Post-transcriptional coordination of immunological responses by RNA-binding proteins

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

(2014) T. Maruyama et al.   Science Signaling

hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene

(2013) Hyun kyung Oh et al.   APOPTOSIS

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

(2013) Seth A. Brooks et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

(2013) Katharina U. Vogel et al.   IMMUNITY

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation

(2013) Alvin Pratama et al.   IMMUNITY

Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease

(2013) Céline Molle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Posttranscriptional Gene Regulation of IL-17 by the RNA-Binding Protein HuR Is Required for Initiation of Experimental Autoimmune Encephalomyelitis

(2013) J. Chen et al.   JOURNAL OF IMMUNOLOGY

An Extraribosomal Function of Ribosomal Protein L13a in Macrophages Resolves Inflammation

(2013) D. Poddar et al.   JOURNAL OF IMMUNOLOGY

Transforming Growth Factor   Regulates P-Body Formation through Induction of the mRNA Decay Factor Tristetraprolin

(2013) F. F. Blanco et al.   MOLECULAR AND CELLULAR BIOLOGY

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR

(2013) Stanimir S Ivanov et al.   NATURE IMMUNOLOGY

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cold-Inducible RNA-Binding Protein Is an Important Mediator of Alcohol-Induced Brain Inflammation

(2013) Salil R. Rajayer et al.   PLoS One

RNA splicing regulates the temporal order of TNF-induced gene expression

(2013) S. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

(2013) V. R. Moulton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

(2013) Kazuya Masuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Changes in Cellular mRNA Stability, Splicing, and Polyadenylation through HuR Protein Sequestration by a Cytoplasmic RNA Virus

(2013) Michael D. Barnhart et al.   Cell Reports

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

(2013) Isabel X. Wang et al.   Cell Reports

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

(2013) Lesly De Arras et al.   PLoS Genetics

Distinct Translational Control in CD4+ T Cell Subsets

(2013) Eva Bjur et al.   PLoS Genetics

Regulation of stress granules and P-bodies during RNA virus infection

(2013) Richard E. Lloyd   Wiley Interdisciplinary Reviews-RNA

Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory Angiogenesis

(2012) Jiange Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Post-transcriptional control of gene expression by AUF1: Mechanisms, physiological targets, and regulation

(2012) Elizabeth J.F. White et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions

(2012) Dev M. Bhatt et al.   CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis

(2012) C von Roretz et al.   CELL DEATH AND DIFFERENTIATION

Functional Interplay between RNA-Binding Protein HuR and microRNAs

(2012) Subramanya Srikantan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite

(2012) Maria Simarro et al.   IMMUNOLOGY LETTERS

Sequence requirements for RNA binding by HuR and AUF1

(2012) Andrew Barker et al.   JOURNAL OF BIOCHEMISTRY

Antagonistic Function of the RNA-binding Protein HuR and miR-200b in Post-transcriptional Regulation of Vascular Endothelial Growth Factor-A Expression and Angiogenesis

(2012) Sung-Hee Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

(2012) Bárbara González-Terán et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells

(2012) M.-C. Gaudreau et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Specific Tristetraprolin Deficiency in Mice Results in Extreme Lipopolysaccharide Sensitivity in an Otherwise Minimal Phenotype

(2012) L.-Q. Qiu et al.   JOURNAL OF IMMUNOLOGY

Heterotrimeric GAIT Complex Drives Transcript-Selective Translation Inhibition in Murine Macrophages

(2012) A. Arif et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNAs Mediate Gene Silencing via Multiple Different Pathways in Drosophila

(2012) Takashi Fukaya et al.   MOLECULAR CELL

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

Erratum: Regulation of cytoplasmic mRNA decay

(2012) Daniel R. Schoenberg et al.   NATURE REVIEWS GENETICS

Protein–RNA interactions: new genomic technologies and perspectives

(2012) Julian König et al.   NATURE REVIEWS GENETICS

MCPIP1 Down-Regulates IL-2 Expression through an ARE-Independent Pathway

(2012) Min Li et al.   PLoS One

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics and Regulatory Impact of Alternative Polyadenylation in Human B-Lymphoblastoid Cells

