Bacterial type I signal peptidases as antibiotic targets

Traffic Jam at the Bacterial Sec Translocase: Targeting the SecA Nanomotor by Small-Molecule Inhibitors

(2011) Kenneth Segers et al.   CHEMISTRY & BIOLOGY

Initial Efforts toward the Optimization of Arylomycins for Antibiotic Activity

(2011) Tucker C. Roberts et al.   JOURNAL OF MEDICINAL CHEMISTRY

In VitroActivities of Arylomycin Natural-Product Antibiotics againstStaphylococcus epidermidisand Other Coagulase-Negative Staphylococci

(2010) Peter A. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Broad-Spectrum Antibiotic Activity of the Arylomycin Natural Products Is Masked by Natural Target Mutations

(2010) Peter A. Smith et al.   CHEMISTRY & BIOLOGY

Intramolecular Suzuki-Miyaura Reaction for the Total Synthesis of Signal Peptidase Inhibitors, Arylomycins A2 and B2

(2010) Jeremy Dufour et al.   CHEMISTRY-A EUROPEAN JOURNAL

Newer antibacterial drugs for a new century

(2010) Gina Devasahayam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Postgenomic strategies in antibacterial drug discovery

(2010) Heike Brötz-Oesterhelt et al.   Future Microbiology

Type I Signal Peptidase and Protein Secretion in Staphylococcus epidermidis

(2010) M. E. Powers et al.   JOURNAL OF BACTERIOLOGY

Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway

(2010) D. Chen et al.   MICROBIOLOGY-SGM

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2and a β-Sultam Inhibitor

(2009) Chuanyun Luo et al.   BIOCHEMISTRY

Substrate based peptide aldehyde inhibits bacterial type I signal peptidase

(2009) Peter Buzder-Lantos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase

(2009) David A. Harris et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments

(2009) Yadunanda Kumar et al.   Cell Host & Microbe

Enzymatic investigation of theStaphylococcus aureustype I signal peptidase SpsB - implications for the search for novel antibiotics

(2009) Smitha Rao et al.   FEBS Journal

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors

(2009) Katrijn Bockstael et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis

(2009) K. Bockstael et al.   MICROBIOLOGY-SGM

Bacterial gene amplification: implications for the evolution of antibiotic resistance

(2009) Linus Sandegren et al.   NATURE REVIEWS MICROBIOLOGY

Solution NMR of signal peptidase, a membrane protein

(2008) Monika Musial-Siwek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Small Subset of Signal Peptidase Residues are Perturbed by Signal Peptide Binding

(2008) Monika Musial-Siwek et al.   Chemical Biology & Drug Design

An Anti-microbial Peptide Derivative of Flesh Fruit Fly Mimics Secretory Signal Sequence and Inhibits Signal Peptidase-I in the Export Pathway

(2008) Naheed N. Kaderbhai et al.   International Journal of Peptide Research and Therapeutics

Recent Developments in Fragment-Based Drug Discovery

(2008) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mining microbial genomes for new natural products and biosynthetic pathways

(2008) G. L. Challis   MICROBIOLOGY-SGM

Unconventional serine proteases: Variations on the catalytic Ser/His/Asp triad configuration

(2008) Özlem Doğan Ekici et al.   PROTEIN SCIENCE

Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—Distinct translocases and mechanisms

(2007) Paolo Natale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES