A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity

Measuring Electrostatic Fields in Both Hydrogen-Bonding and Non-Hydrogen-Bonding Environments Using Carbonyl Vibrational Probes

(2013) Stephen D. Fried et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

(2012) Jin H. Park et al.   BIOCHEMICAL JOURNAL

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation

(2012) Jon M. Steichen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of human CDC7 kinase in complex with its activator DBF4

(2012) Siobhan Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain

(2012) Nicholas M. Levinson et al.   PLoS One

Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition

(2012) Ketan S. Gajiwala et al.   STRUCTURE

Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy

(2011) M. Campone et al.   ANNALS OF ONCOLOGY

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

DFT Study of [2.2]-, [3.3]-, and [4.4]Paracyclophanes: Strain Energy, Conformations, and Rotational Barriers

(2011) Steven M. Bachrach   JOURNAL OF PHYSICAL CHEMISTRY A

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

(2009) M. A. Seeliger et al.   CANCER RESEARCH

Impact of Environmental Tobacco Smoke on the Incidence of Mutations in Epidermal Growth Factor Receptor Gene in Never-Smoker Patients With Non–Small-Cell Lung Cancer

(2009) Young Joo Lee et al.   JOURNAL OF CLINICAL ONCOLOGY

Probability Distributions of Hydration Water Molecules around Polar Protein Atoms Obtained by a Database Analysis

(2009) Daisuke Matsuoka et al.   JOURNAL OF PHYSICAL CHEMISTRY B

MSDmotif: exploring protein sites and motifs

(2008) Adel Golovin et al.   BMC BIOINFORMATICS

Nitrile and thiocyanate IR probes: Quantum chemistry calculation studies and multivariate least-square fitting analysis

(2008) Jun-Ho Choi et al.   JOURNAL OF CHEMICAL PHYSICS

Activity of Bosutinib, Dasatinib, and Nilotinib Against 18 Imatinib-Resistant BCR/ABL Mutants

(2008) Sara Redaelli et al.   JOURNAL OF CLINICAL ONCOLOGY

A conserved protonation-dependent switch controls drug binding in the Abl kinase

(2008) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial expression and purification of Interleukin-2 Tyrosine kinase: Single step separation of the chaperonin impurity

(2008) Raji E. Joseph et al.   PROTEIN EXPRESSION AND PURIFICATION