Article
Oncology
Rohan R. Katipally, Sean P. Pitroda, Ralph R. Weichselbaum, Samuel Hellman
Summary: The oligometastasis hypothesis suggests that metastases exist on a spectrum and are not always disseminated. Identifying patients most likely to have an oligometastatic phenotype is difficult. Recent research on epigenetic regulators of epithelial-mesenchymal transition (EMT) has shed light on the emergence of a spectrum of metastatic behavior.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ester Sanchez-Tillo, Leire Pedrosa, Ingrid Vila, Yongxu Chen, Balazs Gyorffy, Lidia Sanchez-Moral, Laura Siles, Juan J. Lozano, Anna Esteve-Codina, Douglas S. Darling, Miriam Cuatrecasas, Antoni Castells, Joan Maurel, Antonio Postigo
Summary: Mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 has opposite functions in KRAS- and BRAF-mutant CRCs. In KRAS-mutant CRCs, ZEB1 is associated with worse prognosis and more undifferentiated tumors, while in BRAF-mutant CRCs, ZEB1 is associated with better prognosis and more differentiated tumors. ZEB1 is positively correlated with gene signatures for EMT, cell proliferation and survival, and ERK signaling in KRAS-mutant CRC cells, but negatively correlated in BRAF-mutant CRC cells. ZEB1 may function as a tumor suppressor in BRAF-mutant CRCs.
Article
Pharmacology & Pharmacy
Bo Chen, Xiaoli Li, Lihong Wu, Duanfang Zhou, Yi Song, Limei Zhang, Qiuya Wu, Qichen He, Gang Wang, Xu Liu, Hui Hu, Weiying Zhou
Summary: Quercetin significantly inhibits the viability, migration, and invasion ability of glioblastoma cells both in vitro and in vivo. This is achieved by suppressing the GSK-3 beta/beta-catenin/ZEB1 signaling pathway and reversing the EMT-like mesenchymal phenotype.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meng Chen, Liying Shan, Ying Gan, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 plays a role in osteoblast differentiation and bone homeostasis by regulating Src-Wnt/beta-catenin signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
PanFeng Feng, LongXun Zhu, Jing Jie, PengXiang Yang, Nan Sheng, XiangFan Chen, Xia Chen
Summary: The non-psychoactive phytocannabinoid cannabidiol (CBD) effectively inhibits the migration and metastasis of colorectal cancer (CRC) cells by regulating the EMT process and suppressing the Wnt/β-catenin signaling pathway. This study provides the first evidence for the molecular mechanism of CBD in inhibiting EMT and metastasis in CRC cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Shaomin Shi, Chongyang Li, Yanli Zhang, Chaowei Deng, Wei Liu, Juan Du, Qian Li, Yacong Ji, Leiyang Guo, Lichao Liu, Huanrong Hu, Yaling Liu, Hongjuan Cui
Summary: DHC treatment inhibits cell proliferation and migration of melanoma cells by down-regulating beta-catenin and its downstream proteins, suggesting a potential therapeutic strategy for human melanoma through the beta-catenin pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Mei Sun, Saisai Huang, Yongtao Gao
Summary: Lidocaine, as an amide local anesthetic, has been found to inhibit proliferation and metastasis of epithelial ovarian cancer (EOC) cells through the Wnt/beta-catenin signaling pathway. This leads to the downregulation of Snail and vimentin, and the upregulation of E-cadherin, ultimately suppressing epithelial-mesenchymal transition progression in EOC. Additionally, overexpressed Wnt can reverse the antitumor effect of lidocaine, while Wnt inhibitor XAV-939 synergistically enhances the effect of lidocaine.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Oncology
Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu, Jose N. Onuchic, Herbert Levine
Summary: Cancer cells exhibit plasticity in adjusting their metabolic phenotypes for survival and metastasis, with the developmental programme of epithelial-to-mesenchymal transition (EMT) playing a crucial role. The correlation between metabolic changes and EMT, as well as the extensive crosstalk between them, remains poorly understood, compromising the effectiveness of metabolic therapies targeting metastasis.
BRITISH JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Qi Qin, Bingwei Yang, Zixuan Liu, Lei Xu, Erqun Song, Yang Song
Summary: The study found that the metabolite PCB29-pQ of polychlorinated biphenyls can induce the metastasis of breast cancer by increasing the expression of cancer stem cell markers and activating the Wnt/beta-catenin pathway, with the overproduction of reactive oxygen species playing a key role in this process.
Article
Cell Biology
Lisa Donker, Ronja Houtekamer, Marjolein Vliem, Francois Sipieter, Helena Canever, Manuel Gomez-Gonzalez, Miquel Bosch-Padros, Willem-Jan Pannekoek, Xavier Trepat, Nicolas Borghi, Martijn Gloerich
Summary: Epithelial cells adapt their rate of cell division by sensing changes in cell number through mechanosensitive E-cadherin adhesions, which control G2/M cell-cycle progression.
