Editorial Material
Genetics & Heredity
Ivona Aksentijevich
Summary: Immune responses require a delicate balance - too weak or too strong a response can cause issues. Spleen tyrosine kinase plays a crucial role in multiple signaling pathways, and its gain-of-function alterations can lead to various problems, including hypogammaglobulinemia and predisposition to B cell lymphoma.
Article
Nanoscience & Nanotechnology
Yulin Du, Yifan Lyu, Jie Lin, Chunran Ma, Qiang Zhang, Yutong Zhang, Liping Qiu, Weihong Tan
Summary: We manipulated the intermembrane distance between antigen-presenting cells (APCs) and T cells using DNA nanostructures of different sizes. Our results show that the axial distance of the contact zone is critical for T-cell activation, likely through modulating protein reorganization and mechanical force.
NATURE NANOTECHNOLOGY
(2023)
Review
Microbiology
Ioanna Panagi, Teresa L. M. Thurston
Summary: Despite being important for host defences, some intracellular bacteria are able to infect, survive, replicate, and persist in macrophages. This may be due to the heterogeneity of macrophages, which can be divided into pro-inflammatory M1 subset and anti-inflammatory M2 subset. Recent findings suggest that intracellular pathogens can manipulate host cells by activating the STAT3 transcription factor through various mechanisms.
CURRENT OPINION IN MICROBIOLOGY
(2023)
Article
Cell Biology
Hui Yang, Wei Sun, Yan-nan Fan, Shu-yi Li, Ji-qiao Yuan, Zi-qian Zhang, Xu-yu Li, Ming-bao Lin, Qi Hou
Summary: Perilla leaf extract (PLE) exhibits anti-allergic asthma effects by attenuating airway inflammation and might partly mediate through inhibiting the Syk pathway.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biotechnology & Applied Microbiology
Jyoti Rana, Daniel J. Perry, Sandeep R. P. Kumar, Maite Munoz-Melero, Rania Saboungi, Todd M. Brusko, Moanaro Biswas
Summary: Regulatory T cells (Tregs) play a crucial role in modulating immune responses, and redirecting polyclonal Tregs can induce tolerance. In a hemophilia A model, high-affinity chimeric antigen receptor (CAR) Treg cells were able to suppress antibody formation.
Review
Pharmacology & Pharmacy
Yazan Haddad, Marek Remes, Vojtech Adam, Zbynek Heger
Summary: The study utilized variations in 110 crystal structures to assemble eight distinct families highlighting the C-helix orientation in the N-lobe of the EGFR kinase domain. These families shared similar mutational profiles, ligand R-groups facing the C-helix, mutation sites, and DFG domain.
DRUG DISCOVERY TODAY
(2021)
Article
Cell Biology
Jiri Koutnik, Verena Neururer, Thomas Gruber, Sebastian Peer, Natascha Hermann-Kleiter, William J. Olson, Verena Labi, Michael Leitges, Gottfried Baier, Kerstin Siegmund
Summary: The deficiency of PKD3 leads to a skewing of T cell compartment towards an activated phenotype in mice, but it is dispensable for naive CD4(+) T cell differentiation in vitro.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Medicine, Research & Experimental
Ruiyuan Zhang, Ganesan Senthil Kumar, Uwe Hansen, Martina Zoccheddu, Cristiano Sacchetti, Zachary J. Holmes, Megan C. Lee, Denise Beckmann, Yutao Wen, Zbigniew Mikulski, Shen Yang, Eugenio Santelli, Rebecca Page, Francesco Boin, Wolfgang Peti, Nunzio Bottini
Summary: Oxidation of PTP4A1 enhances its association with SRC and its profibrotic action, providing potential routes for developing antifibrotic agents for systemic sclerosis.
Article
Biochemistry & Molecular Biology
Megan Farrell, Andrea C. Nunez, Zhengmin Yang, Pablo Perez-Ferreros, Katharina Gaus, Jesse Goyette
Summary: The study developed a new single-molecule localization microscopy technique pPAINT for visualizing protein binding sites in cellular signaling, by observing the stochastic blinking events necessary for SMLM and quantifying binding coefficients in intact cells.
Article
Immunology
Ryunosuke Muro, Tomoya Narita, Takeshi Nitta, Hiroshi Takayanagi
Summary: We demonstrate that Syk plays a critical role in the early development of γδT cells, as well as in the differentiation of γδT17 cells. Loss of Syk leads to arrested development of γδT cells and a subsequent loss of γδT17 cells, resulting in protection against γδT17-dependent psoriasis-like skin inflammation in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sarah Kowallik, Andreas Kritikos, Matthias Kaestle, Christoph Thurm, Burkhart Schraven, Luca Simeoni
Summary: Experimental data does not support the idea that Cdc37 regulates the activity/stability of Lck, as evidenced by unaffected Lck stability and TCR signaling in T cells with augmented or suppressed Cdc37 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xuejiao Chen, Ziyi Wang, Sheng Han, Zeng Wang, Yu Zhang, Xiangdong Li, Nan Xia, Wenjie Yu, Chenyang Jia, Yong Ni, Liyong Pu
Summary: Liver fibrosis is a danger signal for liver cancer, but there is no effective clinical means to regulate its progress. It has been found that inhibiting SYK in monocyte-derived macrophages may help alleviate chronic liver fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Summer Sofer, Kevin Lamkiewicz, Shir Armoza Eilat, Shirly Partouche, Manja Marz, Neta Moskovits, Salomon M. Stemmer, Amir Shlomai, Ella H. Sklan
Summary: This study identified Hexokinase 1 (HK1) as a top candidate gene associated with tyrosine-kinase inhibitor (TKI) resistance in hepatoma cells. HK1 expression was upregulated in regorafenib-resistant cells, and an HK inhibitor resensitized resistant cells to TKI treatment. These findings suggest that HK1 may serve as a biomarker for treatment success in hepatocellular carcinoma.
Article
Chemistry, Medicinal
Qiangqiang Hou, Wenhua Jiang, Wenqiang Li, Chenyang Huang, Kexin Yang, Xiaoyu Chen, Mengchen Huang, Chengxia Shu, Guangmei Luo, Haopeng Sun, Qian Chu, Xiaoxing Wu
Summary: This study discovered a series of guanidine-based SHP2 allosteric inhibitors, among which compound 23 exhibited potent SHP2 inhibitory activity and showed inhibitory effects on the proliferation, migration, and invasion of pancreatic cancer cells. Compound 23 also demonstrated favorable in vivo pharmacokinetic properties and significant antitumor efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Yun-Yi Li, Haohua Cen, Bei-Ni Gong, Siqi Mai, Qi-Long Wang, Sisi Mou, Yingqiu Li
Summary: Phosphorylation of SENP1 at Y270 induced by TCR stimulation enhances its isopeptidase activity and specifically decreases its endopeptidase activity against pre-SUMO3, finely tuning T cell activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
