The long and winding road from correlation to causation

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

(2010) Natalie J. Prescott et al.   HUMAN MOLECULAR GENETICS

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

(2010) Yukihide Momozawa et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Demonstrating polymorphic miRNA-mediated gene regulation in vivo: Application to the g+6223G->A mutation of Texel sheep

(2010) H. Takeda et al.   RNA

Death and Resurrection of the Human IRGM Gene

(2009) Cemalettin Bekpen et al.   PLoS Genetics

Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients

(2008) K Yamazaki et al.   GUT

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS