Article
Biochemistry & Molecular Biology
Haizhen Yu, Chenfei Zhang, Jie Xia, Bo Xu
Summary: This study demonstrates that aerobic treadmill exercise for APP/PS1 mice can enhance hippocampal neurogenesis by improving the microenvironment, promoting new cell proliferation and differentiation, ultimately leading to improved learning and memory capacity in Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jin-Xiu Pan, Daehoon Lee, Dong Sun, Kai Zhao, Lei Xiong, Hao-Han Guo, Xiao Ren, Peng Chen, Raquel Lopez de Boer, Yuyi Lu, Helena Lin, Lin Mei, Wen-Cheng Xiong
Summary: Alzheimer's disease (AD) patients often suffer from severe sarcopenia. This study using transgenic mice found that the expression of APP(swe) in skeletal muscles leads to systemic and hippocampal inflammation, deficits in neurogenesis and blood-brain barrier, and depression-like behaviors, revealing a link between sarcopenia and AD, as well as an axis of muscular APP(swe) to brain in AD development.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Mei Jiang, Hai-Tao Tu, Ke Zhang, Wei Zhang, Wei-Ping Yu, Jie Xu, Eng-King Tan, Kai-Hua Guo, Li Zeng
Summary: The VPS35 D620N mutation impairs adult hippocampal neurogenesis in transgenic mice, resulting in reduced neural stem cell pool, proliferation, and differentiation, as well as impaired migration and neurite outgrowth. Furthermore, the mutation hyperphosphorylates amyloid precursor protein (APP) and interacts with it, while loss of APP function rescues the inhibited neurogenesis, migration, and maturation caused by the VPS35 D620N mutation.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Raquel Coronel, Adela Bernabeu-Zornoza, Charlotte Palmer, Rosa Gonzalez-Sastre, Andreea Rosca, Patricia Mateos-Martinez, Victoria Lopez-Alonso, Isabel Liste
Summary: This study investigates the effects of amyloid precursor protein (APP) overexpression on human neural stem cells (hNSCs) and identifies differentially expressed genes related to neuronal and glial differentiation processes, as well as signaling pathways such as Notch, Wnt, PI3K-AKT, and JAK-STAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Titanilla Szogi, Emoke Borbely, Ildiko Schuster, Zsolt Bozso, Miklos Santha, Melinda E. Toth, Botond Penke, Livia Fulop
Summary: This study examines the longitudinal alterations in neurogenesis, neuroinflammation, and AD pathology in a transgenic mouse model, and evaluates the potential beneficial effects of long-term P33 treatment on AD-specific neurological changes. The findings suggest that early pharmacological treatment may ameliorate neurological decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Raquel Coronel, Victoria Lopez-Alonso, Marta I. Gallego, Isabel Liste
Summary: This article investigates the biological role of APP in hNSCs cells, revealing its association with cell proliferation and cell fate specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Lili Chen, Qin Qin, Panchuan Huang, Fangli Cao, Maojia Yin, Yachen Xie, Wuchao Wang
Summary: Chronic neuropathic pain may lead to cognitive impairment in elderly patients, possibly due to the inhibitory effect of CCL2/CCR2 signaling on hippocampal neurogenesis.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biology
Karen Arnaud, Vanessa Oliveira Moreira, Jean Vincent, Glenn Dallerac, Chantal Dubreuil, Edmond Dupont, Max Richter, Ulrike C. Mueller, Laure Rondi-Reig, Alain Prochiantz, Ariel A. Di Nardo
Summary: Elevated APP levels in the choroid plexus impact proliferation in neurogenic niches and long-term expression of mutated APP in the choroid plexus leads to reduced hippocampus function and behavioral deficits. Targeting APP in the choroid plexus may provide a means to improve brain function and alleviate disease-related burdens.
