Article
Biochemistry & Molecular Biology
Matin Miryeganeh, Hidetoshi Saze
Summary: This study presents the transcriptome of the widely distributed mangrove Rhizophora stylosa and examines its response to salt stress, providing insights into the molecular mechanisms underlying stress response in mangroves and other plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ika Qurrotul Afifah, Indra Wibowo, Ahmad Faizal
Summary: The aim of this study was to isolate and characterize the gene sequence and predicted protein sequence of Talinum paniculatum beta-amyrin synthase (bAS), a key enzyme involved in the production of oleanane-type saponins. Additionally, the study analyzed the correlation between TpbAS gene expression and saponin production in different plant organs. The results showed that TpbAS is closely related to other plant oxidosqualene cyclase groups and saponins are mainly synthesized and accumulated in the leaves. These findings have implications for increasing saponin content through metabolic engineering.
Review
Plant Sciences
Karina Kalasuba, Mia Miranti, Sri Rejeki Rahayuningsih, Wahyu Safriansyah, Rizky Riscahya Pratama Syamsuri, Kindi Farabi, Dina Oktavia, Arshad Naji Alhasnawi, Febri Doni
Summary: The red mangrove (Rhizophora stylosa Griff.) is a common species in the mangrove ecosystem of Indonesia, and it is rich in various medicinal compounds. It has anti-inflammatory, antibacterial, antioxidant, and antipyretic effects, and is widely used in traditional medicine.
Article
Plant Sciences
Thobias M. Kalenga, Jackson T. Mollel, Joanna Said, Andreas Orthaber, Jas S. Ward, Yoseph Atilaw, Daniel Umereweneza, Monica M. Ndoile, Joan J. E. Munissi, Kari Rissanen, Edward Trybala, Tomas Bergstroem, Stephen S. Nyandoro, Mate Erdelyi
Summary: Two new modified ent-abietane diterpenoids, zanzibariolides A and B, and two known triterpenoids, simiarenol and fi-amyrin, were isolated from the leaf extract of Suregada zanzibariensis. The structures of these compounds were determined using NMR, MS, and X-ray crystallography. The crude extract showed inhibitory activity against HSV-2 and exhibited toxicity on GMK AH1 cells. However, the isolated compounds showed no anti-HSV-2 activity and showed insignificant toxicity against GMK AH1 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Phuc Van Hoang, Thy Dang Uyen Phan, Phuong Vu Quynh Duong, Anh Thi Van Tran, Khoi Tan Nguyen, Nam Van Ho Phan
Summary: This study developed a green method of ultrasound-assisted extraction coupled with gas bubble flotation for extracting fi-amyrin from Dischidia major. The solvent system used was water:ethanol (9:1) and cationic surfactants were employed to improve the adsorption of fi-amyrin onto the air/liquid interface during flotation. High-performance liquid chromatography with spectrophotometric detection was applied to quantify the fi-amyrin content in D. major and its extracts. The foam layer collected from flotation showed high selectivity toward fi-amyrin, and the product content increased significantly after removing surfactants from the solution.
Article
Biology
Panthita Ruang-areerate, Chaiwat Naktang, Wasitthee Kongkachana, Duangjai Sangsrakru, Nattapol Narong, Chatree Maknual, Tamanai Pravinvongvuthi, Waratthaya Promchoo, Suchart Yamprasai, Sithichoke Tangphatsornruang, Wirulda Pootakham
Summary: Through the utilization of 10x Genomics technology, the study obtained a whole-genome sequence of Rhizophora apiculata and identified a moderate genetic diversity and high genetic differentiation among populations along the coasts of Thailand. The analysis revealed two subpopulations corresponding to the Gulf of Thailand and the Andaman Sea, separated by the Malay Peninsula.