Article
Cell Biology
Yan Sun, Lin Wang, Xuehu Xu, Puqing Han, Jinghao Wu, Xuan Tian, Mingsong Li
Summary: The study demonstrated that downregulated FOXO4 in CRC tissues inhibits migration and metastasis of CRC cells by upregulating APC2 expression and enhancing beta-catenin degradation. Overexpressed FOXO4 suppressed the expression of stemness genes, epithelial-mesenchymal transition, migration of CRC cell lines, and metastasis in nude mice, which was reversed by APC2 knockdown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liang-yun Li, Jun-fa Yang, Fan Rong, Zhi-pan Luo, Shuang Hu, Hui Fang, Ying Wu, Rui Yao, Wei-hao Kong, Xiao-wen Feng, Bang-jie Chen, Jun Li, Tao Xu
Summary: ZEB1 plays a crucial role in hepatocellular carcinoma (HCC) by promoting cell proliferation, migration, and invasion through activating the Wnt/β-catenin signaling pathway. Meanwhile, miR-708 inhibits the growth and metastasis of HCC cells by targeting ZEB1.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Xiaohui Guo, Yatian Li, Xiaofang Che, Kezuo Hou, Xiujuan Qu, Ce Li
Summary: The expression of microRNA-569 is down-regulated in pancreatic cancer, and its over-expression inhibits cell migration and invasion, acting as a tumor-suppressing factor. Moreover, microRNA-569 is involved in the regulation of genes including NUSAP1 and ZEB1 in pancreatic cancer cells.
Article
Surgery
Sam E. Mason, Eftychios Manoli, James L. Alexander, Liam Poynter, Lauren Ford, Petra Paizs, Afeez Adebesin, James S. McKenzie, Francesca Rosini, Rob Goldin, Ara Darzi, Zoltan Takats, James M. Kinross
Summary: This study used REIMS to analyze the lipid composition of colorectal tissues and evaluate its accuracy for real-time tissue recognition and risk stratification. The results showed that REIMS can differentiate samples of carcinoma, adenoma, and normal mucosa with 93.1% accuracy and 96.1% negative predictive value for carcinoma. It can also predict the presence of neoplasia (carcinoma or adenoma) with 96.0% accuracy and 91.8% negative predictive value. In addition, the study identified unique lipidomic features associated with colorectal carcinogenesis, such as the progressive increase in relative abundance of phosphatidylglycerols, sphingomyelins, and monounsaturated fatty acid-containing phospholipids.
Article
Biochemistry & Molecular Biology
Naila Rabbani, Antonysunil Adaikalakoteswari, James R. R. Larkin, Sianna Panagiotopoulos, Richard J. J. MacIsaac, Dennis K. K. Yue, Gregory R. R. Fulcher, Matthew A. A. Roberts, Merlin A. Thomas, Elif Ekinci, Paul J. J. Thornalley
Summary: Accumulation of advanced glycation endproducts (AGEs) is associated with decline in renal function, particularly in diabetic patients. This study evaluated levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2-4 chronic kidney disease (CKD), and identified a specific AGE, methylglyoxal-derived hydroimidazolone (MG-H1) free adduct, as the most responsive to CKD status and diabetes. The concentration of MG-H1 free adduct in serum was strongly related to CKD stage and increased in diabetes. This suggests that serum MG-H1 free adduct may serve as a potential AGE risk marker for diabetic and non-diabetic CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Clare McGenity, Rebecca Randell, Christopher Bellamy, Alastair Burt, Alyn Cratchley, Robert Goldin, Stefan G. Hubscher, Desley A. H. Neil, Alberto Quaglia, Dina Tiniakos, Judy Wyatt, Darren Treanor
Summary: This study surveyed members of the UK Liver Pathology Group to understand their attitudes and priorities towards digital pathology and artificial intelligence in liver disease. The majority of liver pathologists in the UK are in favor of using digital pathology and AI in clinical practice, research, and education.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Biochemical Research Methods
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Summary: In this paper, a method of lung nodule image acquisition and analysis using a micro-computed tomography scanner is introduced for translational research in lung cancer that closely mimics clinical environments. The method has the advantages of low radiation dose, high resolution, and high-throughput imaging, and utilizes specific image analysis tools for identifying different types of lung tumors.
Article
Cell Biology
Elliot H. H. Akama-Garren, Paul Miller, Thomas M. M. Carroll, Michael Tellier, Gopinath Sutendra, Ludovico Buti, Justyna Zaborowska, Robert D. D. Goldin, Elizabeth Slee, Francis G. G. Szele, Shona Murphy, Xin Lu
Summary: Maintaining a balance between tolerance and autoimmunity is crucial for preventing human diseases. The protein p53 and its regulator iASPP play important roles in immunological tolerance and tumorigenesis. Deficiency in iASPP promotes tumor development but reduces susceptibility to autoimmune diseases. Furthermore, iASPP-deficient tumors exhibit immunosuppression characteristics, suggesting potential therapeutic opportunities for targeting the iASPP/p53 axis in autoimmune diseases and cancer.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Karl King Yong, Yun He, Hoi Ching Annie Cheung, Ramya Sriskandarajah, William Jenkins, Robert Goldin, Sabina Beg
Summary: This study aimed to determine if combining multiple small colorectal polyps in a single specimen pot can reduce carbon footprint without negatively impacting clinical outcomes. Results showed that consolidating small polyps could decrease carbon footprint, but may also result in missing advanced lesions. Therefore, changing practice at a national level could amplify the reduction in carbon footprint from judicious use of specimen pots.