LIFE SCIENCE ALLIANCE
(2021)
Article
Chemistry, Medicinal
Hong-He Xiao, Ji-Cong Chen, He Li, Rui-Hai Li, Hai-Bo Wang, Hui-Peng Song, Hong-Yan Li, Guo-Shun Shan, Yu Tian, Yu-Meng Zhao, Jin-Ming Tian, Jing-Xian Yang
Summary: The study demonstrated that ICS II could improve neurogenesis dysfunction and inhibit mitochondrial fission by activating the Wnt/beta-catenin signaling pathway, thereby promoting the restoration of cognitive function in APP/PS1 mice.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Kaili Lin, Stephen Cho-Wing Sze, Bin Liu, Zhang Zhang, Zhu Zhang, Peili Zhu, Ying Wang, Qiudi Deng, Ken Kin-Lam Yung, Shiqing Zhang
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder. Enhancing hippocampal neurogenesis through compounds like 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) found in ginseng can alleviate cognitive deficits in animal models by activating the Wnt/GSK3 beta/beta-catenin pathway.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Neurosciences
Li -Jun Deng, Dan Wu, Xiao-Fan Yang, Tao Li
Summary: Alzheimer's disease is a common neurodegenerative disease with no effective treatment. miR-146a-5p plays a significant role in regulating adult hippocampal neurogenesis. This study investigates the involvement of miR-146a-5p in the mechanisms of Alzheimer's disease, and shows that miR-146a-5p can be a potential target for therapeutic intervention.
Article
Biochemistry & Molecular Biology
Xiao-Qian Ren, Xin Huang, Shu-Yun Xing, Yan Long, Dan-Hua Yuan, Hao Hong, Su-Su Tang
Summary: Clinical and experimental studies indicate that the reduction of estrogen is a major factor in the high incidence of Alzheimer's disease (AD) in older women, but there is no effective drug for AD treatment currently available. In this study, we investigated the neuro-protective effects of a novel compound called FMDB in APP/PS1 transgenic mice. FMDB improved cognitive impairment, increased neurogenesis, and prevented apoptotic responses in the hippocampus of APP/PS1 mice. Importantly, FMDB activated nuclear and membrane estrogen receptor beta (ER beta) mediated signaling pathways in the hippocampus. These findings lay the groundwork for the development of new anti-AD drugs.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Neurosciences
Yang Zhao, Jian Bao, Wei Liu, Xiaokang Gong, Zheng Liang, Wenshuang Li, Mengjuan Wu, Yifan Xiao, Binlian Sun, Xiaochuan Wang, Jian-Zhi Wang, Jun Wang, Xiji Shu
Summary: The study demonstrated that one-month MWM training in APP/PS1 mice could attenuate Aβ deposition, decrease BACE1 and AβPP expression, and have long-term effects, while also increasing synapse-related protein expression in the hippocampus. MWM training also increased adult hippocampal neurogenesis in AD model mice, but did not alleviate cognitive deficits at an early stage.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Diego Iacono, Erin K. Murphy, Soundarya S. Avantsa, Daniel P. Perl, Regina M. Day
Summary: The study found changes in neuronal protein levels of the brain after low-dose radiation, without causing significant neurohistological changes, except for astrogliosis in the hippocampus. These findings suggest that brain radiation may be a potential tool to interfere with the accumulation of specific proteins linked to various neurodegenerative disorders.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Fangfang Qi, Zejie Zuo, Kaishun Hu, Rui Wang, Tong Wu, Hao Liu, Jiaoling Tang, Qingbo Wang, Yufeng Xie, Liren Tan, Yunjie Yang, Xiaoran Zhang, Jiaying Zheng, Jie Xu, Zhibin Yao, Shengwen Wang, Long-Jun Wu, Kaihua Guo
Summary: This study investigated the regulation of innate immunity by wild-type serum injection in an AD mouse model. Treatment with wild-type serum reduced the number of neutrophils and microglial reactivity in the AD mouse brains. Serum proteomic analysis identified VEGF-A and CXCL1 as factors enriched in serum samples, which are crucial for neutrophil migration and chemotaxis, leukocyte migration, and cell chemotaxis.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