(2012) Oh Kyu Yoon et al.   PLoS Genetics

ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes

(2011) K. Mazan-Mamczarz et al.   BLOOD

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR

(2011) C. K. Damgaard et al.   GENES & DEVELOPMENT

Posttranscriptional Silencing of Effector Cytokine mRNA Underlies the Anergic Phenotype of Self-Reactive T Cells

(2011) Alejandro V. Villarino et al.   IMMUNITY

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis

(2011) Anthie Yiakouvaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Zinc Finger Protein Tristetraprolin Interacts with CCL3 mRNA and Regulates Tissue Inflammation

(2011) J.-G. Kang et al.   JOURNAL OF IMMUNOLOGY

Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2

(2011) C. X. George et al.   JOURNAL OF VIROLOGY

Signal- and Development-Dependent Alternative Splicing of LEF1 in T Cells Is Controlled by CELF2

(2011) M. J. Mallory et al.   MOLECULAR AND CELLULAR BIOLOGY

Posttranscriptional Control of Type I Interferon Genes by KSRP in the Innate Immune Response against Viral Infection

(2011) W.-J. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation

(2011) F. Kratochvill et al.   Molecular Systems Biology

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

(2011) Hidenori Iwasaki et al.   NATURE IMMUNOLOGY

Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice

(2011) P. A. Frischmeyer-Guerrerio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designer RNA-binding proteins: New tools for manipulating the transcriptome

(2011) Aleksandra Filipovska et al.   RNA Biology

Strict 3' splice site sequence requirements for U2 snRNP recruitment after U2AF binding underlie a genetic defect leading to autoimmune disease

(2011) A. Corrionero et al.   RNA

Functional diversity of the hnRNPs: past, present and perspectives

(2010) Siew Ping Han et al.   BIOCHEMICAL JOURNAL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

RNA-Binding Protein AUF1 Regulates Lipopolysaccharide-Induced IL10 Expression by Activating I B Kinase Complex in Monocytes

(2010) S. Sarkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

(2010) Florian Heyd et al.   MOLECULAR CELL

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

(2010) Elke Glasmacher et al.   NATURE IMMUNOLOGY

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

(2010) Daniel J Hodson et al.   NATURE IMMUNOLOGY

Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R

(2010) José M. Izquierdo   NUCLEIC ACIDS RESEARCH

AREsite: a database for the comprehensive investigation of AU-rich elements

(2010) A. R. Gruber et al.   NUCLEIC ACIDS RESEARCH

Post-transcriptional regulation in Lymphocytes: The case of CD154

(2010) Stefano Vavassori et al.   RNA Biology

Role of PKR and Type I IFNs in Viral Control during Primary and Secondary Infection

(2010) Yumi Nakayama et al.   PLoS Pathogens

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10

(2009) B. Schaljo et al.   JOURNAL OF IMMUNOLOGY

Dicer-Dependent MicroRNA Pathway Controls Invariant NKT Cell Development

(2009) M. Fedeli et al.   JOURNAL OF IMMUNOLOGY

Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR

(2009) O. Papadaki et al.   JOURNAL OF IMMUNOLOGY

Coordinated posttranscriptional mRNA population dynamics during T-cell activation

(2009) Neelanjan Mukherjee et al.   Molecular Systems Biology

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

(2009) Shengli Hao et al.   NATURE IMMUNOLOGY

RNA granules: post-transcriptional and epigenetic modulators of gene expression

(2009) Paul Anderson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The GAIT system: a gatekeeper of inflammatory gene expression

(2009) Rupak Mukhopadhyay et al.   TRENDS IN BIOCHEMICAL SCIENCES

RNA-binding proteins and post-transcriptional gene regulation

(2008) Tina Glisovic et al.   FEBS LETTERS

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

(2008) J. Weischenfeldt et al.   GENES & DEVELOPMENT

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL

(2008) Zuopeng Wu et al.   IMMUNITY

The RNA-stabilizing Protein HuR Regulates the Expression of ζ Chain of the Human T Cell Receptor-associated CD3 Complex

(2008) Vaishali R. Moulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dicer-dependent microRNA pathway safeguards regulatory T cell function

(2008) Adrian Liston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Auf1/Hnrnpd-Deficient Mice Develop Pruritic Inflammatory Skin Disease

(2008) Navid Sadri et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fas Splicing Regulation during Early Apoptosis Is Linked to Caspase-mediated Cleavage of U2AF65

(2008) José M. Izquierdo   MOLECULAR BIOLOGY OF THE CELL