FRONTLINE GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ayse Ertay, Rob M. Ewing, Yihua Wang
Summary: PTEN is a tumor suppressor gene that inhibits the oncogenic AKT signaling pathway by dephosphorylating PIP3 into PIP2. Inactive PTEN is associated with aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes like PTEN is challenging, thus synthetic lethality studies targeting downstream signaling pathways have gained importance. This review focuses on potential synthetic lethality genes discovered in PTEN-inactive cancer types, which could serve as targeted therapies and improve response rates for aggressive types of cancer.
Article
Biochemistry & Molecular Biology
Paul Miller, Elliot H. Akama-Garren, Richard P. Owen, Constantinos Demetriou, Thomas M. Carroll, Elizabeth Slee, Khatoun Al Moussawi, Michael Ellis, Robert Goldin, Eric O'Neill, Xin Lu
Summary: iASPP is an inhibitor of p53 that suppresses inflammation and oncogenic KRAS-driven pancreatic cancer tumorigenesis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Nila Jambulingam, Roberta Forlano, Benjamin Preston, Benjamin H. Mullish, Greta Portone, Yama Baheer, Michael Yee, Robert D. Goldin, Mark R. Thursz, Pinelopi Manousou
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, and fibrosis stage is an important predictor for clinical outcomes. This study investigates the metabolic profile of NAFLD patients in relation to fibrosis progression. The results show that a combination of metabolites and lipoproteins can accurately identify fast fibrosis progressors and perform better than noninvasive markers. These specific metabolic profiles can predict fibrosis progression in patients with NAFLD, and algorithms combining metabolites and lipids could be used for risk stratification of these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Emma Rose McGlone, Matthieu Siebert, Marian Dore, David C. D. Hope, Iona Davies, Bryn Owen, Bernard Khoo, Rob Goldin, Dave Carling, Stephen Bloom, Maude Le Gall, Tricia M-M. Tan
Summary: The study investigated the effects of sleeve gastrectomy on weight-independent improvements in liver steatosis in mice with diet-induced obesity. It was found that VSG not only improves liver fat content but also enhances insulin and glucagon sensitivity.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Diego Calvisi, Luke Boulter, Javier Vaquero, Anna Saborowski, Luca M. Fabris, Pedro Rodrigues, Cedric E. Coulouarn, Rui Castro, Oreste Segatto, Chiara Raggi, Luc J. W. van der Laan, Guido Carpino, Benjamin Goeppert, Stephanie J. Roessler, Timothy Kendall, Matthias Evert, Ester W. Gonzalez-Sanchez, Juan Valle, Arndt Vogel, John J. Bridgewater, Mitesh J. Borad, Gregory R. Gores, Lewis Roberts, Jose J. G. B. Marin, Jesper Andersen, Domenico Alvaro, Alejandro M. Forner, Jesus Banales, Vincenzo Cardinale, Rocio I. R. Macias, Silve Vicent, Xin Chen, Chiara Braconi, Monique M. A. Verstegen, Laura Fouassier, Lewis Roberts, Alexander Scheiter, Florin M. Selaru, Katja Evert, Kirsten Utpatel, Laura Broutier, Massimiliano Cadamuro, Meritxell Huch, Robert Goldin, Sergio A. Gradilone, Yoshimasa Saito
Summary: In this Consensus Statement, experts provide recommendations on the criteria for preclinical models of cholangiocarcinoma (CCA) to increase disease understanding and develop novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Yuan, Guoqiang Qiao, Jiajiao Zhou, Yilu Zhou, Yali Li, Xia Li, Zhenglin Jiang, Yihua Wang
Summary: This study investigated the protective mechanism of repetitive hyperbaric oxygen (HBO) treatment against pulmonary fibrosis. By analyzing expression data from mouse models and IPF patients, potential mechanisms related to IPF pathology, including epithelial-to-mesenchymal transition (EMT) and glycolysis, were identified. High EMT or glycolysis scores were strong independent predictors of mortality. These processes were potentially driven by hypoxia and blocked by HBO treatment. These data support HBO treatment as a viable strategy against pulmonary fibrosis.
Article
Multidisciplinary Sciences
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Summary: Immune checkpoint inhibitors (CPIs) are a new cancer treatment that can potentially cure previously untreatable diseases. However, they can also cause off-target immune-mediated tissue injury. Researchers found that CPI-colitis in mice depends on the composition of the intestinal microbiota and the expression of certain immune molecules. Targeting these factors may hold the key to reversing CPI-colitis.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Shreya Kailas Lovlekar, Yihua Wang
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
