultivation as a case study.
TRENDS IN PLANT SCIENCE
(2023)
Article
Sport Sciences
Anthony B. Ciccone, Andrew C. Fry, Dawn M. Emerson, Philip M. Gallagher, Trent J. Herda, Joseph P. Weir
Summary: The study found that transspinal direct current stimulation in the thoracic spine did not significantly affect cycling performance or perception of effort. Further research is needed to investigate the efficacy of different stimulation methods in enhancing human performance.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
History & Philosophy Of Science
Wade Munroe
Summary: This paper examines the metaphysics of words, focusing on the process of generating word tokens and their relationship with word types. The paper argues that the process of generating word tokens is guided and explained by an individual's knowledge of the word types.
Article
Astronomy & Astrophysics
Stefan Heimersheim, Nina S. Sartorio, Anastasia Fialkov, Duncan R. Lorimer
Summary: In this study, we apply a model-independent approach to measure reionization using Fast Radio Burst (FRB) data, which can provide more accurate constraints on cosmological parameters such as the CMB optical depth and the shape of reionization.
ASTROPHYSICAL JOURNAL
(2022)
Editorial Material
Cell Biology
Kazushige Shiraishi, Edward E. Morrisey
Summary: This article discusses the guidance role of autonomic nerves in lung development, revealing the communication between myofibroblasts and developing nerves through neurotrophins and neurotransmitters to drive alveologenesis, with planar cell polarity signaling playing a critical role.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Dimitrios Matthaios, Maria Tolia, Davide Mauri, Konstantinos Kamposioras, Michalis Karamouzis
Summary: The YAP and Hippo pathway play crucial roles in immune system and cancer, with effects such as modulating immune response, enhancing tumor microenvironment, and regulating immune suppression, suggesting their potential applications in cancer immunotherapy.
Review
Chemistry, Multidisciplinary
Xinchuan Huang, David W. Schwenke, Timothy J. Lee
Summary: The study discusses the Best Theory + Reliable High-Resolution Experiment (BTRHE) strategy for obtaining accurate molecular rovibrational line lists with InfraRed (IR) intensities. The strategy aims to address the need for assigning rovibrational lines of common stable molecules and characterizing exoplanet atmospheres.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Oncology
Cheng Cui, Theresa Barberi, Rahul Suresh, Alan D. Friedman
Summary: This study found that neuroblastoma cells expressing high levels of MYCN grow slower in mice lacking the p50 subunit in macrophages and neutrophils, and that tumors in these mice have increased T-cell numbers. Depletion of these T-cell populations accelerates tumor growth. Anti-PD-1 T-cell checkpoint blockade and epigenetic inhibition further slow tumor growth. Additionally, adoptive transfer of immature myeloid cells lacking p50 also slows tumor growth, highlighting the potential for targeting myeloid NF-kappa B p50 as a strategy for cancer therapy.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Xin Li, Yinling Hu
Summary: CHUK/IKK alpha has emerged as a novel tumor suppressor in several human and mouse organs, with a strong association with NF-kappa B. However, the roles of IKK alpha and NF-kappa B in normal organ development, disease, and cancer pathogenesis require further investigation.