Article
Multidisciplinary Sciences
Jing Zhou, Zhao Feng, Wenfang Zhang, Jing Xu
Summary: Mangrove endophytic fungi have antimicrobial and antitumor potential, especially strains from R. stylosa and R. mucronata.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Ming-Sheng Chen, Fei-Na Li, Xiao-Hui Chen, Zi-Hao Huang, Xiao-Rui Yan, Li Tuo
Summary: A novel Gram-negative bacterium designated as Jiella mangrovi sp. nov. was isolated from the surface-sterilised leaf of Rhizophora stylosa collected from Shankou Mangrove Nature Reserve, Guangxi Zhuang Autonomous Region, China. The strain KSK16Y-1(T) exhibits unique characteristics and genomic information.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Yi-Chan Li, Su-Yuan Li, Tian-Hao Zhang, Lan-Li Qin, Yi-Dong An, Yu-Kun Pang, Guo-Feng Jiang
Summary: The chloroplast genome sequence of Rhizophora apiculata was characterized, revealing its specific gene structure and length, which can serve as a valuable tool for species identification and evolutionary studies.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Microbiology
Brendan P. Scherer, Olivia U. Mason, Austin R. Mast
Summary: Plant-associated microbial communities influence host evolution, but little is known about their taxonomic composition and variation across tissues and host range. This study explores the variation in bacterial communities of red mangrove trees and finds significant differences across tissue types and host populations.
FEMS MICROBIOLOGY ECOLOGY
(2022)
Article
Ecology
Masaya Yoshikai, Takashi Nakamura, Rempei Suwa, Sahadev Sharma, Rene Rollon, Jun Yasuoka, Ryohei Egawa, Kazuo Nadaoka
Summary: Soil salinity is an important environmental factor in mangrove forests, affecting productivity and tree competition. This study developed a model incorporating plant hydraulics to investigate the growth characteristics of mangroves under salt stress. The model predictions aligned with field data, highlighting the influence of salinity on mangrove forest structures.
Article
Construction & Building Technology
Nobuhito Mori, Che-Wei Chang, Tomomi Inoue, Yasuaki Akaji, Ko Hinokidani, Shigeyuki Baba, Masashi Takagi, Sotaro Mori, Hironoshin Koike, Miho Miyauchi, Ryosuke Suganuma, Audrius Sabunas, Takuya Miyashita, Tomoya Shimura
Summary: This study conducted field surveys and data analysis to find significant correlations between geometric properties parameters (such as DBH, tree height, and projected area of the root system) of mangroves and hydrodynamic modeling. These empirical relationships were summarized for numerical modeling.
FRONTIERS IN BUILT ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Amal H. Ahmed, Asmaa S. Abd Elkarim
Summary: The study aimed to identify and purify bioactive compounds from Bougainvillea spectabilis leaves extract and evaluate their activity against rheumatoid arthritis. Seven compounds isolated from the extract showed strong anti-rheumatoid arthritis activity.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Helena Pereira, Rita Simoes, Isabel Miranda
Summary: This study presents a detailed analysis of the chemical composition of the cuticular waxes and cutin in the leaves of Terminalia catappa, a widespread tropical species. The findings suggest that the leaves of T. catappa could be a potential source for the extraction of bioactive compounds due to their high proportion of specific chemical compounds.
Article
Biology
Sabah Hassan, Ahmed Atef, Hani M. Ali, Rahma Alshamrani, Ahmed Ramadan
Summary: The study examines the impact of sunlight and irrigation on p-amyrin production in C. procera and investigates the pathway involving eight key enzymes. The research reveals high expression levels of GPPS, FPPS, SS, SE, and BAS genes during midday. Additionally, it shows that the biosynthetic pathway in C. procera leads to the accumulation of p-amyrin with the highest level at midday.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Li-Hong Yan, Xiao-Ming Li, Lu-Ping Chi, Xin Li, Bin-Gui Wang
Summary: Six new metabolites and six known compounds were isolated and identified from a deep-sea sediment-derived fungus. The new metabolites showed inhibitory activities against bacteria and fungi.