H. Mohammad, F. Marchisella, S. Ortega-Martinez, P. Hollos, K. Eerola, E. Komulainen, N. Kulesskaya, E. Freemantle, V. Fagerholm, E. Savontous, H. Rauvala, B. D. Peterson, H. van Praag, E. T. Coffey
MOLECULAR PSYCHIATRY
(2018)
Review
Physiology
Carmen Vivar, Henriette van Praag
Article
Medicine, Research & Experimental
C'iana Cooper, Hyo Youl Moon, Henriette van Praag
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2018)
Article
Multidisciplinary Sciences
Se Hoon Choi, Enjana Bylykbashi, Zena K. Chatila, Star W. Lee, Benjamin Pulli, Gregory D. Clemenson, Eunhee Kim, Alexander Rompala, Mary K. Oram, Caroline Asselin, Jenna Aronson, Can Zhang, Sean J. Miller, Andrea Lesinski, John W. Chen, Doo Yeon Kim, Henriette van Praag, Bruce M. Spiegelman, Fred H. Gage, Rudolph E. Tanzi
Article
Neurosciences
Minjie Shen, Feifei Wang, Meng Li, Nirnath Sah, Michael E. Stockton, Joseph J. Tidei, Yu Gao, Tomer Korabelnikov, Sudharsan Kannan, Jason D. Vevea, Edwin R. Chapman, Anita Bhattacharyya, Henriette van Praag, Xinyu Zhao
NATURE NEUROSCIENCE
(2019)
Article
Neurosciences
Hyo Youl Moon, Sahar Javadi, Matthew Stremlau, Kyeong Jin Yoon, Benjamin Becker, Sung-Ung Kang, Xinyu Zhao, Henriette van Praag
Article
Neurosciences
Julia Terreros-Roncal, Miguel Flor-Garcia, Elena P. Moreno-Jimenez, Noemi Pallas-Bazarra, Alberto Rabano, Nirnath Sah, Henriette van Praag, Damiana Giacomini, Alejandro F. Schinder, Jesus Avila, Maria Llorens-Martin
JOURNAL OF NEUROSCIENCE
(2019)
Review
Behavioral Sciences
Michelle W. Voss, Carmen Soto, Seungwoo Yoo, Matthew Sodoma, Carmen Vivar, Henriette van Praag
TRENDS IN COGNITIVE SCIENCES
(2019)
Article
Neurosciences
Catherine A. Schweppe, Caitlin Burzynski, Subramaniam Jayanthi, Bruce Ladenheim, Jean Lud Cadet, Eliot L. Gardner, Zheng-Xiong Xi, Henriette van Praag, Amy Hauck Newman, Thomas M. Keck
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Yuyoung Joo, Yutong Xue, Yue Wang, Ross A. McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P. Mattson, Henriette van Praag, Alexei Sharov, Weidong Wang
NATURE COMMUNICATIONS
(2020)
Review
Multidisciplinary Sciences
Xinyu Zhao, Henriette van Praag
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Thomas H. Lee, Brian R. Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-yu Yau
Summary: This study found that low-dose AdipoRon treatment promoted hippocampal cell proliferation in mice, while high-dose AdipoRon treatment had detrimental effects on hippocampal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Julian M. Gaitan, Hyo Youl Moon, Matthew Stremlau, Dena B. Dubal, Dane B. Cook, Ozioma C. Okonkwo, Henriette van Praag
Summary: Research suggests that aerobic exercise training can increase plasma CTSB levels, and changes in CTSB are correlated with cognitive performance. BDNF levels decreased with exercise training, while klotho levels remained unchanged but were closely related to changes in VO(2)peak. Metabolomic analysis showed an increase in PUFAs, reductions in ceramides, sphingo- and phospholipids, as well as changes in gut microbiome metabolites and redox homeostasis with exercise training.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Seungwoo Yoo, Matthew Stremlau, Alejandro Pinto, Hyewon Woo, Olivia Curtis, Henriette van Praag
Summary: This research found that combination treatment of atorvastatin and Captopril can accelerate memory extinction in adult mice, but does not affect hippocampal neurogenesis and vascularization. In middle-aged mice, the combo treatment does not improve spatial memory, but can reduce anxiety.
Editorial Material
Cell Biology
Alejandro Pinto, Henriette van Praag