Review
Biochemistry & Molecular Biology
Bjarki Johannesson, Lina Sui, Donald O. Freytes, Remi J. Creusot, Dieter Egli
Review
Cell & Tissue Engineering
Remi J. Creusot, Manuela Battaglia, Maria-Grazia Roncarolo, C. Garrison Fathman
Article
Medicine, Research & Experimental
Shamael R. Dastagir, Jorge Postigo-Fernandez, Chunliang Xu, James H. Stoeckle, Rebuma Firdessa-Fite, Remi J. Creusot
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2017)
Review
Endocrinology & Metabolism
Remi J. Creusot, Jorge Postigo-Fernandez, Nato Teteloshvili
Article
Medicine, Research & Experimental
Michael J. Kraakman, Qiongming Liu, Jorge Postigo-Fernandez, Ruiping Ji, Ning Kon, Delfina Larre, Maria Namwanje, Lihong Fan, Michelle Chan, Estela Area-Gomez, Wenxian Fu, Remi J. Creusot, Li Qiang
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Editorial Material
Endocrinology & Metabolism
Remi J. Creusot, Nick Giannoukakis, Massimo Trucco, Michael J. Clare-Salzler, C. Garrison Fathman
Article
Endocrinology & Metabolism
Linda Yip, Rebecca Fuhlbrigge, Cariel Taylor, Remi J. Creusot, Teppei Nishikawa-Matsumura, Chan C. Whiting, Jill M. Schartner, Rahima Akter, Matthias von Herrath, C. Garrison Fathman
Article
Cell Biology
Linda Yip, Remi J. Creusot, Cara T. Pager, Peter Sarnow, C. Garrison Fathman
JOURNAL OF MOLECULAR CELL BIOLOGY
(2013)
Article
Immunology
Jorge Postigo-Fernandez, Remi J. Creusot
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Endocrinology & Metabolism
Rebuma Firdessa-Fite, Stephanie N. Johnson, Martin A. Leon, Mohsen Khosravi-Maharlooei, Rocky L. Baker, Joshua O. Sestak, Cory Berkland, Remi J. Creusot
Summary: Utilizing soluble antigen arrays (SAgAs) as a platform for antigen-specific immunotherapy (ASIT) can enhance the treatment efficacy of T1D while mitigating the risks of anaphylaxis.
Review
Biochemical Research Methods
Wei Wang, Remi J. Creusot
Summary: After ten years of development, the optimized multicolor immunofluorescence panel (OMIP) platform has evolved to cover larger panel sizes, increased number of subpopulations, and new species. This review summarizes the content and purpose of this collection for the research community, with the hope that readers will use these panels to enhance and expedite their research.
Article
Multidisciplinary Sciences
Jorge Postigo-Fernandez, Rebuma Firdessa-Fite, Remi J. Creusota
Summary: Antigen-specific immunotherapy using tailored epitopes delivered through proteins, peptides, or nucleic acids can reestablish tolerance and potentially provide precision medicine approach for treating tissue-specific autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biotechnology & Applied Microbiology
Rebuma Firdessa Fite, Camillo Bechi Genzano, Roberto Mallone, Remi J. J. Creusot
Summary: Antigen-specific immunotherapies (ASITs) are important in treating autoimmune diseases, but their effectiveness is influenced by patient characteristics in Type 1 diabetes. Precision medicine targeting specific T cell populations and patient subgroups is a new goal. Profiling methods for antigen-specific T cells need improvement, as well as delivery approaches for tolerance induction. The field is moving toward using patient-specific variations to improve efficacy, but challenges remain.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Wen Du, Junqiang Wang, Taiyi Kuo, Liheng Wang, Wendy M. McKimpson, Jinsook Son, Hitoshi Watanabe, Takumi Kitamoto, Yunkyoung Lee, Remi J. Creusot, Lloyd E. Ratner, Kasi McCune, Ya-Wen Chen, Brendan H. Grubbs, Matthew E. Thornton, Jason Fan, Nishat Sultana, Bryan S. Diaz, Iyshwarya Balasubramanian, Nan Gao, Sandro Belvedere, Domenico Accili
Summary: The study demonstrates the potential of using the intestine as a source for cellular reprogramming to replace lost pancreatic beta cells in diabetes. By ablating FoxO1, the Paneth/goblet cell lineage can be converted into insulin-producing cells. Through a combination treatment targeting FOXO1, Notch, and TGF-beta, near normalization of glucose levels can be achieved in diabetic animals, accompanied by the generation of intestinal insulin-producing cells.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Yang Li, Nato Teteloshvili, Shulian Tan, Samhita Rao, Arnold Han, Yong-Guang Yang, Remi J. Creusot
FRONTIERS IN IMMUNOLOGY
(2019)