Article
Biochemistry & Molecular Biology
Yanhe Li, Xiaoming Li, Xin Li, Suiqun Yang, Bingui Wang, Honglei Li
Summary: Six novel verrucosidin derivatives were isolated and identified from a deep-sea-derived fungus collected in the South China Sea. These compounds exhibited inhibitory activities against several human and aquatic pathogens, highlighting the scientific significance of studying deep-sea-derived fungi.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xue-Yi Hu, Xiao-Ming Li, Bin-Gui Wang, Ling-Hong Meng
Summary: Ten new tanzawaic acids and four known analogues were isolated from the endozoic fungus Penicillium steckii AS-324, obtained from a deep-sea coral. The structures of the new compounds were determined using NMR spectroscopy and mass spectrometry, and their activities against aquatic pathogenic bacteria were evaluated.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Xue-Yi Hu, Xiao-Ming Li, Bin-Gui Wang, Ling-Hong Meng
Summary: Four unusual steckwaic acids E-H along with new analogues and known congeners were isolated from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral. Their structures and configurations were determined using spectroscopic techniques. The compounds were tested for antimicrobial activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xue-Yi Hu, Xiao-Ming Li, Hui Liu, Bin-Gui Wang, Ling-Hong Meng
Summary: The transcriptome analysis of the algal endophytic fungus Penicillium chermesinum EN-480 revealed that fermentation in modified rice solid medium could lead to the production of new meroterpenoids with different structures compared to other media. These compounds showed antimicrobial activity against human- and aqua-bacteria as well as plant-pathogenic fungi. The study also discussed the possible biosynthesis pathway of these compounds.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yan-He Li, Sui-Qun Yang, Xiao-Ming Li, Xin Li, Bin-Gui Wang, Hong-Lei Li
Summary: This article reports the discovery of two novel biosynthetic related compounds, Cyclopiumolides A (1) and B (2), from the fungus Penicillium cyclopium SD-413 obtained from deep-sea sediments in the East China Sea. The structures of Cyclopiumolides A (1) and B (2) were determined through extensive NMR spectroscopic and mass spectrometric data analysis. Their relative and absolute configurations were determined using quantum mechanical calculations and NMR data calculations. Compounds 1 and 2 exhibited significant cytotoxic effects against tumor cell lines and molecular docking simulations were conducted to explore their inhibition modes and binding sites.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Qi Song, Sui-Qun Yang, Xiao-Ming Li, Xue-Yi Hu, Xin Li, Bin-Gui Wang
Summary: Five new aromatic polyketides, including a unique benzofuran derivative, talarominine A (1), and four chromone analogs talamins A-D (2-5), were isolated and identified from the endozoic fungus Talaromyces minioluteus CS-138 obtained from the deep-sea cold seep mussel Gigantidas platifrons. The chemical structures of these compounds were elucidated and their antibacterial and DPPH scavenging activities were evaluated, showing promising bioactivities. This work represents the first report on marine natural products of mussel-derived fungus living in cold seep environments.
Article
Oceanography
Feng-Yi Lv, Attila Mandi, Xiao-Ming Li, Lu-Ping Chi, Xin Li, Bin-Gui Wang, Tibor Kurtan, Ling-Hong Meng
Summary: Three new emestrin-type thiodiketopiperazines and three known analogues were isolated and identified from a fungus obtained from deep-sea cold seep sediment. Their structures and absolute configurations were determined by spectroscopic analysis and TDDFT-ECD calculations. Compounds 3-6 showed antimicrobial activity, while compounds 3-5 exhibited cytotoxic activity against tumor cells. Compound 4 demonstrated the strongest cytotoxic activity with an IC50 value of 0.25 μM, surpassing the positive control sorafenib.
DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
(2023)
Article
Biotechnology & Applied Microbiology
Zhen Ying, Xiao-Ming Li, Bin-Gui Wang, Hong-Lei Li, Ling-Hong Meng
Summary: A new steroid, rubensteroid A (1), with strong antibacterial activity, and its decarboxylic analogue, solitumergosterol A (2), were isolated and identified from the Magellan Seamount-derived fungus Penicillium rubens AS-130. The structure and absolute configuration of compound 1 were determined by detailed NMR spectroscopic analysis, mass spectrometry data, and TDDFT-ECD calculations. Rubensteroid A (1) showed potent antibacterial activity against Escherichia coli and Vibrio parahaemolyticus, with MIC values of 0.5 μg/mL.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Chemistry, Medicinal
Yu-Liang Dong, Xiao-Ming Li, Xiao-Shan Shi, Yi-Ran Wang, Bin-Gui Wang, Ling-Hong Meng
Summary: Two new quinazolinone diketopiperazine alkaloids were isolated from Aspergillus versicolor AS-212, an endozoic fungus associated with a deep-sea coral. Their chemical structures were determined through spectroscopic and X-ray crystallographic analysis. Compound 3 exhibited antibacterial activity against Aeromonas hydrophilia, while compounds 4 and 8 showed inhibitory effects against Vibrio harveyi and V. parahaemolyticus.
Article
Chemistry, Medicinal
Li-Hong Yan, Feng-Yu Du, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang, Xin Li
Summary: Five new antibacterial indole diketopiperazine alkaloids were isolated and characterized from a fungal strain of Aspergillus chevalieri derived from a deep-sea cold seep. These compounds showed inhibitory activities against several pathogenic bacteria, with compound 6 potentially being a novel alternative for antibiotic development.
Article
Oceanography
Xiao-Dan Chen, Sui-Qun Yang, Xiao-Ming Li, Bin-Gui Wang, Xin Li
Summary: Three new secondary metabolites, including a polyketide, an ascochlorin analogue, and a pair of enantiomers, along with nine known ascochlorins, were identified from a fungus isolated from deep-sea sediment samples. The structures were determined through NMR and mass spectrometric data interpretation. Compound 1 demonstrated potent activity against the human pathogenic bacterium Pseudomonas aeruginosa. The isolated ascochlorins also showed potent activities against aquatic bacteria, particularly Vibrio harveyi and V. alginolyticus.
DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
(2023)
Article
Biotechnology & Applied Microbiology
Ying Wang, Zhen Ying, Xiao-Ming Li, Sui-Qun Yang, Hong-Lei Li, Bin-Gui Wang, Ling-Hong Meng
Summary: Two new nonadride derivatives and one new depsidone derivative were identified from the fungus Talaromyces scorteus AS-242, isolated from the Magellan Seamount. These compounds showed potent antimicrobial activities against MRSA, V. parahaemolyticus, and pathogenic fungi, indicating their potential therapeutic effects.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Biotechnology & Applied Microbiology
Fan-Zhong Zhang, Xiao-Ming Li, Ling-Hong Meng, Bin-Gui Wang
Summary: Three new compounds and six known derivatives were isolated from a fungus obtained from a marine red alga. Their structures and stereochemistry were determined by various analytical methods. The antimicrobial activity of the compounds was evaluated, and one compound showed potent inhibition against several pathogenic bacteria.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Chemistry, Organic
Sui-Qun Yang, Qi Song, Xiao-Ming Li, Xin Li, Hong-Lei Li, Ling-Hong Meng, Bin-Gui Wang
Summary: Seven new highly oxygenated natural products, including glucosidic polyketides, aromatic polyketides, azaphilone polyketides, and a drimane sesquiterpene lactone, were isolated from a fungus obtained from deep-sea cold-seep sediments. Some compounds were enhanced minor components and compounds 3 and 4 might be produced by the activation of silent gene clusters triggered by SAHA. Compound 7 exhibited potent activities against agricultural pathogenic fungi. This study provides a useful strategy for activating cryptic fungal metabolites from deep-sea-derived fungi.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
